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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)

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Results for UCCCUUU

Z-value: 0.25

Motif logo

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miRNA associated with seed UCCCUUU

NamemiRBASE accession
hsa-miR-204-5p
MIMAT0000265
hsa-miR-211-5p
MIMAT0000268

Activity profile of UCCCUUU motif

Sorted Z-values of UCCCUUU motif

Network of associatons between targets according to the STRING database.

First level regulatory network of UCCCUUU

PNG image of the network

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Top targets:

Promoter Score Transcript Gene Gene Info
chr12_-_108731505 1.97 ENST00000261401.8
ENST00000552871.5
CORO1C
coronin 1C
chr12_+_65824475 1.92 ENST00000403681.7
HMGA2
high mobility group AT-hook 2
chr13_+_97953652 1.86 ENST00000460070.6
ENST00000481455.6
ENST00000261574.10
ENST00000651721.2
ENST00000493281.6
ENST00000463157.6
ENST00000471898.5
ENST00000489058.6
ENST00000481689.6
IPO5
importin 5
chr1_-_70205531 1.60 ENST00000370952.4
LRRC40
leucine rich repeat containing 40
chr11_-_6683282 1.58 ENST00000532203.1
ENST00000288937.7
MRPL17
mitochondrial ribosomal protein L17
chrX_-_20266834 1.51 ENST00000379565.9
RPS6KA3
ribosomal protein S6 kinase A3
chr1_-_154970735 1.50 ENST00000368445.9
ENST00000448116.7
ENST00000368449.8
SHC1
SHC adaptor protein 1
chr7_+_55887277 1.31 ENST00000426595.1
ENSG00000249773.3
novel zinc finger protein 713 (ZNF713) and mitochondrial ribosomal protein S17 (MRPS17) protein
chr4_-_110198650 1.16 ENST00000394607.7
ELOVL6
ELOVL fatty acid elongase 6
chr7_+_101154445 1.10 ENST00000337619.11
ENST00000429457.1
AP1S1
adaptor related protein complex 1 subunit sigma 1
chr3_+_61561561 1.09 ENST00000474889.6
PTPRG
protein tyrosine phosphatase receptor type G
chrX_+_28587411 0.89 ENST00000378993.6
IL1RAPL1
interleukin 1 receptor accessory protein like 1
chr8_-_121641424 0.88 ENST00000303924.5
HAS2
hyaluronan synthase 2
chr11_+_63938971 0.86 ENST00000539656.5
ENST00000377793.9
NAA40
N-alpha-acetyltransferase 40, NatD catalytic subunit
chr15_+_56918612 0.84 ENST00000438423.6
ENST00000267811.9
ENST00000333725.10
ENST00000559609.5
TCF12
transcription factor 12
chr19_+_34428353 0.83 ENST00000590048.6
ENST00000246548.9
UBA2
ubiquitin like modifier activating enzyme 2
chr6_+_159969070 0.81 ENST00000356956.6
IGF2R
insulin like growth factor 2 receptor
chr2_-_105329685 0.80 ENST00000393359.7
TGFBRAP1
transforming growth factor beta receptor associated protein 1
chr6_-_8102481 0.79 ENST00000502429.5
ENST00000429723.6
ENST00000379715.10
ENST00000507463.1
EEF1E1
eukaryotic translation elongation factor 1 epsilon 1
chr2_+_200811882 0.79 ENST00000409600.6
BZW1
basic leucine zipper and W2 domains 1
chr6_-_158818225 0.79 ENST00000337147.11
EZR
ezrin
chr5_+_95731300 0.76 ENST00000379982.8
RHOBTB3
Rho related BTB domain containing 3
chr2_-_199457931 0.75 ENST00000417098.6
SATB2
SATB homeobox 2
chr13_-_31161890 0.71 ENST00000320027.10
HSPH1
heat shock protein family H (Hsp110) member 1
chr16_-_20900319 0.69 ENST00000564349.5
ENST00000324344.9
ERI2
DCUN1D3
ERI1 exoribonuclease family member 2
defective in cullin neddylation 1 domain containing 3
chrX_-_132218124 0.67 ENST00000342983.6
RAP2C
RAP2C, member of RAS oncogene family
chr6_+_7107941 0.66 ENST00000379938.7
ENST00000467782.5
ENST00000334984.10
ENST00000349384.10
RREB1
ras responsive element binding protein 1
chr9_+_110048598 0.66 ENST00000434623.6
ENST00000374525.5
PALM2AKAP2
PALM2 and AKAP2 fusion
chr6_-_89352706 0.64 ENST00000435041.3
UBE2J1
ubiquitin conjugating enzyme E2 J1
chr3_+_5187697 0.64 ENST00000256497.9
EDEM1
ER degradation enhancing alpha-mannosidase like protein 1
chr6_-_85642922 0.64 ENST00000616122.5
ENST00000678618.1
ENST00000678816.1
ENST00000676630.1
ENST00000678589.1
ENST00000678878.1
ENST00000676542.1
ENST00000355238.11
ENST00000678899.1
SYNCRIP
synaptotagmin binding cytoplasmic RNA interacting protein
chr12_+_4321197 0.62 ENST00000179259.6
TIGAR
TP53 induced glycolysis regulatory phosphatase
chr10_+_58385395 0.61 ENST00000487519.6
ENST00000373895.7
TFAM
transcription factor A, mitochondrial
chr1_-_38859669 0.61 ENST00000373001.4
RRAGC
Ras related GTP binding C
chr20_+_58309704 0.59 ENST00000244040.4
RAB22A
RAB22A, member RAS oncogene family
chr6_+_15246054 0.59 ENST00000341776.7
JARID2
jumonji and AT-rich interaction domain containing 2
