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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)

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Results for TP73

Z-value: 0.83

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Transcription factors associated with TP73

Gene Symbol Gene ID Gene Info
TP73
ENSG00000078900.15 TP73

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
TP73hg38_v1_chr1_+_3652565_36525850.563.1e-19Click!

Activity profile of TP73 motif

Sorted Z-values of TP73 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of TP73

PNG image of the network

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Top targets:

Promoter Score Transcript Gene Gene Info
chr14_+_75279637 22.73 ENST00000555686.1
ENST00000555672.1
FOS
Fos proto-oncogene, AP-1 transcription factor subunit
chr14_+_75278820 21.38 ENST00000554617.1
ENST00000554212.5
ENST00000535987.5
ENST00000303562.9
ENST00000555242.1
FOS
Fos proto-oncogene, AP-1 transcription factor subunit
chr12_-_91179472 15.84 ENST00000550099.5
ENST00000546391.5
DCN
decorin
chr1_-_34859717 14.52 ENST00000423898.1
ENST00000521580.3
ENST00000456842.1
SMIM12
small integral membrane protein 12
chr15_+_74174403 11.15 ENST00000560862.1
ENST00000395118.1
ISLR
immunoglobulin superfamily containing leucine rich repeat
chr16_+_84145256 10.51 ENST00000378553.10
DNAAF1
dynein axonemal assembly factor 1
chr4_+_105710809 9.25 ENST00000360505.9
ENST00000510865.5
ENST00000509336.5
GSTCD
glutathione S-transferase C-terminal domain containing
chr15_+_40844018 8.60 ENST00000344051.8
ENST00000562057.6
SPINT1
serine peptidase inhibitor, Kunitz type 1
chr8_+_119873710 8.41 ENST00000523492.5
ENST00000286234.6
DEPTOR
DEP domain containing MTOR interacting protein
chr3_-_48898813 8.21 ENST00000319017.5
ENST00000430379.5
SLC25A20
solute carrier family 25 member 20
chr6_+_43576119 8.06 ENST00000372236.9
POLH
DNA polymerase eta
chr17_+_75754618 7.46 ENST00000584939.1
ITGB4
integrin subunit beta 4
chr6_+_43576205 7.44 ENST00000372226.1
ENST00000443535.1
POLH
DNA polymerase eta
chrX_-_38327496 7.27 ENST00000642395.2
ENST00000645032.1
ENST00000644238.1
ENST00000642558.1
ENST00000339363.7
ENST00000644337.1
ENST00000647261.1
RPGR
retinitis pigmentosa GTPase regulator
chr9_+_6757633 7.19 ENST00000401787.7
ENST00000381306.7
KDM4C
lysine demethylase 4C
chr11_-_236821 7.16 ENST00000529382.5
ENST00000528469.1
SIRT3
sirtuin 3
chr4_+_38664189 7.02 ENST00000514033.1
ENST00000261438.10
KLF3
Kruppel like factor 3
chr11_+_60429595 6.94 ENST00000528905.1
ENST00000528093.1
MS4A5
membrane spanning 4-domains A5
chr3_+_50205254 6.54 ENST00000614032.5
ENST00000445096.5
SLC38A3
solute carrier family 38 member 3
chr11_+_60429567 6.52 ENST00000300190.7
MS4A5
membrane spanning 4-domains A5
chr2_+_89884740 6.45 ENST00000509129.1
IGKV1D-37
immunoglobulin kappa variable 1D-37 (non-functional)
chr6_-_46735351 6.42 ENST00000274793.12
PLA2G7
phospholipase A2 group VII
chr12_+_49295138 6.14 ENST00000257860.9
PRPH
peripherin
chr2_+_219418369 5.99 ENST00000373960.4
DES
desmin
chr9_+_6757940 5.90 ENST00000381309.8
KDM4C
lysine demethylase 4C
chr10_-_103452356 5.55 ENST00000260743.10
CALHM2
calcium homeostasis modulator family member 2
chr10_+_46375721 5.49 ENST00000616785.1
ENST00000611655.1
ENST00000619162.5
ENSG00000285402.1
ANXA8L1
novel transcript
annexin A8 like 1
chr1_-_203086001 5.47 ENST00000241651.5
MYOG
myogenin
chr3_-_50303565 5.38 ENST00000266031.8
ENST00000395143.6
ENST00000457214.6
ENST00000447605.2
ENST00000395144.7
ENST00000418723.1
HYAL1
hyaluronidase 1
chr14_+_52314280 5.27 ENST00000557436.1
ENST00000245457.6
PTGER2
prostaglandin E receptor 2
chr10_+_46375645 5.25 ENST00000622769.4
ANXA8L1
annexin A8 like 1
chr10_+_46375619 5.18 ENST00000584982.7
ENST00000613703.4
ANXA8L1
annexin A8 like 1
chr8_+_37796850 5.07 ENST00000412232.3
ADGRA2
adhesion G protein-coupled receptor A2
chr22_-_37580075 5.04 ENST00000215886.6
LGALS2
