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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
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Results for UGAAAUG
Z-value: 0.68
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miRNA associated with seed UGAAAUG
| Name | miRBASE accession |
|---|---|
|
hsa-miR-203a-3p.2
|
Network of associatons between targets according to the STRING database.
First level regulatory network of UGAAAUG
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 10.1 | GO:0006409 | tRNA export from nucleus(GO:0006409) tRNA-containing ribonucleoprotein complex export from nucleus(GO:0071431) |
| 0.7 | 9.7 | GO:0044387 | negative regulation of protein kinase activity by regulation of protein phosphorylation(GO:0044387) |
| 0.6 | 7.4 | GO:0090435 | protein localization to nuclear envelope(GO:0090435) |
| 0.5 | 7.4 | GO:0006610 | ribosomal protein import into nucleus(GO:0006610) |
| 1.2 | 7.3 | GO:0006543 | glutamine catabolic process(GO:0006543) |
| 0.0 | 6.8 | GO:0045445 | myoblast differentiation(GO:0045445) |
| 2.1 | 6.4 | GO:0006679 | glucosylceramide biosynthetic process(GO:0006679) |
| 1.5 | 6.1 | GO:1901165 | positive regulation of trophoblast cell migration(GO:1901165) |
| 1.5 | 6.0 | GO:0019860 | uracil metabolic process(GO:0019860) |
| 0.1 | 5.6 | GO:0000079 | regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0000079) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 12.9 | GO:0031965 | nuclear membrane(GO:0031965) |
| 0.0 | 12.9 | GO:0005759 | mitochondrial matrix(GO:0005759) |
| 0.2 | 11.8 | GO:0010494 | cytoplasmic stress granule(GO:0010494) |
| 0.6 | 9.7 | GO:0031080 | nuclear pore outer ring(GO:0031080) |
| 0.6 | 8.9 | GO:0016600 | flotillin complex(GO:0016600) |
| 0.2 | 8.4 | GO:0097346 | INO80-type complex(GO:0097346) |
| 0.0 | 7.7 | GO:0000151 | ubiquitin ligase complex(GO:0000151) |
| 0.0 | 7.6 | GO:0005681 | spliceosomal complex(GO:0005681) |
| 0.3 | 7.2 | GO:0005652 | nuclear lamina(GO:0005652) |
| 0.1 | 7.1 | GO:0005637 | nuclear inner membrane(GO:0005637) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 9.5 | GO:0008536 | Ran GTPase binding(GO:0008536) |
| 0.1 | 9.0 | GO:0048365 | Rac GTPase binding(GO:0048365) |
| 0.2 | 8.1 | GO:0008143 | poly(A) binding(GO:0008143) |
| 0.1 | 7.8 | GO:0008138 | protein tyrosine/serine/threonine phosphatase activity(GO:0008138) |
| 2.5 | 7.4 | GO:0001069 | regulatory region RNA binding(GO:0001069) |
| 1.2 | 7.3 | GO:0004359 | glutaminase activity(GO:0004359) |
| 0.1 | 6.8 | GO:0004843 | thiol-dependent ubiquitin-specific protease activity(GO:0004843) |
| 0.1 | 6.7 | GO:0005160 | transforming growth factor beta receptor binding(GO:0005160) |
| 0.6 | 6.4 | GO:0035251 | UDP-glucosyltransferase activity(GO:0035251) |
| 0.5 | 6.0 | GO:1990825 | sequence-specific mRNA binding(GO:1990825) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 13.0 | PID P53 REGULATION PATHWAY | p53 pathway |
| 0.1 | 8.8 | PID E2F PATHWAY | E2F transcription factor network |
| 0.1 | 6.4 | PID IL2 PI3K PATHWAY | IL2 signaling events mediated by PI3K |
| 0.1 | 6.4 | PID BMP PATHWAY | BMP receptor signaling |
| 0.1 | 5.7 | PID LYMPH ANGIOGENESIS PATHWAY | VEGFR3 signaling in lymphatic endothelium |
| 0.1 | 5.2 | PID INSULIN GLUCOSE PATHWAY | Insulin-mediated glucose transport |
| 0.1 | 5.0 | PID FANCONI PATHWAY | Fanconi anemia pathway |
| 0.1 | 4.6 | PID IGF1 PATHWAY | IGF1 pathway |
| 0.1 | 4.1 | PID AJDISS 2PATHWAY | Posttranslational regulation of adherens junction stability and dissassembly |
| 0.1 | 3.8 | PID TOLL ENDOGENOUS PATHWAY | Endogenous TLR signaling |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 12.5 | REACTOME DOWNREGULATION OF TGF BETA RECEPTOR SIGNALING | Genes involved in Downregulation of TGF-beta receptor signaling |
| 0.3 | 11.8 | REACTOME TRANSPORT OF RIBONUCLEOPROTEINS INTO THE HOST NUCLEUS | Genes involved in Transport of Ribonucleoproteins into the Host Nucleus |
| 0.2 | 7.9 | REACTOME G1 S SPECIFIC TRANSCRIPTION | Genes involved in G1/S-Specific Transcription |
| 0.3 | 7.3 | REACTOME AMINO ACID SYNTHESIS AND INTERCONVERSION TRANSAMINATION | Genes involved in Amino acid synthesis and interconversion (transamination) |
| 0.3 | 7.0 | REACTOME DESTABILIZATION OF MRNA BY TRISTETRAPROLIN TTP | Genes involved in Destabilization of mRNA by Tristetraprolin (TTP) |
| 0.1 | 6.4 | REACTOME GLYCOSPHINGOLIPID METABOLISM | Genes involved in Glycosphingolipid metabolism |
| 0.1 | 5.8 | REACTOME NEGATIVE REGULATORS OF RIG I MDA5 SIGNALING | Genes involved in Negative regulators of RIG-I/MDA5 signaling |
| 0.3 | 5.5 | REACTOME SYNTHESIS OF SUBSTRATES IN N GLYCAN BIOSYTHESIS | Genes involved in Synthesis of substrates in N-glycan biosythesis |
| 0.2 | 5.4 | REACTOME FGFR1 LIGAND BINDING AND ACTIVATION | Genes involved in FGFR1 ligand binding and activation |
| 0.2 | 5.4 | REACTOME CHONDROITIN SULFATE BIOSYNTHESIS | Genes involved in Chondroitin sulfate biosynthesis |