chr17_-_68291116 0.59 ENST00000327268.8
ENST00000580666.6
SLC16A6
solute carrier family 16 member 6
chr2_+_207529892 0.58 ENST00000432329.6
ENST00000445803.5
CREB1
cAMP responsive element binding protein 1
chr6_-_52577012 0.55 ENST00000182527.4
TRAM2
translocation associated membrane protein 2
chr7_-_128343823 0.55 ENST00000415472.6
ENST00000478061.5
ENST00000223073.6
ENST00000459726.1
RBM28
RNA binding motif protein 28
chr7_+_138460238 0.54 ENST00000343526.9
TRIM24
tripartite motif containing 24
chr5_-_128538230 0.52 ENST00000262464.9
FBN2
fibrillin 2
chr9_+_109780292 0.50 ENST00000374530.7
PALM2AKAP2
PALM2 and AKAP2 fusion
chr3_+_155870623 0.50 ENST00000295920.7
ENST00000496455.7
GMPS
guanine monophosphate synthase
chr15_+_41231219 0.50 ENST00000334660.10
ENST00000560397.5
CHP1
calcineurin like EF-hand protein 1
chr4_+_98995709 0.48 ENST00000296411.11
ENST00000625963.1
METAP1
methionyl aminopeptidase 1
chr17_+_57085092 0.47 ENST00000575322.1
ENST00000337714.8
AKAP1
A-kinase anchoring protein 1
chr3_+_152299392 0.46 ENST00000498502.5
ENST00000545754.5
ENST00000357472.7
ENST00000324196.9
MBNL1
muscleblind like splicing regulator 1
chr2_-_151828408 0.46 ENST00000295087.13
ARL5A
ADP ribosylation factor like GTPase 5A
chrX_+_71533095 0.46 ENST00000373719.8
ENST00000373701.7
OGT
O-linked N-acetylglucosamine (GlcNAc) transferase
chr4_-_65670339 0.46 ENST00000273854.7
EPHA5
EPH receptor A5
chr16_+_68085552 0.45 ENST00000329524.8
NFATC3
nuclear factor of activated T cells 3
chr3_+_30606574 0.45 ENST00000295754.10
ENST00000359013.4
TGFBR2
transforming growth factor beta receptor 2
chr3_-_190120881 0.43 ENST00000319332.10
P3H2
prolyl 3-hydroxylase 2
chr3_+_33114007 0.43 ENST00000320954.11
CRTAP
cartilage associated protein
chr1_+_193121950 0.42 ENST00000367435.5
CDC73
cell division cycle 73
chr5_-_143403611 0.41 ENST00000394464.7
ENST00000231509.7
NR3C1
nuclear receptor subfamily 3 group C member 1
chr8_-_56211257 0.41 ENST00000316981.8
ENST00000423799.6
ENST00000429357.2
PLAG1
PLAG1 zinc finger
chr1_+_65147514 0.41 ENST00000545314.5
AK4
adenylate kinase 4
chr11_-_57515686 0.40 ENST00000533263.1
ENST00000278426.8
SLC43A1
solute carrier family 43 member 1
chr6_+_21593742 0.39 ENST00000244745.4
SOX4
SRY-box transcription factor 4
chr16_-_73048104 0.38 ENST00000268489.10
ZFHX3
zinc finger homeobox 3
chr7_-_32490361 0.37 ENST00000410044.5
ENST00000450169.7
ENST00000409987.5
ENST00000409782.5
LSM5
LSM5 homolog, U6 small nuclear RNA and mRNA degradation associated
chr7_+_107580215 0.37 ENST00000465919.5
ENST00000005259.9
ENST00000445771.6
ENST00000479917.5
ENST00000421217.5
ENST00000457837.5
BCAP29
B cell receptor associated protein 29
chr6_+_10555787 0.37 ENST00000316170.9
GCNT2
glucosaminyl (N-acetyl) transferase 2 (I blood group)
chr11_+_34051722 0.36 ENST00000341394.9
ENST00000389645.7
CAPRIN1
cell cycle associated protein 1
chr11_+_114400592 0.33 ENST00000541475.5
RBM7
RNA binding motif protein 7
chr1_+_89821003 0.32 ENST00000525774.5
ENST00000337338.9
LRRC8D
leucine rich repeat containing 8 VRAC subunit D
chr3_+_170222412 0.31 ENST00000295797.5
PRKCI
protein kinase C iota
chr7_+_94656325 0.31 ENST00000482108.1
ENST00000488574.5
ENST00000612748.1
ENST00000613043.1
PEG10
paternally expressed 10
chr3_+_132417487 0.30 ENST00000260818.11
DNAJC13
DnaJ heat shock protein family (Hsp40) member C13
chr8_-_100952918 0.30 ENST00000395957.6
ENST00000395948.6
ENST00000457309.2
YWHAZ
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta
chr10_+_86756580 0.29 ENST00000372037.8
BMPR1A
bone morphogenetic protein receptor type 1A
chr11_-_27472698 0.29 ENST00000389858.4
ENST00000379214.9
LGR4
leucine rich repeat containing G protein-coupled receptor 4
chr15_+_51829644 0.29 ENST00000308580.12
TMOD3
tropomodulin 3
chr2_-_229921963 0.28 ENST00000343290.5
ENST00000389044.8
ENST00000675453.1
ENST00000675903.1
ENST00000283943.9
TRIP12
thyroid hormone receptor interactor 12
chr3_-_100401028 0.27 ENST00000284320.6
TOMM70
translocase of outer mitochondrial membrane 70
chr5_+_65926556 0.27 ENST00000380943.6
ENST00000416865.6
ENST00000380935.5
ENST00000284037.10
ERBIN
erbb2 interacting protein
chr14_+_57268963 0.26 ENST00000261558.8
AP5M1
adaptor related protein complex 5 subunit mu 1
chr4_-_67701113 0.26 ENST00000420827.2
ENST00000322244.10
UBA6
ubiquitin like modifier activating enzyme 6
chr10_+_70815889 0.25 ENST00000373202.8
SGPL1