galectin 2
chr12_-_116881431 5.04 ENST00000257572.5
HRK
harakiri, BCL2 interacting protein
chr10_-_103452384 4.95 ENST00000369788.7
CALHM2
calcium homeostasis modulator family member 2
chr8_+_62248840 4.47 ENST00000675749.1
ENST00000674746.1
ENST00000623646.3
ENST00000674864.1
NKAIN3
sodium/potassium transporting ATPase interacting 3
chr2_-_229271221 4.35 ENST00000392054.7
ENST00000409462.1
ENST00000392055.8
PID1
phosphotyrosine interaction domain containing 1
chr19_+_35106510 4.28 ENST00000648240.1
ENSG00000285526.1
novel protein
chr1_-_236065079 4.13 ENST00000264187.7
ENST00000366595.7
NID1
nidogen 1
chr6_-_46735693 4.12 ENST00000537365.1
PLA2G7
phospholipase A2 group VII
chr19_+_41860236 3.90 ENST00000601492.5
ENST00000600467.6
ENST00000598742.6
ENST00000221975.6
ENST00000598261.2
RPS19
ribosomal protein S19
chr8_+_37796906 3.89 ENST00000315215.11
ADGRA2
adhesion G protein-coupled receptor A2
chr12_-_56488153 3.74 ENST00000311966.9
GLS2
glutaminase 2
chr4_+_6269869 3.68 ENST00000506362.2
WFS1
wolframin ER transmembrane glycoprotein
chr6_+_36676455 3.63 ENST00000615513.4
CDKN1A
cyclin dependent kinase inhibitor 1A
chr11_+_46277648 3.60 ENST00000621158.5
CREB3L1
cAMP responsive element binding protein 3 like 1
chr10_-_89535575 3.58 ENST00000371790.5
SLC16A12
solute carrier family 16 member 12
chr17_+_32928126 3.56 ENST00000579849.6
ENST00000578289.5
ENST00000439138.5
TMEM98
transmembrane protein 98
chr3_-_48088800 3.51 ENST00000423088.5
MAP4
microtubule associated protein 4
chr19_+_17215716 3.50 ENST00000593597.1
USE1
unconventional SNARE in the ER 1
chr11_+_24497155 3.48 ENST00000529015.5
ENST00000533227.5
LUZP2
leucine zipper protein 2
chr20_+_59940362 3.48 ENST00000360816.8
FAM217B
family with sequence similarity 217 member B
chr1_+_155173787 3.35 ENST00000392451.6
ENST00000545012.5
ENST00000334634.9
ENST00000368385.8
ENST00000543729.5
ENST00000368383.7
ENST00000368382.5
TRIM46
tripartite motif containing 46
chrX_+_153642473 3.20 ENST00000370167.8
DUSP9
dual specificity phosphatase 9
chr1_+_26159071 3.15 ENST00000374268.5
FAM110D
family with sequence similarity 110 member D
chr1_-_153615858 3.14 ENST00000476873.5
S100A14
S100 calcium binding protein A14
chr6_+_36676489 3.03 ENST00000448526.6
CDKN1A
cyclin dependent kinase inhibitor 1A
chrX_-_139642835 3.02 ENST00000536274.5
MCF2
MCF.2 cell line derived transforming sequence
chr17_-_76027212 3.01 ENST00000586740.1
EVPL
envoplakin
chr3_-_66038537 3.00 ENST00000483466.5
MAGI1
membrane associated guanylate kinase, WW and PDZ domain containing 1
chr12_+_43758936 2.95 ENST00000440781.6
ENST00000431837.5
ENST00000550616.5
ENST00000613694.5
ENST00000551736.5
IRAK4
interleukin 1 receptor associated kinase 4
chr6_+_31547560 2.69 ENST00000376148.9
ENST00000376145.8
NFKBIL1
NFKB inhibitor like 1
chr9_-_135499846 2.62 ENST00000429260.7
C9orf116
chromosome 9 open reading frame 116
chrX_-_139642889 2.61 ENST00000370576.9
MCF2
MCF.2 cell line derived transforming sequence
chr19_+_43716070 2.58 ENST00000244314.6
IRGC
immunity related GTPase cinema
chr18_-_55586092 2.52 ENST00000563888.6
ENST00000540999.5
ENST00000627685.2
TCF4
transcription factor 4
chr6_-_33289189 2.39 ENST00000374617.9
WDR46
WD repeat domain 46
chr14_-_89954659 2.32 ENST00000555070.1
ENST00000316738.12
ENST00000538485.6
ENST00000556609.5
ENSG00000259053.1
EFCAB11
novel transcript
EF-hand calcium binding domain 11
chr19_+_3721719 2.28 ENST00000589378.5
TJP3
tight junction protein 3
chr9_+_36169382 2.25 ENST00000335119.4
CCIN
calicin
chr16_-_8797624 2.22 ENST00000333050.7
TMEM186
transmembrane protein 186
chr10_-_97426044 2.19 ENST00000536831.5
ENST00000622320.4
ENST00000439965.6
RRP12
ribosomal RNA processing 12 homolog
chr13_+_50910018 2.16 ENST00000645990.1
ENST00000642995.1
ENST00000636524.2
ENST00000643159.1
ENST00000645618.1
ENST00000611510.5
ENST00000642454.1
ENST00000646709.1
RNASEH2B
ribonuclease H2 subunit B
chr22_+_39570753 2.14 ENST00000407673.5
