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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
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Results for UACAGUA
Z-value: 0.55
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miRNA associated with seed UACAGUA
| Name | miRBASE accession |
|---|---|
|
hsa-miR-101-3p.2
|
Network of associatons between targets according to the STRING database.
First level regulatory network of UACAGUA
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 7.5 | GO:0006301 | postreplication repair(GO:0006301) |
| 0.1 | 7.1 | GO:0060999 | positive regulation of dendritic spine development(GO:0060999) |
| 0.1 | 7.0 | GO:0045445 | myoblast differentiation(GO:0045445) |
| 0.5 | 6.9 | GO:0070934 | CRD-mediated mRNA stabilization(GO:0070934) |
| 0.5 | 6.6 | GO:0001886 | endothelial cell morphogenesis(GO:0001886) |
| 0.4 | 6.6 | GO:0034975 | protein folding in endoplasmic reticulum(GO:0034975) |
| 0.2 | 6.2 | GO:0030206 | chondroitin sulfate biosynthetic process(GO:0030206) |
| 1.5 | 6.1 | GO:0018242 | protein O-linked glycosylation via serine(GO:0018242) |
| 0.3 | 5.6 | GO:0032486 | Rap protein signal transduction(GO:0032486) |
| 0.8 | 5.1 | GO:0014005 | microglia differentiation(GO:0014004) microglia development(GO:0014005) collateral sprouting in absence of injury(GO:0048669) smooth endoplasmic reticulum calcium ion homeostasis(GO:0051563) cellular response to norepinephrine stimulus(GO:0071874) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 13.7 | GO:0032580 | Golgi cisterna membrane(GO:0032580) |
| 0.1 | 12.4 | GO:0005643 | nuclear pore(GO:0005643) |
| 0.1 | 10.4 | GO:0010494 | cytoplasmic stress granule(GO:0010494) |
| 0.0 | 8.8 | GO:0030027 | lamellipodium(GO:0030027) |
| 0.1 | 7.1 | GO:0005778 | peroxisomal membrane(GO:0005778) microbody membrane(GO:0031903) |
| 0.1 | 6.8 | GO:0005876 | spindle microtubule(GO:0005876) |
| 0.0 | 6.6 | GO:0042470 | melanosome(GO:0042470) pigment granule(GO:0048770) |
| 0.0 | 6.2 | GO:0000151 | ubiquitin ligase complex(GO:0000151) |
| 0.0 | 5.7 | GO:0101002 | ficolin-1-rich granule(GO:0101002) ficolin-1-rich granule lumen(GO:1904813) |
| 0.4 | 5.6 | GO:0034663 | endoplasmic reticulum chaperone complex(GO:0034663) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 23.7 | GO:0045296 | cadherin binding(GO:0045296) |
| 0.2 | 15.3 | GO:0019003 | GDP binding(GO:0019003) |
| 0.3 | 11.9 | GO:0008139 | nuclear localization sequence binding(GO:0008139) |
| 0.2 | 8.7 | GO:0061631 | ubiquitin conjugating enzyme activity(GO:0061631) |
| 2.3 | 7.0 | GO:0001069 | regulatory region RNA binding(GO:0001069) |
| 0.1 | 7.0 | GO:0004407 | histone deacetylase activity(GO:0004407) |
| 0.2 | 6.9 | GO:0050699 | WW domain binding(GO:0050699) |
| 0.2 | 6.6 | GO:0004707 | MAP kinase activity(GO:0004707) |
| 0.4 | 6.1 | GO:0004653 | polypeptide N-acetylgalactosaminyltransferase activity(GO:0004653) |
| 0.2 | 6.1 | GO:0070410 | co-SMAD binding(GO:0070410) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 8.7 | PID INTEGRIN A4B1 PATHWAY | Alpha4 beta1 integrin signaling events |
| 0.1 | 8.1 | PID ECADHERIN STABILIZATION PATHWAY | Stabilization and expansion of the E-cadherin adherens junction |
| 0.1 | 6.8 | PID PLK1 PATHWAY | PLK1 signaling events |
| 0.1 | 5.9 | PID NECTIN PATHWAY | Nectin adhesion pathway |
| 0.1 | 5.7 | PID SMAD2 3PATHWAY | Regulation of cytoplasmic and nuclear SMAD2/3 signaling |
| 0.2 | 5.5 | PID BETA CATENIN DEG PATHWAY | Degradation of beta catenin |
| 0.1 | 5.1 | PID GLYPICAN 1PATHWAY | Glypican 1 network |
| 0.2 | 5.0 | PID ARF 3PATHWAY | Arf1 pathway |
| 0.1 | 5.0 | PID SYNDECAN 2 PATHWAY | Syndecan-2-mediated signaling events |
| 0.1 | 4.5 | PID TGFBR PATHWAY | TGF-beta receptor signaling |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 9.4 | REACTOME ANTIVIRAL MECHANISM BY IFN STIMULATED GENES | Genes involved in Antiviral mechanism by IFN-stimulated genes |
| 0.3 | 7.6 | REACTOME CTNNB1 PHOSPHORYLATION CASCADE | Genes involved in Beta-catenin phosphorylation cascade |
| 0.0 | 7.3 | REACTOME SIGNALING BY PDGF | Genes involved in Signaling by PDGF |
| 0.0 | 6.7 | REACTOME MRNA SPLICING | Genes involved in mRNA Splicing |
| 0.2 | 6.2 | REACTOME P130CAS LINKAGE TO MAPK SIGNALING FOR INTEGRINS | Genes involved in p130Cas linkage to MAPK signaling for integrins |
| 0.2 | 6.2 | REACTOME CHONDROITIN SULFATE BIOSYNTHESIS | Genes involved in Chondroitin sulfate biosynthesis |
| 0.3 | 6.1 | REACTOME DESTABILIZATION OF MRNA BY TRISTETRAPROLIN TTP | Genes involved in Destabilization of mRNA by Tristetraprolin (TTP) |
| 0.2 | 6.1 | REACTOME INHIBITION OF THE PROTEOLYTIC ACTIVITY OF APC C REQUIRED FOR THE ONSET OF ANAPHASE BY MITOTIC SPINDLE CHECKPOINT COMPONENTS | Genes involved in Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components |
| 0.1 | 6.1 | REACTOME O LINKED GLYCOSYLATION OF MUCINS | Genes involved in O-linked glycosylation of mucins |
| 0.1 | 5.9 | REACTOME GOLGI ASSOCIATED VESICLE BIOGENESIS | Genes involved in Golgi Associated Vesicle Biogenesis |