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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)

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Results for ZBTB12

Z-value: 1.00

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Transcription factors associated with ZBTB12

Gene Symbol Gene ID Gene Info
ZBTB12
ENSG00000204366.4 ZBTB12

Activity profile of ZBTB12 motif

Sorted Z-values of ZBTB12 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of ZBTB12

PNG image of the network

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Top targets:

Promoter Score Transcript Gene Gene Info
chr8_-_27837765 27.59 ENST00000521226.2
ENST00000301905.9
PBK
PDZ binding kinase
chr11_+_66002225 23.53 ENST00000445560.6
ENST00000530204.1
BANF1
BAF nuclear assembly factor 1
chr11_+_66002475 21.90 ENST00000312175.7
ENST00000533166.5
BANF1
BAF nuclear assembly factor 1
chr15_+_40161003 21.27 ENST00000412359.7
ENST00000287598.11
BUB1B
BUB1 mitotic checkpoint serine/threonine kinase B
chr19_+_41262480 20.24 ENST00000352456.7
ENST00000595018.5
ENST00000597725.5
HNRNPUL1
heterogeneous nuclear ribonucleoprotein U like 1
chr14_-_54441325 19.76 ENST00000556113.1
ENST00000553660.5
ENST00000216416.9
ENST00000395573.8
ENST00000557690.5
CNIH1
cornichon family AMPA receptor auxiliary protein 1
chr15_-_55270874 19.76 ENST00000567380.5
ENST00000565972.5
ENST00000569493.5
RAB27A
RAB27A, member RAS oncogene family
chr12_-_6967962 18.73 ENST00000545555.2
PHB2
prohibitin 2
chr12_+_49265071 18.07 ENST00000549183.1
ENST00000639419.1
ENST00000301072.11
TUBA1C
tubulin alpha 1c
chrX_-_103688090 17.96 ENST00000433176.6
MORF4L2
mortality factor 4 like 2
chr14_+_61695777 17.08 ENST00000323441.10
HIF1A
hypoxia inducible factor 1 subunit alpha
chr1_+_155613221 16.95 ENST00000462250.2
MSTO1
misato mitochondrial distribution and morphology regulator 1
chr11_+_65040895 16.62 ENST00000531072.1
ENST00000398846.6
SAC3D1
SAC3 domain containing 1
chr10_+_75210151 16.55 ENST00000298468.9
ENST00000543351.5
VDAC2
voltage dependent anion channel 2
chrX_-_103688033 16.36 ENST00000434230.5
ENST00000418819.5
ENST00000360458.5
MORF4L2
mortality factor 4 like 2
chr19_-_17405554 15.84 ENST00000252593.7
BST2
bone marrow stromal cell antigen 2
chr1_+_44746401 15.75 ENST00000372217.5
KIF2C
kinesin family member 2C
chr1_-_244862381 15.49 ENST00000640001.1
ENST00000639628.1
HNRNPU
heterogeneous nuclear ribonucleoprotein U
chr12_+_53454764 15.08 ENST00000439930.7
ENST00000548933.5
PCBP2
poly(rC) binding protein 2
chr22_-_41688799 14.29 ENST00000469028.2
ENST00000463675.6
ENST00000649479.1
ENST00000469522.1
SNU13
small nuclear ribonucleoprotein 13
chr4_-_10116724 14.21 ENST00000502702.5
WDR1
WD repeat domain 1
chr1_+_159009886 14.11 ENST00000340979.10
ENST00000368131.8
ENST00000295809.12
ENST00000368132.7
IFI16
interferon gamma inducible protein 16
chr1_+_159010002 14.09 ENST00000359709.7
IFI16
interferon gamma inducible protein 16
chr7_-_121396284 13.89 ENST00000359943.8
ENST00000426156.1
ENST00000412653.5
FAM3C
FAM3 metabolism regulating signaling molecule C
chr15_-_55270280 13.69 ENST00000564609.5
RAB27A
RAB27A, member RAS oncogene family
chr20_+_62302093 13.69 ENST00000491935.5
ADRM1
adhesion regulating molecule 1
chr2_-_105396943 13.62 ENST00000409807.5
FHL2
four and a half LIM domains 2
chr20_-_34955635 13.25 ENST00000644793.1
ENST00000642498.1
ENST00000646735.1
ENST00000644608.1
ENST00000651619.1
GSS
glutathione synthetase
chr8_-_54022441 12.79 ENST00000396401.7
ENST00000521604.7