ENST00000401624.5
ENST00000404898.5
ENST00000402142.4
CACNA1I
calcium voltage-gated channel subunit alpha1 I
chr17_+_20009320 2.14 ENST00000679049.1
ENST00000472876.5
ENST00000583528.6
ENST00000680019.1
ENST00000681593.1
ENST00000395527.8
ENST00000583482.7
ENST00000679255.1
ENST00000681202.1
ENST00000677914.1
SPECC1
sperm antigen with calponin homology and coiled-coil domains 1
chr18_-_4455257 2.11 ENST00000581527.5
DLGAP1
DLG associated protein 1
chr2_+_176116768 1.98 ENST00000249501.5
HOXD10
homeobox D10
chr14_-_100569780 1.98 ENST00000355173.7
BEGAIN
brain enriched guanylate kinase associated
chr7_-_100896123 1.93 ENST00000428317.7
ACHE
acetylcholinesterase (Cartwright blood group)
chr16_+_8797813 1.91 ENST00000268261.9
ENST00000569958.5
PMM2
phosphomannomutase 2
chr17_+_39200302 1.87 ENST00000579374.5
RPL19
ribosomal protein L19
chr18_-_55585773 1.86 ENST00000563824.5
ENST00000626425.2
ENST00000566514.5
ENST00000568673.5
ENST00000562847.5
ENST00000568147.5
TCF4
transcription factor 4
chr1_-_160862880 1.85 ENST00000368034.9
CD244
CD244 molecule
chr16_+_56191728 1.84 ENST00000638705.1
ENST00000262494.12
GNAO1
G protein subunit alpha o1
chr17_+_74431338 1.84 ENST00000342648.9
ENST00000652232.1
ENST00000481232.2
GPRC5C
G protein-coupled receptor class C group 5 member C
chr17_+_39200275 1.76 ENST00000225430.9
RPL19
ribosomal protein L19
chr17_+_39200334 1.67 ENST00000579260.5
ENST00000582193.5
RPL19
ribosomal protein L19
chr10_-_60141004 1.63 ENST00000355288.6
ANK3
ankyrin 3
chr14_+_71933116 1.60 ENST00000553530.5
ENST00000556437.5
RGS6
regulator of G protein signaling 6
chr2_+_113406368 1.55 ENST00000453673.3
IGKV1OR2-108
immunoglobulin kappa variable 1/OR2-108 (non-functional)
chr14_+_103385374 1.52 ENST00000678179.1
ENST00000676938.1
ENST00000678619.1
ENST00000440884.7
ENST00000560417.6
ENST00000679330.1
ENST00000556744.2
ENST00000676897.1
ENST00000677560.1
ENST00000561314.6
ENST00000677829.1
ENST00000677133.1
ENST00000676645.1
ENST00000678175.1
ENST00000429436.7
ENST00000677360.1
ENST00000678237.1
ENST00000677347.1
ENST00000677432.1
MARK3
microtubule affinity regulating kinase 3
chr5_-_11904417 1.49 ENST00000304623.13
CTNND2
catenin delta 2
chr3_+_42160160 1.48 ENST00000341421.7
ENST00000396175.5
TRAK1
trafficking kinesin protein 1
chr17_-_42683057 1.45 ENST00000591765.1
CCR10
C-C motif chemokine receptor 10
chr1_-_77979054 1.45 ENST00000370768.7
ENST00000370767.5
ENST00000421641.1
FUBP1
far upstream element binding protein 1
chr18_+_13277351 1.36 ENST00000679091.1
LDLRAD4
low density lipoprotein receptor class A domain containing 4
chr19_+_12995554 1.36 ENST00000397661.6
NFIX
nuclear factor I X
chr1_+_16043736 1.36 ENST00000619181.4
CLCNKB
chloride voltage-gated channel Kb
chr16_+_12901591 1.34 ENST00000558583.3
SHISA9
shisa family member 9
chr22_+_35383106 1.33 ENST00000678411.1
HMOX1
heme oxygenase 1
chr14_+_103385450 1.30 ENST00000416682.6
MARK3
microtubule affinity regulating kinase 3
chr1_-_204190324 1.29 ENST00000638118.1
REN
renin
chrX_-_139642518 1.19 ENST00000370573.8
ENST00000338585.6
MCF2
MCF.2 cell line derived transforming sequence
chr1_+_100352925 1.16 ENST00000644813.1
CDC14A
cell division cycle 14A
chr14_-_24576240 1.16 ENST00000216336.3
CTSG
cathepsin G
chrX_+_73447042 1.02 ENST00000373514.3
CDX4
caudal type homeobox 4
chr13_+_48303709 1.01 ENST00000646097.1
ENST00000650461.1
ENST00000267163.6
RB1
RB transcriptional corepressor 1
chr15_+_75206398 0.97 ENST00000565074.1
C15orf39
chromosome 15 open reading frame 39
chr17_-_76027296 0.88 ENST00000301607.8
EVPL
envoplakin
chr10_-_95441015 0.81 ENST00000371241.5
ENST00000354106.7
ENST00000371239.5
ENST00000361941.7
ENST00000277982.9
ENST00000371245.7
SORBS1
sorbin and SH3 domain containing 1
chr9_-_114505437 0.78 ENST00000374057.3
ENST00000362057.4
ENST00000673697.1
WHRN
whirlin
chr2_+_219572304 0.73 ENST00000243786.3
INHA
inhibin subunit alpha
chr16_+_56191476 0.65 ENST00000262493.12
GNAO1
