ISMARA results: TWIST1

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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)

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Results for TWIST1_SNAI1

Z-value: 1.08

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Transcription factors associated with TWIST1_SNAI1

Gene Symbol	Gene ID	Gene Info
TWIST1 Ensembl NCBI GeneCards UniProt	ENSG00000122691.13	TWIST1
SNAI1 Ensembl NCBI GeneCards UniProt	ENSG00000124216.4	SNAI1

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
TWIST1	hg38_v1_chr7_-_19117625_19117645	0.18	6.4e-03	Click!
SNAI1	hg38_v1_chr20_+_49982969_49982989	-0.06	3.4e-01	Click!

Activity profile of TWIST1_SNAI1 motif

Sorted Z-values of TWIST1_SNAI1 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of TWIST1_SNAI1

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Top targets:

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Promoter	Score	Transcript	Gene	Gene Info
chr12_+_52949107 Show fit	40.58	ENST00000388835.4	KRT18 Ensembl NCBI GeneCards UniProt Show fit	keratin 18
chr18_-_74291924 Show fit	17.90	ENST00000494131.6 ENST00000340533.9 ENST00000397914.4	CYB5A Ensembl NCBI GeneCards UniProt Show fit	cytochrome b5 type A
chr1_-_12616762 Show fit	17.68	ENST00000464917.5	DHRS3 Ensembl NCBI GeneCards UniProt Show fit	dehydrogenase/reductase 3
chr12_+_52948840 Show fit	17.65	ENST00000388837.6 ENST00000550600.5	KRT18 Ensembl NCBI GeneCards UniProt Show fit	keratin 18
chr7_+_116525524 Show fit	17.05	ENST00000405348.6	CAV1 Ensembl NCBI GeneCards UniProt Show fit	caveolin 1
chr3_-_120450981 Show fit	16.82	ENST00000424703.6 ENST00000469005.1 ENST00000295633.8	FSTL1 Ensembl NCBI GeneCards UniProt Show fit	follistatin like 1
chr20_+_17570046 Show fit	15.98	ENST00000246069.12 ENST00000474024.5	DSTN Ensembl NCBI GeneCards UniProt Show fit	destrin, actin depolymerizing factor
chr18_+_31498168 Show fit	15.36	ENST00000261590.13 ENST00000585206.1 ENST00000683654.1	DSG2 Ensembl NCBI GeneCards UniProt Show fit	desmoglein 2
chr7_+_116526277 Show fit	15.12	ENST00000393468.1 ENST00000393467.1	CAV1 Ensembl NCBI GeneCards UniProt Show fit	caveolin 1
chr1_+_98661666 Show fit	14.45	ENST00000529992.5	SNX7 Ensembl NCBI GeneCards UniProt Show fit	sorting nexin 7

Showing 1 to 10 of 200 entries

Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.4	56.9	GO:0097284	hepatocyte apoptotic process(GO:0097284)
7.9	39.7	GO:0003065	positive regulation of heart rate by epinephrine(GO:0003065)
1.8	38.0	GO:0043162	ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway(GO:0043162)
8.0	32.2	GO:1903609	negative regulation of peptidyl-tyrosine autophosphorylation(GO:1900085) negative regulation of inward rectifier potassium channel activity(GO:1903609)
5.1	25.6	GO:1902766	skeletal muscle satellite cell migration(GO:1902766)
3.2	25.3	GO:0086073	bundle of His cell-Purkinje myocyte adhesion involved in cell communication(GO:0086073)
0.7	23.4	GO:0016338	calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules(GO:0016338)
0.3	22.1	GO:0045652	regulation of megakaryocyte differentiation(GO:0045652)
4.1	20.3	GO:0019087	transformation of host cell by virus(GO:0019087) renal water absorption(GO:0070295)
0.9	18.2	GO:0019852	L-ascorbic acid metabolic process(GO:0019852)

