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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
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Results for UCACAUU
Z-value: 0.59
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miRNA associated with seed UCACAUU
Network of associatons between targets according to the STRING database.
First level regulatory network of UCACAUU
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.9 | 11.3 | GO:0006265 | DNA topological change(GO:0006265) |
| 0.5 | 7.7 | GO:0006610 | ribosomal protein import into nucleus(GO:0006610) |
| 1.5 | 7.3 | GO:0070433 | negative regulation of nucleotide-binding oligomerization domain containing signaling pathway(GO:0070425) negative regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway(GO:0070433) |
| 1.0 | 7.1 | GO:0090204 | protein localization to nuclear pore(GO:0090204) |
| 0.1 | 6.4 | GO:0001504 | neurotransmitter uptake(GO:0001504) |
| 0.9 | 6.3 | GO:1902231 | positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage(GO:1902231) |
| 0.3 | 6.2 | GO:0030208 | dermatan sulfate biosynthetic process(GO:0030208) |
| 1.0 | 6.1 | GO:2000301 | negative regulation of synaptic vesicle exocytosis(GO:2000301) |
| 1.5 | 6.0 | GO:1901165 | positive regulation of trophoblast cell migration(GO:1901165) |
| 0.1 | 5.3 | GO:0006369 | termination of RNA polymerase II transcription(GO:0006369) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 16.2 | GO:0034399 | nuclear periphery(GO:0034399) |
| 0.1 | 10.3 | GO:0000793 | condensed chromosome(GO:0000793) |
| 0.0 | 7.5 | GO:0000151 | ubiquitin ligase complex(GO:0000151) |
| 0.1 | 6.6 | GO:0005796 | Golgi lumen(GO:0005796) |
| 0.2 | 6.5 | GO:0090545 | NuRD complex(GO:0016581) CHD-type complex(GO:0090545) |
| 0.3 | 6.0 | GO:0030056 | hemidesmosome(GO:0030056) |
| 0.0 | 5.9 | GO:0000790 | nuclear chromatin(GO:0000790) |
| 0.4 | 5.8 | GO:0034663 | endoplasmic reticulum chaperone complex(GO:0034663) |
| 0.8 | 5.7 | GO:0031415 | NatA complex(GO:0031415) |
| 0.1 | 5.3 | GO:0090544 | BAF-type complex(GO:0090544) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 9.4 | GO:0008139 | nuclear localization sequence binding(GO:0008139) |
| 0.4 | 8.9 | GO:0070273 | phosphatidylinositol-4-phosphate binding(GO:0070273) |
| 0.0 | 7.7 | GO:0045296 | cadherin binding(GO:0045296) |
| 0.1 | 7.4 | GO:0004407 | histone deacetylase activity(GO:0004407) |
| 0.1 | 6.8 | GO:0019888 | protein phosphatase regulator activity(GO:0019888) |
| 1.6 | 6.6 | GO:0044378 | non-sequence-specific DNA binding, bending(GO:0044378) |
| 0.2 | 6.5 | GO:0005540 | hyaluronic acid binding(GO:0005540) |
| 0.0 | 6.5 | GO:0017124 | SH3 domain binding(GO:0017124) |
| 0.3 | 6.0 | GO:0005176 | ErbB-2 class receptor binding(GO:0005176) |
| 0.6 | 5.7 | GO:0004727 | prenylated protein tyrosine phosphatase activity(GO:0004727) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 9.2 | PID TOLL ENDOGENOUS PATHWAY | Endogenous TLR signaling |
| 0.1 | 5.4 | PID NECTIN PATHWAY | Nectin adhesion pathway |
| 0.1 | 5.4 | PID P53 REGULATION PATHWAY | p53 pathway |
| 0.1 | 5.1 | PID PRL SIGNALING EVENTS PATHWAY | Signaling events mediated by PRL |
| 0.1 | 4.9 | PID CASPASE PATHWAY | Caspase cascade in apoptosis |
| 0.1 | 4.9 | PID IL6 7 PATHWAY | IL6-mediated signaling events |
| 0.1 | 4.6 | PID BMP PATHWAY | BMP receptor signaling |
| 0.1 | 4.3 | PID PLK1 PATHWAY | PLK1 signaling events |
| 0.1 | 3.6 | PID IL5 PATHWAY | IL5-mediated signaling events |
| 0.1 | 3.1 | PID BARD1 PATHWAY | BARD1 signaling events |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 11.0 | REACTOME DOWNREGULATION OF SMAD2 3 SMAD4 TRANSCRIPTIONAL ACTIVITY | Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity |
| 0.2 | 8.9 | REACTOME AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE | Genes involved in Amino acid transport across the plasma membrane |
| 0.3 | 8.8 | REACTOME CHONDROITIN SULFATE BIOSYNTHESIS | Genes involved in Chondroitin sulfate biosynthesis |
| 0.5 | 6.9 | REACTOME APOPTOSIS INDUCED DNA FRAGMENTATION | Genes involved in Apoptosis induced DNA fragmentation |
| 0.3 | 6.6 | REACTOME DESTABILIZATION OF MRNA BY TRISTETRAPROLIN TTP | Genes involved in Destabilization of mRNA by Tristetraprolin (TTP) |
| 0.2 | 6.3 | REACTOME CTNNB1 PHOSPHORYLATION CASCADE | Genes involved in Beta-catenin phosphorylation cascade |
| 0.1 | 5.9 | REACTOME NEGATIVE REGULATORS OF RIG I MDA5 SIGNALING | Genes involved in Negative regulators of RIG-I/MDA5 signaling |
| 0.1 | 5.7 | REACTOME GOLGI ASSOCIATED VESICLE BIOGENESIS | Genes involved in Golgi Associated Vesicle Biogenesis |
| 0.2 | 5.4 | REACTOME P130CAS LINKAGE TO MAPK SIGNALING FOR INTEGRINS | Genes involved in p130Cas linkage to MAPK signaling for integrins |
| 0.2 | 4.7 | REACTOME ACTIVATION OF RAC | Genes involved in Activation of Rac |