G protein subunit alpha o1
chr19_+_43716095 0.64 ENST00000596627.1
IRGC
immunity related GTPase cinema
chr14_+_103385506 0.62 ENST00000303622.13
MARK3
microtubule affinity regulating kinase 3
chr20_+_41136944 0.61 ENST00000244007.7
PLCG1
phospholipase C gamma 1
chr16_+_89918855 0.52 ENST00000555147.2
MC1R
melanocortin 1 receptor
chr17_+_39200507 0.51 ENST00000678573.1
RPL19
ribosomal protein L19
chr2_-_165794190 0.50 ENST00000392701.8
ENST00000422973.1
GALNT3
polypeptide N-acetylgalactosaminyltransferase 3
chr1_+_16043776 0.48 ENST00000375679.9
CLCNKB
chloride voltage-gated channel Kb
chr1_-_51878799 0.48 ENST00000354831.11
ENST00000544028.5
NRDC
nardilysin convertase
chr16_-_67966793 0.39 ENST00000541864.6
SLC12A4
solute carrier family 12 member 4
chr14_+_104699368 0.32 ENST00000675207.1
INF2
inverted formin 2
chr1_-_68232539 0.29 ENST00000370976.7
ENST00000354777.6
WLS
Wnt ligand secretion mediator
chr15_+_75206014 0.27 ENST00000567617.1
C15orf39
chromosome 15 open reading frame 39
chr1_-_68232514 0.27 ENST00000262348.9
ENST00000370973.2
ENST00000370971.1
WLS
Wnt ligand secretion mediator
chr16_+_4958289 0.26 ENST00000251170.12
SEC14L5
SEC14 like lipid binding 5
chr9_+_35673917 0.24 ENST00000617161.1
ENST00000378357.9
CA9
carbonic anhydrase 9
chr11_+_119149029 0.13 ENST00000619701.5
ABCG4
ATP binding cassette subfamily G member 4
chr16_-_2531408 0.10 ENST00000567119.1
ENST00000565480.1
CEMP1
cementum protein 1
chr3_-_48088824 0.01 ENST00000439356.2
ENST00000395734.7
ENST00000426837.6
MAP4
microtubule associated protein 4

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
4.9 44.1 GO:0001661 conditioned taste aversion(GO:0001661)
3.1 15.5 GO:0071494 cellular response to UV-C(GO:0071494)
2.2 6.5 GO:0051365 cellular response to potassium ion starvation(GO:0051365)
1.9 24.8 GO:1900747 negative regulation of vascular endothelial growth factor signaling pathway(GO:1900747)
1.8 5.5 GO:0014878 response to muscle activity involved in regulation of muscle adaptation(GO:0014873) response to electrical stimulus involved in regulation of muscle adaptation(GO:0014878)
1.8 10.5 GO:0034441 plasma lipoprotein particle oxidation(GO:0034441)
1.8 10.5 GO:0035469 determination of pancreatic left/right asymmetry(GO:0035469)
1.6 13.1 GO:1900113 negative regulation of histone H3-K9 trimethylation(GO:1900113)
1.4 4.3 GO:1901859 positive regulation of fat cell proliferation(GO:0070346) negative regulation of mitochondrial DNA replication(GO:0090298) negative regulation of mitochondrial DNA metabolic process(GO:1901859)
1.3 5.4 GO:1900106 hyaluranon cable assembly(GO:0036118) regulation of hyaluranon cable assembly(GO:1900104) positive regulation of hyaluranon cable assembly(GO:1900106)
1.3 3.9 GO:0060266 negative regulation of respiratory burst involved in inflammatory response(GO:0060266)
1.2 3.7 GO:1903892 negative regulation of ATF6-mediated unfolded protein response(GO:1903892)
0.7 6.7 GO:0060574 intestinal epithelial cell maturation(GO:0060574)
0.6 3.7 GO:0006543 glutamine catabolic process(GO:0006543)
0.6 1.8 GO:2000566 positive regulation of CD8-positive, alpha-beta T cell proliferation(GO:2000566)
0.6 3.6 GO:0070278 extracellular matrix constituent secretion(GO:0070278)
0.6 7.2 GO:0034983 peptidyl-lysine deacetylation(GO:0034983)
0.6 3.5 GO:0051012 microtubule sliding(GO:0051012)
0.5 8.4 GO:0045792 negative regulation of cell size(GO:0045792)
0.5 7.5 GO:0035878 nail development(GO:0035878)
0.5 1.9 GO:0009298 GDP-mannose biosynthetic process(GO:0009298)
0.5 8.6 GO:0060670 branching involved in labyrinthine layer morphogenesis(GO:0060670)
0.4 1.6 GO:0072660 maintenance of protein location in membrane(GO:0072658) maintenance of protein location in plasma membrane(GO:0072660) positive regulation of membrane depolarization during cardiac muscle cell action potential(GO:1900827)
0.4 1.2 GO:0032223 negative regulation of synaptic transmission, cholinergic(GO:0032223) neurotransmitter receptor biosynthetic process(GO:0045212)