ENST00000640382.1
ENST00000640041.1
TCEA1
transcription elongation factor A1
chr5_-_97183203 12.64 ENST00000508447.1
ENST00000283109.8
RIOK2
RIO kinase 2
chr16_-_67936808 12.11 ENST00000358514.9
PSMB10
proteasome 20S subunit beta 10
chr6_+_2988606 12.01 ENST00000380472.7
ENST00000605901.1
ENST00000454015.1
NQO2
LINC01011
N-ribosyldihydronicotinamide:quinone reductase 2
long intergenic non-protein coding RNA 1011
chr17_+_75261864 11.77 ENST00000245539.11
ENST00000579002.5
MRPS7
mitochondrial ribosomal protein S7
chr17_+_38752731 11.60 ENST00000619426.5
ENST00000610434.4
PSMB3
proteasome 20S subunit beta 3
chr12_+_53454819 11.33 ENST00000562264.5
PCBP2
poly(rC) binding protein 2
chr20_+_11892493 11.22 ENST00000422390.5
ENST00000618918.4
BTBD3
BTB domain containing 3
chr15_-_55270383 11.03 ENST00000396307.6
RAB27A
RAB27A, member RAS oncogene family
chrX_-_154371210 10.67 ENST00000369856.8
ENST00000422373.6
ENST00000360319.9
FLNA
filamin A
chr20_+_37744630 10.27 ENST00000373473.5
CTNNBL1
catenin beta like 1
chr14_-_74493322 10.09 ENST00000553490.5
ENST00000557510.5
NPC2
NPC intracellular cholesterol transporter 2
chr14_-_74493275 10.04 ENST00000541064.5
NPC2
NPC intracellular cholesterol transporter 2
chr3_+_14178808 9.64 ENST00000306024.4
LSM3
LSM3 homolog, U6 small nuclear RNA and mRNA degradation associated
chr14_-_74493291 9.08 ENST00000238633.6
ENST00000555619.6
ENST00000434013.6
NPC2
NPC intracellular cholesterol transporter 2
chr11_-_105035113 8.91 ENST00000526568.5
ENST00000531166.5
ENST00000534497.5
ENST00000527979.5
ENST00000533400.6
ENST00000528974.1
ENST00000525825.5
ENST00000353247.9
ENST00000446369.5
ENST00000436863.7
CASP1
caspase 1
chr19_-_13116719 8.16 ENST00000588229.1
ENST00000357720.9
TRMT1
tRNA methyltransferase 1
chr22_-_35840218 8.13 ENST00000414461.6
ENST00000416721.6
ENST00000449924.6
ENST00000262829.11
ENST00000397305.3
RBFOX2
RNA binding fox-1 homolog 2
chrX_-_132219439 8.12 ENST00000370874.2
RAP2C
RAP2C, member of RAS oncogene family
chr10_+_5412542 8.05 ENST00000355029.9
NET1
neuroepithelial cell transforming 1
chrX_-_132219473 8.02 ENST00000620646.4
RAP2C
RAP2C, member of RAS oncogene family
chr3_+_138621225 7.82 ENST00000479848.1
FAIM
Fas apoptotic inhibitory molecule
chr5_-_177351522 7.22 ENST00000513877.1
ENST00000515209.5
ENST00000514458.5
ENST00000502560.5
ENST00000303127.12
LMAN2
lectin, mannose binding 2
chr1_+_161153968 7.20 ENST00000368003.6
UFC1
ubiquitin-fold modifier conjugating enzyme 1
chr19_+_54115726 7.11 ENST00000445811.5
ENST00000321030.9
ENST00000445124.5
ENST00000447810.5
PRPF31
pre-mRNA processing factor 31
chr19_-_8321354 6.77 ENST00000301457.3
NDUFA7
NADH:ubiquinone oxidoreductase subunit A7
chr3_+_133573637 6.58 ENST00000264993.8
CDV3
CDV3 homolog
chr7_-_103344588 6.34 ENST00000426036.6
ENST00000249270.11
ENST00000379263.8
ENST00000454277.5
ENST00000412522.1
DNAJC2
DnaJ heat shock protein family (Hsp40) member C2
chr3_+_138621207 6.11 ENST00000464668.5
FAIM
Fas apoptotic inhibitory molecule
chr5_+_141182369 5.64 ENST00000609684.3
ENST00000625044.1
ENST00000623407.1
ENST00000623884.1
PCDHB16
ENSG00000279068.1
protocadherin beta 16
novel transcript
chr12_-_46372763 5.59 ENST00000256689.10
SLC38A2
solute carrier family 38 member 2
chr14_+_61762405 5.38 ENST00000216294.5
SNAPC1
small nuclear RNA activating complex polypeptide 1
chr8_-_143944737 5.31 ENST00000398774.6
PLEC
plectin
chr1_+_84408230 4.51 ENST00000370662.3
DNASE2B
deoxyribonuclease 2 beta
chr4_-_167234552 4.48 ENST00000512648.5
SPOCK3
