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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)

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Results for UBP1

Z-value: 0.58

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Transcription factors associated with UBP1

Gene Symbol Gene ID Gene Info
UBP1
ENSG00000153560.12 UBP1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
UBP1hg38_v1_chr3_-_33440343_33440413-0.194.3e-03Click!

Activity profile of UBP1 motif

Sorted Z-values of UBP1 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of UBP1

PNG image of the network

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Top targets:

Promoter Score Transcript Gene Gene Info
chr11_-_125592448 14.55 ENST00000648911.1
FEZ1
fasciculation and elongation protein zeta 1
chr17_-_5234801 13.62 ENST00000571800.5
ENST00000574081.6
ENST00000399600.8
ENST00000574297.1
SCIMP
SLP adaptor and CSK interacting membrane protein
chr2_+_17540670 10.60 ENST00000451533.5
ENST00000295156.9
VSNL1
visinin like 1
chr3_-_98523013 7.08 ENST00000394181.6
ENST00000508902.5
ENST00000394180.6
CLDND1
claudin domain containing 1
chr3_+_111999189 6.88 ENST00000455401.6
TAGLN3
transgelin 3
chr3_+_111999326 6.61 ENST00000494932.1
TAGLN3
transgelin 3
chr7_+_142800957 6.54 ENST00000466254.1
TRBC2
T cell receptor beta constant 2
chr3_-_98522869 6.39 ENST00000502288.5
ENST00000512147.5
ENST00000341181.11
ENST00000510541.5
ENST00000503621.5
ENST00000511081.5
ENST00000507874.5
ENST00000502299.5
ENST00000508659.5
ENST00000510545.5
ENST00000511667.5
ENST00000394185.6
CLDND1
claudin domain containing 1
chr3_+_111998915 6.38 ENST00000478951.6
TAGLN3
transgelin 3
chr6_+_31587268 6.09 ENST00000396101.7
ENST00000490742.5
LST1
leukocyte specific transcript 1
chr6_+_31587185 5.06 ENST00000376092.7
ENST00000376086.7
ENST00000303757.12
ENST00000376093.6
LST1
leukocyte specific transcript 1
chr2_-_89010515 4.24 ENST00000493819.1
IGKV1-9
immunoglobulin kappa variable 1-9
chr5_-_111757704 3.91 ENST00000379671.7
NREP
neuronal regeneration related protein
chr22_-_36817510 3.80 ENST00000443735.1
PVALB
parvalbumin
chr7_+_143132069 3.79 ENST00000291009.4
PIP
prolactin induced protein
chr5_-_111758061 3.76 ENST00000509979.5
ENST00000513100.5
ENST00000508161.5
ENST00000455559.6
NREP
neuronal regeneration related protein
chr5_-_94111627 3.62 ENST00000505869.5
ENST00000395965.8
ENST00000509163.5
FAM172A
family with sequence similarity 172 member A
chr5_-_111757643 3.56 ENST00000508870.5
NREP
neuronal regeneration related protein
chr3_-_56468346 3.51 ENST00000288221.11
ERC2
ELKS/RAB6-interacting/CAST family member 2
chr2_-_2331336 3.50 ENST00000648933.1
ENST00000644820.1
MYT1L
myelin transcription factor 1 like
chr5_-_111757549 3.11 ENST00000419114.6
