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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)

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Results for UAAGACG

Z-value: 0.23

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miRNA associated with seed UAAGACG

NamemiRBASE accession
hsa-miR-208a-3p
MIMAT0000241
hsa-miR-208b-3p
MIMAT0004960

Activity profile of UAAGACG motif

Sorted Z-values of UAAGACG motif

Network of associatons between targets according to the STRING database.

First level regulatory network of UAAGACG

PNG image of the network

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Top targets:

Promoter Score Transcript Gene Gene Info
chr3_+_43286512 1.79 ENST00000454177.5
ENST00000429705.6
ENST00000296088.12
ENST00000437827.1
SNRK
SNF related kinase
chr3_-_18425295 1.49 ENST00000338745.11
ENST00000450898.1
SATB1
SATB homeobox 1
chr1_-_107965009 1.45 ENST00000527011.5
ENST00000370056.9
VAV3
vav guanine nucleotide exchange factor 3
chr12_-_92145838 1.38 ENST00000256015.5
BTG1
BTG anti-proliferation factor 1
chr6_+_21593742 1.34 ENST00000244745.4
SOX4
SRY-box transcription factor 4
chr5_+_122775062 1.29 ENST00000379516.7
ENST00000505934.5
ENST00000514949.1
SNX2
sorting nexin 2
chr8_+_55102012 1.28 ENST00000327381.7
XKR4
XK related 4
chr13_+_49997019 1.27 ENST00000420995.6
ENST00000356017.8
ENST00000378182.4
ENST00000457662.2
TRIM13
tripartite motif containing 13
chr14_-_21269451 1.27 ENST00000336053.10
HNRNPC
heterogeneous nuclear ribonucleoprotein C
chr2_+_119759875 1.21 ENST00000263708.7
PTPN4
protein tyrosine phosphatase non-receptor type 4
chr13_-_106568107 1.14 ENST00000400198.8
ARGLU1
arginine and glutamate rich 1
chr7_-_140176970 1.13 ENST00000397560.7
KDM7A
lysine demethylase 7A
chr15_+_52019206 1.12 ENST00000681888.1
ENST00000261845.7
ENST00000680066.1
ENST00000680777.1
ENST00000680652.1
MAPK6
mitogen-activated protein kinase 6
chr10_+_110871903 1.09 ENST00000280154.12
PDCD4
programmed cell death 4
chr4_-_99950262 1.09 ENST00000296417.6
ENST00000651623.1
H2AZ1
H2A.Z variant histone 1
chr15_+_56918612 1.07 ENST00000438423.6
ENST00000267811.9
ENST00000333725.10
ENST00000559609.5
TCF12
transcription factor 12
chr3_-_72446623 1.00 ENST00000477973.4
RYBP
RING1 and YY1 binding protein
chr1_+_42682388 0.99 ENST00000321358.12
ENST00000332220.10
YBX1
Y-box binding protein 1
chr8_+_48008409 0.97 ENST00000523432.5
ENST00000521346.5
ENST00000523111.7
ENST00000517630.5
UBE2V2
ubiquitin conjugating enzyme E2 V2
chr7_-_26200734 0.94 ENST00000354667.8
ENST00000618183.5
HNRNPA2B1
heterogeneous nuclear ribonucleoprotein A2/B1
chr20_+_49936371 0.93 ENST00000244061.6
ENST00000625177.3
ENST00000622920.1
RNF114
