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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
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Results for UBP1
Z-value: 0.58
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Transcription factors associated with UBP1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| UBP1 | hg38_v1_chr3_-_33440343_33440413 | -0.19 | 4.3e-03 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of UBP1
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 19.9 | GO:0000122 | negative regulation of transcription from RNA polymerase II promoter(GO:0000122) |
| 1.6 | 14.5 | GO:1902902 | negative regulation of autophagosome assembly(GO:1902902) |
| 0.1 | 13.6 | GO:0007127 | meiosis I(GO:0007127) |
| 0.1 | 12.8 | GO:0032945 | negative regulation of mononuclear cell proliferation(GO:0032945) negative regulation of lymphocyte proliferation(GO:0050672) |
| 0.2 | 10.6 | GO:0035774 | positive regulation of insulin secretion involved in cellular response to glucose stimulus(GO:0035774) |
| 0.1 | 6.5 | GO:0006910 | phagocytosis, recognition(GO:0006910) |
| 0.2 | 6.4 | GO:0048665 | neuron fate specification(GO:0048665) |
| 0.0 | 5.7 | GO:0002377 | immunoglobulin production(GO:0002377) |
| 0.2 | 4.6 | GO:0050860 | negative regulation of T cell receptor signaling pathway(GO:0050860) |
| 0.2 | 3.9 | GO:0003322 | pancreatic A cell development(GO:0003322) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 19.9 | GO:0043209 | myelin sheath(GO:0043209) |
| 0.0 | 14.5 | GO:0030424 | axon(GO:0030424) |
| 1.4 | 13.6 | GO:0097197 | tetraspanin-enriched microdomain(GO:0097197) |
| 0.0 | 10.1 | GO:0009986 | cell surface(GO:0009986) |
| 0.1 | 6.5 | GO:0042571 | immunoglobulin complex, circulating(GO:0042571) |
| 0.0 | 4.0 | GO:0016324 | apical plasma membrane(GO:0016324) |
| 0.0 | 3.8 | GO:0043195 | terminal bouton(GO:0043195) |
| 0.1 | 3.5 | GO:0048786 | presynaptic active zone(GO:0048786) |
| 0.1 | 3.0 | GO:0005762 | organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762) |
| 0.0 | 2.8 | GO:0031902 | late endosome membrane(GO:0031902) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 18.1 | GO:0051015 | actin filament binding(GO:0051015) |
| 0.4 | 14.5 | GO:0043015 | gamma-tubulin binding(GO:0043015) |
| 0.0 | 8.4 | GO:0003823 | antigen binding(GO:0003823) |
| 0.1 | 6.5 | GO:0034987 | immunoglobulin receptor binding(GO:0034987) |
| 0.0 | 6.4 | GO:0001078 | transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078) |
| 0.1 | 3.9 | GO:0035035 | histone acetyltransferase binding(GO:0035035) |
| 0.2 | 3.8 | GO:0019864 | IgG binding(GO:0019864) |
| 0.6 | 3.0 | GO:0004045 | aminoacyl-tRNA hydrolase activity(GO:0004045) |
| 0.0 | 2.8 | GO:0005544 | calcium-dependent phospholipid binding(GO:0005544) |
| 0.0 | 2.3 | GO:0005089 | Rho guanyl-nucleotide exchange factor activity(GO:0005089) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 3.9 | PID CDC42 PATHWAY | CDC42 signaling events |
| 0.0 | 3.3 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.0 | 2.3 | PID RHOA REG PATHWAY | Regulation of RhoA activity |
| 0.0 | 1.4 | PID TRKR PATHWAY | Neurotrophic factor-mediated Trk receptor signaling |
| 0.0 | 1.0 | PID RAC1 REG PATHWAY | Regulation of RAC1 activity |
| 0.0 | 0.5 | PID S1P META PATHWAY | Sphingosine 1-phosphate (S1P) pathway |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 3.9 | REACTOME SYNTHESIS SECRETION AND INACTIVATION OF GIP | Genes involved in Synthesis, Secretion, and Inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) |
| 0.0 | 2.0 | REACTOME TOLL RECEPTOR CASCADES | Genes involved in Toll Receptor Cascades |
| 0.1 | 1.6 | REACTOME SYNTHESIS OF VERY LONG CHAIN FATTY ACYL COAS | Genes involved in Synthesis of very long-chain fatty acyl-CoAs |
| 0.0 | 1.4 | REACTOME PROLACTIN RECEPTOR SIGNALING | Genes involved in Prolactin receptor signaling |
| 0.0 | 1.4 | REACTOME RNA POL III TRANSCRIPTION INITIATION FROM TYPE 3 PROMOTER | Genes involved in RNA Polymerase III Transcription Initiation From Type 3 Promoter |
| 0.0 | 1.3 | REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL | Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell |
| 0.0 | 0.9 | REACTOME ADHERENS JUNCTIONS INTERACTIONS | Genes involved in Adherens junctions interactions |
| 0.0 | 0.8 | REACTOME OTHER SEMAPHORIN INTERACTIONS | Genes involved in Other semaphorin interactions |
| 0.0 | 0.5 | REACTOME SPHINGOLIPID DE NOVO BIOSYNTHESIS | Genes involved in Sphingolipid de novo biosynthesis |
| 0.0 | 0.3 | REACTOME NFKB ACTIVATION THROUGH FADD RIP1 PATHWAY MEDIATED BY CASPASE 8 AND10 | Genes involved in NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 |