NREP
neuronal regeneration related protein
chr12_+_123233420 3.00 ENST00000253233.6
ENST00000366329.7
ENST00000546132.2
ENST00000536130.2
C12orf65
chromosome 12 open reading frame 65
chr4_+_155666718 2.91 ENST00000621234.4
ENST00000511108.5
GUCY1A1
guanylate cyclase 1 soluble subunit alpha 1
chr2_-_2331225 2.87 ENST00000648627.1
ENST00000649663.1
ENST00000650560.1
ENST00000428368.7
ENST00000648316.1
ENST00000648665.1
ENST00000649313.1
ENST00000399161.7
ENST00000647738.2
MYT1L
myelin transcription factor 1 like
chr5_-_151141631 2.79 ENST00000523714.5
ENST00000521749.5
ANXA6
annexin A6
chr21_+_42403856 2.77 ENST00000291535.11
UBASH3A
ubiquitin associated and SH3 domain containing A
chr2_-_89143133 2.62 ENST00000492167.1
IGKV3-20
immunoglobulin kappa variable 3-20
chr4_+_155666963 2.53 ENST00000455639.6
GUCY1A1
guanylate cyclase 1 soluble subunit alpha 1
chr1_+_17580474 2.29 ENST00000375415.5
ARHGEF10L
Rho guanine nucleotide exchange factor 10 like
chrX_+_54920796 2.21 ENST00000442098.5
ENST00000430420.5
ENST00000453081.5
ENST00000319167.12
ENST00000622017.4
ENST00000375022.8
ENST00000399736.5
ENST00000440072.5
ENST00000173898.12
ENST00000431115.5
ENST00000440759.5
ENST00000375041.6
TRO
trophinin
chr1_-_152360004 2.20 ENST00000388718.5
FLG2
filaggrin family member 2
chrX_-_19970298 2.16 ENST00000379687.7
ENST00000379682.8
BCLAF3
BCLAF1 and THRAP3 family member 3
chr11_-_31803663 2.16 ENST00000638802.1
ENST00000638878.1
PAX6
paired box 6
chr8_+_28890365 2.12 ENST00000519662.5
ENST00000558662.5
ENST00000287701.15
ENST00000523613.5
ENST00000560599.5
ENST00000397358.7
HMBOX1
homeobox containing 1
chr4_+_155666827 2.07 ENST00000511507.5
ENST00000506455.6
GUCY1A1
guanylate cyclase 1 soluble subunit alpha 1
chr6_+_6588082 1.96 ENST00000379953.6
LY86
lymphocyte antigen 86
chr21_+_42403874 1.85 ENST00000319294.11
ENST00000398367.1
UBASH3A
ubiquitin associated and SH3 domain containing A
chr11_-_84317296 1.83 ENST00000280241.12
ENST00000398301.6
DLG2
discs large MAGUK scaffold protein 2
chr1_+_220528785 1.82 ENST00000678435.1
MARK1
microtubule affinity regulating kinase 1
chr2_-_227379297 1.78 ENST00000304568.4
TM4SF20
transmembrane 4 L six family member 20
chr11_-_31803620 1.73 ENST00000639006.1
PAX6
paired box 6
chrX_-_66033664 1.69 ENST00000427538.5
VSIG4
V-set and immunoglobulin domain containing 4
chr4_-_82430192 1.65 ENST00000621267.4
ENST00000614627.4
HNRNPDL
heterogeneous nuclear ribonucleoprotein D like
chr5_-_131994225 1.63 ENST00000543479.5
ENST00000431707.5
ACSL6
acyl-CoA synthetase long chain family member 6
chr5_-_151224069 1.55 ENST00000355417.7
CCDC69
coiled-coil domain containing 69
chr22_+_22811737 1.54 ENST00000390315.3
IGLV3-10
immunoglobulin lambda variable 3-10
chr7_+_49773632 1.50 ENST00000340652.5
