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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
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Results for UGCAUAG
Z-value: 1.03
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miRNA associated with seed UGCAUAG
| Name | miRBASE accession |
|---|---|
|
hsa-miR-153-3p
|
MIMAT0000439 |
Network of associatons between targets according to the STRING database.
First level regulatory network of UGCAUAG
| Promoter | Score | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr20_+_10218808 Show fit | 30.20 |
ENST00000254976.7
ENST00000304886.6 |
synaptosome associated protein 25 |
|
| chr8_+_24914942 Show fit | 24.63 |
ENST00000433454.3
|
neurofilament medium |
|
| chr3_+_111998739 Show fit | 20.23 |
ENST00000393917.6
ENST00000273368.8 |
transgelin 3 |
|
| chr5_+_141359970 Show fit | 19.76 |
ENST00000522605.2
ENST00000622527.1 |
protocadherin gamma subfamily B, 2 |
|
| chr5_+_141489066 Show fit | 18.50 |
ENST00000252087.3
|
protocadherin gamma subfamily C, 5 |
|
| chr5_+_141382702 Show fit | 18.29 |
ENST00000617050.1
ENST00000518325.2 |
protocadherin gamma subfamily A, 7 |
|
| chr5_+_141350081 Show fit | 16.95 |
ENST00000523390.2
ENST00000611598.1 |
protocadherin gamma subfamily B, 1 |
|
| chr10_-_15371225 Show fit | 16.76 |
ENST00000378116.9
|
family with sequence similarity 171 member A1 |
|
| chr5_+_141370236 Show fit | 16.31 |
ENST00000576222.2
ENST00000618934.1 |
protocadherin gamma subfamily B, 3 |
|
| chr12_+_78864768 Show fit | 16.20 |
ENST00000261205.9
ENST00000457153.6 |
synaptotagmin 1 |
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.9 | 327.0 | GO:0007156 | homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156) |
| 6.7 | 33.5 | GO:0099590 | neurotransmitter receptor internalization(GO:0099590) |
| 6.2 | 24.6 | GO:0033693 | neurofilament bundle assembly(GO:0033693) |
| 5.4 | 16.2 | GO:0098746 | fast, calcium ion-dependent exocytosis of neurotransmitter(GO:0098746) |
| 4.4 | 13.3 | GO:0098928 | presynaptic signal transduction(GO:0098928) presynapse to nucleus signaling pathway(GO:0099526) |
| 4.4 | 13.3 | GO:0010847 | regulation of chromatin assembly(GO:0010847) |
| 3.3 | 13.3 | GO:0031117 | positive regulation of microtubule depolymerization(GO:0031117) |
| 0.7 | 12.8 | GO:0046325 | negative regulation of glucose import(GO:0046325) |
| 3.1 | 12.5 | GO:2000297 | negative regulation of synapse maturation(GO:2000297) |
| 0.7 | 12.0 | GO:0050812 | regulation of acyl-CoA biosynthetic process(GO:0050812) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 345.0 | GO:0005887 | integral component of plasma membrane(GO:0005887) |
| 9.4 | 37.5 | GO:0070032 | synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex(GO:0070032) |
| 0.1 | 33.7 | GO:0043025 | neuronal cell body(GO:0043025) |
| 1.6 | 24.6 | GO:0097418 | neurofibrillary tangle(GO:0097418) |
| 0.9 | 17.2 | GO:0005641 | nuclear envelope lumen(GO:0005641) |
| 0.2 | 16.7 | GO:0032588 | trans-Golgi network membrane(GO:0032588) |