sphingosine-1-phosphate lyase 1
chr22_-_41621014 0.25 ENST00000263256.7
DESI1
desumoylating isopeptidase 1
chr17_-_81927699 0.24 ENST00000574686.1
ENST00000357736.9
MAFG
MAF bZIP transcription factor G
chrX_-_120560947 0.24 ENST00000674137.11
ENST00000371322.11
ENST00000681090.1
CUL4B
cullin 4B
chr15_-_74938027 0.23 ENST00000564811.1
ENST00000562233.5
ENST00000322347.11
ENST00000567270.5
ENST00000568783.5
COX5A
cytochrome c oxidase subunit 5A
chr10_-_119596495 0.23 ENST00000369093.6
TIAL1
TIA1 cytotoxic granule associated RNA binding protein like 1
chr19_-_14518383 0.23 ENST00000254322.3
ENST00000595139.2
DNAJB1
DnaJ heat shock protein family (Hsp40) member B1
chr2_-_131093378 0.23 ENST00000409185.5
ENST00000389915.4
FAM168B
family with sequence similarity 168 member B
chr4_-_88284553 0.22 ENST00000608933.6
ENST00000295908.11
PPM1K
protein phosphatase, Mg2+/Mn2+ dependent 1K
chr13_-_74133892 0.22 ENST00000377669.7
KLF12
Kruppel like factor 12
chr13_+_49997019 0.21 ENST00000420995.6
ENST00000356017.8
ENST00000378182.4
ENST00000457662.2
TRIM13
tripartite motif containing 13
chr3_-_138834752 0.21 ENST00000477593.5
ENST00000483968.5
PIK3CB
phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta
chr2_-_171160833 0.21 ENST00000360843.7
ENST00000431350.7
TLK1
tousled like kinase 1
chr18_-_63319987 0.21 ENST00000398117.1
BCL2
BCL2 apoptosis regulator
chr1_+_32013848 0.20 ENST00000327300.12
ENST00000492989.1
KHDRBS1
KH RNA binding domain containing, signal transduction associated 1
chrX_+_68499021 0.20 ENST00000462683.6
YIPF6
Yip1 domain family member 6
chr22_+_40177917 0.19 ENST00000454349.7
ENST00000335727.13
TNRC6B
trinucleotide repeat containing adaptor 6B
chr1_+_35883189 0.19 ENST00000674304.1
ENST00000373204.6
ENST00000674426.1
AGO1
argonaute RISC component 1
chr10_-_77926724 0.18 ENST00000372391.7
DLG5
discs large MAGUK scaffold protein 5
chrX_+_49922605 0.18 ENST00000376088.7
CLCN5
chloride voltage-gated channel 5
chr21_-_14383125 0.18 ENST00000285667.4
HSPA13
heat shock protein family A (Hsp70) member 13
chr1_+_147541491 0.17 ENST00000683836.1
ENST00000234739.8
BCL9
BCL9 transcription coactivator
chr12_+_20368495 0.17 ENST00000359062.4
PDE3A
phosphodiesterase 3A
chr10_+_91923762 0.17 ENST00000265990.11
BTAF1
B-TFIID TATA-box binding protein associated factor 1
chr12_-_89352487 0.16 ENST00000548755.1
ENST00000279488.8
DUSP6
dual specificity phosphatase 6
chr2_+_96266211 0.16 ENST00000488633.2
CIAO1
cytosolic iron-sulfur assembly component 1
chr2_+_5692357 0.16 ENST00000322002.5
SOX11
SRY-box transcription factor 11
chr3_+_10141763 0.15 ENST00000256474.3
ENST00000345392.2
VHL
von Hippel-Lindau tumor suppressor
chrX_-_15854791 0.14 ENST00000545766.7
ENST00000380291.5
ENST00000672987.1
ENST00000329235.6
AP1S2
adaptor related protein complex 1 subunit sigma 2
chr2_+_108719473 0.14 ENST00000283195.11
RANBP2
RAN binding protein 2
chr18_+_52340179 0.13 ENST00000442544.7
DCC
DCC netrin 1 receptor
chr2_+_191678122 0.13 ENST00000425611.9
ENST00000410026.7
NABP1
nucleic acid binding protein 1
chr7_-_129952901 0.13 ENST00000472396.5
ENST00000355621.8
UBE2H
ubiquitin conjugating enzyme E2 H
chr17_+_30378903 0.13 ENST00000225719.9
CPD
carboxypeptidase D
chr12_-_48788995 0.13 ENST00000550422.5
ENST00000357869.8
ADCY6
adenylate cyclase 6
chr16_-_71724700 0.13 ENST00000568954.5
PHLPP2
PH domain and leucine rich repeat protein phosphatase 2
chr8_+_103819244 0.13 ENST00000262231.14
ENST00000507740.5
ENST00000408894.6
RIMS2
regulating synaptic membrane exocytosis 2
chr6_+_50818857 0.12 ENST00000393655.4
TFAP2B
transcription factor AP-2 beta
chr3_-_171460368 0.12 ENST00000436636.7
ENST00000465393.1
ENST00000341852.10
TNIK
TRAF2 and NCK interacting kinase
chr3_+_184155310 0.12 ENST00000313143.9
DVL3
dishevelled segment polarity protein 3
chr3_-_52278620 0.12 ENST00000296490.8
WDR82
WD repeat domain 82
chr16_-_30787169 0.11 ENST00000262525.6
ZNF629
zinc finger protein 629
chrX_-_112082776 0.11 ENST00000262839.3
TRPC5
transient receptor potential cation channel subfamily C member 5
chr5_-_16936231 0.11 ENST00000507288.1
ENST00000274203.13
ENST00000513610.6
MYO10
myosin X
chr12_-_56636318 0.11 ENST00000549506.5
ENST00000379441.7
ENST00000551812.5
BAZ2A
bromodomain adjacent to zinc finger domain 2A
chr17_+_32142454 0.11 ENST00000333942.10
ENST00000358365.7
ENST00000545287.7
RHOT1
ras homolog family member T1
chr4_-_23890035 0.11 ENST00000507380.1
ENST00000264867.7
