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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
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Results for WT1_MTF1_ZBTB7B
Z-value: 3.94
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Transcription factors associated with WT1_MTF1_ZBTB7B
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| ZBTB7B | hg38_v1_chr1_+_155002630_155002689 | 0.75 | 2.8e-41 | Click! |
| WT1 | hg38_v1_chr11_-_32435360_32435419 | 0.37 | 1.1e-08 | Click! |
| MTF1 | hg38_v1_chr1_-_37859583_37859609 | -0.20 | 3.2e-03 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of WT1_MTF1_ZBTB7B
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 33.3 | 665.0 | GO:0051823 | regulation of synapse structural plasticity(GO:0051823) |
| 12.3 | 592.0 | GO:0007214 | gamma-aminobutyric acid signaling pathway(GO:0007214) |
| 8.5 | 501.3 | GO:0009214 | cyclic nucleotide catabolic process(GO:0009214) |
| 8.9 | 499.5 | GO:0015701 | bicarbonate transport(GO:0015701) |
| 11.3 | 462.0 | GO:0048791 | calcium ion-regulated exocytosis of neurotransmitter(GO:0048791) |
| 3.3 | 460.2 | GO:0006813 | potassium ion transport(GO:0006813) |
| 9.8 | 401.5 | GO:0050650 | chondroitin sulfate proteoglycan biosynthetic process(GO:0050650) |
| 13.1 | 365.7 | GO:0032011 | ARF protein signal transduction(GO:0032011) |
| 25.7 | 333.5 | GO:2001135 | regulation of endocytic recycling(GO:2001135) |
| 61.1 | 305.7 | GO:0031630 | regulation of synaptic vesicle fusion to presynaptic membrane(GO:0031630) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.6 | 6214.0 | GO:0016021 | integral component of membrane(GO:0016021) |
| 5.4 | 1258.5 | GO:0060076 | excitatory synapse(GO:0060076) |
| 3.5 | 945.8 | GO:0005578 | proteinaceous extracellular matrix(GO:0005578) |
| 4.8 | 842.9 | GO:0098793 | presynapse(GO:0098793) |
| 14.0 | 826.2 | GO:0033017 | sarcoplasmic reticulum membrane(GO:0033017) |
| 6.3 | 742.3 | GO:0034705 | voltage-gated potassium channel complex(GO:0008076) potassium channel complex(GO:0034705) |
| 8.8 | 672.5 | GO:0030672 | synaptic vesicle membrane(GO:0030672) exocytic vesicle membrane(GO:0099501) |
| 2.8 | 608.1 | GO:0016323 | basolateral plasma membrane(GO:0016323) |
| 8.7 | 542.5 | GO:0005891 | voltage-gated calcium channel complex(GO:0005891) |
| 4.4 | 492.7 | GO:0005796 | Golgi lumen(GO:0005796) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.7 | 825.8 | GO:0003700 | nucleic acid binding transcription factor activity(GO:0001071) transcription factor activity, sequence-specific DNA binding(GO:0003700) |
| 16.0 | 802.1 | GO:0004683 | calmodulin-dependent protein kinase activity(GO:0004683) |
| 6.1 | 709.1 | GO:0005089 | Rho guanyl-nucleotide exchange factor activity(GO:0005089) |
| 1.9 | 673.6 | GO:0004930 | G-protein coupled receptor activity(GO:0004930) |
| 10.4 | 511.7 | GO:0005245 | voltage-gated calcium channel activity(GO:0005245) |
| 8.2 | 500.4 | GO:0004112 | cyclic-nucleotide phosphodiesterase activity(GO:0004112) |
| 15.7 | 485.6 | GO:0017075 | syntaxin-1 binding(GO:0017075) |
| 10.5 | 428.7 | GO:0004890 | GABA-A receptor activity(GO:0004890) GABA receptor activity(GO:0016917) |
| 14.6 | 393.6 | GO:0004012 | phospholipid-translocating ATPase activity(GO:0004012) |
| 84.6 | 338.3 | GO:0015018 | galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity(GO:0015018) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 18.1 | 762.0 | ST WNT CA2 CYCLIC GMP PATHWAY | Wnt/Ca2+/cyclic GMP signaling. |
| 3.7 | 749.2 | NABA ECM GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 2.3 | 740.8 | NABA SECRETED FACTORS | Genes encoding secreted soluble factors |
| 6.0 | 555.0 | PID FGF PATHWAY | FGF signaling pathway |
| 8.6 | 456.3 | ST WNT BETA CATENIN PATHWAY | Wnt/beta-catenin Pathway |
| 6.7 | 414.3 | SIG CD40PATHWAYMAP | Genes related to CD40 signaling |
| 1.4 | 380.6 | NABA MATRISOME ASSOCIATED | Ensemble of genes encoding ECM-associated proteins including ECM-affilaited proteins, ECM regulators and secreted factors |
| 4.3 | 362.4 | PID RHOA REG PATHWAY | Regulation of RhoA activity |
| 5.5 | 328.3 | PID ERBB1 INTERNALIZATION PATHWAY | Internalization of ErbB1 |
| 4.0 | 286.1 | PID HNF3A PATHWAY | FOXA1 transcription factor network |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 13.9 | 751.9 | REACTOME ION TRANSPORT BY P TYPE ATPASES | Genes involved in Ion transport by P-type ATPases |
| 4.2 | 691.5 | REACTOME G ALPHA I SIGNALLING EVENTS | Genes involved in G alpha (i) signalling events |
| 15.4 | 662.4 | REACTOME INTERACTION BETWEEN L1 AND ANKYRINS | Genes involved in Interaction between L1 and Ankyrins |
| 20.2 | 647.9 | REACTOME UNBLOCKING OF NMDA RECEPTOR GLUTAMATE BINDING AND ACTIVATION | Genes involved in Unblocking of NMDA receptor, glutamate binding and activation |
| 25.2 | 580.6 | REACTOME DOPAMINE NEUROTRANSMITTER RELEASE CYCLE | Genes involved in Dopamine Neurotransmitter Release Cycle |
| 4.6 | 564.3 | REACTOME TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES | Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides |
| 7.7 | 562.4 | REACTOME NCAM1 INTERACTIONS | Genes involved in NCAM1 interactions |
| 4.8 | 536.3 | REACTOME TRANSMISSION ACROSS CHEMICAL SYNAPSES | Genes involved in Transmission across Chemical Synapses |
| 12.6 | 517.8 | REACTOME A TETRASACCHARIDE LINKER SEQUENCE IS REQUIRED FOR GAG SYNTHESIS | Genes involved in A tetrasaccharide linker sequence is required for GAG synthesis |
| 4.2 | 501.1 | REACTOME G ALPHA S SIGNALLING EVENTS | Genes involved in G alpha (s) signalling events |