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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
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Results for UGUGCUU
Z-value: 1.57
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miRNA associated with seed UGUGCUU
| Name | miRBASE accession |
|---|---|
|
hsa-miR-218-5p
|
MIMAT0000275 |
Network of associatons between targets according to the STRING database.
First level regulatory network of UGUGCUU
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 77.0 | GO:0007156 | homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156) |
| 1.5 | 61.4 | GO:0050650 | chondroitin sulfate proteoglycan biosynthetic process(GO:0050650) |
| 0.9 | 38.8 | GO:0035235 | ionotropic glutamate receptor signaling pathway(GO:0035235) |
| 11.2 | 33.6 | GO:0098746 | fast, calcium ion-dependent exocytosis of neurotransmitter(GO:0098746) |
| 1.8 | 31.0 | GO:2001135 | regulation of endocytic recycling(GO:2001135) |
| 0.8 | 30.7 | GO:0048791 | calcium ion-regulated exocytosis of neurotransmitter(GO:0048791) |
| 0.6 | 30.1 | GO:0071377 | cellular response to glucagon stimulus(GO:0071377) |
| 0.6 | 29.1 | GO:0042417 | dopamine metabolic process(GO:0042417) |
| 9.5 | 28.5 | GO:0051939 | gamma-aminobutyric acid import(GO:0051939) |
| 2.6 | 28.1 | GO:0042985 | negative regulation of amyloid precursor protein biosynthetic process(GO:0042985) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 104.2 | GO:0005887 | integral component of plasma membrane(GO:0005887) |
| 0.1 | 85.6 | GO:0044431 | Golgi apparatus part(GO:0044431) |
| 0.2 | 69.7 | GO:0016323 | basolateral plasma membrane(GO:0016323) |
| 0.4 | 59.3 | GO:0043204 | perikaryon(GO:0043204) |
| 1.3 | 58.0 | GO:0048786 | presynaptic active zone(GO:0048786) |
| 0.1 | 53.3 | GO:0030424 | axon(GO:0030424) |
| 0.5 | 50.1 | GO:0042734 | presynaptic membrane(GO:0042734) |
| 0.6 | 45.0 | GO:0099501 | synaptic vesicle membrane(GO:0030672) exocytic vesicle membrane(GO:0099501) |
| 0.6 | 39.3 | GO:0005834 | heterotrimeric G-protein complex(GO:0005834) |
| 12.1 | 36.2 | GO:0098843 | postsynaptic endocytic zone(GO:0098843) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 77.8 | GO:0005509 | calcium ion binding(GO:0005509) |
| 0.2 | 65.6 | GO:0005096 | GTPase activator activity(GO:0005096) |
| 0.2 | 36.8 | GO:0005200 | structural constituent of cytoskeleton(GO:0005200) |
| 4.5 | 36.2 | GO:0004971 | AMPA glutamate receptor activity(GO:0004971) |
| 6.7 | 33.6 | GO:0030348 | syntaxin-3 binding(GO:0030348) |
| 0.3 | 33.4 | GO:0004867 | serine-type endopeptidase inhibitor activity(GO:0004867) |
| 0.2 | 33.1 | GO:0044325 | ion channel binding(GO:0044325) |
| 8.2 | 33.0 | GO:0015018 | galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity(GO:0015018) |
| 2.1 | 32.1 | GO:0008195 | phosphatidate phosphatase activity(GO:0008195) lipid phosphatase activity(GO:0042577) |
| 1.6 | 31.3 | GO:0031702 | angiotensin receptor binding(GO:0031701) type 1 angiotensin receptor binding(GO:0031702) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.1 | 70.4 | PID NCADHERIN PATHWAY | N-cadherin signaling events |
| 0.7 | 43.9 | SIG CD40PATHWAYMAP | Genes related to CD40 signaling |
| 0.7 | 39.4 | SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES | Genes related to regulation of the actin cytoskeleton |
| 0.6 | 26.9 | ST WNT BETA CATENIN PATHWAY | Wnt/beta-catenin Pathway |
| 0.2 | 26.1 | PID MYC ACTIV PATHWAY | Validated targets of C-MYC transcriptional activation |
| 0.9 | 25.1 | PID SYNDECAN 3 PATHWAY | Syndecan-3-mediated signaling events |
| 0.1 | 21.1 | NABA SECRETED FACTORS | Genes encoding secreted soluble factors |
| 0.4 | 17.3 | PID REELIN PATHWAY | Reelin signaling pathway |
| 0.5 | 12.1 | PID PI3K PLC TRK PATHWAY | Trk receptor signaling mediated by PI3K and PLC-gamma |
| 0.3 | 10.5 | PID ERBB4 PATHWAY | ErbB4 signaling events |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.7 | 58.7 | REACTOME NOREPINEPHRINE NEUROTRANSMITTER RELEASE CYCLE | Genes involved in Norepinephrine Neurotransmitter Release Cycle |
| 1.3 | 54.1 | REACTOME A TETRASACCHARIDE LINKER SEQUENCE IS REQUIRED FOR GAG SYNTHESIS | Genes involved in A tetrasaccharide linker sequence is required for GAG synthesis |
| 1.4 | 36.2 | REACTOME TRAFFICKING OF GLUR2 CONTAINING AMPA RECEPTORS | Genes involved in Trafficking of GluR2-containing AMPA receptors |
| 0.8 | 32.4 | REACTOME RAP1 SIGNALLING | Genes involved in Rap1 signalling |
| 1.3 | 31.6 | REACTOME G BETA GAMMA SIGNALLING THROUGH PLC BETA | Genes involved in G beta:gamma signalling through PLC beta |
| 1.3 | 28.5 | REACTOME GABA SYNTHESIS RELEASE REUPTAKE AND DEGRADATION | Genes involved in GABA synthesis, release, reuptake and degradation |
| 0.8 | 22.2 | REACTOME KINESINS | Genes involved in Kinesins |
| 0.1 | 20.2 | REACTOME PEPTIDE LIGAND BINDING RECEPTORS | Genes involved in Peptide ligand-binding receptors |
| 0.9 | 18.5 | REACTOME CLASS C 3 METABOTROPIC GLUTAMATE PHEROMONE RECEPTORS | Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors) |
| 1.0 | 17.2 | REACTOME HS GAG BIOSYNTHESIS | Genes involved in HS-GAG biosynthesis |