ring finger protein 114
chrX_+_41334154 0.86 ENST00000441189.4
ENST00000644513.1
ENST00000644109.1
ENST00000646122.1
ENST00000644074.1
ENST00000644876.2
ENST00000399959.7
ENST00000646319.1
DDX3X
DEAD-box helicase 3 X-linked
chr14_-_99272184 0.84 ENST00000357195.8
BCL11B
BAF chromatin remodeling complex subunit BCL11B
chr10_-_26860888 0.80 ENST00000376170.8
ABI1
abl interactor 1
chr12_+_71754834 0.79 ENST00000261263.5
RAB21
RAB21, member RAS oncogene family
chr9_-_125189721 0.74 ENST00000456642.1
ENST00000373547.9
ENST00000415905.5
ENST00000451402.5
PPP6C
protein phosphatase 6 catalytic subunit
chr17_+_68512379 0.66 ENST00000392711.5
ENST00000585427.5
ENST00000589228.6
ENST00000536854.6
ENST00000588702.5
ENST00000589309.5
PRKAR1A
protein kinase cAMP-dependent type I regulatory subunit alpha
chr13_-_49792675 0.65 ENST00000261667.8
KPNA3
karyopherin subunit alpha 3
chr10_+_61901678 0.64 ENST00000644638.1
ENST00000681100.1
ENST00000279873.12
ARID5B
AT-rich interaction domain 5B
chr6_-_13711817 0.64 ENST00000011619.6
RANBP9
RAN binding protein 9
chr7_-_105388881 0.64 ENST00000460391.5
ENST00000393651.8
SRPK2
SRSF protein kinase 2
chr3_-_15332526 0.60 ENST00000383791.8
SH3BP5
SH3 domain binding protein 5
chr17_-_50707855 0.53 ENST00000285243.7
ANKRD40
ankyrin repeat domain 40
chr2_-_68062974 0.51 ENST00000407324.5
ENST00000355848.7
ENST00000410067.8
ENST00000409302.1
C1D
C1D nuclear receptor corepressor
chr3_+_186783567 0.51 ENST00000323963.10
ENST00000440191.6
EIF4A2
eukaryotic translation initiation factor 4A2
chrY_+_12904860 0.47 ENST00000336079.8
DDX3Y
DEAD-box helicase 3 Y-linked
chr12_+_49741802 0.45 ENST00000423828.5
ENST00000550445.5
TMBIM6
transmembrane BAX inhibitor motif containing 6
chr21_-_15064934 0.42 ENST00000400199.5
ENST00000400202.5
ENST00000318948.7
NRIP1
nuclear receptor interacting protein 1
chr1_-_225653045 0.38 ENST00000366843.6
ENST00000366844.7
ENAH
ENAH actin regulator
chr5_-_157142839 0.37 ENST00000286317.6
ENST00000524219.1
MED7
HAVCR2
mediator complex subunit 7
hepatitis A virus cellular receptor 2
chr2_+_42169332 0.35 ENST00000402711.6
ENST00000318522.10
EML4
EMAP like 4
chr17_-_75779758 0.33 ENST00000592643.5
ENST00000591890.5
ENST00000587171.1
ENST00000254810.8
ENST00000589599.5
H3-3B
H3.3 histone B
chr16_-_46621345 0.31 ENST00000303383.8
SHCBP1
SHC binding and spindle associated 1
chr2_-_173965356 0.31 ENST00000310015.12
SP3
Sp3 transcription factor
chr20_+_52972347 0.30 ENST00000371497.10
TSHZ2
teashirt zinc finger homeobox 2
chr14_-_105021043 0.30 ENST00000392590.3
ENST00000336219.4
CDCA4
cell division cycle associated 4
chr1_-_38873322 0.30 ENST00000397572.5
ENST00000494695.4
MYCBP
MYC binding protein
chr1_-_154870264 0.26 ENST00000618040.4