VWC2
von Willebrand factor C domain containing 2
chr19_-_51372269 1.47 ENST00000593572.5
ENST00000595157.1
NKG7
natural killer cell granule protein 7
chr1_+_148889403 1.47 ENST00000464103.5
ENST00000534536.5
ENST00000369356.8
ENST00000369354.7
ENST00000369347.8
ENST00000369349.7
ENST00000369351.7
PDE4DIP
phosphodiesterase 4D interacting protein
chr5_+_80035341 1.45 ENST00000350881.6
THBS4
thrombospondin 4
chr16_+_28846674 1.42 ENST00000322610.12
SH2B1
SH2B adaptor protein 1
chr9_+_15422704 1.35 ENST00000380821.7
ENST00000610884.4
ENST00000421710.5
SNAPC3
small nuclear RNA activating complex polypeptide 3
chr1_-_150235972 1.32 ENST00000534220.1
ANP32E
acidic nuclear phosphoprotein 32 family member E
chr3_+_111542178 1.28 ENST00000283285.10
ENST00000352690.9
CD96
CD96 molecule
chr12_-_11310420 1.27 ENST00000621732.4
ENST00000445719.2
ENST00000279575.7
PRB4
proline rich protein BstNI subfamily 4
chr13_+_24270681 1.04 ENST00000343003.10
ENST00000399949.6
SPATA13
spermatogenesis associated 13
chr12_+_8914525 1.01 ENST00000543824.5
PHC1
polyhomeotic homolog 1
chr5_-_22853320 0.91 ENST00000504376.6
ENST00000382254.6
CDH12
cadherin 12
chr17_-_3292600 0.85 ENST00000615105.1
OR3A1
olfactory receptor family 3 subfamily A member 1
chr7_-_83649097 0.84 ENST00000643230.2
SEMA3E
semaphorin 3E
chr8_-_119855838 0.76 ENST00000313655.5
DSCC1
DNA replication and sister chromatid cohesion 1
chrX_-_55030970 0.55 ENST00000493869.2
ENST00000396198.7
ENST00000650242.1
ENST00000335854.8
ENST00000477869.6
ENST00000455688.2
ENST00000644983.1
ALAS2
5'-aminolevulinate synthase 2
chr16_-_89719369 0.54 ENST00000561976.5
VPS9D1
VPS9 domain containing 1
chr17_+_76385256 0.51 ENST00000392496.3
SPHK1
sphingosine kinase 1
chr10_+_103493931 0.47 ENST00000369780.8
NEURL1
neuralized E3 ubiquitin protein ligase 1
chr19_+_49361783 0.46 ENST00000594268.1
DKKL1
dickkopf like acrosomal protein 1
chr6_+_69866546 0.33 ENST00000620364.5
COL19A1
collagen type XIX alpha 1 chain
chr13_-_23375431 0.33 ENST00000683270.1
ENST00000684163.1
ENST00000402364.1
ENST00000683367.1
SACS
sacsin molecular chaperone
chr19_-_4581755 0.32 ENST00000676793.1
SEMA6B
semaphorin 6B
chr9_-_6015607 0.25 ENST00000485372.1
ENST00000259569.6
ENST00000623170.1
RANBP6
RAN binding protein 6
chr12_+_80716906 0.23 ENST00000228644.4
MYF5
myogenic factor 5
chr5_-_59430600 0.22 ENST00000636120.1
PDE4D
phosphodiesterase 4D
chr2_-_162318475 0.21 ENST00000648433.1
IFIH1
interferon induced with helicase C domain 1
chr2_-_162318129 0.07 ENST00000679938.1
IFIH1
interferon induced with helicase C domain 1
chr2_-_162318613 0.06 ENST00000649979.2
ENST00000421365.2
IFIH1
interferon induced with helicase C domain 1
chr11_+_7485492 0.03 ENST00000534244.1
ENST00000329293.4
OLFML1
olfactomedin like 1

