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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
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Results for UUGGCAC
Z-value: 1.21
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miRNA associated with seed UUGGCAC
Network of associatons between targets according to the STRING database.
First level regulatory network of UUGGCAC
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.7 | 33.4 | GO:0051491 | positive regulation of filopodium assembly(GO:0051491) |
| 2.8 | 33.2 | GO:0051581 | negative regulation of neurotransmitter uptake(GO:0051581) regulation of serotonin uptake(GO:0051611) negative regulation of serotonin uptake(GO:0051612) |
| 0.8 | 32.4 | GO:0048791 | calcium ion-regulated exocytosis of neurotransmitter(GO:0048791) |
| 0.3 | 25.1 | GO:0003333 | amino acid transmembrane transport(GO:0003333) |
| 0.4 | 23.2 | GO:0046839 | phospholipid dephosphorylation(GO:0046839) |
| 2.4 | 21.5 | GO:0035507 | regulation of myosin-light-chain-phosphatase activity(GO:0035507) |
| 0.1 | 20.9 | GO:0006367 | transcription initiation from RNA polymerase II promoter(GO:0006367) |
| 0.7 | 20.4 | GO:0047497 | establishment of mitochondrion localization, microtubule-mediated(GO:0034643) mitochondrion transport along microtubule(GO:0047497) |
| 6.5 | 19.5 | GO:0006210 | pyrimidine nucleobase catabolic process(GO:0006208) thymine catabolic process(GO:0006210) thymine metabolic process(GO:0019859) |
| 2.2 | 19.5 | GO:0016198 | axon choice point recognition(GO:0016198) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.8 | 43.1 | GO:0044295 | axonal growth cone(GO:0044295) |
| 0.6 | 34.1 | GO:0048786 | presynaptic active zone(GO:0048786) |
| 0.4 | 33.8 | GO:0030672 | synaptic vesicle membrane(GO:0030672) exocytic vesicle membrane(GO:0099501) |
| 0.0 | 29.2 | GO:0005887 | integral component of plasma membrane(GO:0005887) |
| 0.2 | 28.1 | GO:0005913 | cell-cell adherens junction(GO:0005913) |
| 0.2 | 28.0 | GO:0030426 | growth cone(GO:0030426) |
| 0.1 | 27.6 | GO:0005667 | transcription factor complex(GO:0005667) |
| 0.1 | 27.1 | GO:0045211 | postsynaptic membrane(GO:0045211) |
| 0.2 | 26.1 | GO:0005814 | centriole(GO:0005814) |
| 0.3 | 24.4 | GO:0005891 | voltage-gated calcium channel complex(GO:0005891) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 44.7 | GO:0017124 | SH3 domain binding(GO:0017124) |
| 0.3 | 34.4 | GO:0005262 | calcium channel activity(GO:0005262) |
| 0.1 | 32.2 | GO:0004930 | G-protein coupled receptor activity(GO:0004930) |
| 0.5 | 28.2 | GO:0017112 | Rab guanyl-nucleotide exchange factor activity(GO:0017112) |
| 9.4 | 28.1 | GO:0008427 | calcium-dependent protein kinase inhibitor activity(GO:0008427) |
| 0.6 | 22.6 | GO:0030742 | GTP-dependent protein binding(GO:0030742) |
| 0.7 | 22.3 | GO:0030676 | Rac guanyl-nucleotide exchange factor activity(GO:0030676) |
| 1.4 | 21.2 | GO:0008195 | phosphatidate phosphatase activity(GO:0008195) lipid phosphatase activity(GO:0042577) |
| 0.0 | 21.1 | GO:0046982 | protein heterodimerization activity(GO:0046982) |
| 0.2 | 20.2 | GO:0004222 | metalloendopeptidase activity(GO:0004222) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.6 | 26.5 | PID LIS1 PATHWAY | Lissencephaly gene (LIS1) in neuronal migration and development |
| 0.3 | 24.4 | PID ECADHERIN NASCENT AJ PATHWAY | E-cadherin signaling in the nascent adherens junction |
| 0.1 | 17.8 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.2 | 16.6 | PID AR TF PATHWAY | Regulation of Androgen receptor activity |
| 0.2 | 16.5 | PID HIF1 TFPATHWAY | HIF-1-alpha transcription factor network |
| 0.3 | 15.9 | PID PI3KCI AKT PATHWAY | Class I PI3K signaling events mediated by Akt |
| 0.1 | 15.7 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.2 | 14.0 | SIG CHEMOTAXIS | Genes related to chemotaxis |
| 0.8 | 13.1 | PID THROMBIN PAR4 PATHWAY | PAR4-mediated thrombin signaling events |
| 0.3 | 12.6 | PID MTOR 4PATHWAY | mTOR signaling pathway |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 20.9 | REACTOME A TETRASACCHARIDE LINKER SEQUENCE IS REQUIRED FOR GAG SYNTHESIS | Genes involved in A tetrasaccharide linker sequence is required for GAG synthesis |
| 0.4 | 20.2 | REACTOME ION TRANSPORT BY P TYPE ATPASES | Genes involved in Ion transport by P-type ATPases |
| 0.6 | 18.7 | REACTOME BRANCHED CHAIN AMINO ACID CATABOLISM | Genes involved in Branched-chain amino acid catabolism |
| 0.5 | 17.9 | REACTOME GLUTAMATE NEUROTRANSMITTER RELEASE CYCLE | Genes involved in Glutamate Neurotransmitter Release Cycle |
| 0.5 | 17.6 | REACTOME RAP1 SIGNALLING | Genes involved in Rap1 signalling |
| 0.5 | 16.4 | REACTOME KERATAN SULFATE BIOSYNTHESIS | Genes involved in Keratan sulfate biosynthesis |
| 0.2 | 14.6 | REACTOME REGULATION OF BETA CELL DEVELOPMENT | Genes involved in Regulation of beta-cell development |
| 0.2 | 14.4 | REACTOME TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES | Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides |
| 0.1 | 14.3 | REACTOME FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION | Genes involved in Factors involved in megakaryocyte development and platelet production |
| 1.0 | 13.8 | REACTOME ACTIVATION OF CHAPERONE GENES BY ATF6 ALPHA | Genes involved in Activation of Chaperone Genes by ATF6-alpha |