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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
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Results for UAUUGCU
Z-value: 0.82
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miRNA associated with seed UAUUGCU
| Name | miRBASE accession |
|---|---|
|
hsa-miR-137
|
MIMAT0000429 |
Network of associatons between targets according to the STRING database.
First level regulatory network of UAUUGCU
| Promoter | Score | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr5_-_131796921 Show fit | 16.52 |
ENST00000307968.11
ENST00000307954.12 |
folliculin interacting protein 1 |
|
| chr2_+_112275588 Show fit | 15.53 |
ENST00000409871.6
ENST00000343936.4 |
zinc finger CCCH-type containing 6 |
|
| chr11_-_113875555 Show fit | 14.76 |
ENST00000003302.8
ENST00000545540.5 |
ubiquitin specific peptidase 28 |
|
| chr6_+_11537738 Show fit | 11.33 |
ENST00000379426.2
|
transmembrane protein 170B |
|
| chr18_-_61892997 Show fit | 9.41 |
ENST00000312828.4
|
ring finger protein 152 |
|
| chr4_+_7043315 Show fit | 8.81 |
ENST00000310074.8
ENST00000512388.1 |
transcriptional adaptor 2B |
|
| chr7_+_139231225 Show fit | 8.74 |
ENST00000473989.8
|
ubinuclein 2 |
|
| chr22_+_41381923 Show fit | 8.68 |
ENST00000266304.9
|
TEF transcription factor, PAR bZIP family member |
|
| chr17_-_76240478 Show fit | 8.28 |
ENST00000269391.11
|
ring finger protein 157 |
|
| chr19_+_1205761 Show fit | 8.12 |
ENST00000326873.12
ENST00000586243.5 |
serine/threonine kinase 11 |
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.6 | 17.5 | GO:1904262 | negative regulation of TORC1 signaling(GO:1904262) |
| 3.3 | 16.5 | GO:0002904 | positive regulation of B cell apoptotic process(GO:0002904) |
| 0.3 | 12.3 | GO:1901985 | positive regulation of protein acetylation(GO:1901985) |
| 0.2 | 11.9 | GO:0006198 | cAMP catabolic process(GO:0006198) |
| 0.1 | 11.2 | GO:0042771 | intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator(GO:0042771) |
| 2.7 | 10.8 | GO:0071409 | cellular response to cycloheximide(GO:0071409) |
| 0.6 | 9.3 | GO:0043117 | positive regulation of vascular permeability(GO:0043117) |
| 1.5 | 9.0 | GO:0035881 | amacrine cell differentiation(GO:0035881) |
| 0.2 | 9.0 | GO:0000083 | regulation of transcription involved in G1/S transition of mitotic cell cycle(GO:0000083) |
| 2.8 | 8.5 | GO:0046619 | optic placode formation involved in camera-type eye formation(GO:0046619) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 15.7 | GO:0016605 | PML body(GO:0016605) |
| 0.2 | 14.3 | GO:0031463 | Cul3-RING ubiquitin ligase complex(GO:0031463) |
| 0.1 | 13.9 | GO:0042734 | presynaptic membrane(GO:0042734) |
| 0.2 | 11.7 | GO:0043198 | dendritic shaft(GO:0043198) |
| 0.6 | 11.2 | GO:0031588 | nucleotide-activated protein kinase complex(GO:0031588) |
| 0.6 | 10.2 | GO:0030914 | STAGA complex(GO:0030914) |
| 0.1 | 9.2 | GO:0031594 | neuromuscular junction(GO:0031594) |
| 1.8 | 8.9 | GO:0036398 | TCR signalosome(GO:0036398) |
| 0.4 | 8.8 | GO:0005721 | pericentric heterochromatin(GO:0005721) |
| 0.1 | 7.7 | GO:0031093 | platelet alpha granule lumen(GO:0031093) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 27.7 | GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding(GO:0000981) |
| 0.2 | 24.7 | GO:0036459 | thiol-dependent ubiquitinyl hydrolase activity(GO:0036459) ubiquitinyl hydrolase activity(GO:0101005) |
| 4.1 | 16.5 | GO:0042030 | ATPase inhibitor activity(GO:0042030) |
| 2.5 | 14.7 | GO:0061665 | SUMO ligase activity(GO:0061665) |
| 0.3 | 12.2 | GO:0017091 | AU-rich element binding(GO:0017091) |
| 0.3 | 11.9 | GO:0004115 | 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115) |
| 0.0 | 11.8 | GO:0001071 | nucleic acid binding transcription factor activity(GO:0001071) transcription factor activity, sequence-specific DNA binding(GO:0003700) |
| 0.4 | 10.8 | GO:0005251 | delayed rectifier potassium channel activity(GO:0005251) |
| 0.8 | 10.5 | GO:0022820 | potassium:chloride symporter activity(GO:0015379) potassium ion symporter activity(GO:0022820) |
| 0.8 | 8.5 | GO:0004679 | AMP-activated protein kinase activity(GO:0004679) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 15.1 | PID LKB1 PATHWAY | LKB1 signaling events |
| 0.1 | 12.1 | PID TRKR PATHWAY | Neurotrophic factor-mediated Trk receptor signaling |
| 0.2 | 10.9 | PID P38 ALPHA BETA PATHWAY | Regulation of p38-alpha and p38-beta |
| 0.2 | 10.9 | PID TNF PATHWAY | TNF receptor signaling pathway |
| 0.2 | 10.4 | PID MYC PATHWAY | C-MYC pathway |
| 0.2 | 9.4 | PID FRA PATHWAY | Validated transcriptional targets of AP1 family members Fra1 and Fra2 |
| 0.1 | 9.1 | PID P53 DOWNSTREAM PATHWAY | Direct p53 effectors |
| 0.1 | 8.7 | PID BETA CATENIN NUC PATHWAY | Regulation of nuclear beta catenin signaling and target gene transcription |
| 0.2 | 8.1 | PID PRL SIGNALING EVENTS PATHWAY | Signaling events mediated by PRL |
| 0.0 | 7.7 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 25.7 | REACTOME TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES | Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides |
| 0.8 | 19.3 | REACTOME REGULATION OF AMPK ACTIVITY VIA LKB1 | Genes involved in Regulation of AMPK activity via LKB1 |
| 0.3 | 15.4 | REACTOME VOLTAGE GATED POTASSIUM CHANNELS | Genes involved in Voltage gated Potassium channels |
| 0.3 | 10.5 | REACTOME UNBLOCKING OF NMDA RECEPTOR GLUTAMATE BINDING AND ACTIVATION | Genes involved in Unblocking of NMDA receptor, glutamate binding and activation |
| 0.4 | 9.9 | REACTOME REGULATION OF KIT SIGNALING | Genes involved in Regulation of KIT signaling |
| 0.1 | 9.5 | REACTOME PPARA ACTIVATES GENE EXPRESSION | Genes involved in PPARA Activates Gene Expression |
| 0.1 | 8.3 | REACTOME G ALPHA S SIGNALLING EVENTS | Genes involved in G alpha (s) signalling events |
| 0.2 | 7.3 | REACTOME INTERACTION BETWEEN L1 AND ANKYRINS | Genes involved in Interaction between L1 and Ankyrins |
| 0.2 | 7.0 | REACTOME A TETRASACCHARIDE LINKER SEQUENCE IS REQUIRED FOR GAG SYNTHESIS | Genes involved in A tetrasaccharide linker sequence is required for GAG synthesis |
| 0.1 | 6.7 | REACTOME NITRIC OXIDE STIMULATES GUANYLATE CYCLASE | Genes involved in Nitric oxide stimulates guanylate cyclase |