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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
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Results for UAAUGCU
Z-value: 0.44
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miRNA associated with seed UAAUGCU
| Name | miRBASE accession |
|---|---|
|
hsa-miR-155-5p
|
MIMAT0000646 |
Network of associatons between targets according to the STRING database.
First level regulatory network of UAAUGCU
| Promoter | Score | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr20_+_50190821 Show fit | 5.41 |
ENST00000303004.5
|
CCAAT enhancer binding protein beta |
|
| chr16_-_10580577 Show fit | 3.62 |
ENST00000359543.8
|
epithelial membrane protein 2 |
|
| chr12_-_14885845 Show fit | 3.31 |
ENST00000539261.6
ENST00000228938.5 |
matrix Gla protein |
|
| chr20_-_40689228 Show fit | 3.12 |
ENST00000373313.3
|
MAF bZIP transcription factor B |
|
| chrX_-_74614612 Show fit | 2.92 |
ENST00000349225.2
ENST00000332687.11 |
ring finger protein, LIM domain interacting |
|
| chr7_-_140176970 Show fit | 2.90 |
ENST00000397560.7
|
lysine demethylase 7A |
|
| chr2_+_28392802 Show fit | 2.79 |
ENST00000379619.5
ENST00000264716.9 |
FOS like 2, AP-1 transcription factor subunit |
|
| chr10_-_118754956 Show fit | 2.37 |
ENST00000369151.8
|
CDK2 associated cullin domain 1 |
|
| chr3_-_123884290 Show fit | 2.27 |
ENST00000346322.9
ENST00000360772.7 ENST00000360304.8 |
myosin light chain kinase |
|
| chr2_+_66435558 Show fit | 2.08 |
ENST00000488550.5
|
Meis homeobox 1 |
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 5.4 | GO:1990440 | positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress(GO:1990440) |
| 0.4 | 3.6 | GO:0070836 | caveola assembly(GO:0070836) |
| 0.2 | 3.3 | GO:0003334 | keratinocyte development(GO:0003334) |
| 0.1 | 3.3 | GO:0001502 | cartilage condensation(GO:0001502) |
| 0.8 | 3.1 | GO:0021571 | rhombomere 5 development(GO:0021571) central nervous system segmentation(GO:0035283) brain segmentation(GO:0035284) |
| 0.1 | 3.0 | GO:0000083 | regulation of transcription involved in G1/S transition of mitotic cell cycle(GO:0000083) |
| 1.0 | 2.9 | GO:0035574 | histone H4-K20 demethylation(GO:0035574) |
| 0.3 | 2.9 | GO:0007549 | dosage compensation(GO:0007549) dosage compensation by inactivation of X chromosome(GO:0009048) |
| 0.5 | 2.8 | GO:0060414 | aorta smooth muscle tissue morphogenesis(GO:0060414) |
| 0.1 | 2.8 | GO:0060044 | negative regulation of cardiac muscle cell proliferation(GO:0060044) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 7.5 | GO:0090575 | RNA polymerase II transcription factor complex(GO:0090575) |
| 0.0 | 7.4 | GO:0005667 | transcription factor complex(GO:0005667) |
| 0.1 | 6.4 | GO:0017053 | transcriptional repressor complex(GO:0017053) |
| 0.0 | 3.9 | GO:0001725 | stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517) |
| 0.0 | 3.6 | GO:0005901 | caveola(GO:0005901) |
| 0.1 | 2.5 | GO:1990454 | L-type voltage-gated calcium channel complex(GO:1990454) |
| 0.0 | 2.4 | GO:0005923 | bicellular tight junction(GO:0005923) |
| 0.0 | 2.0 | GO:0016363 | nuclear matrix(GO:0016363) |
| 0.0 | 1.8 | GO:0001772 | immunological synapse(GO:0001772) |
| 0.3 | 1.7 | GO:0020016 | ciliary pocket(GO:0020016) ciliary pocket membrane(GO:0020018) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 11.0 | GO:0001228 | transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001228) |
| 0.2 | 5.8 | GO:0035259 | glucocorticoid receptor binding(GO:0035259) |
| 0.0 | 5.3 | GO:0061630 | ubiquitin protein ligase activity(GO:0061630) |
| 0.0 | 4.2 | GO:0001046 | core promoter sequence-specific DNA binding(GO:0001046) |
| 0.0 | 3.8 | GO:0005178 | integrin binding(GO:0005178) |
| 0.3 | 3.7 | GO:0001206 | transcriptional repressor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001206) |
| 0.0 | 3.3 | GO:0005201 | extracellular matrix structural constituent(GO:0005201) |
| 1.0 | 2.9 | GO:0035575 | histone demethylase activity (H4-K20 specific)(GO:0035575) |
| 0.2 | 2.5 | GO:0086007 | voltage-gated calcium channel activity involved in cardiac muscle cell action potential(GO:0086007) |
| 0.6 | 2.3 | GO:0004687 | myosin light chain kinase activity(GO:0004687) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 9.9 | PID HNF3A PATHWAY | FOXA1 transcription factor network |
| 0.1 | 6.1 | PID FRA PATHWAY | Validated transcriptional targets of AP1 family members Fra1 and Fra2 |
| 0.1 | 2.6 | PID HIF2PATHWAY | HIF-2-alpha transcription factor network |
| 0.0 | 2.3 | SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES | Genes related to regulation of the actin cytoskeleton |
| 0.0 | 2.2 | PID IL2 PI3K PATHWAY | IL2 signaling events mediated by PI3K |
| 0.0 | 2.1 | PID GLYPICAN 1PATHWAY | Glypican 1 network |
| 0.0 | 2.0 | PID P53 DOWNSTREAM PATHWAY | Direct p53 effectors |
| 0.1 | 1.9 | PID IL8 CXCR1 PATHWAY | IL8- and CXCR1-mediated signaling events |
| 0.0 | 1.6 | PID NECTIN PATHWAY | Nectin adhesion pathway |
| 0.0 | 1.6 | PID RHOA PATHWAY | RhoA signaling pathway |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 7.8 | REACTOME TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION | Genes involved in Transcriptional Regulation of White Adipocyte Differentiation |
| 0.0 | 5.0 | REACTOME FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION | Genes involved in Factors involved in megakaryocyte development and platelet production |
| 0.1 | 3.7 | REACTOME REGULATION OF KIT SIGNALING | Genes involved in Regulation of KIT signaling |
| 0.0 | 2.3 | REACTOME SMOOTH MUSCLE CONTRACTION | Genes involved in Smooth Muscle Contraction |
| 0.1 | 2.2 | REACTOME SPHINGOLIPID DE NOVO BIOSYNTHESIS | Genes involved in Sphingolipid de novo biosynthesis |
| 0.1 | 1.8 | REACTOME SIGNALING BY NODAL | Genes involved in Signaling by NODAL |
| 0.1 | 1.7 | REACTOME ACTIVATION OF THE AP1 FAMILY OF TRANSCRIPTION FACTORS | Genes involved in Activation of the AP-1 family of transcription factors |
| 0.1 | 1.4 | REACTOME COMMON PATHWAY | Genes involved in Common Pathway |
| 0.0 | 1.3 | REACTOME HS GAG BIOSYNTHESIS | Genes involved in HS-GAG biosynthesis |
| 0.0 | 1.3 | REACTOME GABA A RECEPTOR ACTIVATION | Genes involved in GABA A receptor activation |