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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
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Results for UCCAGUU
Z-value: 1.06
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miRNA associated with seed UCCAGUU
Network of associatons between targets according to the STRING database.
First level regulatory network of UCCAGUU
| Promoter | Score | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr1_+_85580751 Show fit | 20.72 |
ENST00000451137.7
|
cellular communication network factor 1 |
|
| chr1_-_159923717 Show fit | 19.95 |
ENST00000368096.5
|
transgelin 2 |
|
| chr18_+_3247778 Show fit | 15.87 |
ENST00000217652.8
ENST00000578611.5 ENST00000583449.1 |
myosin light chain 12A |
|
| chr19_-_2456924 Show fit | 15.50 |
ENST00000325327.4
|
lamin B2 |
|
| chr12_-_92145838 Show fit | 15.02 |
ENST00000256015.5
|
BTG anti-proliferation factor 1 |
|
| chr11_-_102452758 Show fit | 14.79 |
ENST00000398136.7
ENST00000361236.7 |
transmembrane protein 123 |
|
| chr8_+_97644164 Show fit | 14.59 |
ENST00000336273.8
|
metadherin |
|
| chr12_+_12891554 Show fit | 12.88 |
ENST00000014914.6
|
G protein-coupled receptor class C group 5 member A |
|
| chr12_+_71754834 Show fit | 12.70 |
ENST00000261263.5
|
RAB21, member RAS oncogene family |
|
| chr2_-_173965356 Show fit | 12.66 |
ENST00000310015.12
|
Sp3 transcription factor |
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 35.5 | GO:0002576 | platelet degranulation(GO:0002576) |
| 0.1 | 21.5 | GO:0000398 | RNA splicing, via transesterification reactions with bulged adenosine as nucleophile(GO:0000377) mRNA splicing, via spliceosome(GO:0000398) |
| 2.0 | 19.7 | GO:0060136 | embryonic process involved in female pregnancy(GO:0060136) |
| 0.8 | 15.4 | GO:0006474 | N-terminal protein amino acid acetylation(GO:0006474) |
| 1.2 | 15.0 | GO:2000271 | positive regulation of fibroblast apoptotic process(GO:2000271) |
| 0.9 | 14.8 | GO:0045793 | positive regulation of cell size(GO:0045793) |
| 0.2 | 14.0 | GO:0070830 | bicellular tight junction assembly(GO:0070830) |
| 1.0 | 12.9 | GO:0007175 | negative regulation of epidermal growth factor-activated receptor activity(GO:0007175) |
| 1.1 | 12.7 | GO:2000643 | positive regulation of early endosome to late endosome transport(GO:2000643) |
| 0.8 | 12.5 | GO:0035020 | regulation of Rac protein signal transduction(GO:0035020) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 24.6 | GO:0032580 | Golgi cisterna membrane(GO:0032580) |
| 0.2 | 22.2 | GO:0005811 | lipid particle(GO:0005811) |
| 1.1 | 22.1 | GO:0005885 | Arp2/3 protein complex(GO:0005885) |
| 0.2 | 16.4 | GO:0031093 | platelet alpha granule lumen(GO:0031093) |
| 0.1 | 16.2 | GO:0017053 | transcriptional repressor complex(GO:0017053) |
| 2.6 | 15.8 | GO:0070022 | transforming growth factor beta receptor homodimeric complex(GO:0070022) |
| 0.2 | 15.8 | GO:0010494 | cytoplasmic stress granule(GO:0010494) |
| 0.1 | 15.6 | GO:0016459 | myosin complex(GO:0016459) |
| 1.4 | 15.5 | GO:0005638 | lamin filament(GO:0005638) |
| 1.5 | 14.6 | GO:0046581 | intercellular canaliculus(GO:0046581) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 66.1 | GO:0045296 | cadherin binding(GO:0045296) |
| 0.1 | 34.7 | GO:0003712 | transcription cofactor activity(GO:0003712) |
| 0.2 | 22.5 | GO:0000979 | RNA polymerase II core promoter sequence-specific DNA binding(GO:0000979) |
| 0.3 | 20.9 | GO:0019003 | GDP binding(GO:0019003) |
| 1.5 | 17.7 | GO:1990247 | N6-methyladenosine-containing RNA binding(GO:1990247) |
| 0.0 | 17.6 | GO:0005198 | structural molecule activity(GO:0005198) |
| 0.8 | 16.8 | GO:0017049 | GTP-Rho binding(GO:0017049) |
| 0.3 | 14.9 | GO:0004864 | protein phosphatase inhibitor activity(GO:0004864) |
| 0.4 | 14.6 | GO:0051059 | NF-kappaB binding(GO:0051059) |
| 0.1 | 13.1 | GO:0003735 | structural constituent of ribosome(GO:0003735) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 30.9 | PID SMAD2 3NUCLEAR PATHWAY | Regulation of nuclear SMAD2/3 signaling |
| 0.1 | 28.4 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.3 | 27.5 | PID RAC1 PATHWAY | RAC1 signaling pathway |
| 0.4 | 27.3 | PID RET PATHWAY | Signaling events regulated by Ret tyrosine kinase |
| 0.5 | 18.3 | ST ERK1 ERK2 MAPK PATHWAY | ERK1/ERK2 MAPK Pathway |
| 0.1 | 17.0 | PID MYC ACTIV PATHWAY | Validated targets of C-MYC transcriptional activation |
| 0.4 | 16.1 | PID ALK1 PATHWAY | ALK1 signaling events |
| 0.1 | 13.8 | PID CASPASE PATHWAY | Caspase cascade in apoptosis |
| 0.3 | 13.7 | PID IL2 PI3K PATHWAY | IL2 signaling events mediated by PI3K |
| 0.8 | 13.4 | PID THROMBIN PAR4 PATHWAY | PAR4-mediated thrombin signaling events |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.8 | 18.0 | REACTOME SOS MEDIATED SIGNALLING | Genes involved in SOS-mediated signalling |
| 0.3 | 17.5 | REACTOME SMAD2 SMAD3 SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION | Genes involved in SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription |
| 0.4 | 13.7 | REACTOME NUCLEAR EVENTS KINASE AND TRANSCRIPTION FACTOR ACTIVATION | Genes involved in Nuclear Events (kinase and transcription factor activation) |
| 0.2 | 11.4 | REACTOME SPHINGOLIPID METABOLISM | Genes involved in Sphingolipid metabolism |
| 0.2 | 11.2 | REACTOME GOLGI ASSOCIATED VESICLE BIOGENESIS | Genes involved in Golgi Associated Vesicle Biogenesis |
| 0.3 | 10.8 | REACTOME SULFUR AMINO ACID METABOLISM | Genes involved in Sulfur amino acid metabolism |
| 0.5 | 10.4 | REACTOME TGF BETA RECEPTOR SIGNALING IN EMT EPITHELIAL TO MESENCHYMAL TRANSITION | Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) |
| 0.4 | 10.2 | REACTOME FGFR1 LIGAND BINDING AND ACTIVATION | Genes involved in FGFR1 ligand binding and activation |
| 0.2 | 9.7 | REACTOME O LINKED GLYCOSYLATION OF MUCINS | Genes involved in O-linked glycosylation of mucins |
| 0.2 | 8.8 | REACTOME SEMA4D INDUCED CELL MIGRATION AND GROWTH CONE COLLAPSE | Genes involved in Sema4D induced cell migration and growth-cone collapse |