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
1.6 14.5 GO:1902902 negative regulation of autophagosome assembly(GO:1902902)
0.5 1.5 GO:0071603 endothelial cell-cell adhesion(GO:0071603)
0.3 3.0 GO:0072344 rescue of stalled ribosome(GO:0072344)
0.3 1.3 GO:0002727 natural killer cell cytokine production(GO:0002370) regulation of natural killer cell cytokine production(GO:0002727)
0.2 10.6 GO:0035774 positive regulation of insulin secretion involved in cellular response to glucose stimulus(GO:0035774)
0.2 3.9 GO:0003322 pancreatic A cell development(GO:0003322)
0.2 2.0 GO:0031666 positive regulation of lipopolysaccharide-mediated signaling pathway(GO:0031666)
0.2 3.8 GO:0070233 negative regulation of T cell apoptotic process(GO:0070233)
0.2 0.5 GO:0046521 sphingoid catabolic process(GO:0046521)
0.2 6.4 GO:0048665 neuron fate specification(GO:0048665)
0.2 4.6 GO:0050860 negative regulation of T cell receptor signaling pathway(GO:0050860)
0.2 0.8 GO:1900264 regulation of DNA-directed DNA polymerase activity(GO:1900262) positive regulation of DNA-directed DNA polymerase activity(GO:1900264)
0.1 2.1 GO:0035563 positive regulation of chromatin binding(GO:0035563)
0.1 13.6 GO:0007127 meiosis I(GO:0007127)
0.1 12.8 GO:0032945 negative regulation of mononuclear cell proliferation(GO:0032945) negative regulation of lymphocyte proliferation(GO:0050672)
0.1 2.8 GO:0051560 mitochondrial calcium ion homeostasis(GO:0051560)
0.1 1.6 GO:0051255 spindle midzone assembly(GO:0051255)
0.1 6.5 GO:0006910 phagocytosis, recognition(GO:0006910)
0.1 2.6 GO:0003094 glomerular filtration(GO:0003094)
0.1 2.2 GO:0061436 establishment of skin barrier(GO:0061436)
0.1 0.3 GO:0034343 type III interferon production(GO:0034343) regulation of type III interferon production(GO:0034344)
0.1 0.5 GO:0048170 positive regulation of long-term neuronal synaptic plasticity(GO:0048170)
0.1 0.6 GO:0032364 oxygen homeostasis(GO:0032364)
0.1 1.8 GO:0097120 receptor localization to synapse(GO:0097120)
0.0 1.6 GO:0035338 long-chain fatty-acyl-CoA biosynthetic process(GO:0035338)
0.0 0.5 GO:0015986 energy coupled proton transport, down electrochemical gradient(GO:0015985) ATP synthesis coupled proton transport(GO:0015986)
0.0 1.5 GO:0030514 negative regulation of BMP signaling pathway(GO:0030514)
0.0 2.2 GO:0007566 embryo implantation(GO:0007566)
0.0 5.7 GO:0002377 immunoglobulin production(GO:0002377)
0.0 0.8 GO:0071526 semaphorin-plexin signaling pathway(GO:0071526)
0.0 2.5 GO:0030032 lamellipodium assembly(GO:0030032)
0.0 0.2 GO:0086024 adrenergic receptor signaling pathway involved in positive regulation of heart rate(GO:0086024)
0.0 1.0 GO:0016574 histone ubiquitination(GO:0016574)
0.0 1.4 GO:0006383 transcription from RNA polymerase III promoter(GO:0006383)
0.0 1.7 GO:0035722 interleukin-12-mediated signaling pathway(GO:0035722) cellular response to interleukin-12(GO:0071349)
0.0 0.2 GO:0048743 positive regulation of skeletal muscle fiber development(GO:0048743)
0.0 0.3 GO:0090084 negative regulation of inclusion body assembly(GO:0090084)
0.0 0.3 GO:0006610 ribosomal protein import into nucleus(GO:0006610)
0.0 19.9 GO:0000122 negative regulation of transcription from RNA polymerase II promoter(GO:0000122)
0.0 2.3 GO:0035023 regulation of Rho protein signal transduction(GO:0035023)
0.0 1.8 GO:0001764 neuron migration(GO:0001764)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
1.4 13.6 GO:0097197 tetraspanin-enriched microdomain(GO:0097197)
0.9 2.6 GO:0071753 IgM immunoglobulin complex(GO:0071753) IgM immunoglobulin complex, circulating(GO:0071754) pentameric IgM immunoglobulin complex(GO:0071756)
0.2 1.5 GO:0005614 interstitial matrix(GO:0005614)
0.1 6.5 GO:0042571 immunoglobulin complex, circulating(GO:0042571)
0.1 0.8 GO:0031390 Ctf18 RFC-like complex(GO:0031390)
0.1 3.0 GO:0005762 organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762)
0.1 19.9 GO:0043209 myelin sheath(GO:0043209)