PPARGC1A
PPARG coactivator 1 alpha
chr6_-_16761447 0.11 ENST00000244769.8
ENST00000436367.6
ATXN1
ataxin 1
chr5_-_67196791 0.11 ENST00000256447.5
CD180
CD180 molecule
chr7_-_81770039 0.10 ENST00000222390.11
ENST00000453411.6
ENST00000457544.7
ENST00000444829.7
HGF
hepatocyte growth factor
chr1_-_22143088 0.10 ENST00000290167.11
WNT4
Wnt family member 4
chr1_+_78004930 0.09 ENST00000370763.6
DNAJB4
DnaJ heat shock protein family (Hsp40) member B4
chr1_+_2228310 0.09 ENST00000378536.5
SKI
SKI proto-oncogene
chr8_-_17413345 0.09 ENST00000180173.10
MTMR7
myotubularin related protein 7
chr7_+_28412511 0.08 ENST00000357727.7
CREB5
cAMP responsive element binding protein 5
chr4_-_139177185 0.08 ENST00000394235.6
ELF2
E74 like ETS transcription factor 2
chr7_-_127585566 0.08 ENST00000321407.3
GCC1
GRIP and coiled-coil domain containing 1
chr4_-_41748713 0.08 ENST00000226382.4
PHOX2B
paired like homeobox 2B
chr11_+_112086853 0.07 ENST00000528182.5
ENST00000528048.5
ENST00000375549.8
ENST00000528021.6
ENST00000526592.5
ENST00000525291.5
SDHD
succinate dehydrogenase complex subunit D
chr1_+_154405193 0.07 ENST00000622330.4
ENST00000344086.8
IL6R
interleukin 6 receptor
chr7_+_39950187 0.06 ENST00000181839.10
CDK13
cyclin dependent kinase 13
chr8_-_42896677 0.06 ENST00000526349.5
ENST00000534961.5
RNF170
ring finger protein 170
chr13_-_41961078 0.06 ENST00000379310.8
ENST00000281496.6
VWA8
von Willebrand factor A domain containing 8
chr3_+_11272413 0.06 ENST00000446450.6
ENST00000354956.9
ENST00000354449.7
ENST00000419112.5
ATG7
autophagy related 7
chr2_-_110115811 0.06 ENST00000272462.3
MALL
mal, T cell differentiation protein like
chr11_+_35618450 0.06 ENST00000317811.6
FJX1
four-jointed box kinase 1
chr1_-_209806124 0.05 ENST00000367021.8
ENST00000542854.5
IRF6
interferon regulatory factor 6
chr11_+_35662739 0.05 ENST00000299413.7
TRIM44
tripartite motif containing 44
chr10_-_59906509 0.05 ENST00000263102.7
CCDC6
coiled-coil domain containing 6
chr11_+_118572373 0.04 ENST00000392859.7
ENST00000264028.5
ENST00000614498.4
ENST00000359415.8
ENST00000534182.2
ARCN1
archain 1
chr5_-_37840035 0.04 ENST00000326524.7
GDNF
glial cell derived neurotrophic factor
chrX_-_24672654 0.04 ENST00000379145.5
PCYT1B
phosphate cytidylyltransferase 1, choline, beta
chr1_+_16367088 0.04 ENST00000471507.5
ENST00000401089.3
ENST00000401088.9
ENST00000492354.1
SZRD1
SUZ RNA binding domain containing 1
chr10_-_80205551 0.03 ENST00000372231.7
ENST00000438331.5
ANXA11
annexin A11
chr17_+_58755821 0.03 ENST00000308249.4
PPM1E
protein phosphatase, Mg2+/Mn2+ dependent 1E
chr16_-_88941198 0.02 ENST00000327483.9
ENST00000564416.1
CBFA2T3
CBFA2/RUNX1 partner transcriptional co-repressor 3
chr9_+_74497308 0.02 ENST00000376896.8
RORB
RAR related orphan receptor B
chr22_+_32043253 0.02 ENST00000266088.9
SLC5A1
solute carrier family 5 member 1
chr12_-_122526929 0.01 ENST00000331738.12
ENST00000528279.1
ENST00000344591.8
ENST00000526560.6
RSRC2
arginine and serine rich coiled-coil 2
chr15_-_26773022 0.01 ENST00000311550.10
ENST00000622697.4
GABRB3
gamma-aminobutyric acid type A receptor subunit beta3
chr18_+_33578213 0.00 ENST00000681521.1
ENST00000269197.12
ASXL3
ASXL transcriptional regulator 3

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 1.9 GO:0090402 oncogene-induced cell senescence(GO:0090402)
0.2 0.7 GO:1903691 positive regulation of wound healing, spreading of epidermal cells(GO:1903691)
0.2 1.1 GO:1903385 regulation of homophilic cell adhesion(GO:1903385)
0.2 0.6 GO:0036510 trimming of terminal mannose on C branch(GO:0036510)
0.2 0.6 GO:0043465 fermentation(GO:0006113) regulation of fermentation(GO:0043465)
0.2 0.6 GO:0006391 transcription initiation from mitochondrial promoter(GO:0006391)
0.2 0.7 GO:0003186 tricuspid valve development(GO:0003175) tricuspid valve morphogenesis(GO:0003186)
0.2 0.9 GO:1900127 renal water absorption(GO:0070295) positive regulation of hyaluronan biosynthetic process(GO:1900127)
0.2 2.0 GO:2000394 positive regulation of lamellipodium morphogenesis(GO:2000394)
0.2 0.8 GO:1902896 terminal web assembly(GO:1902896)
0.1 0.6 GO:1904550 chemotaxis to arachidonic acid(GO:0034670) response to arachidonic acid(GO:1904550)
0.1 1.2 GO:0034626 fatty acid elongation, saturated fatty acid(GO:0019367) fatty acid elongation, unsaturated fatty acid(GO:0019368) fatty acid elongation, monounsaturated fatty acid(GO:0034625) fatty acid elongation, polyunsaturated fatty acid(GO:0034626)
