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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
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Results for UAAGGCA
Z-value: 0.84
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miRNA associated with seed UAAGGCA
Network of associatons between targets according to the STRING database.
First level regulatory network of UAAGGCA
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.8 | 18.6 | GO:0032486 | Rap protein signal transduction(GO:0032486) |
| 0.8 | 16.4 | GO:0019511 | peptidyl-proline hydroxylation(GO:0019511) |
| 1.7 | 13.6 | GO:1903593 | regulation of histamine secretion by mast cell(GO:1903593) |
| 0.2 | 13.4 | GO:0050819 | negative regulation of coagulation(GO:0050819) |
| 0.7 | 13.1 | GO:0070831 | basement membrane assembly(GO:0070831) |
| 1.6 | 12.7 | GO:0036444 | calcium ion transmembrane import into mitochondrion(GO:0036444) |
| 0.7 | 12.5 | GO:0016540 | protein autoprocessing(GO:0016540) |
| 3.0 | 12.0 | GO:1903070 | negative regulation of ER-associated ubiquitin-dependent protein catabolic process(GO:1903070) |
| 1.1 | 11.3 | GO:0043353 | enucleate erythrocyte differentiation(GO:0043353) |
| 0.4 | 10.6 | GO:0051923 | sulfation(GO:0051923) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 25.0 | GO:0032580 | Golgi cisterna membrane(GO:0032580) |
| 0.2 | 23.4 | GO:0035578 | azurophil granule lumen(GO:0035578) |
| 0.1 | 20.7 | GO:0005788 | endoplasmic reticulum lumen(GO:0005788) |
| 0.3 | 19.1 | GO:0055038 | recycling endosome membrane(GO:0055038) |
| 0.3 | 17.2 | GO:0035577 | azurophil granule membrane(GO:0035577) |
| 0.0 | 17.2 | GO:0000139 | Golgi membrane(GO:0000139) |
| 0.6 | 15.2 | GO:0005685 | U1 snRNP(GO:0005685) |
| 0.2 | 15.0 | GO:0000502 | proteasome complex(GO:0000502) |
| 0.9 | 14.7 | GO:0097038 | perinuclear endoplasmic reticulum(GO:0097038) |
| 0.1 | 13.9 | GO:0016328 | lateral plasma membrane(GO:0016328) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 30.3 | GO:0045296 | cadherin binding(GO:0045296) |
| 0.4 | 26.2 | GO:0019003 | GDP binding(GO:0019003) |
| 0.2 | 18.7 | GO:0048306 | calcium-dependent protein binding(GO:0048306) |
| 3.3 | 16.4 | GO:0004656 | procollagen-proline 4-dioxygenase activity(GO:0004656) |
| 0.4 | 15.3 | GO:0004198 | calcium-dependent cysteine-type endopeptidase activity(GO:0004198) |
| 0.1 | 13.6 | GO:0003697 | single-stranded DNA binding(GO:0003697) |
| 0.5 | 13.4 | GO:0004859 | phospholipase inhibitor activity(GO:0004859) |
| 0.3 | 13.4 | GO:0050699 | WW domain binding(GO:0050699) |
| 0.5 | 12.6 | GO:0030898 | actin-dependent ATPase activity(GO:0030898) |
| 3.0 | 12.0 | GO:0008192 | RNA guanylyltransferase activity(GO:0008192) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 21.2 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.3 | 19.6 | PID ECADHERIN NASCENT AJ PATHWAY | E-cadherin signaling in the nascent adherens junction |
| 0.2 | 11.6 | PID PLK1 PATHWAY | PLK1 signaling events |
| 0.0 | 11.4 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.4 | 11.2 | PID IL5 PATHWAY | IL5-mediated signaling events |
| 0.1 | 11.2 | PID MYC ACTIV PATHWAY | Validated targets of C-MYC transcriptional activation |
| 0.6 | 10.7 | PID INTEGRIN4 PATHWAY | Alpha6 beta4 integrin-ligand interactions |
| 0.2 | 10.7 | ST WNT BETA CATENIN PATHWAY | Wnt/beta-catenin Pathway |
| 0.2 | 10.1 | PID NCADHERIN PATHWAY | N-cadherin signaling events |
| 0.2 | 9.7 | PID ARF6 TRAFFICKING PATHWAY | Arf6 trafficking events |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 27.8 | REACTOME L1CAM INTERACTIONS | Genes involved in L1CAM interactions |
| 0.3 | 13.4 | REACTOME SEMA4D INDUCED CELL MIGRATION AND GROWTH CONE COLLAPSE | Genes involved in Sema4D induced cell migration and growth-cone collapse |
| 0.5 | 13.1 | REACTOME HS GAG DEGRADATION | Genes involved in HS-GAG degradation |
| 0.3 | 10.3 | REACTOME CHONDROITIN SULFATE BIOSYNTHESIS | Genes involved in Chondroitin sulfate biosynthesis |
| 0.1 | 9.6 | REACTOME GOLGI ASSOCIATED VESICLE BIOGENESIS | Genes involved in Golgi Associated Vesicle Biogenesis |
| 0.6 | 8.9 | REACTOME KERATAN SULFATE DEGRADATION | Genes involved in Keratan sulfate degradation |
| 0.2 | 8.9 | REACTOME CHOLESTEROL BIOSYNTHESIS | Genes involved in Cholesterol biosynthesis |
| 0.5 | 8.6 | REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT | Genes involved in Chylomicron-mediated lipid transport |
| 0.3 | 8.6 | REACTOME P130CAS LINKAGE TO MAPK SIGNALING FOR INTEGRINS | Genes involved in p130Cas linkage to MAPK signaling for integrins |
| 0.3 | 8.4 | REACTOME INSULIN RECEPTOR RECYCLING | Genes involved in Insulin receptor recycling |