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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
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Results for YBX1_FOS_NFYC_NFYA_NFYB_CEBPZ
Z-value: 7.85
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Transcription factors associated with YBX1_FOS_NFYC_NFYA_NFYB_CEBPZ
| Gene Symbol | Gene ID | Gene Info |
|---|---|---|
| ENSG00000065978.19 | YBX1 | |
| ENSG00000170345.10 | FOS | |
| ENSG00000066136.20 | NFYC | |
| ENSG00000001167.15 | NFYA | |
| ENSG00000120837.8 | NFYB | |
| ENSG00000115816.15 | CEBPZ |
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| CEBPZ | hg38_v1_chr2_-_37231549_37231603 | 0.85 | 4.0e-62 | Click! |
| YBX1 | hg38_v1_chr1_+_42682954_42683039 | 0.79 | 1.9e-47 | Click! |
| NFYC | hg38_v1_chr1_+_40738834_40738874 | 0.68 | 1.2e-30 | Click! |
| NFYB | hg38_v1_chr12_-_104138007_104138035 | 0.48 | 9.1e-14 | Click! |
| FOS | hg38_v1_chr14_+_75279637_75279670 | -0.40 | 9.1e-10 | Click! |
| NFYA | hg38_v1_chr6_+_41072939_41072984 | -0.03 | 7.1e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of YBX1_FOS_NFYC_NFYA_NFYB_CEBPZ
| Promoter | Score | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr1_+_154974672 Show fit | 338.21 |
ENST00000308987.6
ENST00000368436.1 |
CDC28 protein kinase regulatory subunit 1B |
|
| chr1_+_154974653 Show fit | 323.20 |
ENST00000368439.5
|
CDC28 protein kinase regulatory subunit 1B |
|
| chr17_-_40417873 Show fit | 299.19 |
ENST00000423485.6
|
DNA topoisomerase II alpha |
|
| chr14_+_54397021 Show fit | 299.08 |
ENST00000541304.5
|
cyclin dependent kinase inhibitor 3 |
|
| chr4_-_173334385 Show fit | 279.97 |
ENST00000446922.6
|
high mobility group box 2 |
|
| chr14_+_54396949 Show fit | 279.85 |
ENST00000611205.4
|
cyclin dependent kinase inhibitor 3 |
|
| chr9_+_89311187 Show fit | 278.36 |
ENST00000314355.7
|
CDC28 protein kinase regulatory subunit 2 |
|
| chr14_+_54396964 Show fit | 277.84 |
ENST00000543789.6
ENST00000442975.6 ENST00000458126.6 ENST00000556102.6 ENST00000335183.11 |
cyclin dependent kinase inhibitor 3 |
|
| chr1_-_197146620 Show fit | 271.08 |
ENST00000367409.9
ENST00000680265.1 |
assembly factor for spindle microtubules |
|
| chr1_-_197146688 Show fit | 270.46 |
ENST00000294732.11
|
assembly factor for spindle microtubules |
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 73.9 | 960.8 | GO:0006265 | DNA topological change(GO:0006265) |
| 14.6 | 947.9 | GO:0000079 | regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0000079) |
| 22.2 | 932.1 | GO:0045737 | positive regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0045737) |
| 17.6 | 899.2 | GO:0043486 | histone exchange(GO:0043486) |
| 82.5 | 742.4 | GO:0010994 | regulation of ubiquitin homeostasis(GO:0010993) free ubiquitin chain polymerization(GO:0010994) |
| 65.6 | 721.5 | GO:0000056 | ribosomal small subunit export from nucleus(GO:0000056) |
| 35.8 | 679.7 | GO:0034975 | protein folding in endoplasmic reticulum(GO:0034975) |
| 8.0 | 644.3 | GO:0006695 | cholesterol biosynthetic process(GO:0006695) secondary alcohol biosynthetic process(GO:1902653) |
| 11.0 | 547.7 | GO:0007077 | mitotic nuclear envelope disassembly(GO:0007077) |
| 180.5 | 541.5 | GO:0009786 | regulation of asymmetric cell division(GO:0009786) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 6.5 | 1230.2 | GO:0000793 | condensed chromosome(GO:0000793) |
| 41.7 | 1208.3 | GO:0005680 | anaphase-promoting complex(GO:0005680) |
