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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
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Results for UUGUUCG
Z-value: 0.23
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miRNA associated with seed UUGUUCG
| Name | miRBASE accession |
|---|---|
|
hsa-miR-375
|
MIMAT0000728 |
Network of associatons between targets according to the STRING database.
First level regulatory network of UUGUUCG
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 3.0 | GO:0043568 | positive regulation of insulin-like growth factor receptor signaling pathway(GO:0043568) |
| 0.1 | 1.3 | GO:0048386 | positive regulation of retinoic acid receptor signaling pathway(GO:0048386) |
| 0.4 | 1.1 | GO:0032912 | negative regulation of transforming growth factor beta2 production(GO:0032912) |
| 0.0 | 1.1 | GO:0032728 | positive regulation of interferon-beta production(GO:0032728) |
| 0.1 | 1.0 | GO:2000601 | positive regulation of Arp2/3 complex-mediated actin nucleation(GO:2000601) |
| 0.2 | 0.9 | GO:0061304 | retinal blood vessel morphogenesis(GO:0061304) |
| 0.1 | 0.9 | GO:1902459 | positive regulation of stem cell population maintenance(GO:1902459) |
| 0.0 | 0.9 | GO:0043586 | tongue development(GO:0043586) |
| 0.1 | 0.8 | GO:1900020 | regulation of protein kinase C activity(GO:1900019) positive regulation of protein kinase C activity(GO:1900020) |
| 0.1 | 0.8 | GO:0032534 | regulation of microvillus assembly(GO:0032534) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 3.9 | GO:0005788 | endoplasmic reticulum lumen(GO:0005788) |
| 0.1 | 1.3 | GO:0097470 | ribbon synapse(GO:0097470) |
| 0.0 | 1.2 | GO:0045334 | clathrin-coated endocytic vesicle(GO:0045334) |
| 0.1 | 1.0 | GO:0031209 | SCAR complex(GO:0031209) |
| 0.3 | 0.9 | GO:0071148 | TEAD-1-YAP complex(GO:0071148) |
| 0.0 | 0.9 | GO:0005782 | peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907) |
| 0.1 | 0.6 | GO:0071204 | histone pre-mRNA 3'end processing complex(GO:0071204) |
| 0.1 | 0.5 | GO:0017059 | serine C-palmitoyltransferase complex(GO:0017059) endoplasmic reticulum palmitoyltransferase complex(GO:0031211) |
| 0.1 | 0.5 | GO:1990851 | Wnt-Frizzled-LRP5/6 complex(GO:1990851) |
| 0.1 | 0.5 | GO:1990037 | Lewy body core(GO:1990037) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 3.0 | GO:0031995 | insulin-like growth factor II binding(GO:0031995) |
| 0.1 | 1.9 | GO:0070064 | proline-rich region binding(GO:0070064) |
| 0.2 | 1.3 | GO:0016618 | hydroxypyruvate reductase activity(GO:0016618) glyoxylate reductase (NADP) activity(GO:0030267) |
| 0.0 | 1.2 | GO:0001103 | RNA polymerase II repressing transcription factor binding(GO:0001103) |
| 0.0 | 1.0 | GO:0050699 | WW domain binding(GO:0050699) |
| 0.0 | 0.9 | GO:0005161 | platelet-derived growth factor receptor binding(GO:0005161) |
| 0.1 | 0.8 | GO:0004415 | hyalurononglucosaminidase activity(GO:0004415) ER retention sequence binding(GO:0046923) |
| 0.0 | 0.8 | GO:0035497 | cAMP response element binding(GO:0035497) |
| 0.1 | 0.7 | GO:0010859 | calcium-dependent cysteine-type endopeptidase inhibitor activity(GO:0010859) |
| 0.0 | 0.7 | GO:0071949 | FAD binding(GO:0071949) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 3.9 | PID WNT SIGNALING PATHWAY | Wnt signaling network |
| 0.0 | 1.1 | PID ERBB4 PATHWAY | ErbB4 signaling events |
| 0.0 | 1.0 | PID HES HEY PATHWAY | Notch-mediated HES/HEY network |
| 0.0 | 1.0 | PID ECADHERIN NASCENT AJ PATHWAY | E-cadherin signaling in the nascent adherens junction |
| 0.0 | 0.9 | PID RAC1 PATHWAY | RAC1 signaling pathway |
| 0.0 | 0.8 | PID PDGFRA PATHWAY | PDGFR-alpha signaling pathway |
| 0.0 | 0.4 | PID WNT NONCANONICAL PATHWAY | Noncanonical Wnt signaling pathway |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 3.0 | REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS | Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs) |
| 0.0 | 1.9 | REACTOME FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION | Genes involved in Factors involved in megakaryocyte development and platelet production |
| 0.0 | 1.0 | REACTOME GENERATION OF SECOND MESSENGER MOLECULES | Genes involved in Generation of second messenger molecules |
| 0.0 | 0.9 | REACTOME YAP1 AND WWTR1 TAZ STIMULATED GENE EXPRESSION | Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression |
| 0.0 | 0.8 | REACTOME VEGF LIGAND RECEPTOR INTERACTIONS | Genes involved in VEGF ligand-receptor interactions |
| 0.0 | 0.7 | REACTOME PEROXISOMAL LIPID METABOLISM | Genes involved in Peroxisomal lipid metabolism |
| 0.0 | 0.7 | REACTOME ADHERENS JUNCTIONS INTERACTIONS | Genes involved in Adherens junctions interactions |
| 0.0 | 0.5 | REACTOME METAL ION SLC TRANSPORTERS | Genes involved in Metal ion SLC transporters |
| 0.0 | 0.5 | REACTOME HYALURONAN METABOLISM | Genes involved in Hyaluronan metabolism |
| 0.0 | 0.5 | REACTOME ACTIVATION OF GENES BY ATF4 | Genes involved in Activation of Genes by ATF4 |