SPARC (osteonectin), cwcv and kazal like domains proteoglycan 3
chr11_+_74592567 4.41 ENST00000263681.7
ENST00000527458.5
ENST00000532497.5
ENST00000530511.5
POLD3
DNA polymerase delta 3, accessory subunit
chr19_+_44954577 4.40 ENST00000546079.5
ENST00000541297.6
CLPTM1
CLPTM1 regulator of GABA type A receptor forward trafficking
chr22_-_35840577 4.30 ENST00000405409.6
RBFOX2
RNA binding fox-1 homolog 2
chr1_+_45583846 4.25 ENST00000437901.6
ENST00000537798.5
ENST00000350030.8
ENST00000527470.5
ENST00000525515.5
ENST00000528238.5
ENST00000470768.5
ENST00000372052.8
ENST00000629893.1
ENST00000351223.7
NASP
nuclear autoantigenic sperm protein
chr22_-_41688859 3.83 ENST00000401959.6
ENST00000648674.1
SNU13
small nuclear ribonucleoprotein 13
chr1_-_116667668 3.69 ENST00000369486.8
ENST00000369483.5
IGSF3
immunoglobulin superfamily member 3
chr3_-_52770856 3.49 ENST00000461689.5
ENST00000535191.5
ENST00000383721.8
ENST00000233027.10
NEK4
NIMA related kinase 4
chr17_-_29078857 3.42 ENST00000359450.6
TIAF1
TGFB1-induced anti-apoptotic factor 1
chr14_+_67240713 3.05 ENST00000677382.1
MPP5
membrane palmitoylated protein 5
chr1_-_165445088 3.04 ENST00000359842.10
RXRG
retinoid X receptor gamma
chr20_-_38165261 2.75 ENST00000361475.7
TGM2
transglutaminase 2
chr11_+_8683201 2.71 ENST00000526562.5
ENST00000525981.1
RPL27A
ribosomal protein L27a
chr19_-_54115271 2.71 ENST00000391757.1
TFPT
TCF3 fusion partner
chr5_-_123036664 2.39 ENST00000306442.5
PPIC
peptidylprolyl isomerase C
chr20_-_8019744 2.34 ENST00000246024.7
TMX4
thioredoxin related transmembrane protein 4
chr8_+_2045058 2.30 ENST00000523438.1
MYOM2
myomesin 2
chr7_+_90154442 2.28 ENST00000297205.7
STEAP1
STEAP family member 1
chr17_-_41521719 2.19 ENST00000393976.6
KRT15
keratin 15
chr4_-_167234579 2.04 ENST00000502330.5
ENST00000357154.7
ENST00000421836.6
SPOCK3
SPARC (osteonectin), cwcv and kazal like domains proteoglycan 3
chr6_-_11232658 1.76 ENST00000379433.5
ENST00000379446.10
ENST00000620854.4
NEDD9
neural precursor cell expressed, developmentally down-regulated 9
chr4_-_167234266 1.72 ENST00000511269.5
ENST00000506697.5
ENST00000512042.1
SPOCK3
SPARC (osteonectin), cwcv and kazal like domains proteoglycan 3
chr8_-_140718661 1.71 ENST00000430260.6
PTK2
protein tyrosine kinase 2
chr4_-_167234426 1.67 ENST00000541354.5
ENST00000509854.5
ENST00000512681.5
ENST00000357545.9
ENST00000510741.5
ENST00000510403.5
SPOCK3
SPARC (osteonectin), cwcv and kazal like domains proteoglycan 3
chr2_-_111884117 1.52 ENST00000341068.8
ANAPC1
anaphase promoting complex subunit 1
chr5_+_42548043 1.36 ENST00000618088.4
ENST00000612382.4
GHR
growth hormone receptor
chr5_-_140303073 1.36 ENST00000524074.1
ENST00000261813.9
ENST00000510217.1
PFDN1
prefoldin subunit 1
chr6_-_53061740 1.31 ENST00000350082.10
ENST00000356971.3
ENST00000676107.1
CILK1
ciliogenesis associated kinase 1
chrX_-_24672654 1.27 ENST00000379145.5
PCYT1B
phosphate cytidylyltransferase 1, choline, beta
chr14_-_23408265 1.20 ENST00000405093.9
MYH6
myosin heavy chain 6
chr13_+_45120493 1.12 ENST00000340473.8
GTF2F2
general transcription factor IIF subunit 2
chr8_+_109086585 1.05 ENST00000518632.2
TRHR
thyrotropin releasing hormone receptor
chr3_+_89107613 1.02 ENST00000336596.7
EPHA3
EPH receptor A3
chr3_+_155083523 1.02 ENST00000680057.1
MME
membrane metalloendopeptidase
chr13_-_77919390 0.98 ENST00000475537.2
ENST00000646605.1
EDNRB
endothelin receptor type B
chr17_+_48107743 0.96 ENST00000359238.7
ENST00000582104.5
ENST00000584335.5
SNX11
sorting nexin 11