| 17.6 | 969.5 | GO:0019005 | SCF ubiquitin ligase complex(GO:0019005) |
| 2.0 | 840.0 | GO:0005635 | nuclear envelope(GO:0005635) |
| 50.3 | 754.7 | GO:0034663 | endoplasmic reticulum chaperone complex(GO:0034663) |
| 41.6 | 664.9 | GO:0005642 | annulate lamellae(GO:0005642) |
| 71.6 | 644.1 | GO:0032133 | chromosome passenger complex(GO:0032133) |
| 124.7 | 623.7 | GO:0097149 | centralspindlin complex(GO:0097149) |
| 3.8 | 594.4 | GO:0005681 | spliceosomal complex(GO:0005681) |
| 29.9 | 567.4 | GO:0000812 | Swr1 complex(GO:0000812) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 196.0 | 1176.0 | GO:0061575 | cyclin-dependent protein serine/threonine kinase activator activity(GO:0061575) |
| 6.8 | 1161.2 | GO:0042393 | histone binding(GO:0042393) |
| 18.7 | 878.0 | GO:0061631 | ubiquitin conjugating enzyme activity(GO:0061631) |
| 54.0 | 810.7 | GO:0005049 | nuclear export signal receptor activity(GO:0005049) |
| 13.7 | 795.5 | GO:0008138 | protein tyrosine/serine/threonine phosphatase activity(GO:0008138) |
| 17.4 | 729.8 | GO:0008139 | nuclear localization sequence binding(GO:0008139) |
| 13.1 | 603.5 | GO:0031492 | nucleosomal DNA binding(GO:0031492) |
| 14.3 | 573.3 | GO:0004003 | ATP-dependent DNA helicase activity(GO:0004003) |
| 138.3 | 553.1 | GO:0044378 | non-sequence-specific DNA binding, bending(GO:0044378) |
| 0.4 | 480.5 | GO:0003723 | RNA binding(GO:0003723) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 31.9 | 2421.6 | PID FOXM1 PATHWAY | FOXM1 transcription factor network |
| 23.9 | 1580.0 | PID PLK1 PATHWAY | PLK1 signaling events |
| 8.4 | 819.3 | PID E2F PATHWAY | E2F transcription factor network |
| 30.7 | 706.2 | PID RANBP2 PATHWAY | Sumoylation by RanBP2 regulates transcriptional repression |
| 14.1 | 674.4 | PID AURORA B PATHWAY | Aurora B signaling |
| 14.0 | 502.5 | PID SMAD2 3PATHWAY | Regulation of cytoplasmic and nuclear SMAD2/3 signaling |
| 10.0 | 459.6 | PID ATR PATHWAY | ATR signaling pathway |
| 2.9 | 422.2 | PID P53 DOWNSTREAM PATHWAY | Direct p53 effectors |
| 11.5 | 379.7 | PID AURORA A PATHWAY | Aurora A signaling |
| 13.3 | 372.2 | PID BARD1 PATHWAY | BARD1 signaling events |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 56.8 | 1648.6 | REACTOME CYCLIN A B1 ASSOCIATED EVENTS DURING G2 M TRANSITION | Genes involved in Cyclin A/B1 associated events during G2/M transition |
| 41.0 | 1638.5 | REACTOME CHOLESTEROL BIOSYNTHESIS | Genes involved in Cholesterol biosynthesis |
| 46.0 | 1287.7 | REACTOME INHIBITION OF THE PROTEOLYTIC ACTIVITY OF APC C REQUIRED FOR THE ONSET OF ANAPHASE BY MITOTIC SPINDLE CHECKPOINT COMPONENTS | Genes involved in Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components |
| 7.3 | 1105.9 | REACTOME MRNA SPLICING | Genes involved in mRNA Splicing |
| 12.6 | 993.2 | REACTOME SCFSKP2 MEDIATED DEGRADATION OF P27 P21 | Genes involved in SCF(Skp2)-mediated degradation of p27/p21 |
| 57.5 | 862.5 | REACTOME APOPTOSIS INDUCED DNA FRAGMENTATION | Genes involved in Apoptosis induced DNA fragmentation |
| 8.7 | 746.3 | REACTOME MITOTIC PROMETAPHASE | Genes involved in Mitotic Prometaphase |
| 40.5 | 607.5 | REACTOME REMOVAL OF THE FLAP INTERMEDIATE FROM THE C STRAND | Genes involved in Removal of the Flap Intermediate from the C-strand |
| 40.3 | 604.4 | REACTOME UNWINDING OF DNA | Genes involved in Unwinding of DNA |
| 6.8 | 591.0 | REACTOME ANTIVIRAL MECHANISM BY IFN STIMULATED GENES | Genes involved in Antiviral mechanism by IFN-stimulated genes |