0.1 0.4 GO:1901874 negative regulation of post-translational protein modification(GO:1901874)
0.1 0.4 GO:0034402 recruitment of 3'-end processing factors to RNA polymerase II holoenzyme complex(GO:0034402)
0.1 0.6 GO:0045048 protein insertion into ER membrane(GO:0045048)
0.1 1.9 GO:0006610 ribosomal protein import into nucleus(GO:0006610)
0.1 0.1 GO:1901857 positive regulation of cellular respiration(GO:1901857)
0.1 0.7 GO:1903751 regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide(GO:1903750) negative regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide(GO:1903751)
0.1 0.5 GO:0006177 GMP biosynthetic process(GO:0006177)
0.1 0.4 GO:0035910 ascending aorta development(GO:0035905) ascending aorta morphogenesis(GO:0035910)
0.1 0.3 GO:0072204 cell-cell signaling involved in kidney development(GO:0060995) Wnt signaling pathway involved in kidney development(GO:0061289) canonical Wnt signaling pathway involved in metanephric kidney development(GO:0061290) cell-cell signaling involved in metanephros development(GO:0072204)
0.1 0.9 GO:0097105 presynaptic membrane assembly(GO:0097105)
0.1 0.6 GO:1904153 negative regulation of protein exit from endoplasmic reticulum(GO:0070862) negative regulation of retrograde protein transport, ER to cytosol(GO:1904153)
0.1 0.5 GO:0070562 regulation of vitamin D receptor signaling pathway(GO:0070562)
0.1 0.4 GO:1904059 regulation of locomotor rhythm(GO:1904059)
0.1 0.3 GO:1902954 regulation of early endosome to recycling endosome transport(GO:1902954)
0.1 0.5 GO:0035583 sequestering of TGFbeta in extracellular matrix(GO:0035583)
0.1 0.5 GO:0070885 positive regulation of sodium:proton antiporter activity(GO:0032417) negative regulation of calcineurin-NFAT signaling cascade(GO:0070885)
0.1 0.5 GO:0018206 peptidyl-methionine modification(GO:0018206)
0.1 0.5 GO:0061087 positive regulation of histone H3-K27 methylation(GO:0061087)
0.1 0.4 GO:0070973 protein localization to endoplasmic reticulum exit site(GO:0070973)
0.1 0.7 GO:2000774 positive regulation of cellular senescence(GO:2000774)
0.1 0.7 GO:0060252 positive regulation of glial cell proliferation(GO:0060252)
0.1 0.3 GO:0070433 negative regulation of nucleotide-binding oligomerization domain containing signaling pathway(GO:0070425) negative regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway(GO:0070433)
0.1 0.5 GO:0021902 commitment of neuronal cell to specific neuron type in forebrain(GO:0021902)
0.1 0.4 GO:0036438 maintenance of lens transparency(GO:0036438)
0.1 0.2 GO:0061386 closure of optic fissure(GO:0061386)
0.1 0.2 GO:0046671 negative regulation of cellular pH reduction(GO:0032848) CD8-positive, alpha-beta T cell lineage commitment(GO:0043375) negative regulation of retinal cell programmed cell death(GO:0046671)
0.1 0.3 GO:0021764 amygdala development(GO:0021764)
0.1 0.2 GO:0046833 positive regulation of RNA export from nucleus(GO:0046833)
0.0 0.6 GO:0051574 positive regulation of histone H3-K9 methylation(GO:0051574)
0.0 0.4 GO:0043402 glucocorticoid mediated signaling pathway(GO:0043402)
0.0 1.5 GO:0043555 regulation of translation in response to stress(GO:0043555)
0.0 0.6 GO:0070934 CRD-mediated mRNA stabilization(GO:0070934)
0.0 0.4 GO:0046940 nucleoside monophosphate phosphorylation(GO:0046940)
0.0 0.3 GO:0051694 pointed-end actin filament capping(GO:0051694)
0.0 0.9 GO:0006474 N-terminal protein amino acid acetylation(GO:0006474)
0.0 0.4 GO:0034058 endosomal vesicle fusion(GO:0034058)
0.0 0.7 GO:0045116 response to UV-C(GO:0010225) protein neddylation(GO:0045116)
0.0 1.6 GO:0000002 mitochondrial genome maintenance(GO:0000002)
0.0 0.2 GO:0060282 positive regulation of oocyte development(GO:0060282)
0.0 0.2 GO:0033031 positive regulation of neutrophil apoptotic process(GO:0033031)
0.0 0.1 GO:0097272 ammonia homeostasis(GO:0097272)
0.0 0.2 GO:0042663 regulation of endodermal cell fate specification(GO:0042663)
0.0 0.3 GO:1902915 negative regulation of histone ubiquitination(GO:0033183) negative regulation of protein K63-linked ubiquitination(GO:1900045) regulation of histone H2A K63-linked ubiquitination(GO:1901314) negative regulation of histone H2A K63-linked ubiquitination(GO:1901315) negative regulation of protein polyubiquitination(GO:1902915)
0.0 0.1 GO:1902630 regulation of membrane hyperpolarization(GO:1902630)
0.0 0.1 GO:0021965 spinal cord ventral commissure morphogenesis(GO:0021965)