chr6_+_26158115 0.80 ENST00000377777.5
ENST00000289316.2
H2BC5
H2B clustered histone 5
chr19_-_54115626 0.78 ENST00000391759.6
TFPT
TCF3 fusion partner
chr12_-_102481744 0.53 ENST00000644491.1
IGF1
insulin like growth factor 1
chr3_-_151329539 0.36 ENST00000325602.6
P2RY13
purinergic receptor P2Y13
chr7_-_22194709 0.32 ENST00000458533.5
RAPGEF5
Rap guanine nucleotide exchange factor 5
chr6_-_55875583 0.29 ENST00000370830.4
BMP5
bone morphogenetic protein 5
chr8_+_2045037 0.27 ENST00000262113.9
MYOM2
myomesin 2
chr13_-_37059603 0.24 ENST00000497318.1
ENST00000475892.5
ENST00000356185.7
ENST00000350612.11
ENST00000360252.8
SUPT20H
SPT20 homolog, SAGA complex component
chr1_+_26317950 0.23 ENST00000374213.3
CD52
CD52 molecule
chr15_+_81182579 0.12 ENST00000302987.9
IL16
interleukin 16
chr5_-_35089620 0.03 ENST00000511486.5
ENST00000310101.9
ENST00000231423.7
ENST00000513753.5
ENST00000348262.7
PRLR
prolactin receptor

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
7.4 44.5 GO:1903435 positive regulation of constitutive secretory pathway(GO:1903435)
5.8 29.2 GO:0019747 regulation of isoprenoid metabolic process(GO:0019747)
5.3 15.8 GO:1901253 negative regulation of intracellular transport of viral material(GO:1901253)
4.3 21.3 GO:0051754 meiotic sister chromatid cohesion, centromeric(GO:0051754)
4.2 12.6 GO:0090070 positive regulation of ribosome biogenesis(GO:0090070) positive regulation of rRNA processing(GO:2000234)
3.6 10.7 GO:1905000 regulation of membrane repolarization during atrial cardiac muscle cell action potential(GO:1905000)
3.6 14.2 GO:0016333 morphogenesis of follicular epithelium(GO:0016333) establishment or maintenance of polarity of follicular epithelium(GO:0016334) establishment of planar polarity of follicular epithelium(GO:0042247)
3.4 13.6 GO:0055011 atrial cardiac muscle cell differentiation(GO:0055011) atrial cardiac muscle cell development(GO:0055014)
3.2 45.4 GO:0015074 DNA integration(GO:0015074)
3.0 8.9 GO:0050717 positive regulation of interleukin-1 alpha secretion(GO:0050717)
2.8 17.1 GO:0061030 epithelial cell differentiation involved in mammary gland alveolus development(GO:0061030) positive regulation of chemokine-mediated signaling pathway(GO:0070101)
2.4 7.1 GO:0048254 snoRNA localization(GO:0048254)
2.1 18.7 GO:0060762 positive regulation of exit from mitosis(GO:0031536) negative regulation of mammary gland epithelial cell proliferation(GO:0033600) thelarche(GO:0042695) mammary gland branching involved in thelarche(GO:0060744) regulation of branching involved in mammary gland duct morphogenesis(GO:0060762)
1.8 12.4 GO:0010724 regulation of definitive erythrocyte differentiation(GO:0010724)
1.7 15.7 GO:0030951 establishment or maintenance of microtubule cytoskeleton polarity(GO:0030951)
1.5 34.3 GO:0043968 histone H2A acetylation(GO:0043968)
1.5 26.4 GO:0075522 IRES-dependent viral translational initiation(GO:0075522)
1.3 18.1 GO:0000492 box C/D snoRNP assembly(GO:0000492)
1.1 15.5 GO:0070934 CRD-mediated mRNA stabilization(GO:0070934)
1.1 5.4 GO:0042796 snRNA transcription from RNA polymerase III promoter(GO:0042796)
1.0 7.2 GO:1990592 protein polyufmylation(GO:1990564) protein K69-linked ufmylation(GO:1990592)
0.9 13.7 GO:0043248 proteasome assembly(GO:0043248)
0.8 5.6 GO:0032328 alanine transport(GO:0032328)
0.8 16.9 GO:0048311 mitochondrion distribution(GO:0048311)
0.8 3.1 GO:0035750 protein localization to myelin sheath abaxonal region(GO:0035750)
0.7 16.1 GO:0032486 Rap protein signal transduction(GO:0032486)