0.4 8.2 GO:0006853 carnitine shuttle(GO:0006853)
0.4 1.5 GO:0098957 anterograde axonal transport of mitochondrion(GO:0098957)
0.3 1.0 GO:0034085 establishment of sister chromatid cohesion(GO:0034085) cohesin loading(GO:0071921) regulation of cohesin loading(GO:0071922)
0.3 1.3 GO:0032764 smooth muscle hyperplasia(GO:0014806) negative regulation of mast cell cytokine production(GO:0032764)
0.3 4.1 GO:0032836 glomerular basement membrane development(GO:0032836)
0.2 0.7 GO:0045578 negative regulation of B cell differentiation(GO:0045578)
0.2 6.0 GO:0045109 intermediate filament organization(GO:0045109)
0.2 2.2 GO:0035331 negative regulation of hippo signaling(GO:0035331)
0.2 1.3 GO:0002018 renin-angiotensin regulation of aldosterone production(GO:0002018)
0.2 5.3 GO:0071380 cellular response to prostaglandin E stimulus(GO:0071380)
0.2 3.3 GO:0099612 protein localization to axon(GO:0099612)
0.2 5.0 GO:0032464 positive regulation of protein homooligomerization(GO:0032464)
0.2 0.6 GO:0061357 positive regulation of Wnt protein secretion(GO:0061357)
0.2 2.0 GO:0021520 spinal cord motor neuron cell fate specification(GO:0021520)
0.2 3.1 GO:0090026 positive regulation of monocyte chemotaxis(GO:0090026)
0.1 2.7 GO:0031665 negative regulation of lipopolysaccharide-mediated signaling pathway(GO:0031665)
0.1 3.0 GO:0034162 toll-like receptor 9 signaling pathway(GO:0034162)
0.1 1.2 GO:0070942 neutrophil mediated cytotoxicity(GO:0070942) neutrophil mediated killing of symbiont cell(GO:0070943) neutrophil mediated killing of bacterium(GO:0070944)
0.1 5.8 GO:0097421 liver regeneration(GO:0097421)
0.1 7.3 GO:0042073 intraciliary transport(GO:0042073)
0.1 0.5 GO:0018242 protein O-linked glycosylation via serine(GO:0018242)
0.1 3.9 GO:0018149 peptide cross-linking(GO:0018149)
0.1 1.4 GO:0010991 negative regulation of SMAD protein complex assembly(GO:0010991)
0.1 2.2 GO:2000001 regulation of DNA damage checkpoint(GO:2000001)
0.1 3.6 GO:0072337 modified amino acid transport(GO:0072337)
0.1 1.3 GO:0048172 regulation of short-term neuronal synaptic plasticity(GO:0048172)
0.1 3.2 GO:0000188 inactivation of MAPK activity(GO:0000188)
0.1 1.2 GO:0051256 mitotic spindle midzone assembly(GO:0051256)
0.1 2.1 GO:0045956 positive regulation of calcium ion-dependent exocytosis(GO:0045956)
0.1 2.4 GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000462)
0.1 0.5 GO:0090037 positive regulation of protein kinase C signaling(GO:0090037)
0.1 0.8 GO:0045725 positive regulation of glycogen biosynthetic process(GO:0045725)
0.1 2.5 GO:0043278 response to isoquinoline alkaloid(GO:0014072) response to morphine(GO:0043278)
0.1 11.2 GO:0002576 platelet degranulation(GO:0002576)
0.0 8.0 GO:0002377 immunoglobulin production(GO:0002377)
0.0 6.9 GO:1990830 response to leukemia inhibitory factor(GO:1990823) cellular response to leukemia inhibitory factor(GO:1990830)
0.0 0.8 GO:0060122 inner ear receptor stereocilium organization(GO:0060122)
0.0 1.8 GO:1903959 regulation of anion transmembrane transport(GO:1903959)
0.0 3.5 GO:0006890 retrograde vesicle-mediated transport, Golgi to ER(GO:0006890)
0.0 4.5 GO:0002028 regulation of sodium ion transport(GO:0002028)
0.0 1.0 GO:0009948 anterior/posterior axis specification(GO:0009948)
0.0 0.6 GO:0043536 positive regulation of blood vessel endothelial cell migration(GO:0043536)
0.0 1.5 GO:0060997 dendritic spine morphogenesis(GO:0060997)
0.0 0.4 GO:0006884 cell volume homeostasis(GO:0006884)
0.0 1.4 GO:0070098 chemokine-mediated signaling pathway(GO:0070098)
0.0 5.6 GO:1901653 cellular response to peptide(GO:1901653)
0.0 0.3 GO:0090140 regulation of mitochondrial fission(GO:0090140)
0.0 3.3 GO:0006367 transcription initiation from RNA polymerase II promoter(GO:0006367)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
5.5 44.1 GO:0035976 AP1 complex(GO:0035976)
1.3 6.7 GO:0070557 PCNA-p21 complex(GO:0070557)