0.0 0.1 GO:1904116 response to vasopressin(GO:1904116) cellular response to vasopressin(GO:1904117)
0.0 0.1 GO:0061183 dermatome development(GO:0061054) regulation of dermatome development(GO:0061183) positive regulation of dermatome development(GO:0061184) positive regulation of steroid hormone biosynthetic process(GO:0090031) regulation of testosterone biosynthetic process(GO:2000224)
0.0 0.2 GO:0090625 mRNA cleavage involved in gene silencing by miRNA(GO:0035279) mRNA cleavage involved in gene silencing by siRNA(GO:0090625) mRNA cleavage involved in gene silencing(GO:0098795)
0.0 0.7 GO:0032486 Rap protein signal transduction(GO:0032486)
0.0 0.2 GO:0061428 negative regulation of transcription from RNA polymerase II promoter in response to hypoxia(GO:0061428)
0.0 0.2 GO:0071896 protein localization to adherens junction(GO:0071896)
0.0 1.0 GO:0007176 regulation of epidermal growth factor-activated receptor activity(GO:0007176)
0.0 0.1 GO:1901299 negative regulation of hydrogen peroxide-mediated programmed cell death(GO:1901299)
0.0 0.4 GO:0019511 peptidyl-proline hydroxylation(GO:0019511)
0.0 0.1 GO:0006121 mitochondrial electron transport, succinate to ubiquinone(GO:0006121)
0.0 0.2 GO:0045974 miRNA mediated inhibition of translation(GO:0035278) negative regulation of translation, ncRNA-mediated(GO:0040033) regulation of translation, ncRNA-mediated(GO:0045974)
0.0 0.3 GO:0033327 Leydig cell differentiation(GO:0033327)
0.0 0.1 GO:1903301 positive regulation of glucokinase activity(GO:0033133) positive regulation of hexokinase activity(GO:1903301)
0.0 0.3 GO:0090168 Golgi reassembly(GO:0090168)
0.0 0.1 GO:0031064 negative regulation of histone deacetylation(GO:0031064)
0.0 0.1 GO:0002322 B cell proliferation involved in immune response(GO:0002322)
0.0 0.6 GO:1903432 regulation of TORC1 signaling(GO:1903432)
0.0 0.5 GO:0032793 positive regulation of CREB transcription factor activity(GO:0032793)
0.0 1.9 GO:0042147 retrograde transport, endosome to Golgi(GO:0042147)
0.0 0.0 GO:0072106 regulation of ureteric bud formation(GO:0072106) positive regulation of ureteric bud formation(GO:0072107)
0.0 0.2 GO:0001672 regulation of chromatin assembly or disassembly(GO:0001672)
0.0 0.4 GO:1902894 negative regulation of pri-miRNA transcription from RNA polymerase II promoter(GO:1902894)
0.0 0.2 GO:0097201 negative regulation of transcription from RNA polymerase II promoter in response to stress(GO:0097201)
0.0 0.1 GO:0002384 hepatic immune response(GO:0002384)
0.0 0.1 GO:0007256 activation of JNKK activity(GO:0007256)
0.0 0.1 GO:0048880 sensory system development(GO:0048880)
0.0 0.1 GO:0038031 non-canonical Wnt signaling pathway via JNK cascade(GO:0038031)
0.0 0.1 GO:0061669 spontaneous neurotransmitter secretion(GO:0061669) spontaneous synaptic transmission(GO:0098814)
0.0 0.2 GO:0035562 negative regulation of chromatin binding(GO:0035562)
0.0 0.7 GO:0048009 insulin-like growth factor receptor signaling pathway(GO:0048009)
0.0 0.2 GO:0070914 UV-damage excision repair(GO:0070914)
0.0 0.2 GO:1902187 negative regulation of viral release from host cell(GO:1902187)
0.0 0.2 GO:0006123 mitochondrial electron transport, cytochrome c to oxygen(GO:0006123)
0.0 0.2 GO:0060576 intestinal epithelial cell development(GO:0060576)
0.0 0.1 GO:0000183 chromatin silencing at rDNA(GO:0000183)
0.0 0.0 GO:0021691 cerebellar Purkinje cell layer maturation(GO:0021691)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.5 GO:0070435 Shc-EGFR complex(GO:0070435)
0.3 1.9 GO:0035985 senescence-associated heterochromatin focus(GO:0035985)
0.3 0.8 GO:0044393 microspike(GO:0044393)
0.2 0.8 GO:0031510 SUMO activating enzyme complex(GO:0031510)
0.2 0.8 GO:0033263 CORVET complex(GO:0033263)
0.2 1.1 GO:0030121 AP-1 adaptor complex(GO:0030121)
0.1 0.8 GO:0017101 aminoacyl-tRNA synthetase multienzyme complex(GO:0017101)
0.1 2.0 GO:0016600 flotillin complex(GO:0016600)
0.1 0.6 GO:1990589 ATF4-CREB1 transcription factor complex(GO:1990589)
0.1 0.5 GO:0005726 perichromatin fibrils(GO:0005726)
0.1 0.6 GO:1990131 EGO complex(GO:0034448) Gtr1-Gtr2 GTPase complex(GO:1990131)
0.1 0.4 GO:0070022 transforming growth factor beta receptor homodimeric complex(GO:0070022)
0.1 0.6 GO:0097452 GAIT complex(GO:0097452)
0.1 0.4 GO:1990726 Lsm1-7-Pat1 complex(GO:1990726)
0.0 0.1 GO:1990723 cytoplasmic periphery of the nuclear pore complex(GO:1990723)
0.0 0.8 GO:0005641 nuclear envelope lumen(GO:0005641)