0.7 8.1 GO:0051451 myoblast migration(GO:0051451)
0.6 13.3 GO:0006750 glutathione biosynthetic process(GO:0006750)
0.6 9.9 GO:0019800 peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan(GO:0019800)
0.5 27.0 GO:0032731 positive regulation of interleukin-1 beta production(GO:0032731)
0.5 11.8 GO:0000028 ribosomal small subunit assembly(GO:0000028)
0.5 4.2 GO:0006335 DNA replication-dependent nucleosome assembly(GO:0006335) DNA replication-dependent nucleosome organization(GO:0034723)
0.5 2.3 GO:0098706 ferric iron import into cell(GO:0097461) ferric iron import across plasma membrane(GO:0098706)
0.4 12.0 GO:1904707 positive regulation of vascular smooth muscle cell proliferation(GO:1904707)
0.3 27.6 GO:0032435 negative regulation of proteasomal ubiquitin-dependent protein catabolic process(GO:0032435)
0.3 9.6 GO:0033962 cytoplasmic mRNA processing body assembly(GO:0033962)
0.3 2.6 GO:0002074 extraocular skeletal muscle development(GO:0002074)
0.3 16.6 GO:1903959 regulation of anion transmembrane transport(GO:1903959)
0.3 25.2 GO:0051439 negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle(GO:0051436) regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle(GO:0051439)
0.2 3.7 GO:0032808 lacrimal gland development(GO:0032808)
0.2 3.5 GO:0001302 replicative cell aging(GO:0001302)
0.2 19.8 GO:0048208 vesicle targeting, rough ER to cis-Golgi(GO:0048207) COPII vesicle coating(GO:0048208)
0.2 1.0 GO:0035645 enteric smooth muscle cell differentiation(GO:0035645)
0.2 2.7 GO:0060662 tube lumen cavitation(GO:0060605) salivary gland cavitation(GO:0060662)
0.2 1.4 GO:0000255 allantoin metabolic process(GO:0000255)
0.2 5.3 GO:0031581 hemidesmosome assembly(GO:0031581)
0.2 17.2 GO:0006283 transcription-coupled nucleotide-excision repair(GO:0006283)
0.2 1.2 GO:0055009 atrial cardiac muscle tissue development(GO:0003228) atrial cardiac muscle tissue morphogenesis(GO:0055009)
0.2 4.5 GO:0006309 apoptotic DNA fragmentation(GO:0006309)
0.1 1.0 GO:0046449 creatinine metabolic process(GO:0046449)
0.1 5.6 GO:0016339 calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0016339)
0.1 1.7 GO:0051964 negative regulation of synapse assembly(GO:0051964)
0.1 4.4 GO:0033081 regulation of T cell differentiation in thymus(GO:0033081) regulation of thymocyte aggregation(GO:2000398)
0.1 10.3 GO:0016445 somatic diversification of immunoglobulins(GO:0016445)
0.1 7.2 GO:0050766 positive regulation of phagocytosis(GO:0050766)
0.1 6.3 GO:2000279 negative regulation of DNA biosynthetic process(GO:2000279)
0.1 1.3 GO:0006657 CDP-choline pathway(GO:0006657)
0.1 0.5 GO:1904073 regulation of trophectodermal cell proliferation(GO:1904073) positive regulation of trophectodermal cell proliferation(GO:1904075)
0.1 6.8 GO:0006120 mitochondrial electron transport, NADH to ubiquinone(GO:0006120)
0.1 0.3 GO:0071676 negative regulation of mononuclear cell migration(GO:0071676)
0.1 2.1 GO:0030488 tRNA methylation(GO:0030488)
0.1 3.0 GO:1901522 positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus(GO:1901522)
0.1 13.9 GO:0002576 platelet degranulation(GO:0002576)
0.1 14.9 GO:0030705 cytoskeleton-dependent intracellular transport(GO:0030705)
0.1 1.1 GO:0006370 7-methylguanosine mRNA capping(GO:0006370)
0.1 11.2 GO:0021987 cerebral cortex development(GO:0021987)
0.0 2.4 GO:0000413 protein peptidyl-prolyl isomerization(GO:0000413)
0.0 14.9 GO:0000398 RNA splicing, via transesterification reactions with bulged adenosine as nucleophile(GO:0000377) mRNA splicing, via spliceosome(GO:0000398)