1.2 15.8 GO:0005589 collagen type VI trimer(GO:0005589) collagen beaded filament(GO:0098647)
0.7 2.2 GO:0033011 perinuclear theca(GO:0033011) cytoskeletal calyx(GO:0033150)
0.6 13.1 GO:0005721 pericentric heterochromatin(GO:0005721)
0.6 3.3 GO:1990769 proximal neuron projection(GO:1990769)
0.4 2.2 GO:0032299 ribonuclease H2 complex(GO:0032299)
0.4 10.5 GO:0034362 low-density lipoprotein particle(GO:0034362)
0.4 6.0 GO:0097512 cardiac myofibril(GO:0097512)
0.3 1.0 GO:0035189 Rb-E2F complex(GO:0035189)
0.3 6.0 GO:0030056 hemidesmosome(GO:0030056)
0.2 0.7 GO:0043511 inhibin complex(GO:0043511) inhibin A complex(GO:0043512)
0.2 0.8 GO:0005899 insulin receptor complex(GO:0005899)
0.2 1.2 GO:0060091 kinocilium(GO:0060091)
0.2 14.0 GO:0005930 axoneme(GO:0005930) ciliary plasm(GO:0097014)
0.1 3.9 GO:0030057 desmosome(GO:0030057)
0.1 5.3 GO:0005605 basal lamina(GO:0005605)
0.1 11.2 GO:0031093 platelet alpha granule lumen(GO:0031093)
0.1 7.3 GO:0036126 sperm flagellum(GO:0036126)
0.1 2.4 GO:0030686 90S preribosome(GO:0030686)
0.1 1.6 GO:0043194 axon initial segment(GO:0043194)
0.1 9.0 GO:0030175 filopodium(GO:0030175)
0.1 1.3 GO:0032591 dendritic spine membrane(GO:0032591)
0.1 4.1 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.1 3.9 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
0.1 5.8 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
0.1 9.9 GO:0032993 protein-DNA complex(GO:0032993)
0.0 5.4 GO:0043202 lysosomal lumen(GO:0043202)
0.0 2.1 GO:0005891 voltage-gated calcium channel complex(GO:0005891)
0.0 1.5 GO:1904115 axon cytoplasm(GO:1904115)
0.0 0.8 GO:0032420 stereocilium(GO:0032420)
0.0 0.6 GO:0032590 dendrite membrane(GO:0032590)
0.0 1.8 GO:0034707 chloride channel complex(GO:0034707)
0.0 10.9 GO:0005759 mitochondrial matrix(GO:0005759)
0.0 2.4 GO:0005882 intermediate filament(GO:0005882)
0.0 2.8 GO:0005923 bicellular tight junction(GO:0005923)
0.0 1.2 GO:0010494 cytoplasmic stress granule(GO:0010494)
0.0 2.0 GO:0000932 cytoplasmic mRNA processing body(GO:0000932)
0.0 0.2 GO:0031528 microvillus membrane(GO:0031528)
0.0 1.3 GO:0005901 caveola(GO:0005901)
0.0 0.6 GO:0008180 COP9 signalosome(GO:0008180)
0.0 1.5 GO:0043204 perikaryon(GO:0043204)
0.0 3.7 GO:0005788 endoplasmic reticulum lumen(GO:0005788)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
2.7 8.2 GO:0015226 amino-acid betaine transmembrane transporter activity(GO:0015199) carnitine transmembrane transporter activity(GO:0015226)
1.8 5.4 GO:0050501 hyaluronan synthase activity(GO:0050501)
1.3 6.7 GO:0019912 cyclin-dependent protein kinase activating kinase activity(GO:0019912)
1.3 6.5 GO:0022858 L-alanine transmembrane transporter activity(GO:0015180) alanine transmembrane transporter activity(GO:0022858) azole transmembrane transporter activity(GO:1901474)
1.2 10.5 GO:0047499 1-alkyl-2-acetylglycerophosphocholine esterase activity(GO:0003847) calcium-independent phospholipase A2 activity(GO:0047499)
1.2 5.8 GO:0070180 large ribosomal subunit rRNA binding(GO:0070180)
1.0 5.0 GO:0016936 galactoside binding(GO:0016936)
0.9 13.1 GO:0051864 histone demethylase activity (H3-K36 specific)(GO:0051864)
0.7 45.1 GO:0001102 RNA polymerase II activating transcription factor binding(GO:0001102)
0.7 4.1 GO:0043237 laminin-1 binding(GO:0043237)
0.6 3.7 GO:0004359 glutaminase activity(GO:0004359)
0.6 7.5 GO:0038132 neuregulin binding(GO:0038132)
0.5 5.3 GO:0004957 prostaglandin E receptor activity(GO:0004957)
0.5 15.5 GO:0003887 DNA-directed DNA polymerase activity(GO:0003887)
0.4 2.1 GO:0008332 low voltage-gated calcium channel activity(GO:0008332)
0.3 7.2 GO:0070403 NAD+ binding(GO:0070403)
0.3 1.2 GO:0003990 acetylcholinesterase activity(GO:0003990)
0.3 1.3 GO:0004392 heme oxygenase (decyclizing) activity(GO:0004392)
0.3 3.6 GO:0035497 cAMP response element binding(GO:0035497)
0.2 10.5 GO:0070840 dynein complex binding(GO:0070840)
0.2 3.9 GO:0019215 intermediate filament binding(GO:0019215)