0.0 0.2 GO:0071817 MMXD complex(GO:0071817)
0.0 1.6 GO:0005762 organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762)
0.0 0.4 GO:0016593 Cdc73/Paf1 complex(GO:0016593)
0.0 0.3 GO:0005742 mitochondrial outer membrane translocase complex(GO:0005742)
0.0 0.1 GO:0070876 SOSS complex(GO:0070876)
0.0 0.9 GO:0044322 endoplasmic reticulum quality control compartment(GO:0044322)
0.0 0.1 GO:0042272 nuclear RNA export factor complex(GO:0042272)
0.0 0.3 GO:0071203 WASH complex(GO:0071203)
0.0 0.1 GO:0033553 rDNA heterochromatin(GO:0033553)
0.0 0.2 GO:0031465 Cul4B-RING E3 ubiquitin ligase complex(GO:0031465)
0.0 0.2 GO:0030891 VCB complex(GO:0030891)
0.0 0.2 GO:0035068 micro-ribonucleoprotein complex(GO:0035068)
0.0 0.3 GO:1990712 HFE-transferrin receptor complex(GO:1990712)
0.0 0.5 GO:0035098 ESC/E(Z) complex(GO:0035098)
0.0 0.4 GO:0043205 microfibril(GO:0001527) fibril(GO:0043205)
0.0 0.2 GO:0005751 mitochondrial respiratory chain complex IV(GO:0005751)
0.0 0.1 GO:0002945 cyclin K-CDK13 complex(GO:0002945)
0.0 1.9 GO:0005643 nuclear pore(GO:0005643)
0.0 0.3 GO:0043220 Schmidt-Lanterman incisure(GO:0043220)
0.0 0.1 GO:0005749 mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone)(GO:0005749) succinate dehydrogenase complex (ubiquinone)(GO:0045257) respiratory chain complex II(GO:0045273) succinate dehydrogenase complex(GO:0045281) fumarate reductase complex(GO:0045283)
0.0 0.1 GO:0005896 interleukin-6 receptor complex(GO:0005896)
0.0 1.0 GO:0010494 cytoplasmic stress granule(GO:0010494)
0.0 0.6 GO:0009295 nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645)
0.0 0.3 GO:0030056 hemidesmosome(GO:0030056)
0.0 0.2 GO:0046930 pore complex(GO:0046930)
0.0 0.3 GO:0071682 endocytic vesicle lumen(GO:0071682)
0.0 0.1 GO:0072357 PTW/PP1 phosphatase complex(GO:0072357)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.9 GO:0004677 DNA-dependent protein kinase activity(GO:0004677)
0.3 0.9 GO:0050501 hyaluronan synthase activity(GO:0050501)
0.3 0.8 GO:0005010 insulin-like growth factor-activated receptor activity(GO:0005010)
0.2 1.5 GO:0048408 epidermal growth factor binding(GO:0048408)
0.2 0.9 GO:1990189 peptide-serine-N-acetyltransferase activity(GO:1990189)
0.2 0.6 GO:0034416 bisphosphoglycerate phosphatase activity(GO:0034416)
0.2 0.5 GO:0001069 regulatory region RNA binding(GO:0001069)
0.2 0.5 GO:0016262 protein N-acetylglucosaminyltransferase activity(GO:0016262)
0.2 0.6 GO:0070363 mitochondrial light strand promoter sense binding(GO:0070363)
0.1 0.4 GO:0005026 transforming growth factor beta receptor activity, type II(GO:0005026)
0.1 1.2 GO:0102338 fatty acid elongase activity(GO:0009922) 3-oxo-arachidoyl-CoA synthase activity(GO:0102336) 3-oxo-cerotoyl-CoA synthase activity(GO:0102337) 3-oxo-lignoceronyl-CoA synthase activity(GO:0102338)
0.1 0.4 GO:0019797 procollagen-proline 3-dioxygenase activity(GO:0019797)
0.1 0.6 GO:1990763 arrestin family protein binding(GO:1990763)
0.1 1.1 GO:0008641 small protein activating enzyme activity(GO:0008641)
0.1 0.4 GO:0038051 glucocorticoid receptor activity(GO:0004883) glucocorticoid-activated RNA polymerase II transcription factor binding transcription factor activity(GO:0038051)
0.1 0.4 GO:0046899 nucleoside triphosphate adenylate kinase activity(GO:0046899)
0.1 0.6 GO:0004571 mannosyl-oligosaccharide 1,2-alpha-mannosidase activity(GO:0004571)
0.1 0.5 GO:0030023 extracellular matrix constituent conferring elasticity(GO:0030023)
0.1 1.9 GO:0005095 GTPase inhibitor activity(GO:0005095)
0.1 0.8 GO:0035497 cAMP response element binding(GO:0035497)
0.1 0.2 GO:0004119 cGMP-inhibited cyclic-nucleotide phosphodiesterase activity(GO:0004119)
0.1 0.9 GO:0019966 interleukin-1 binding(GO:0019966)
0.1 0.7 GO:0000774 adenyl-nucleotide exchange factor activity(GO:0000774)
0.1 0.5 GO:0034056 estrogen response element binding(GO:0034056)
0.1 0.4 GO:0008109 N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity(GO:0008109)
0.0 0.1 GO:0005042 netrin receptor activity(GO:0005042)
0.0 1.3 GO:0034237 protein kinase A regulatory subunit binding(GO:0034237)
0.0 0.3 GO:0098821 BMP receptor activity(GO:0098821)
0.0 0.7 GO:0097602 cullin family protein binding(GO:0097602)
0.0 0.3 GO:0005225 volume-sensitive anion channel activity(GO:0005225)
0.0 1.1 GO:0019198 transmembrane receptor protein tyrosine phosphatase activity(GO:0005001) transmembrane receptor protein phosphatase activity(GO:0019198)