0.0 2.7 GO:0002181 cytoplasmic translation(GO:0002181)
0.0 2.3 GO:0045454 cell redox homeostasis(GO:0045454)
0.0 0.4 GO:0035589 G-protein coupled purinergic nucleotide receptor signaling pathway(GO:0035589)
0.0 2.2 GO:0070268 cornification(GO:0070268)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
3.6 18.1 GO:0001651 dense fibrillar component(GO:0001651)
3.4 44.5 GO:0033093 Weibel-Palade body(GO:0033093)
3.0 8.9 GO:0072557 IPAF inflammasome complex(GO:0072557)
2.8 14.2 GO:0042643 actomyosin, actin portion(GO:0042643)
2.1 10.7 GO:0031523 Myb complex(GO:0031523)
1.8 21.3 GO:0000940 condensed chromosome outer kinetochore(GO:0000940)
1.7 12.1 GO:1990111 spermatoproteasome complex(GO:1990111)
1.6 12.6 GO:0030688 preribosome, small subunit precursor(GO:0030688)
1.5 11.6 GO:0019774 proteasome core complex, beta-subunit complex(GO:0019774)
1.4 9.6 GO:1990726 Lsm1-7-Pat1 complex(GO:1990726)
1.2 13.7 GO:0008541 proteasome regulatory particle, lid subcomplex(GO:0008541)
1.1 34.3 GO:1902562 NuA4 histone acetyltransferase complex(GO:0035267) H4/H2A histone acetyltransferase complex(GO:0043189) H4 histone acetyltransferase complex(GO:1902562)
1.0 15.5 GO:0070937 CRD-mediated mRNA stability complex(GO:0070937)
0.9 4.4 GO:0043625 delta DNA polymerase complex(GO:0043625)
0.7 16.6 GO:0046930 pore complex(GO:0046930)
0.7 13.9 GO:0031089 platelet dense granule lumen(GO:0031089)
0.5 15.7 GO:0035371 microtubule plus-end(GO:0035371)
0.5 10.3 GO:0000974 Prp19 complex(GO:0000974)
0.5 7.1 GO:0005687 U4 snRNP(GO:0005687)
0.5 1.4 GO:0070195 growth hormone receptor complex(GO:0070195)
0.4 11.8 GO:0000314 organellar small ribosomal subunit(GO:0000314) mitochondrial small ribosomal subunit(GO:0005763)
0.4 1.1 GO:0005674 transcription factor TFIIF complex(GO:0005674)
0.3 17.1 GO:1904115 axon cytoplasm(GO:1904115)
0.3 5.3 GO:0030056 hemidesmosome(GO:0030056)
0.3 16.2 GO:0031430 M band(GO:0031430)
0.3 12.8 GO:0005669 transcription factor TFIID complex(GO:0005669)
0.3 19.8 GO:0012507 ER to Golgi transport vesicle membrane(GO:0012507)
0.2 3.5 GO:0031011 Ino80 complex(GO:0031011) DNA helicase complex(GO:0033202)
0.2 16.1 GO:0055038 recycling endosome membrane(GO:0055038)
0.2 15.8 GO:0005771 multivesicular body(GO:0005771)
0.2 3.1 GO:0035749 myelin sheath adaxonal region(GO:0035749)
0.2 29.2 GO:0035578 azurophil granule lumen(GO:0035578)
0.2 11.2 GO:0019005 SCF ubiquitin ligase complex(GO:0019005)
0.2 45.4 GO:0000793 condensed chromosome(GO:0000793)
0.2 1.4 GO:0016272 prefoldin complex(GO:0016272)
0.2 6.8 GO:0000313 organellar ribosome(GO:0000313) mitochondrial ribosome(GO:0005761)
0.1 29.3 GO:0005741 mitochondrial outer membrane(GO:0005741)
0.1 0.5 GO:0035867 alphav-beta3 integrin-IGF-1-IGF1R complex(GO:0035867)
0.1 1.2 GO:0032982 myosin filament(GO:0032982)
0.1 1.5 GO:0005680 anaphase-promoting complex(GO:0005680)
0.0 6.6 GO:0005903 brush border(GO:0005903)
0.0 30.4 GO:0005925 focal adhesion(GO:0005925)
0.0 0.2 GO:0000124 SAGA complex(GO:0000124)
0.0 2.5 GO:0033116 endoplasmic reticulum-Golgi intermediate compartment membrane(GO:0033116)
0.0 5.4 GO:0044798 nuclear transcription factor complex(GO:0044798)
0.0 27.0 GO:0005730 nucleolus(GO:0005730)
0.0 2.2 GO:0005882 intermediate filament(GO:0005882)
0.0 11.6 GO:0030529 intracellular ribonucleoprotein complex(GO:0030529)
0.0 7.9 GO:0005578 proteinaceous extracellular matrix(GO:0005578)
0.0 5.8 GO:0031965 nuclear membrane(GO:0031965)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