0.2 3.2 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017)
0.2 15.8 GO:0050840 extracellular matrix binding(GO:0050840)
0.2 4.4 GO:0001011 transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, TFIIB-class binding(GO:0001087)
0.2 3.6 GO:0072349 modified amino acid transmembrane transporter activity(GO:0072349)
0.2 2.2 GO:0004523 RNA-DNA hybrid ribonuclease activity(GO:0004523)
0.2 11.9 GO:0005544 calcium-dependent phospholipid binding(GO:0005544)
0.2 3.0 GO:0005149 interleukin-1 receptor binding(GO:0005149)
0.2 0.5 GO:0004980 melanocyte-stimulating hormone receptor activity(GO:0004980)
0.2 2.5 GO:0031821 G-protein coupled serotonin receptor binding(GO:0031821)
0.1 1.9 GO:0016868 intramolecular transferase activity, phosphotransferases(GO:0016868)
0.1 5.5 GO:0070888 E-box binding(GO:0070888)
0.1 3.9 GO:0017134 fibroblast growth factor binding(GO:0017134)
0.1 1.8 GO:0005247 voltage-gated chloride channel activity(GO:0005247)
0.1 0.7 GO:0034711 inhibin binding(GO:0034711)
0.1 8.6 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.1 1.4 GO:0016493 C-C chemokine receptor activity(GO:0016493)
0.1 1.5 GO:0050811 GABA receptor binding(GO:0050811)
0.1 3.7 GO:0033613 activating transcription factor binding(GO:0033613)
0.1 3.0 GO:0051393 alpha-actinin binding(GO:0051393)
0.1 1.8 GO:0042288 MHC class I protein binding(GO:0042288)
0.1 6.8 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.1 3.1 GO:0042379 chemokine receptor binding(GO:0042379)
0.0 0.6 GO:0005168 neurotrophin TRKA receptor binding(GO:0005168)
0.0 1.3 GO:0070001 aspartic-type endopeptidase activity(GO:0004190) aspartic-type peptidase activity(GO:0070001)
0.0 0.5 GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity(GO:0004653)
0.0 0.1 GO:0034041 sterol-transporting ATPase activity(GO:0034041)
0.0 0.4 GO:0022820 potassium:chloride symporter activity(GO:0015379) potassium ion symporter activity(GO:0022820)
0.0 0.6 GO:0031852 mu-type opioid receptor binding(GO:0031852)
0.0 1.2 GO:0008138 protein tyrosine/serine/threonine phosphatase activity(GO:0008138)
0.0 1.6 GO:0030507 spectrin binding(GO:0030507)
0.0 1.4 GO:0070412 R-SMAD binding(GO:0070412)
0.0 0.8 GO:0005158 insulin receptor binding(GO:0005158)
0.0 2.5 GO:0005200 structural constituent of cytoskeleton(GO:0005200)
0.0 5.4 GO:0005085 guanyl-nucleotide exchange factor activity(GO:0005085)
0.0 0.2 GO:0004089 carbonate dehydratase activity(GO:0004089)
0.0 1.3 GO:0030165 PDZ domain binding(GO:0030165)
0.0 1.4 GO:0003705 transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0003705)
0.0 3.5 GO:0008017 microtubule binding(GO:0008017)
0.0 8.9 GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding(GO:0000977)
0.0 3.2 GO:0003924 GTPase activity(GO:0003924)
0.0 6.0 GO:0004930 G-protein coupled receptor activity(GO:0004930)
0.0 1.4 GO:0003697 single-stranded DNA binding(GO:0003697)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
2.0 44.1 PID TCR RAS PATHWAY Ras signaling in the CD4+ TCR pathway
0.5 6.7 SA G2 AND M PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.4 7.5 PID INTEGRIN4 PATHWAY Alpha6 beta4 integrin-ligand interactions
0.3 15.8 NABA PROTEOGLYCANS Genes encoding proteoglycans
0.2 10.5 PID LIS1 PATHWAY Lissencephaly gene (LIS1) in neuronal migration and development
0.2 6.1 PID HDAC CLASSIII PATHWAY Signaling events mediated by HDAC Class III
0.2 3.1 PID S1P S1P4 PATHWAY S1P4 pathway
0.1 17.5 PID AR PATHWAY Coregulation of Androgen receptor activity
0.1 4.1 NABA BASEMENT MEMBRANES Genes encoding structural components of basement membranes
0.1 8.4 PID MTOR 4PATHWAY mTOR signaling pathway
0.1 6.8 PID CDC42 REG PATHWAY Regulation of CDC42 activity
0.1 6.0 PID AURORA B PATHWAY Aurora B signaling
0.1 16.9 NABA ECM AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.1 7.2 PID ATF2 PATHWAY ATF-2 transcription factor network
0.1 3.2 ST ERK1 ERK2 MAPK PATHWAY ERK1/ERK2 MAPK Pathway
0.1 6.5 PID BETA CATENIN NUC PATHWAY Regulation of nuclear beta catenin signaling and target gene transcription