| 3.2 | 16.2 | GO:0060200 | clathrin-sculpted acetylcholine transport vesicle(GO:0060200) clathrin-sculpted acetylcholine transport vesicle membrane(GO:0060201) |
| 4.4 | 13.3 | GO:0099569 | cytoskeleton of presynaptic active zone(GO:0048788) presynaptic active zone cytoplasmic component(GO:0098831) presynaptic cytoskeleton(GO:0099569) |
| 0.5 | 11.5 | GO:0014731 | spectrin-associated cytoskeleton(GO:0014731) |
| 0.8 | 10.9 | GO:0060077 | inhibitory synapse(GO:0060077) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 296.1 | GO:0005509 | calcium ion binding(GO:0005509) |
| 1.5 | 46.3 | GO:0017075 | syntaxin-1 binding(GO:0017075) |
| 0.2 | 24.7 | GO:0005200 | structural constituent of cytoskeleton(GO:0005200) |
| 0.1 | 23.0 | GO:0051015 | actin filament binding(GO:0051015) |
| 0.5 | 19.2 | GO:0048306 | calcium-dependent protein binding(GO:0048306) |
| 0.8 | 17.4 | GO:0031005 | filamin binding(GO:0031005) |
| 3.2 | 16.2 | GO:0030348 | syntaxin-3 binding(GO:0030348) |
| 0.3 | 15.3 | GO:0030507 | spectrin binding(GO:0030507) |
| 0.3 | 14.0 | GO:0070888 | E-box binding(GO:0070888) |
| 1.3 | 13.3 | GO:0001042 | RNA polymerase I core binding(GO:0001042) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 20.2 | SIG CD40PATHWAYMAP | Genes related to CD40 signaling |
| 0.2 | 11.9 | PID TNF PATHWAY | TNF receptor signaling pathway |
| 0.1 | 11.0 | PID P73PATHWAY | p73 transcription factor network |
| 0.2 | 10.0 | PID IL12 STAT4 PATHWAY | IL12 signaling mediated by STAT4 |
| 0.1 | 9.4 | PID AR PATHWAY | Coregulation of Androgen receptor activity |
| 0.2 | 6.7 | PID INSULIN GLUCOSE PATHWAY | Insulin-mediated glucose transport |
| 0.2 | 5.7 | PID WNT SIGNALING PATHWAY | Wnt signaling network |
| 0.0 | 5.5 | PID MYC REPRESS PATHWAY | Validated targets of C-MYC transcriptional repression |
| 0.1 | 4.8 | PID ALPHA SYNUCLEIN PATHWAY | Alpha-synuclein signaling |
| 0.1 | 4.3 | PID IL12 2PATHWAY | IL12-mediated signaling events |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.6 | 59.6 | REACTOME DOPAMINE NEUROTRANSMITTER RELEASE CYCLE | Genes involved in Dopamine Neurotransmitter Release Cycle |
| 0.5 | 15.0 | REACTOME CRMPS IN SEMA3A SIGNALING | Genes involved in CRMPs in Sema3A signaling |
| 0.3 | 13.4 | REACTOME INTERACTION BETWEEN L1 AND ANKYRINS | Genes involved in Interaction between L1 and Ankyrins |
| 0.7 | 12.0 | REACTOME REGULATION OF PYRUVATE DEHYDROGENASE PDH COMPLEX | Genes involved in Regulation of pyruvate dehydrogenase (PDH) complex |
| 0.2 | 11.5 | REACTOME DARPP 32 EVENTS | Genes involved in DARPP-32 events |
| 0.1 | 8.6 | REACTOME TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES | Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides |
| 0.2 | 8.3 | REACTOME A TETRASACCHARIDE LINKER SEQUENCE IS REQUIRED FOR GAG SYNTHESIS | Genes involved in A tetrasaccharide linker sequence is required for GAG synthesis |
| 0.1 | 7.3 | REACTOME MYOGENESIS | Genes involved in Myogenesis |
| 0.4 | 7.2 | REACTOME THE NLRP3 INFLAMMASOME | Genes involved in The NLRP3 inflammasome |
| 0.3 | 6.0 | REACTOME SOS MEDIATED SIGNALLING | Genes involved in SOS-mediated signalling |