6.3 25.2 GO:0030622 U4atac snRNA binding(GO:0030622)
3.3 26.4 GO:1990829 C-rich single-stranded DNA binding(GO:1990829)
3.0 12.0 GO:1904408 dihydronicotinamide riboside quinone reductase activity(GO:0001512) melatonin binding(GO:1904408)
2.1 10.7 GO:0034988 Fc-gamma receptor I complex binding(GO:0034988)
2.1 16.6 GO:0015288 porin activity(GO:0015288)
2.0 15.7 GO:0019237 centromeric DNA binding(GO:0019237)
2.0 13.7 GO:0061133 endopeptidase activator activity(GO:0061133)
1.7 44.5 GO:0031489 myosin V binding(GO:0031489)
1.6 8.2 GO:0004809 tRNA (guanine-N2-)-methyltransferase activity(GO:0004809)
1.5 4.5 GO:0004531 deoxyribonuclease II activity(GO:0004531)
1.3 6.3 GO:0061649 ubiquitinated histone binding(GO:0061649)
1.2 25.7 GO:0008191 metalloendopeptidase inhibitor activity(GO:0008191)
0.8 23.7 GO:0070003 threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003)
0.8 13.3 GO:0043295 glutathione binding(GO:0043295)
0.8 3.0 GO:0004886 9-cis retinoic acid receptor activity(GO:0004886)
0.7 8.9 GO:0050700 CARD domain binding(GO:0050700)
0.6 2.3 GO:0052851 cupric reductase activity(GO:0008823) ferric-chelate reductase (NADPH) activity(GO:0052851)
0.5 15.5 GO:0070034 telomerase RNA binding(GO:0070034)
0.5 29.2 GO:0015485 cholesterol binding(GO:0015485)
0.4 2.7 GO:0003810 protein-glutamine gamma-glutamyltransferase activity(GO:0003810)
0.4 8.1 GO:0017049 GTP-Rho binding(GO:0017049)
0.4 21.3 GO:0051879 Hsp90 protein binding(GO:0051879)
0.3 64.2 GO:0047485 protein N-terminus binding(GO:0047485)
0.3 7.2 GO:0005537 mannose binding(GO:0005537)
0.3 1.3 GO:0004105 choline-phosphate cytidylyltransferase activity(GO:0004105)
0.2 1.2 GO:0017018 myosin phosphatase activity(GO:0017018)
0.2 13.6 GO:0050681 androgen receptor binding(GO:0050681)
0.2 16.1 GO:0019003 GDP binding(GO:0019003)
0.2 11.8 GO:0019843 rRNA binding(GO:0019843)
0.1 4.4 GO:0003887 DNA-directed DNA polymerase activity(GO:0003887)
0.1 2.4 GO:0016018 cyclosporin A binding(GO:0016018)
0.1 1.0 GO:0004962 endothelin receptor activity(GO:0004962)
0.1 1.1 GO:0000990 transcription factor activity, core RNA polymerase binding(GO:0000990)
0.1 6.8 GO:0008137 NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.1 35.0 GO:0003924 GTPase activity(GO:0003924)
0.1 22.5 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.1 2.6 GO:0097493 structural molecule activity conferring elasticity(GO:0097493)
0.1 1.7 GO:0008432 JUN kinase binding(GO:0008432)
0.1 2.3 GO:0003756 protein disulfide isomerase activity(GO:0003756) intramolecular oxidoreductase activity, transposing S-S bonds(GO:0016864)
0.1 60.7 GO:0004674 protein serine/threonine kinase activity(GO:0004674)
0.1 5.3 GO:0008307 structural constituent of muscle(GO:0008307)
0.1 14.2 GO:0051015 actin filament binding(GO:0051015)
0.0 1.4 GO:0070064 proline-rich region binding(GO:0070064)
0.0 1.4 GO:0044183 protein binding involved in protein folding(GO:0044183)
0.0 9.8 GO:0005125 cytokine activity(GO:0005125)
0.0 2.2 GO:0097110 scaffold protein binding(GO:0097110)
0.0 0.3 GO:0017034 Rap guanyl-nucleotide exchange factor activity(GO:0017034)
0.0 0.4 GO:0001608 G-protein coupled nucleotide receptor activity(GO:0001608) G-protein coupled purinergic nucleotide receptor activity(GO:0045028)
0.0 6.5 GO:0044822 mRNA binding(GO:0003729) poly(A) RNA binding(GO:0044822)
0.0 6.7 GO:0031625 ubiquitin protein ligase binding(GO:0031625)
0.0 2.7 GO:0003735 structural constituent of ribosome(GO:0003735)
0.0 0.5 GO:0005159 insulin-like growth factor receptor binding(GO:0005159)