0.0 0.5 GO:0016884 carbon-nitrogen ligase activity, with glutamine as amido-N-donor(GO:0016884)
0.0 0.5 GO:0005004 GPI-linked ephrin receptor activity(GO:0005004)
0.0 1.3 GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027)
0.0 2.1 GO:0048365 Rac GTPase binding(GO:0048365)
0.0 0.1 GO:0070119 ciliary neurotrophic factor binding(GO:0070119)
0.0 1.9 GO:0019003 GDP binding(GO:0019003)
0.0 0.1 GO:0035033 histone deacetylase regulator activity(GO:0035033)
0.0 0.8 GO:0008143 poly(A) binding(GO:0008143)
0.0 0.2 GO:1904264 ubiquitin protein ligase activity involved in ERAD pathway(GO:1904264)
0.0 0.2 GO:0035005 1-phosphatidylinositol-4-phosphate 3-kinase activity(GO:0035005)
0.0 0.6 GO:0000993 RNA polymerase II core binding(GO:0000993)
0.0 0.3 GO:0008320 protein transmembrane transporter activity(GO:0008320)
0.0 0.1 GO:0008177 succinate dehydrogenase (ubiquinone) activity(GO:0008177)
0.0 0.1 GO:0034046 poly(G) binding(GO:0034046)
0.0 0.2 GO:0051434 BH3 domain binding(GO:0051434)
0.0 0.8 GO:0061631 ubiquitin conjugating enzyme activity(GO:0061631)
0.0 0.8 GO:0004364 glutathione transferase activity(GO:0004364)
0.0 0.3 GO:0005176 ErbB-2 class receptor binding(GO:0005176)
0.0 0.1 GO:0060002 plus-end directed microfilament motor activity(GO:0060002)
0.0 0.6 GO:0032452 histone demethylase activity(GO:0032452)
0.0 0.3 GO:0004697 protein kinase C activity(GO:0004697)
0.0 0.1 GO:0015279 store-operated calcium channel activity(GO:0015279)
0.0 0.2 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017)
0.0 0.3 GO:0098641 cadherin binding involved in cell-cell adhesion(GO:0098641)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 3.0 SA B CELL RECEPTOR COMPLEXES Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases.
0.0 0.7 PID LPA4 PATHWAY LPA4-mediated signaling events
0.0 0.8 PID SMAD2 3PATHWAY Regulation of cytoplasmic and nuclear SMAD2/3 signaling
0.0 0.8 PID SYNDECAN 2 PATHWAY Syndecan-2-mediated signaling events
0.0 0.6 PID INSULIN GLUCOSE PATHWAY Insulin-mediated glucose transport
0.0 0.4 PID EPHA FWDPATHWAY EPHA forward signaling
0.0 0.4 PID GLYPICAN 1PATHWAY Glypican 1 network

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.8 REACTOME CYTOSOLIC TRNA AMINOACYLATION Genes involved in Cytosolic tRNA aminoacylation
0.1 1.2 REACTOME NEF MEDIATED DOWNREGULATION OF MHC CLASS I COMPLEX CELL SURFACE EXPRESSION Genes involved in Nef mediated downregulation of MHC class I complex cell surface expression
0.1 1.5 REACTOME SIGNAL ATTENUATION Genes involved in Signal attenuation
0.0 2.2 REACTOME NUCLEAR EVENTS KINASE AND TRANSCRIPTION FACTOR ACTIVATION Genes involved in Nuclear Events (kinase and transcription factor activation)
0.0 0.6 REACTOME CALNEXIN CALRETICULIN CYCLE Genes involved in Calnexin/calreticulin cycle
0.0 1.2 REACTOME SYNTHESIS OF VERY LONG CHAIN FATTY ACYL COAS Genes involved in Synthesis of very long-chain fatty acyl-CoAs
0.0 0.5 REACTOME PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS Genes involved in Purine ribonucleoside monophosphate biosynthesis
0.0 0.9 REACTOME HYALURONAN METABOLISM Genes involved in Hyaluronan metabolism
0.0 0.4 REACTOME TGF BETA RECEPTOR SIGNALING IN EMT EPITHELIAL TO MESENCHYMAL TRANSITION Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
0.0 0.3 REACTOME P75NTR RECRUITS SIGNALLING COMPLEXES Genes involved in p75NTR recruits signalling complexes
0.0 0.2 REACTOME ROLE OF SECOND MESSENGERS IN NETRIN1 SIGNALING Genes involved in Role of second messengers in netrin-1 signaling
0.0 0.5 REACTOME SIGNALING BY FGFR1 FUSION MUTANTS Genes involved in Signaling by FGFR1 fusion mutants
0.0 0.9 REACTOME NETRIN1 SIGNALING Genes involved in Netrin-1 signaling
0.0 0.2 REACTOME REGULATORY RNA PATHWAYS Genes involved in Regulatory RNA pathways
0.0 0.8 REACTOME MYOGENESIS Genes involved in Myogenesis
0.0 0.3 REACTOME DESTABILIZATION OF MRNA BY KSRP Genes involved in Destabilization of mRNA by KSRP
0.0 0.8 REACTOME GOLGI ASSOCIATED VESICLE BIOGENESIS Genes involved in Golgi Associated Vesicle Biogenesis
0.0 0.2 REACTOME TIE2 SIGNALING Genes involved in Tie2 Signaling
0.0 1.9 REACTOME INFLUENZA VIRAL RNA TRANSCRIPTION AND REPLICATION Genes involved in Influenza Viral RNA Transcription and Replication
0.0 0.5 REACTOME BMAL1 CLOCK NPAS2 ACTIVATES CIRCADIAN EXPRESSION Genes involved in BMAL1:CLOCK/NPAS2 Activates Circadian Expression
0.0 0.1 REACTOME IL 6 SIGNALING Genes involved in Interleukin-6 signaling