0.1 3.5 GO:0048786 presynaptic active zone(GO:0048786)
0.1 1.0 GO:0035102 PRC1 complex(GO:0035102)
0.1 2.1 GO:0005697 telomerase holoenzyme complex(GO:0005697)
0.0 1.8 GO:0044224 juxtaparanode region of axon(GO:0044224)
0.0 3.8 GO:0043195 terminal bouton(GO:0043195)
0.0 1.6 GO:0051233 spindle midzone(GO:0051233)
0.0 0.3 GO:0070852 cell body fiber(GO:0070852)
0.0 14.5 GO:0030424 axon(GO:0030424)
0.0 0.5 GO:0097440 apical dendrite(GO:0097440)
0.0 2.8 GO:0031902 late endosome membrane(GO:0031902)
0.0 1.6 GO:0005778 peroxisomal membrane(GO:0005778) microbody membrane(GO:0031903)
0.0 1.5 GO:0016529 sarcoplasmic reticulum(GO:0016529)
0.0 1.0 GO:0030175 filopodium(GO:0030175)
0.0 4.0 GO:0016324 apical plasma membrane(GO:0016324)
0.0 10.1 GO:0009986 cell surface(GO:0009986)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 3.0 GO:0004045 aminoacyl-tRNA hydrolase activity(GO:0004045)
0.4 14.5 GO:0043015 gamma-tubulin binding(GO:0043015)
0.2 3.8 GO:0019864 IgG binding(GO:0019864)
0.2 2.1 GO:0003720 telomerase activity(GO:0003720) RNA-directed DNA polymerase activity(GO:0003964)
0.1 0.6 GO:0003870 5-aminolevulinate synthase activity(GO:0003870) N-succinyltransferase activity(GO:0016749)
0.1 6.5 GO:0034987 immunoglobulin receptor binding(GO:0034987)
0.1 0.8 GO:0003689 DNA clamp loader activity(GO:0003689) protein-DNA loading ATPase activity(GO:0033170)
0.1 1.8 GO:0050321 tau-protein kinase activity(GO:0050321)
0.1 0.5 GO:0008481 sphinganine kinase activity(GO:0008481) D-erythro-sphingosine kinase activity(GO:0017050)
0.1 18.1 GO:0051015 actin filament binding(GO:0051015)
0.1 1.6 GO:0102391 decanoate--CoA ligase activity(GO:0102391)
0.1 3.9 GO:0035035 histone acetyltransferase binding(GO:0035035)
0.0 2.8 GO:0005544 calcium-dependent phospholipid binding(GO:0005544)
0.0 8.4 GO:0003823 antigen binding(GO:0003823)
0.0 6.4 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.0 1.0 GO:0030676 Rac guanyl-nucleotide exchange factor activity(GO:0030676)
0.0 0.5 GO:0030215 semaphorin receptor binding(GO:0030215)
0.0 2.3 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.0 1.8 GO:0035255 ionotropic glutamate receptor binding(GO:0035255)
0.0 0.2 GO:0031698 beta-2 adrenergic receptor binding(GO:0031698)
0.0 0.3 GO:0070628 proteasome binding(GO:0070628)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 3.9 PID CDC42 PATHWAY CDC42 signaling events
0.0 2.3 PID RHOA REG PATHWAY Regulation of RhoA activity
0.0 1.0 PID RAC1 REG PATHWAY Regulation of RAC1 activity
0.0 3.3 NABA ECM AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.0 1.4 PID TRKR PATHWAY Neurotrophic factor-mediated Trk receptor signaling
0.0 0.5 PID S1P META PATHWAY Sphingosine 1-phosphate (S1P) pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 3.9 REACTOME SYNTHESIS SECRETION AND INACTIVATION OF GIP Genes involved in Synthesis, Secretion, and Inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)
0.1 1.6 REACTOME SYNTHESIS OF VERY LONG CHAIN FATTY ACYL COAS Genes involved in Synthesis of very long-chain fatty acyl-CoAs
0.0 1.4 REACTOME PROLACTIN RECEPTOR SIGNALING Genes involved in Prolactin receptor signaling
0.0 1.4 REACTOME RNA POL III TRANSCRIPTION INITIATION FROM TYPE 3 PROMOTER Genes involved in RNA Polymerase III Transcription Initiation From Type 3 Promoter
0.0 0.8 REACTOME OTHER SEMAPHORIN INTERACTIONS Genes involved in Other semaphorin interactions
0.0 0.9 REACTOME ADHERENS JUNCTIONS INTERACTIONS Genes involved in Adherens junctions interactions
0.0 0.3 REACTOME NFKB ACTIVATION THROUGH FADD RIP1 PATHWAY MEDIATED BY CASPASE 8 AND10 Genes involved in NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10
0.0 0.5 REACTOME SPHINGOLIPID DE NOVO BIOSYNTHESIS Genes involved in Sphingolipid de novo biosynthesis
0.0 1.3 REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
0.0 2.0 REACTOME TOLL RECEPTOR CASCADES Genes involved in Toll Receptor Cascades