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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
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Results for UUGGCAA
Z-value: 0.65
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miRNA associated with seed UUGGCAA
| Name | miRBASE accession |
|---|---|
|
hsa-miR-182-5p
|
MIMAT0000259 |
Network of associatons between targets according to the STRING database.
First level regulatory network of UUGGCAA
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.1 | 12.0 | GO:1904262 | negative regulation of TORC1 signaling(GO:1904262) |
| 0.1 | 9.6 | GO:0003333 | amino acid transmembrane transport(GO:0003333) |
| 0.3 | 8.3 | GO:0008053 | mitochondrial fusion(GO:0008053) |
| 0.6 | 8.0 | GO:0061162 | establishment of monopolar cell polarity(GO:0061162) establishment or maintenance of monopolar cell polarity(GO:0061339) |
| 0.7 | 7.8 | GO:0090232 | positive regulation of spindle checkpoint(GO:0090232) |
| 0.2 | 6.1 | GO:2000300 | regulation of synaptic vesicle exocytosis(GO:2000300) |
| 0.6 | 5.9 | GO:0042415 | norepinephrine metabolic process(GO:0042415) |
| 0.3 | 5.8 | GO:0046051 | UTP metabolic process(GO:0046051) |
| 0.6 | 5.7 | GO:2000049 | positive regulation of cell-cell adhesion mediated by cadherin(GO:2000049) |
| 0.2 | 5.6 | GO:0045332 | lipid translocation(GO:0034204) phospholipid translocation(GO:0045332) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 20.8 | GO:0005765 | lysosomal membrane(GO:0005765) lytic vacuole membrane(GO:0098852) |
| 0.1 | 18.4 | GO:0005913 | cell-cell adherens junction(GO:0005913) |
| 0.1 | 11.9 | GO:0055037 | recycling endosome(GO:0055037) |
| 0.1 | 9.9 | GO:0031225 | anchored component of membrane(GO:0031225) |
| 0.0 | 9.3 | GO:0005741 | mitochondrial outer membrane(GO:0005741) |
| 0.0 | 8.7 | GO:0005788 | endoplasmic reticulum lumen(GO:0005788) |
| 0.1 | 7.7 | GO:0001750 | photoreceptor outer segment(GO:0001750) |
| 0.0 | 7.6 | GO:0016607 | nuclear speck(GO:0016607) |
| 0.0 | 7.2 | GO:0045211 | postsynaptic membrane(GO:0045211) |
| 1.0 | 6.3 | GO:1990316 | ATG1/ULK1 kinase complex(GO:1990316) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 15.3 | GO:0030165 | PDZ domain binding(GO:0030165) |
| 0.3 | 13.6 | GO:0017112 | Rab guanyl-nucleotide exchange factor activity(GO:0017112) |
| 0.2 | 9.1 | GO:0043015 | gamma-tubulin binding(GO:0043015) |
| 0.3 | 7.2 | GO:0004012 | phospholipid-translocating ATPase activity(GO:0004012) |
| 0.1 | 7.2 | GO:0035035 | histone acetyltransferase binding(GO:0035035) |
| 2.3 | 6.9 | GO:0008427 | calcium-dependent protein kinase inhibitor activity(GO:0008427) |
| 0.0 | 6.9 | GO:0004842 | ubiquitin-protein transferase activity(GO:0004842) |
| 0.1 | 6.5 | GO:0002039 | p53 binding(GO:0002039) |
| 0.0 | 6.2 | GO:0017137 | Rab GTPase binding(GO:0017137) |
| 0.1 | 6.0 | GO:0015171 | amino acid transmembrane transporter activity(GO:0015171) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 10.5 | PID HIF1 TFPATHWAY | HIF-1-alpha transcription factor network |
| 0.1 | 9.3 | PID ECADHERIN NASCENT AJ PATHWAY | E-cadherin signaling in the nascent adherens junction |
| 0.2 | 8.0 | PID LIS1 PATHWAY | Lissencephaly gene (LIS1) in neuronal migration and development |
| 0.1 | 7.2 | PID HIF2PATHWAY | HIF-2-alpha transcription factor network |
| 0.1 | 6.3 | PID AR TF PATHWAY | Regulation of Androgen receptor activity |
| 0.0 | 4.9 | PID PDGFRB PATHWAY | PDGFR-beta signaling pathway |
| 0.1 | 4.8 | PID RHOA REG PATHWAY | Regulation of RhoA activity |
| 0.0 | 4.8 | NABA ECM GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 0.1 | 4.0 | PID P38 ALPHA BETA PATHWAY | Regulation of p38-alpha and p38-beta |
| 0.1 | 3.9 | PID INTEGRIN A9B1 PATHWAY | Alpha9 beta1 integrin signaling events |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 9.5 | REACTOME AMINO ACID AND OLIGOPEPTIDE SLC TRANSPORTERS | Genes involved in Amino acid and oligopeptide SLC transporters |
| 0.2 | 8.2 | REACTOME A TETRASACCHARIDE LINKER SEQUENCE IS REQUIRED FOR GAG SYNTHESIS | Genes involved in A tetrasaccharide linker sequence is required for GAG synthesis |
| 0.0 | 8.2 | REACTOME SIGNALING BY RHO GTPASES | Genes involved in Signaling by Rho GTPases |
| 0.1 | 7.2 | REACTOME ION TRANSPORT BY P TYPE ATPASES | Genes involved in Ion transport by P-type ATPases |
| 0.2 | 6.9 | REACTOME OXYGEN DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA INDUCIBLE FACTOR ALPHA | Genes involved in Oxygen-dependent Proline Hydroxylation of Hypoxia-inducible Factor Alpha |
| 0.1 | 6.0 | REACTOME INTERACTION BETWEEN L1 AND ANKYRINS | Genes involved in Interaction between L1 and Ankyrins |
| 0.1 | 6.0 | REACTOME REGULATION OF BETA CELL DEVELOPMENT | Genes involved in Regulation of beta-cell development |
| 0.0 | 5.9 | REACTOME GENERIC TRANSCRIPTION PATHWAY | Genes involved in Generic Transcription Pathway |
| 0.1 | 5.2 | REACTOME ELONGATION ARREST AND RECOVERY | Genes involved in Elongation arrest and recovery |
| 0.1 | 4.8 | REACTOME ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS | Genes involved in Association of TriC/CCT with target proteins during biosynthesis |