ENST00000271915.9
KCNN3
potassium calcium-activated channel subfamily N member 3
chr1_+_35931076 0.24 ENST00000397828.3
ENST00000373191.9
AGO3
argonaute RISC catalytic component 3
chr12_+_67648737 0.24 ENST00000344096.4
ENST00000393555.3
DYRK2
dual specificity tyrosine phosphorylation regulated kinase 2
chr6_+_20401864 0.24 ENST00000346618.8
ENST00000613242.4
E2F3
E2F transcription factor 3
chr5_-_77492309 0.22 ENST00000296679.9
ENST00000507029.5
WDR41
WD repeat domain 41
chr10_-_32056376 0.22 ENST00000302418.5
KIF5B
kinesin family member 5B
chr5_-_115544734 0.21 ENST00000274457.5
FEM1C
fem-1 homolog C
chr18_-_61892997 0.21 ENST00000312828.4
RNF152
ring finger protein 152
chr2_-_131093378 0.20 ENST00000409185.5
ENST00000389915.4
FAM168B
family with sequence similarity 168 member B
chr17_-_42154916 0.19 ENST00000592574.1
ENST00000550406.1
ENST00000547517.5
ENST00000346213.9
ENST00000393860.7
ENSG00000267261.5
RAB5C
novel protein
RAB5C, member RAS oncogene family
chr4_-_65670339 0.17 ENST00000273854.7
EPHA5
EPH receptor A5
chr9_+_79571767 0.16 ENST00000376544.7
TLE4
TLE family member 4, transcriptional corepressor
chr11_-_2929412 0.15 ENST00000314222.5
PHLDA2
pleckstrin homology like domain family A member 2
chr15_+_44537136 0.15 ENST00000261868.10
ENST00000535391.5
EIF3J
eukaryotic translation initiation factor 3 subunit J
chr1_-_20786610 0.14 ENST00000375000.5
ENST00000312239.10
ENST00000419490.5
ENST00000414993.1
ENST00000443615.1
HP1BP3
heterochromatin protein 1 binding protein 3
chr14_+_103334176 0.13 ENST00000560338.5
ENST00000560763.5
ENST00000216554.8
EIF5
eukaryotic translation initiation factor 5
chr1_-_55215345 0.11 ENST00000294383.7
USP24
ubiquitin specific peptidase 24
chr2_-_86337654 0.10 ENST00000165698.9
REEP1
receptor accessory protein 1
chr22_+_29883158 0.10 ENST00000333027.7
ENST00000401950.7
ENST00000445401.5
ENST00000323630.9
ENST00000351488.7
MTMR3
myotubularin related protein 3
chr17_-_5486157 0.09 ENST00000572834.5
ENST00000158771.9
ENST00000570848.5
ENST00000571971.1
DERL2
derlin 2
chr9_-_16870662 0.09 ENST00000380672.9
BNC2
basonuclin 2
chr2_-_239400949 0.04 ENST00000345617.7
HDAC4
histone deacetylase 4
chr1_+_96721762 0.04 ENST00000675735.1
ENST00000609116.5
ENST00000674951.1
ENST00000426398.3
ENST00000370197.5
ENST00000370198.5
PTBP2
polypyrimidine tract binding protein 2
chr9_+_99105098 0.03 ENST00000374990.6
ENST00000374994.9
ENST00000552516.5
TGFBR1
transforming growth factor beta receptor 1
chr22_+_21417357 0.01 ENST00000407464.7
HIC2
HIC ZBTB transcriptional repressor 2
chr2_+_227164607 0.00 ENST00000396578.8
COL4A3
collagen type IV alpha 3 chain
chr2_+_176122712 0.00 ENST00000249499.8
HOXD9
homeobox D9