Showing 1 to 10 of 363 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.5	61.1	GO:0034451	centriolar satellite(GO:0034451)
0.2	59.6	GO:0005788	endoplasmic reticulum lumen(GO:0005788)
3.5	48.7	GO:0005862	muscle thin filament tropomyosin(GO:0005862)
2.4	40.9	GO:0034098	VCP-NPL4-UFD1 AAA ATPase complex(GO:0034098)
0.7	36.9	GO:0016460	myosin II complex(GO:0016460)
0.2	35.2	GO:0005795	Golgi stack(GO:0005795)
1.0	32.4	GO:0030057	desmosome(GO:0030057)
1.0	32.3	GO:0031233	intrinsic component of external side of plasma membrane(GO:0031233)
0.6	26.3	GO:0032420	stereocilium(GO:0032420)
0.7	22.7	GO:0016327	apicolateral plasma membrane(GO:0016327)

Showing 1 to 10 of 140 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
2.4	69.0	GO:0098641	cadherin binding involved in cell-cell adhesion(GO:0098641)
0.4	60.4	GO:0043130	ubiquitin binding(GO:0043130)
0.5	47.7	GO:0008307	structural constituent of muscle(GO:0008307)
0.1	37.1	GO:0005525	GTP binding(GO:0005525)
1.8	37.0	GO:0032036	myosin heavy chain binding(GO:0032036)
8.0	32.2	GO:0070320	inward rectifier potassium channel inhibitor activity(GO:0070320)
3.2	25.3	GO:0086083	cell adhesive protein binding involved in bundle of His cell-Purkinje myocyte communication(GO:0086083)
4.1	20.3	GO:0033906	hyaluronoglucuronidase activity(GO:0033906)
0.6	17.9	GO:0016676	cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
2.2	17.7	GO:0052650	NADP-retinol dehydrogenase activity(GO:0052650)

Showing 1 to 10 of 245 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.6	61.5	PID CASPASE PATHWAY	Caspase cascade in apoptosis
0.1	38.6	NABA ECM REGULATORS	Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.9	31.7	PID WNT CANONICAL PATHWAY	Canonical Wnt signaling pathway
0.4	26.6	PID PLK1 PATHWAY	PLK1 signaling events
0.6	25.6	PID PRL SIGNALING EVENTS PATHWAY	Signaling events mediated by PRL
0.1	24.6	NABA ECM GLYCOPROTEINS	Genes encoding structural ECM glycoproteins
0.3	23.2	PID ILK PATHWAY	Integrin-linked kinase signaling
0.5	18.9	ST WNT BETA CATENIN PATHWAY	Wnt/beta-catenin Pathway
0.6	17.3	PID INTEGRIN5 PATHWAY	Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.3	17.3	PID NCADHERIN PATHWAY	N-cadherin signaling events

Showing 1 to 10 of 57 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.8	97.6	REACTOME SMOOTH MUSCLE CONTRACTION	Genes involved in Smooth Muscle Contraction
1.2	32.2	REACTOME ENOS ACTIVATION AND REGULATION	Genes involved in eNOS activation and regulation
1.3	27.7	REACTOME APOPTOTIC CLEAVAGE OF CELL ADHESION PROTEINS	Genes involved in Apoptotic cleavage of cell adhesion proteins
0.7	26.1	REACTOME SEMA4D INDUCED CELL MIGRATION AND GROWTH CONE COLLAPSE	Genes involved in Sema4D induced cell migration and growth-cone collapse
0.6	21.6	REACTOME TIGHT JUNCTION INTERACTIONS	Genes involved in Tight junction interactions
0.5	21.5	REACTOME SIGNALING BY BMP	Genes involved in Signaling by BMP
0.4	20.1	REACTOME SIGNALING BY ROBO RECEPTOR	Genes involved in Signaling by Robo receptor
0.8	19.7	REACTOME HYALURONAN UPTAKE AND DEGRADATION	Genes involved in Hyaluronan uptake and degradation
0.2	15.0	REACTOME METABOLISM OF VITAMINS AND COFACTORS	Genes involved in Metabolism of vitamins and cofactors
0.6	14.2	REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT	Genes involved in Chylomicron-mediated lipid transport

Showing 1 to 10 of 104 entries

Results for TWIST1_SNAI1

Z-value: 1.08

Motif logo

Transcription factors associated with TWIST1_SNAI1

Activity-expression correlation:

Activity profile of TWIST1_SNAI1 motif

Sorted Z-values of TWIST1_SNAI1 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of TWIST1_SNAI1

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.

Top targets:

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: