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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
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Results for VDR
Z-value: 1.05
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Transcription factors associated with VDR
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| VDR | hg38_v1_chr12_-_47905003_47905043 | 0.45 | 3.3e-12 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of VDR
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.8 | 75.1 | GO:0031338 | regulation of vesicle fusion(GO:0031338) |
| 7.4 | 36.8 | GO:0061107 | seminal vesicle development(GO:0061107) |
| 0.0 | 21.3 | GO:0006954 | inflammatory response(GO:0006954) |
| 0.2 | 20.0 | GO:0050911 | detection of chemical stimulus involved in sensory perception of smell(GO:0050911) |
| 0.5 | 18.0 | GO:0045730 | respiratory burst(GO:0045730) |
| 0.9 | 17.4 | GO:0033539 | fatty acid beta-oxidation using acyl-CoA dehydrogenase(GO:0033539) |
| 4.3 | 12.9 | GO:0001868 | regulation of complement activation, lectin pathway(GO:0001868) negative regulation of complement activation, lectin pathway(GO:0001869) |
| 3.7 | 11.2 | GO:0001207 | histone displacement(GO:0001207) positive regulation of transcription involved in meiotic cell cycle(GO:0051039) |
| 2.6 | 10.3 | GO:0002399 | MHC class II protein complex assembly(GO:0002399) |
| 0.1 | 10.2 | GO:0007286 | spermatid development(GO:0007286) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 12.3 | 36.8 | GO:0036028 | protein C inhibitor-TMPRSS7 complex(GO:0036024) protein C inhibitor-TMPRSS11E complex(GO:0036025) protein C inhibitor-PLAT complex(GO:0036026) protein C inhibitor-PLAU complex(GO:0036027) protein C inhibitor-thrombin complex(GO:0036028) protein C inhibitor-KLK3 complex(GO:0036029) protein C inhibitor-plasma kallikrein complex(GO:0036030) serine protease inhibitor complex(GO:0097180) protein C inhibitor-coagulation factor V complex(GO:0097181) protein C inhibitor-coagulation factor Xa complex(GO:0097182) protein C inhibitor-coagulation factor XI complex(GO:0097183) |
| 0.2 | 19.8 | GO:0001669 | acrosomal vesicle(GO:0001669) |
| 2.0 | 18.0 | GO:0032010 | phagolysosome(GO:0032010) |
| 0.3 | 17.4 | GO:0031907 | peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907) |
| 0.1 | 13.1 | GO:0072562 | blood microparticle(GO:0072562) |
| 0.1 | 12.9 | GO:0031093 | platelet alpha granule lumen(GO:0031093) |
| 0.1 | 10.7 | GO:0000932 | cytoplasmic mRNA processing body(GO:0000932) |
| 0.5 | 10.3 | GO:0042613 | MHC class II protein complex(GO:0042613) |
| 0.0 | 8.7 | GO:0005765 | lysosomal membrane(GO:0005765) lytic vacuole membrane(GO:0098852) |
| 0.6 | 8.0 | GO:0033256 | I-kappaB/NF-kappaB complex(GO:0033256) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 79.1 | GO:0017137 | Rab GTPase binding(GO:0017137) |
| 4.1 | 36.8 | GO:0032190 | acrosin binding(GO:0032190) |
| 0.2 | 20.0 | GO:0004984 | olfactory receptor activity(GO:0004984) |
| 6.1 | 18.2 | GO:0050528 | acyloxyacyl hydrolase activity(GO:0050528) |
| 2.3 | 18.0 | GO:0016176 | superoxide-generating NADPH oxidase activator activity(GO:0016176) |
| 2.9 | 17.4 | GO:0016402 | pristanoyl-CoA oxidase activity(GO:0016402) |
| 0.2 | 16.5 | GO:0004867 | serine-type endopeptidase inhibitor activity(GO:0004867) |
| 0.4 | 16.3 | GO:0003950 | NAD+ ADP-ribosyltransferase activity(GO:0003950) |
| 0.1 | 11.3 | GO:0008201 | heparin binding(GO:0008201) |
| 0.3 | 11.2 | GO:0070577 | lysine-acetylated histone binding(GO:0070577) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 58.0 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.3 | 14.0 | ST GAQ PATHWAY | G alpha q Pathway |
| 0.1 | 13.1 | NABA ECM GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 0.1 | 12.2 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.2 | 10.3 | PID IL12 STAT4 PATHWAY | IL12 signaling mediated by STAT4 |
| 0.1 | 9.8 | PID RAC1 PATHWAY | RAC1 signaling pathway |
| 0.1 | 7.9 | PID CD8 TCR PATHWAY | TCR signaling in naïve CD8+ T cells |
| 0.2 | 7.8 | PID S1P META PATHWAY | Sphingosine 1-phosphate (S1P) pathway |
| 0.0 | 5.6 | NABA SECRETED FACTORS | Genes encoding secreted soluble factors |
| 0.1 | 4.1 | ST P38 MAPK PATHWAY | p38 MAPK Pathway |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 20.0 | REACTOME OLFACTORY SIGNALING PATHWAY | Genes involved in Olfactory Signaling Pathway |
| 0.7 | 16.0 | REACTOME PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS | Genes involved in Phosphorylation of CD3 and TCR zeta chains |
| 0.3 | 13.0 | REACTOME LATENT INFECTION OF HOMO SAPIENS WITH MYCOBACTERIUM TUBERCULOSIS | Genes involved in Latent infection of Homo sapiens with Mycobacterium tuberculosis |
| 0.5 | 12.9 | REACTOME INTRINSIC PATHWAY | Genes involved in Intrinsic Pathway |
| 0.1 | 11.9 | REACTOME AMINO ACID AND OLIGOPEPTIDE SLC TRANSPORTERS | Genes involved in Amino acid and oligopeptide SLC transporters |
| 0.0 | 9.4 | REACTOME GENERIC TRANSCRIPTION PATHWAY | Genes involved in Generic Transcription Pathway |
| 0.2 | 7.0 | REACTOME SPHINGOLIPID DE NOVO BIOSYNTHESIS | Genes involved in Sphingolipid de novo biosynthesis |
| 0.0 | 6.8 | REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION | Genes involved in Antigen processing: Ubiquitination & Proteasome degradation |
| 0.5 | 6.5 | REACTOME NFKB IS ACTIVATED AND SIGNALS SURVIVAL | Genes involved in NF-kB is activated and signals survival |
| 0.1 | 5.9 | REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES | Genes involved in Chemokine receptors bind chemokines |