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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
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Results for WRNIP1
Z-value: 3.32
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Transcription factors associated with WRNIP1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| WRNIP1 | hg38_v1_chr6_+_2765361_2765563 | 0.54 | 3.2e-18 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of WRNIP1
| Promoter | Score | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr11_-_111912871 Show fit | 120.67 |
ENST00000528628.5
|
crystallin alpha B |
|
| chr11_-_111913195 Show fit | 109.86 |
ENST00000531198.5
ENST00000616970.5 ENST00000527899.6 |
crystallin alpha B |
|
| chr11_-_111910888 Show fit | 82.13 |
ENST00000525823.1
ENST00000528961.6 |
crystallin alpha B |
|
| chr11_-_111913134 Show fit | 80.15 |
ENST00000533971.2
ENST00000526180.6 |
crystallin alpha B |
|
| chr11_-_111910790 Show fit | 74.21 |
ENST00000533280.6
|
crystallin alpha B |
|
| chr3_+_10992175 Show fit | 74.18 |
ENST00000646702.1
|
solute carrier family 6 member 1 |
|
| chr11_-_111910830 Show fit | 71.44 |
ENST00000526167.5
ENST00000651650.1 |
crystallin alpha B |
|
| chr9_+_136980211 Show fit | 70.59 |
ENST00000444903.2
|
prostaglandin D2 synthase |
|
| chr9_+_71911468 Show fit | 68.29 |
ENST00000377031.7
|
chromosome 9 open reading frame 85 |
|
| chr8_+_24913752 Show fit | 65.51 |
ENST00000518131.5
ENST00000221166.10 ENST00000437366.2 |
neurofilament medium |
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.3 | 654.6 | GO:0043547 | positive regulation of GTPase activity(GO:0043547) |
| 34.0 | 578.2 | GO:0090360 | platelet-derived growth factor production(GO:0090360) regulation of platelet-derived growth factor production(GO:0090361) |
| 30.6 | 520.2 | GO:0007021 | tubulin complex assembly(GO:0007021) |
| 8.3 | 397.5 | GO:0007214 | gamma-aminobutyric acid signaling pathway(GO:0007214) |
| 8.2 | 346.3 | GO:0048791 | calcium ion-regulated exocytosis of neurotransmitter(GO:0048791) |
| 2.0 | 235.7 | GO:0006958 | complement activation, classical pathway(GO:0006958) |
| 26.8 | 187.5 | GO:0070560 | protein secretion by platelet(GO:0070560) |
| 3.8 | 186.9 | GO:0015701 | bicarbonate transport(GO:0015701) |
| 5.1 | 183.0 | GO:0008038 | neuron recognition(GO:0008038) |
| 2.9 | 181.8 | GO:0030574 | collagen catabolic process(GO:0030574) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.0 | 3814.3 | GO:0016021 | integral component of membrane(GO:0016021) |
| 4.7 | 902.4 | GO:0030426 | growth cone(GO:0030426) |
| 2.6 | 797.0 | GO:0005578 | proteinaceous extracellular matrix(GO:0005578) |
| 41.1 | 658.3 | GO:0097512 | cardiac myofibril(GO:0097512) |
| 0.7 | 574.0 | GO:0005615 | extracellular space(GO:0005615) |
| 2.6 | 563.3 | GO:0060076 | excitatory synapse(GO:0060076) |
| 3.8 | 466.4 | GO:0043204 | perikaryon(GO:0043204) |
| 2.4 | 441.7 | GO:0072562 | blood microparticle(GO:0072562) |
| 1.9 | 433.9 | GO:0016323 | basolateral plasma membrane(GO:0016323) |
| 3.0 | 335.0 | GO:0097060 | synaptic membrane(GO:0097060) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 3.2 | 911.2 | GO:0004252 | serine-type endopeptidase activity(GO:0004252) |
| 0.7 | 900.7 | GO:0001071 | nucleic acid binding transcription factor activity(GO:0001071) transcription factor activity, sequence-specific DNA binding(GO:0003700) |
| 20.6 | 617.3 | GO:0005212 | structural constituent of eye lens(GO:0005212) |
| 7.3 | 554.6 | GO:0001540 | beta-amyloid binding(GO:0001540) |
| 1.5 | 458.7 | GO:0004930 | G-protein coupled receptor activity(GO:0004930) |
| 6.8 | 424.0 | GO:0030507 | spectrin binding(GO:0030507) |
| 3.3 | 384.3 | GO:0005089 | Rho guanyl-nucleotide exchange factor activity(GO:0005089) |
| 0.7 | 348.5 | GO:0005509 | calcium ion binding(GO:0005509) |
| 3.1 | 310.8 | GO:0004867 | serine-type endopeptidase inhibitor activity(GO:0004867) |
| 1.9 | 285.6 | GO:0005516 | calmodulin binding(GO:0005516) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.4 | 663.7 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 3.6 | 527.7 | PID MYC REPRESS PATHWAY | Validated targets of C-MYC transcriptional repression |
| 2.1 | 439.5 | NABA ECM GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 1.2 | 371.6 | NABA SECRETED FACTORS | Genes encoding secreted soluble factors |
| 1.9 | 337.5 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 4.1 | 221.3 | PID NCADHERIN PATHWAY | N-cadherin signaling events |
| 4.4 | 209.3 | NABA COLLAGENS | Genes encoding collagen proteins |
| 4.9 | 207.2 | ST WNT CA2 CYCLIC GMP PATHWAY | Wnt/Ca2+/cyclic GMP signaling. |
| 2.6 | 195.4 | PID RAC1 REG PATHWAY | Regulation of RAC1 activity |
| 3.9 | 194.0 | NABA PROTEOGLYCANS | Genes encoding proteoglycans |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 4.4 | 601.2 | REACTOME TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES | Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides |
| 10.6 | 422.5 | REACTOME GABA SYNTHESIS RELEASE REUPTAKE AND DEGRADATION | Genes involved in GABA synthesis, release, reuptake and degradation |
| 3.1 | 417.5 | REACTOME PEPTIDE LIGAND BINDING RECEPTORS | Genes involved in Peptide ligand-binding receptors |
| 5.4 | 408.0 | REACTOME NCAM1 INTERACTIONS | Genes involved in NCAM1 interactions |
| 2.9 | 342.3 | REACTOME CLASS B 2 SECRETIN FAMILY RECEPTORS | Genes involved in Class B/2 (Secretin family receptors) |
| 3.8 | 295.5 | REACTOME G ALPHA I SIGNALLING EVENTS | Genes involved in G alpha (i) signalling events |
| 5.4 | 293.4 | REACTOME ION TRANSPORT BY P TYPE ATPASES | Genes involved in Ion transport by P-type ATPases |
| 2.7 | 274.3 | REACTOME G ALPHA Q SIGNALLING EVENTS | Genes involved in G alpha (q) signalling events |
| 5.8 | 273.1 | REACTOME AMYLOIDS | Genes involved in Amyloids |
| 2.6 | 268.5 | REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY | Genes involved in Nuclear Receptor transcription pathway |