0.1 3.9 PID TAP63 PATHWAY Validated transcriptional targets of TAp63 isoforms
0.1 2.7 ST B CELL ANTIGEN RECEPTOR B Cell Antigen Receptor
0.0 1.3 PID FRA PATHWAY Validated transcriptional targets of AP1 family members Fra1 and Fra2
0.0 1.2 PID UPA UPAR PATHWAY Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
0.0 5.4 NABA ECM REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.0 0.8 SIG INSULIN RECEPTOR PATHWAY IN CARDIAC MYOCYTES Genes related to the insulin receptor pathway
0.0 3.9 NABA SECRETED FACTORS Genes encoding secreted soluble factors

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
1.6 44.1 REACTOME ACTIVATION OF THE AP1 FAMILY OF TRANSCRIPTION FACTORS Genes involved in Activation of the AP-1 family of transcription factors
0.8 21.2 REACTOME CS DS DEGRADATION Genes involved in CS/DS degradation
0.6 10.5 REACTOME SYNTHESIS SECRETION AND DEACYLATION OF GHRELIN Genes involved in Synthesis, Secretion, and Deacylation of Ghrelin
0.4 5.3 REACTOME PROSTANOID LIGAND RECEPTORS Genes involved in Prostanoid ligand receptors
0.3 6.7 REACTOME AKT PHOSPHORYLATES TARGETS IN THE CYTOSOL Genes involved in AKT phosphorylates targets in the cytosol
0.3 3.0 REACTOME TRAF6 MEDIATED IRF7 ACTIVATION IN TLR7 8 OR 9 SIGNALING Genes involved in TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling
0.3 8.2 REACTOME ACTIVATED AMPK STIMULATES FATTY ACID OXIDATION IN MUSCLE Genes involved in Activated AMPK stimulates fatty-acid oxidation in muscle
0.1 9.9 REACTOME MYOGENESIS Genes involved in Myogenesis
0.1 6.5 REACTOME AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE Genes involved in Amino acid transport across the plasma membrane
0.1 1.9 REACTOME SYNTHESIS OF SUBSTRATES IN N GLYCAN BIOSYTHESIS Genes involved in Synthesis of substrates in N-glycan biosythesis
0.1 3.7 REACTOME GLUTAMATE NEUROTRANSMITTER RELEASE CYCLE Genes involved in Glutamate Neurotransmitter Release Cycle
0.1 15.5 REACTOME DNA REPAIR Genes involved in DNA Repair
0.1 6.8 REACTOME NRAGE SIGNALS DEATH THROUGH JNK Genes involved in NRAGE signals death through JNK
0.1 6.0 REACTOME STRIATED MUSCLE CONTRACTION Genes involved in Striated Muscle Contraction
0.1 9.7 REACTOME PEPTIDE CHAIN ELONGATION Genes involved in Peptide chain elongation
0.1 0.7 REACTOME GLYCOPROTEIN HORMONES Genes involved in Glycoprotein hormones
0.1 2.5 REACTOME INHIBITION OF INSULIN SECRETION BY ADRENALINE NORADRENALINE Genes involved in Inhibition of Insulin Secretion by Adrenaline/Noradrenaline
0.1 1.0 REACTOME INHIBITION OF REPLICATION INITIATION OF DAMAGED DNA BY RB1 E2F1 Genes involved in Inhibition of replication initiation of damaged DNA by RB1/E2F1
0.1 7.5 REACTOME INTEGRIN CELL SURFACE INTERACTIONS Genes involved in Integrin cell surface interactions
0.1 0.6 REACTOME PECAM1 INTERACTIONS Genes involved in PECAM1 interactions
0.0 1.2 REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.0 1.3 REACTOME METABOLISM OF PORPHYRINS Genes involved in Metabolism of porphyrins
0.0 1.2 REACTOME CONVERSION FROM APC C CDC20 TO APC C CDH1 IN LATE ANAPHASE Genes involved in Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase
0.0 1.2 REACTOME SYNTHESIS OF PC Genes involved in Synthesis of PC
0.0 1.6 REACTOME INTERACTION BETWEEN L1 AND ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.0 2.1 REACTOME NCAM1 INTERACTIONS Genes involved in NCAM1 interactions
0.0 1.8 REACTOME ACTIVATION OF CHAPERONE GENES BY XBP1S Genes involved in Activation of Chaperone Genes by XBP1(S)
0.0 1.4 REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES Genes involved in Chemokine receptors bind chemokines
0.0 0.8 REACTOME MUSCLE CONTRACTION Genes involved in Muscle contraction
0.0 0.2 REACTOME REVERSIBLE HYDRATION OF CARBON DIOXIDE Genes involved in Reversible Hydration of Carbon Dioxide
0.0 0.5 REACTOME O LINKED GLYCOSYLATION OF MUCINS Genes involved in O-linked glycosylation of mucins