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.1 GO:0035574 histone H4-K20 demethylation(GO:0035574)
0.4 1.1 GO:0036446 myofibroblast differentiation(GO:0036446) regulation of myofibroblast differentiation(GO:1904760)
0.3 0.8 GO:0097535 lymphoid lineage cell migration(GO:0097534) lymphoid lineage cell migration into thymus(GO:0097535)
0.3 1.3 GO:0035905 N-terminal peptidyl-lysine acetylation(GO:0018076) ascending aorta development(GO:0035905) ascending aorta morphogenesis(GO:0035910)
0.2 0.7 GO:1902594 viral penetration into host nucleus(GO:0075732) multi-organism nuclear import(GO:1902594)
0.1 0.9 GO:0044806 G-quadruplex DNA unwinding(GO:0044806)
0.1 0.4 GO:0002461 tolerance induction dependent upon immune response(GO:0002461) negative regulation of immunological synapse formation(GO:2000521)
0.1 1.8 GO:1903608 protein localization to cytoplasmic stress granule(GO:1903608)
0.1 0.6 GO:0035063 nuclear speck organization(GO:0035063)
0.1 1.4 GO:2000271 positive regulation of fibroblast apoptotic process(GO:2000271)
0.1 1.5 GO:0043374 CD8-positive, alpha-beta T cell differentiation(GO:0043374)
0.1 1.3 GO:0034498 early endosome to Golgi transport(GO:0034498)
0.1 0.5 GO:1904721 negative regulation of mRNA cleavage(GO:0031438) negative regulation of mRNA endonucleolytic cleavage involved in unfolded protein response(GO:1904721)
0.1 1.3 GO:1902187 negative regulation of viral release from host cell(GO:1902187)
0.1 1.3 GO:0070935 3'-UTR-mediated mRNA stabilization(GO:0070935)
0.1 0.8 GO:2000643 positive regulation of early endosome to late endosome transport(GO:2000643)
0.0 0.7 GO:0046007 negative regulation of activated T cell proliferation(GO:0046007)
0.0 1.0 GO:0035518 histone H2A monoubiquitination(GO:0035518)
0.0 0.2 GO:0098795 mRNA cleavage involved in gene silencing by miRNA(GO:0035279) mRNA cleavage involved in gene silencing by siRNA(GO:0090625) mRNA cleavage involved in gene silencing(GO:0098795)
0.0 0.2 GO:0051534 negative regulation of NFAT protein import into nucleus(GO:0051534)
0.0 0.2 GO:0035617 stress granule disassembly(GO:0035617)
0.0 0.3 GO:0043353 enucleate erythrocyte differentiation(GO:0043353)
0.0 0.7 GO:0035855 megakaryocyte development(GO:0035855)
0.0 1.0 GO:0000729 DNA double-strand break processing(GO:0000729)
0.0 1.5 GO:0043552 positive regulation of phosphatidylinositol 3-kinase activity(GO:0043552)
0.0 0.2 GO:0070345 negative regulation of fat cell proliferation(GO:0070345)
0.0 0.4 GO:0001542 ovulation from ovarian follicle(GO:0001542)
0.0 0.2 GO:1904262 negative regulation of TORC1 signaling(GO:1904262)
0.0 1.0 GO:0010501 RNA secondary structure unwinding(GO:0010501)
0.0 0.6 GO:0007020 microtubule nucleation(GO:0007020)
0.0 0.6 GO:0016577 histone demethylation(GO:0016577)
0.0 0.6 GO:0061099 negative regulation of protein tyrosine kinase activity(GO:0061099)
0.0 0.2 GO:0048227 plasma membrane to endosome transport(GO:0048227)
0.0 0.5 GO:0000460 maturation of 5.8S rRNA(GO:0000460)
0.0 0.1 GO:0001731 formation of translation preinitiation complex(GO:0001731)
0.0 1.1 GO:0060999 positive regulation of dendritic spine development(GO:0060999)
0.0 0.1 GO:1904153 negative regulation of protein exit from endoplasmic reticulum(GO:0070862) negative regulation of retrograde protein transport, ER to cytosol(GO:1904153)
0.0 0.0 GO:1905075 occluding junction disassembly(GO:1905071) regulation of occluding junction disassembly(GO:1905073) positive regulation of occluding junction disassembly(GO:1905075)
0.0 0.2 GO:0060712 spongiotrophoblast layer development(GO:0060712)
0.0 0.2 GO:0032793 positive regulation of CREB transcription factor activity(GO:0032793)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.3 GO:0030905 retromer, tubulation complex(GO:0030905)
0.1 0.8 GO:0098559 cytoplasmic side of early endosome membrane(GO:0098559)
0.1 1.0 GO:0071204 histone pre-mRNA 3'end processing complex(GO:0071204)
0.1 1.0 GO:0031371 ubiquitin conjugating enzyme complex(GO:0031371)
