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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
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Results for UGGUCCC
Z-value: 0.87
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miRNA associated with seed UGGUCCC
| Name | miRBASE accession |
|---|---|
|
hsa-miR-133a-3p.1
|
Network of associatons between targets according to the STRING database.
First level regulatory network of UGGUCCC
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.9 | 150.6 | GO:0007156 | homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156) |
| 0.1 | 17.1 | GO:0048813 | dendrite morphogenesis(GO:0048813) |
| 0.7 | 11.8 | GO:0042532 | negative regulation of tyrosine phosphorylation of STAT protein(GO:0042532) |
| 1.4 | 11.2 | GO:1903551 | regulation of extracellular exosome assembly(GO:1903551) |
| 0.8 | 10.8 | GO:0044387 | negative regulation of protein kinase activity by regulation of protein phosphorylation(GO:0044387) |
| 1.0 | 10.6 | GO:0032914 | positive regulation of transforming growth factor beta1 production(GO:0032914) |
| 0.2 | 9.9 | GO:0051491 | positive regulation of filopodium assembly(GO:0051491) |
| 1.4 | 9.7 | GO:0070294 | renal sodium ion absorption(GO:0070294) |
| 2.3 | 9.3 | GO:1900126 | negative regulation of hyaluronan biosynthetic process(GO:1900126) |
| 2.2 | 8.9 | GO:0009051 | pentose-phosphate shunt, oxidative branch(GO:0009051) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 112.7 | GO:0005887 | integral component of plasma membrane(GO:0005887) |
| 0.4 | 17.4 | GO:0000159 | protein phosphatase type 2A complex(GO:0000159) |
| 1.7 | 17.0 | GO:0071439 | clathrin complex(GO:0071439) |
| 0.0 | 16.2 | GO:0005789 | endoplasmic reticulum membrane(GO:0005789) |
| 0.0 | 14.1 | GO:0031965 | nuclear membrane(GO:0031965) |
| 0.2 | 12.3 | GO:0055038 | recycling endosome membrane(GO:0055038) |
| 0.1 | 12.2 | GO:0070821 | tertiary granule membrane(GO:0070821) |
| 0.5 | 12.1 | GO:0044295 | axonal growth cone(GO:0044295) |
| 0.1 | 11.4 | GO:0000922 | spindle pole(GO:0000922) |
| 3.7 | 11.2 | GO:0033565 | ESCRT-0 complex(GO:0033565) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 177.2 | GO:0005509 | calcium ion binding(GO:0005509) |
| 0.2 | 19.2 | GO:0005070 | SH3/SH2 adaptor activity(GO:0005070) |
| 0.6 | 12.6 | GO:0050811 | GABA receptor binding(GO:0050811) |
| 0.4 | 11.9 | GO:0019198 | transmembrane receptor protein tyrosine phosphatase activity(GO:0005001) transmembrane receptor protein phosphatase activity(GO:0019198) |
| 0.8 | 11.2 | GO:0032050 | clathrin heavy chain binding(GO:0032050) |
| 0.1 | 10.8 | GO:0048365 | Rac GTPase binding(GO:0048365) |
| 0.5 | 10.4 | GO:0070273 | phosphatidylinositol-4-phosphate binding(GO:0070273) |
| 0.1 | 9.8 | GO:0005262 | calcium channel activity(GO:0005262) |
| 0.4 | 9.7 | GO:0017081 | chloride channel regulator activity(GO:0017081) |
| 0.8 | 9.3 | GO:0032051 | clathrin light chain binding(GO:0032051) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 12.8 | PID IL8 CXCR2 PATHWAY | IL8- and CXCR2-mediated signaling events |
| 0.2 | 12.7 | PID IL2 1PATHWAY | IL2-mediated signaling events |
| 0.2 | 12.1 | PID INSULIN PATHWAY | Insulin Pathway |
| 0.2 | 12.0 | PID ARF6 TRAFFICKING PATHWAY | Arf6 trafficking events |
| 0.2 | 10.5 | PID ER NONGENOMIC PATHWAY | Plasma membrane estrogen receptor signaling |
| 0.3 | 9.7 | PID WNT SIGNALING PATHWAY | Wnt signaling network |
| 0.3 | 8.6 | PID ARF 3PATHWAY | Arf1 pathway |
| 0.2 | 5.9 | PID SMAD2 3PATHWAY | Regulation of cytoplasmic and nuclear SMAD2/3 signaling |
| 0.1 | 5.9 | PID TELOMERASE PATHWAY | Regulation of Telomerase |
| 0.1 | 5.3 | PID CASPASE PATHWAY | Caspase cascade in apoptosis |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.8 | 17.0 | REACTOME GAP JUNCTION DEGRADATION | Genes involved in Gap junction degradation |
| 0.9 | 15.8 | REACTOME INHIBITION OF REPLICATION INITIATION OF DAMAGED DNA BY RB1 E2F1 | Genes involved in Inhibition of replication initiation of damaged DNA by RB1/E2F1 |
| 0.5 | 15.8 | REACTOME EGFR DOWNREGULATION | Genes involved in EGFR downregulation |
| 0.6 | 12.0 | REACTOME TETRAHYDROBIOPTERIN BH4 SYNTHESIS RECYCLING SALVAGE AND REGULATION | Genes involved in Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation |
| 0.4 | 9.6 | REACTOME NOREPINEPHRINE NEUROTRANSMITTER RELEASE CYCLE | Genes involved in Norepinephrine Neurotransmitter Release Cycle |
| 0.3 | 8.8 | REACTOME SYNTHESIS OF VERY LONG CHAIN FATTY ACYL COAS | Genes involved in Synthesis of very long-chain fatty acyl-CoAs |
| 0.4 | 8.7 | REACTOME METABOLISM OF POLYAMINES | Genes involved in Metabolism of polyamines |
| 0.3 | 8.7 | REACTOME SPHINGOLIPID DE NOVO BIOSYNTHESIS | Genes involved in Sphingolipid de novo biosynthesis |
| 0.3 | 8.6 | REACTOME SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI AND TRIPHOSPHATES | Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates |
| 0.1 | 7.9 | REACTOME REGULATION OF ORNITHINE DECARBOXYLASE ODC | Genes involved in Regulation of ornithine decarboxylase (ODC) |