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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
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Results for UCAAGUA
Z-value: 1.08
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miRNA associated with seed UCAAGUA
Network of associatons between targets according to the STRING database.
First level regulatory network of UCAAGUA
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.0 | 32.3 | GO:0006607 | NLS-bearing protein import into nucleus(GO:0006607) |
| 2.0 | 27.9 | GO:0018206 | peptidyl-methionine modification(GO:0018206) |
| 9.2 | 27.6 | GO:0090402 | oncogene-induced cell senescence(GO:0090402) |
| 0.7 | 22.5 | GO:0051016 | barbed-end actin filament capping(GO:0051016) |
| 1.1 | 20.3 | GO:0032486 | Rap protein signal transduction(GO:0032486) |
| 6.6 | 19.7 | GO:1902594 | viral penetration into host nucleus(GO:0075732) multi-organism nuclear import(GO:1902594) |
| 0.5 | 19.5 | GO:0045737 | positive regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0045737) |
| 1.4 | 19.0 | GO:2000643 | positive regulation of early endosome to late endosome transport(GO:2000643) |
| 0.9 | 17.4 | GO:0018345 | protein palmitoylation(GO:0018345) |
| 0.3 | 16.8 | GO:0031663 | lipopolysaccharide-mediated signaling pathway(GO:0031663) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 40.1 | GO:0005643 | nuclear pore(GO:0005643) |
| 0.3 | 28.6 | GO:0005811 | lipid particle(GO:0005811) |
| 3.9 | 27.6 | GO:0035985 | senescence-associated heterochromatin focus(GO:0035985) |
| 0.2 | 24.6 | GO:0070821 | tertiary granule membrane(GO:0070821) |
| 1.5 | 18.2 | GO:0008290 | F-actin capping protein complex(GO:0008290) WASH complex(GO:0071203) |
| 1.7 | 16.8 | GO:0046581 | intercellular canaliculus(GO:0046581) |
| 0.3 | 16.7 | GO:0019005 | SCF ubiquitin ligase complex(GO:0019005) |
| 2.0 | 16.2 | GO:0098559 | cytoplasmic side of early endosome membrane(GO:0098559) |
| 1.2 | 16.2 | GO:0035749 | myelin sheath adaxonal region(GO:0035749) |
| 0.8 | 15.4 | GO:0005885 | Arp2/3 protein complex(GO:0005885) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.1 | 50.7 | GO:0008139 | nuclear localization sequence binding(GO:0008139) |
| 0.4 | 36.1 | GO:0019003 | GDP binding(GO:0019003) |
| 0.1 | 29.2 | GO:0045296 | cadherin binding(GO:0045296) |
| 0.2 | 29.1 | GO:0001046 | core promoter sequence-specific DNA binding(GO:0001046) |
| 0.1 | 29.0 | GO:0051015 | actin filament binding(GO:0051015) |
| 7.1 | 21.4 | GO:0051717 | inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity(GO:0051717) |
| 0.5 | 19.8 | GO:0051059 | NF-kappaB binding(GO:0051059) |
| 0.3 | 19.7 | GO:0003743 | translation initiation factor activity(GO:0003743) |
| 0.4 | 19.1 | GO:0061650 | ubiquitin conjugating enzyme activity(GO:0061631) ubiquitin-like protein conjugating enzyme activity(GO:0061650) |
| 1.4 | 18.6 | GO:0042975 | peroxisome proliferator activated receptor binding(GO:0042975) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 65.5 | PID MYC ACTIV PATHWAY | Validated targets of C-MYC transcriptional activation |
| 0.6 | 46.4 | SIG CHEMOTAXIS | Genes related to chemotaxis |
| 0.9 | 37.7 | PID SMAD2 3PATHWAY | Regulation of cytoplasmic and nuclear SMAD2/3 signaling |
| 0.4 | 16.7 | PID NECTIN PATHWAY | Nectin adhesion pathway |
| 0.1 | 16.4 | PID P53 DOWNSTREAM PATHWAY | Direct p53 effectors |
| 0.2 | 15.1 | PID NOTCH PATHWAY | Notch signaling pathway |
| 0.2 | 12.7 | PID CERAMIDE PATHWAY | Ceramide signaling pathway |
| 0.6 | 12.2 | SA PROGRAMMED CELL DEATH | Programmed cell death, or apoptosis, eliminates damaged or unneeded cells. |
| 0.2 | 10.8 | PID CASPASE PATHWAY | Caspase cascade in apoptosis |
| 0.4 | 10.4 | PID ARF6 DOWNSTREAM PATHWAY | Arf6 downstream pathway |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 46.9 | REACTOME ANTIVIRAL MECHANISM BY IFN STIMULATED GENES | Genes involved in Antiviral mechanism by IFN-stimulated genes |
| 0.6 | 31.4 | REACTOME AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE | Genes involved in Amino acid transport across the plasma membrane |
| 1.7 | 18.6 | REACTOME APOBEC3G MEDIATED RESISTANCE TO HIV1 INFECTION | Genes involved in APOBEC3G mediated resistance to HIV-1 infection |
| 0.7 | 16.7 | REACTOME P130CAS LINKAGE TO MAPK SIGNALING FOR INTEGRINS | Genes involved in p130Cas linkage to MAPK signaling for integrins |
| 1.3 | 16.2 | REACTOME NEGATIVE REGULATION OF THE PI3K AKT NETWORK | Genes involved in Negative regulation of the PI3K/AKT network |
| 0.5 | 14.9 | REACTOME CHONDROITIN SULFATE BIOSYNTHESIS | Genes involved in Chondroitin sulfate biosynthesis |
| 0.6 | 14.0 | REACTOME ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING | Genes involved in Advanced glycosylation endproduct receptor signaling |
| 0.6 | 12.8 | REACTOME ACTIVATION OF BH3 ONLY PROTEINS | Genes involved in Activation of BH3-only proteins |
| 0.1 | 12.3 | REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION | Genes involved in Antigen processing: Ubiquitination & Proteasome degradation |
| 0.6 | 11.4 | REACTOME DESTABILIZATION OF MRNA BY TRISTETRAPROLIN TTP | Genes involved in Destabilization of mRNA by Tristetraprolin (TTP) |