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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
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Results for UCACAGU
Z-value: 0.61
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miRNA associated with seed UCACAGU
Network of associatons between targets according to the STRING database.
First level regulatory network of UCACAGU
| Promoter | Score | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chrX_+_65488735 Show fit | 16.74 |
ENST00000338957.4
|
zinc finger CCCH-type containing 12B |
|
| chr20_+_10218808 Show fit | 11.65 |
ENST00000254976.7
ENST00000304886.6 |
synaptosome associated protein 25 |
|
| chr6_+_11537738 Show fit | 9.12 |
ENST00000379426.2
|
transmembrane protein 170B |
|
| chr16_-_4242068 Show fit | 9.07 |
ENST00000399609.7
|
sarcalumenin |
|
| chr10_+_102714595 Show fit | 7.05 |
ENST00000602647.5
ENST00000602439.5 ENST00000602764.5 ENST00000369893.10 |
sideroflexin 2 |
|
| chr16_-_70685975 Show fit | 6.48 |
ENST00000338779.11
|
MTSS I-BAR domain containing 2 |
|
| chr1_-_39672080 Show fit | 6.46 |
ENST00000235628.2
|
5'-nucleotidase, cytosolic IA |
|
| chr12_+_78864768 Show fit | 6.41 |
ENST00000261205.9
ENST00000457153.6 |
synaptotagmin 1 |
|
| chrX_-_54357993 Show fit | 6.16 |
ENST00000375169.7
ENST00000354646.6 |
WNK lysine deficient protein kinase 3 |
|
| chr7_-_103989649 Show fit | 6.04 |
ENST00000428762.6
|
reelin |
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.3 | 11.5 | GO:0099590 | neurotransmitter receptor internalization(GO:0099590) |
| 0.1 | 9.0 | GO:0007156 | homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156) |
| 0.0 | 8.8 | GO:0031032 | actomyosin structure organization(GO:0031032) |
| 0.5 | 6.6 | GO:0090160 | Golgi to lysosome transport(GO:0090160) |
| 0.4 | 6.5 | GO:0009128 | purine nucleoside monophosphate catabolic process(GO:0009128) |
| 2.1 | 6.4 | GO:0098746 | fast, calcium ion-dependent exocytosis of neurotransmitter(GO:0098746) |
| 0.1 | 6.1 | GO:0055072 | iron ion homeostasis(GO:0055072) |
| 2.0 | 6.0 | GO:0097477 | spinal cord motor neuron migration(GO:0097476) lateral motor column neuron migration(GO:0097477) |
| 0.1 | 5.9 | GO:0042795 | snRNA transcription(GO:0009301) snRNA transcription from RNA polymerase II promoter(GO:0042795) |
| 0.3 | 5.6 | GO:0006012 | galactose metabolic process(GO:0006012) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.9 | 11.7 | GO:0070032 | synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex(GO:0070032) |
| 0.2 | 9.4 | GO:0048786 | presynaptic active zone(GO:0048786) |
| 0.0 | 9.4 | GO:0005578 | proteinaceous extracellular matrix(GO:0005578) |
| 0.9 | 9.1 | GO:0033018 | sarcoplasmic reticulum lumen(GO:0033018) |
| 0.0 | 8.5 | GO:0030426 | growth cone(GO:0030426) |
| 0.0 | 8.5 | GO:0030424 | axon(GO:0030424) |
| 0.1 | 7.0 | GO:0030315 | T-tubule(GO:0030315) |
| 1.3 | 6.4 | GO:0060201 | clathrin-sculpted acetylcholine transport vesicle(GO:0060200) clathrin-sculpted acetylcholine transport vesicle membrane(GO:0060201) |
| 0.1 | 6.1 | GO:0043195 | terminal bouton(GO:0043195) |
| 0.0 | 6.0 | GO:0008076 | voltage-gated potassium channel complex(GO:0008076) potassium channel complex(GO:0034705) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 11.7 | GO:0017075 | syntaxin-1 binding(GO:0017075) |
| 0.1 | 9.2 | GO:0030507 | spectrin binding(GO:0030507) |
| 0.1 | 7.2 | GO:0004222 | metalloendopeptidase activity(GO:0004222) |
| 0.0 | 6.8 | GO:0004519 | endonuclease activity(GO:0004519) |
| 0.1 | 6.6 | GO:0030374 | ligand-dependent nuclear receptor transcription coactivator activity(GO:0030374) |
| 0.5 | 6.5 | GO:0008253 | 5'-nucleotidase activity(GO:0008253) |
| 1.3 | 6.4 | GO:0030348 | syntaxin-3 binding(GO:0030348) |
| 0.4 | 6.1 | GO:0005078 | MAP-kinase scaffold activity(GO:0005078) |
| 1.5 | 6.0 | GO:0070326 | very-low-density lipoprotein particle receptor binding(GO:0070326) |
| 0.1 | 5.8 | GO:0035255 | ionotropic glutamate receptor binding(GO:0035255) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 23.5 | PID REELIN PATHWAY | Reelin signaling pathway |
| 0.1 | 7.0 | SIG CD40PATHWAYMAP | Genes related to CD40 signaling |
| 0.0 | 6.7 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.1 | 5.3 | PID TCR CALCIUM PATHWAY | Calcium signaling in the CD4+ TCR pathway |
| 0.1 | 5.3 | PID RHOA REG PATHWAY | Regulation of RhoA activity |
| 0.1 | 4.9 | PID MYC PATHWAY | C-MYC pathway |
| 0.0 | 4.9 | PID ERA GENOMIC PATHWAY | Validated nuclear estrogen receptor alpha network |
| 0.1 | 3.8 | PID WNT NONCANONICAL PATHWAY | Noncanonical Wnt signaling pathway |
| 0.1 | 3.0 | SA CASPASE CASCADE | Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade. |
| 0.1 | 2.9 | PID INTEGRIN CS PATHWAY | Integrin family cell surface interactions |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.8 | 18.1 | REACTOME NOREPINEPHRINE NEUROTRANSMITTER RELEASE CYCLE | Genes involved in Norepinephrine Neurotransmitter Release Cycle |
| 0.2 | 9.4 | REACTOME INTERACTION BETWEEN L1 AND ANKYRINS | Genes involved in Interaction between L1 and Ankyrins |
| 0.1 | 7.7 | REACTOME RNA POL II PRE TRANSCRIPTION EVENTS | Genes involved in RNA Polymerase II Pre-transcription Events |
| 0.4 | 6.5 | REACTOME PURINE CATABOLISM | Genes involved in Purine catabolism |
| 0.2 | 5.1 | REACTOME JNK C JUN KINASES PHOSPHORYLATION AND ACTIVATION MEDIATED BY ACTIVATED HUMAN TAK1 | Genes involved in JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 |
| 0.2 | 5.1 | REACTOME CASPASE MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS | Genes involved in Caspase-mediated cleavage of cytoskeletal proteins |
| 0.2 | 5.0 | REACTOME OTHER SEMAPHORIN INTERACTIONS | Genes involved in Other semaphorin interactions |
| 0.1 | 4.9 | REACTOME ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS | Genes involved in Association of TriC/CCT with target proteins during biosynthesis |
| 0.2 | 4.5 | REACTOME GABA SYNTHESIS RELEASE REUPTAKE AND DEGRADATION | Genes involved in GABA synthesis, release, reuptake and degradation |
| 0.1 | 4.2 | REACTOME VOLTAGE GATED POTASSIUM CHANNELS | Genes involved in Voltage gated Potassium channels |