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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
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Results for TP73
Z-value: 0.83
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Transcription factors associated with TP73
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| TP73 | hg38_v1_chr1_+_3652565_3652585 | 0.56 | 3.1e-19 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of TP73
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 4.9 | 44.1 | GO:0001661 | conditioned taste aversion(GO:0001661) |
| 1.9 | 24.8 | GO:1900747 | negative regulation of vascular endothelial growth factor signaling pathway(GO:1900747) |
| 3.1 | 15.5 | GO:0071494 | cellular response to UV-C(GO:0071494) |
| 1.6 | 13.1 | GO:1900113 | negative regulation of histone H3-K9 trimethylation(GO:1900113) |
| 0.1 | 11.2 | GO:0002576 | platelet degranulation(GO:0002576) |
| 1.8 | 10.5 | GO:0034441 | plasma lipoprotein particle oxidation(GO:0034441) |
| 1.8 | 10.5 | GO:0035469 | determination of pancreatic left/right asymmetry(GO:0035469) |
| 0.5 | 8.6 | GO:0060670 | branching involved in labyrinthine layer morphogenesis(GO:0060670) |
| 0.5 | 8.4 | GO:0045792 | negative regulation of cell size(GO:0045792) |
| 0.4 | 8.2 | GO:0006853 | carnitine shuttle(GO:0006853) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 5.5 | 44.1 | GO:0035976 | AP1 complex(GO:0035976) |
| 1.2 | 15.8 | GO:0005589 | collagen type VI trimer(GO:0005589) collagen beaded filament(GO:0098647) |
| 0.2 | 14.0 | GO:0005930 | axoneme(GO:0005930) ciliary plasm(GO:0097014) |
| 0.6 | 13.1 | GO:0005721 | pericentric heterochromatin(GO:0005721) |
| 0.1 | 11.2 | GO:0031093 | platelet alpha granule lumen(GO:0031093) |
| 0.0 | 10.9 | GO:0005759 | mitochondrial matrix(GO:0005759) |
| 0.4 | 10.5 | GO:0034362 | low-density lipoprotein particle(GO:0034362) |
| 0.1 | 9.9 | GO:0032993 | protein-DNA complex(GO:0032993) |
| 0.1 | 9.0 | GO:0030175 | filopodium(GO:0030175) |
| 0.1 | 7.3 | GO:0036126 | sperm flagellum(GO:0036126) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.7 | 45.1 | GO:0001102 | RNA polymerase II activating transcription factor binding(GO:0001102) |
| 0.2 | 15.8 | GO:0050840 | extracellular matrix binding(GO:0050840) |
| 0.5 | 15.5 | GO:0003887 | DNA-directed DNA polymerase activity(GO:0003887) |
| 0.9 | 13.1 | GO:0051864 | histone demethylase activity (H3-K36 specific)(GO:0051864) |
| 0.2 | 11.9 | GO:0005544 | calcium-dependent phospholipid binding(GO:0005544) |
| 1.2 | 10.5 | GO:0047499 | 1-alkyl-2-acetylglycerophosphocholine esterase activity(GO:0003847) calcium-independent phospholipase A2 activity(GO:0047499) |
| 0.2 | 10.5 | GO:0070840 | dynein complex binding(GO:0070840) |
| 0.0 | 8.9 | GO:0000977 | RNA polymerase II regulatory region sequence-specific DNA binding(GO:0000977) |
| 0.1 | 8.6 | GO:0004867 | serine-type endopeptidase inhibitor activity(GO:0004867) |
| 2.7 | 8.2 | GO:0015226 | amino-acid betaine transmembrane transporter activity(GO:0015199) carnitine transmembrane transporter activity(GO:0015226) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.0 | 44.1 | PID TCR RAS PATHWAY | Ras signaling in the CD4+ TCR pathway |
| 0.1 | 17.5 | PID AR PATHWAY | Coregulation of Androgen receptor activity |
| 0.1 | 16.9 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.3 | 15.8 | NABA PROTEOGLYCANS | Genes encoding proteoglycans |
| 0.2 | 10.5 | PID LIS1 PATHWAY | Lissencephaly gene (LIS1) in neuronal migration and development |
| 0.1 | 8.4 | PID MTOR 4PATHWAY | mTOR signaling pathway |
| 0.4 | 7.5 | PID INTEGRIN4 PATHWAY | Alpha6 beta4 integrin-ligand interactions |
| 0.1 | 7.2 | PID ATF2 PATHWAY | ATF-2 transcription factor network |
| 0.1 | 6.8 | PID CDC42 REG PATHWAY | Regulation of CDC42 activity |
| 0.5 | 6.7 | SA G2 AND M PHASES | Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition. |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.6 | 44.1 | REACTOME ACTIVATION OF THE AP1 FAMILY OF TRANSCRIPTION FACTORS | Genes involved in Activation of the AP-1 family of transcription factors |
| 0.8 | 21.2 | REACTOME CS DS DEGRADATION | Genes involved in CS/DS degradation |
| 0.1 | 15.5 | REACTOME DNA REPAIR | Genes involved in DNA Repair |
| 0.6 | 10.5 | REACTOME SYNTHESIS SECRETION AND DEACYLATION OF GHRELIN | Genes involved in Synthesis, Secretion, and Deacylation of Ghrelin |
| 0.1 | 9.9 | REACTOME MYOGENESIS | Genes involved in Myogenesis |
| 0.1 | 9.7 | REACTOME PEPTIDE CHAIN ELONGATION | Genes involved in Peptide chain elongation |
| 0.3 | 8.2 | REACTOME ACTIVATED AMPK STIMULATES FATTY ACID OXIDATION IN MUSCLE | Genes involved in Activated AMPK stimulates fatty-acid oxidation in muscle |
| 0.1 | 7.5 | REACTOME INTEGRIN CELL SURFACE INTERACTIONS | Genes involved in Integrin cell surface interactions |
| 0.1 | 6.8 | REACTOME NRAGE SIGNALS DEATH THROUGH JNK | Genes involved in NRAGE signals death through JNK |
| 0.3 | 6.7 | REACTOME AKT PHOSPHORYLATES TARGETS IN THE CYTOSOL | Genes involved in AKT phosphorylates targets in the cytosol |