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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
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Results for UGGCACU
Z-value: 0.55
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miRNA associated with seed UGGCACU
| Name | miRBASE accession |
|---|---|
|
hsa-miR-183-5p.2
|
Network of associatons between targets according to the STRING database.
First level regulatory network of UGGCACU
| Promoter | Score | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr1_-_20486197 Show fit | 11.12 |
ENST00000375078.4
|
calcium/calmodulin dependent protein kinase II inhibitor 1 |
|
| chr15_+_66386902 Show fit | 7.07 |
ENST00000307102.10
|
mitogen-activated protein kinase kinase 1 |
|
| chr4_-_176002332 Show fit | 6.78 |
ENST00000280187.11
ENST00000512509.5 |
glycoprotein M6A |
|
| chr13_+_26557659 Show fit | 5.91 |
ENST00000335327.6
ENST00000361042.8 ENST00000671038.1 |
WASP family member 3 |
|
| chr16_+_56638659 Show fit | 5.67 |
ENST00000290705.12
|
metallothionein 1A |
|
| chr15_-_52569197 Show fit | 4.94 |
ENST00000563277.5
ENST00000566423.5 |
cAMP regulated phosphoprotein 19 |
|
| chrX_-_13938618 Show fit | 4.87 |
ENST00000454189.6
|
glycoprotein M6B |
|
| chr3_-_15332526 Show fit | 4.86 |
ENST00000383791.8
|
SH3 domain binding protein 5 |
|
| chr11_-_45665578 Show fit | 4.63 |
ENST00000308064.7
|
carbohydrate sulfotransferase 1 |
|
| chr5_+_77210667 Show fit | 4.25 |
ENST00000264917.10
|
phosphodiesterase 8B |
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.0 | 7.2 | GO:0090170 | regulation of Golgi inheritance(GO:0090170) |
| 0.1 | 6.2 | GO:0051491 | positive regulation of filopodium assembly(GO:0051491) |
| 0.2 | 5.9 | GO:0031643 | positive regulation of myelination(GO:0031643) |
| 0.2 | 5.7 | GO:0071294 | cellular response to zinc ion(GO:0071294) |
| 0.1 | 5.6 | GO:0046676 | negative regulation of insulin secretion(GO:0046676) |
| 0.0 | 5.6 | GO:0006469 | negative regulation of protein kinase activity(GO:0006469) |
| 0.6 | 5.3 | GO:0016198 | axon choice point recognition(GO:0016198) |
| 0.1 | 5.3 | GO:0046839 | phospholipid dephosphorylation(GO:0046839) |
| 0.0 | 5.3 | GO:0048813 | dendrite morphogenesis(GO:0048813) |
| 0.5 | 5.0 | GO:0080182 | histone H3-K4 trimethylation(GO:0080182) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 9.3 | GO:0045211 | postsynaptic membrane(GO:0045211) |
| 0.0 | 8.9 | GO:0005769 | early endosome(GO:0005769) |
| 0.3 | 8.3 | GO:0044295 | axonal growth cone(GO:0044295) |
| 0.0 | 7.2 | GO:0000139 | Golgi membrane(GO:0000139) |
| 0.0 | 5.4 | GO:0030027 | lamellipodium(GO:0030027) |
| 0.0 | 4.9 | GO:0043204 | perikaryon(GO:0043204) |
| 0.0 | 4.4 | GO:0042734 | presynaptic membrane(GO:0042734) |
| 0.1 | 3.8 | GO:0019005 | SCF ubiquitin ligase complex(GO:0019005) |
| 0.2 | 3.5 | GO:0032045 | guanyl-nucleotide exchange factor complex(GO:0032045) |
| 0.1 | 3.4 | GO:0005720 | nuclear heterochromatin(GO:0005720) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 3.7 | 11.1 | GO:0008427 | calcium-dependent protein kinase inhibitor activity(GO:0008427) |
| 0.2 | 7.1 | GO:0043539 | protein serine/threonine kinase activator activity(GO:0043539) |
| 0.0 | 5.8 | GO:0003779 | actin binding(GO:0003779) |
| 0.0 | 5.6 | GO:0017124 | SH3 domain binding(GO:0017124) |
| 0.7 | 4.6 | GO:0001517 | N-acetylglucosamine 6-O-sulfotransferase activity(GO:0001517) |
| 0.1 | 4.6 | GO:0051721 | protein phosphatase 2A binding(GO:0051721) |
| 0.0 | 4.5 | GO:0005200 | structural constituent of cytoskeleton(GO:0005200) |
| 0.3 | 4.2 | GO:0042577 | phosphatidate phosphatase activity(GO:0008195) lipid phosphatase activity(GO:0042577) |
| 0.1 | 4.2 | GO:0004115 | 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115) |
| 1.0 | 3.9 | GO:0004598 | peptidylglycine monooxygenase activity(GO:0004504) peptidylamidoglycolate lyase activity(GO:0004598) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 8.1 | PID TCR RAS PATHWAY | Ras signaling in the CD4+ TCR pathway |
| 0.1 | 7.5 | PID MTOR 4PATHWAY | mTOR signaling pathway |
| 0.1 | 5.2 | PID NECTIN PATHWAY | Nectin adhesion pathway |
| 0.1 | 4.6 | PID BCR 5PATHWAY | BCR signaling pathway |
| 0.1 | 4.2 | PID NCADHERIN PATHWAY | N-cadherin signaling events |
| 0.1 | 3.7 | PID AMB2 NEUTROPHILS PATHWAY | amb2 Integrin signaling |
| 0.1 | 3.4 | SA G1 AND S PHASES | Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition. |
| 0.1 | 3.3 | PID INTEGRIN A4B1 PATHWAY | Alpha4 beta1 integrin signaling events |
| 0.1 | 2.9 | PID ERBB1 INTERNALIZATION PATHWAY | Internalization of ErbB1 |
| 0.0 | 2.7 | PID AR PATHWAY | Coregulation of Androgen receptor activity |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.6 | 8.1 | REACTOME RAF MAP KINASE CASCADE | Genes involved in RAF/MAP kinase cascade |
| 0.1 | 4.5 | REACTOME KERATAN SULFATE BIOSYNTHESIS | Genes involved in Keratan sulfate biosynthesis |
| 0.3 | 3.5 | REACTOME ARMS MEDIATED ACTIVATION | Genes involved in ARMS-mediated activation |
| 0.1 | 3.4 | REACTOME SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE | Genes involved in Synthesis of PIPs at the Golgi membrane |
| 0.1 | 3.4 | REACTOME RAP1 SIGNALLING | Genes involved in Rap1 signalling |
| 0.0 | 3.4 | REACTOME APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS | Genes involved in Apoptotic cleavage of cellular proteins |
| 0.1 | 2.9 | REACTOME PKA MEDIATED PHOSPHORYLATION OF CREB | Genes involved in PKA-mediated phosphorylation of CREB |
| 0.0 | 2.8 | REACTOME G ALPHA S SIGNALLING EVENTS | Genes involved in G alpha (s) signalling events |
| 0.1 | 2.4 | REACTOME IL 7 SIGNALING | Genes involved in Interleukin-7 signaling |
| 0.1 | 2.4 | REACTOME CHOLESTEROL BIOSYNTHESIS | Genes involved in Cholesterol biosynthesis |