0.1 1.3 GO:0097038 perinuclear endoplasmic reticulum(GO:0097038)
0.1 0.8 GO:0031209 SCAR complex(GO:0031209)
0.0 0.5 GO:0000176 nuclear exosome (RNase complex)(GO:0000176)
0.0 0.2 GO:1990316 ATG1/ULK1 kinase complex(GO:1990316)
0.0 1.5 GO:0005720 nuclear heterochromatin(GO:0005720)
0.0 1.3 GO:0005697 telomerase holoenzyme complex(GO:0005697)
0.0 1.0 GO:0005852 eukaryotic translation initiation factor 3 complex(GO:0005852)
0.0 0.7 GO:0031588 nucleotide-activated protein kinase complex(GO:0031588)
0.0 0.5 GO:0016281 eukaryotic translation initiation factor 4F complex(GO:0016281)
0.0 0.2 GO:0035068 micro-ribonucleoprotein complex(GO:0035068)
0.0 1.0 GO:0031519 PcG protein complex(GO:0031519)
0.0 0.2 GO:0035253 ciliary rootlet(GO:0035253)
0.0 0.9 GO:0015030 Cajal body(GO:0015030)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.1 GO:0035575 histone demethylase activity (H4-K20 specific)(GO:0035575)
0.3 1.3 GO:1990460 leptin receptor binding(GO:1990460)
0.2 0.9 GO:0043273 CTPase activity(GO:0043273)
0.2 2.2 GO:1990247 N6-methyladenosine-containing RNA binding(GO:1990247)
0.1 1.3 GO:1904264 ubiquitin protein ligase activity involved in ERAD pathway(GO:1904264)
0.1 1.2 GO:0004726 non-membrane spanning protein tyrosine phosphatase activity(GO:0004726)
0.1 0.5 GO:0060698 endoribonuclease inhibitor activity(GO:0060698)
0.1 0.2 GO:0099609 microtubule lateral binding(GO:0099609)
0.1 1.1 GO:0035497 cAMP response element binding(GO:0035497)
0.0 1.5 GO:0030676 Rac guanyl-nucleotide exchange factor activity(GO:0030676)
0.0 1.1 GO:0004707 MAP kinase activity(GO:0004707)
0.0 0.1 GO:0031849 olfactory receptor binding(GO:0031849)
0.0 0.7 GO:0008603 cAMP-dependent protein kinase regulator activity(GO:0008603)
0.0 0.9 GO:0031624 ubiquitin conjugating enzyme binding(GO:0031624)
0.0 0.3 GO:0016286 small conductance calcium-activated potassium channel activity(GO:0016286)
0.0 0.1 GO:0071074 eukaryotic initiation factor eIF2 binding(GO:0071074)
0.0 0.8 GO:0030296 protein tyrosine kinase activator activity(GO:0030296)
0.0 1.0 GO:0061631 ubiquitin conjugating enzyme activity(GO:0061631)
0.0 1.3 GO:0001105 RNA polymerase II transcription coactivator activity(GO:0001105)
0.0 0.6 GO:0032452 histone demethylase activity(GO:0032452)
0.0 0.5 GO:0016922 ligand-dependent nuclear receptor binding(GO:0016922)
0.0 0.4 GO:0035259 glucocorticoid receptor binding(GO:0035259)
0.0 0.6 GO:0008536 Ran GTPase binding(GO:0008536)
0.0 0.7 GO:0008139 nuclear localization sequence binding(GO:0008139)
0.0 0.2 GO:0005005 transmembrane-ephrin receptor activity(GO:0005005)
0.0 1.0 GO:0004004 ATP-dependent RNA helicase activity(GO:0004004)
0.0 1.0 GO:0019003 GDP binding(GO:0019003)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 1.5 PID EPHA2 FWD PATHWAY EPHA2 forward signaling
0.0 1.5 PID INTEGRIN A4B1 PATHWAY Alpha4 beta1 integrin signaling events
0.0 1.3 PID THROMBIN PAR1 PATHWAY PAR1-mediated thrombin signaling events
0.0 1.5 PID CASPASE PATHWAY Caspase cascade in apoptosis
0.0 1.1 PID MTOR 4PATHWAY mTOR signaling pathway
0.0 1.6 PID TELOMERASE PATHWAY Regulation of Telomerase
0.0 0.2 PID NCADHERIN PATHWAY N-cadherin signaling events
0.0 0.4 PID RETINOIC ACID PATHWAY Retinoic acid receptors-mediated signaling

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 1.5 REACTOME GPVI MEDIATED ACTIVATION CASCADE Genes involved in GPVI-mediated activation cascade
0.0 0.7 REACTOME PKA MEDIATED PHOSPHORYLATION OF CREB Genes involved in PKA-mediated phosphorylation of CREB
0.0 3.2 REACTOME MRNA SPLICING Genes involved in mRNA Splicing
0.0 1.5 REACTOME GOLGI ASSOCIATED VESICLE BIOGENESIS Genes involved in Golgi Associated Vesicle Biogenesis
0.0 1.5 REACTOME APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS Genes involved in Apoptotic cleavage of cellular proteins
0.0 0.5 REACTOME DEADENYLATION OF MRNA Genes involved in Deadenylation of mRNA
0.0 0.4 REACTOME GENERATION OF SECOND MESSENGER MOLECULES Genes involved in Generation of second messenger molecules