0.0 15.8 GO:0003723 RNA binding(GO:0003723)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 17.1 PID HIF1A PATHWAY Hypoxic and oxygen homeostasis regulation of HIF-1-alpha
0.3 12.6 PID HDAC CLASSIII PATHWAY Signaling events mediated by HDAC Class III
0.3 15.7 PID AURORA B PATHWAY Aurora B signaling
0.3 21.3 PID PLK1 PATHWAY PLK1 signaling events
0.2 10.7 SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES Genes related to regulation of the actin cytoskeleton
0.2 9.9 NABA PROTEOGLYCANS Genes encoding proteoglycans
0.2 13.7 PID DELTA NP63 PATHWAY Validated transcriptional targets of deltaNp63 isoforms
0.2 8.9 PID IL1 PATHWAY IL1-mediated signaling events
0.1 12.4 PID ERA GENOMIC PATHWAY Validated nuclear estrogen receptor alpha network
0.1 3.0 PID RETINOIC ACID PATHWAY Retinoic acid receptors-mediated signaling
0.1 11.7 PID TRKR PATHWAY Neurotrophic factor-mediated Trk receptor signaling
0.1 8.1 PID RHOA REG PATHWAY Regulation of RhoA activity
0.1 1.7 PID EPHA2 FWD PATHWAY EPHA2 forward signaling
0.1 2.7 PID INTEGRIN A9B1 PATHWAY Alpha9 beta1 integrin signaling events
0.0 1.4 PID HES HEY PATHWAY Notch-mediated HES/HEY network
0.0 0.5 PID IGF1 PATHWAY IGF1 pathway
0.0 1.0 PID ENDOTHELIN PATHWAY Endothelins

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
4.1 45.4 REACTOME APOBEC3G MEDIATED RESISTANCE TO HIV1 INFECTION Genes involved in APOBEC3G mediated resistance to HIV-1 infection
1.8 44.5 REACTOME INSULIN SYNTHESIS AND PROCESSING Genes involved in Insulin Synthesis and Processing
0.8 22.8 REACTOME INHIBITION OF THE PROTEOLYTIC ACTIVITY OF APC C REQUIRED FOR THE ONSET OF ANAPHASE BY MITOTIC SPINDLE CHECKPOINT COMPONENTS Genes involved in Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components
0.6 18.1 REACTOME POST CHAPERONIN TUBULIN FOLDING PATHWAY Genes involved in Post-chaperonin tubulin folding pathway
0.6 26.4 REACTOME NEGATIVE REGULATORS OF RIG I MDA5 SIGNALING Genes involved in Negative regulators of RIG-I/MDA5 signaling
0.6 15.7 REACTOME KINESINS Genes involved in Kinesins
0.5 9.6 REACTOME MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE Genes involved in mRNA Decay by 5' to 3' Exoribonuclease
0.5 17.1 REACTOME OXYGEN DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA INDUCIBLE FACTOR ALPHA Genes involved in Oxygen-dependent Proline Hydroxylation of Hypoxia-inducible Factor Alpha
0.5 8.9 REACTOME THE NLRP3 INFLAMMASOME Genes involved in The NLRP3 inflammasome
0.4 13.3 REACTOME GLUTATHIONE CONJUGATION Genes involved in Glutathione conjugation
0.4 23.7 REACTOME AUTODEGRADATION OF CDH1 BY CDH1 APC C Genes involved in Autodegradation of Cdh1 by Cdh1:APC/C
0.4 13.9 REACTOME ELONGATION ARREST AND RECOVERY Genes involved in Elongation arrest and recovery
0.3 4.4 REACTOME REMOVAL OF THE FLAP INTERMEDIATE FROM THE C STRAND Genes involved in Removal of the Flap Intermediate from the C-strand
0.3 5.4 REACTOME RNA POL III TRANSCRIPTION INITIATION FROM TYPE 3 PROMOTER Genes involved in RNA Polymerase III Transcription Initiation From Type 3 Promoter
0.2 30.4 REACTOME MRNA SPLICING Genes involved in mRNA Splicing
0.2 5.6 REACTOME GLUTAMATE NEUROTRANSMITTER RELEASE CYCLE Genes involved in Glutamate Neurotransmitter Release Cycle
0.2 5.3 REACTOME CASPASE MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS Genes involved in Caspase-mediated cleavage of cytoskeletal proteins
0.1 1.7 REACTOME P130CAS LINKAGE TO MAPK SIGNALING FOR INTEGRINS Genes involved in p130Cas linkage to MAPK signaling for integrins
0.1 8.1 REACTOME NRAGE SIGNALS DEATH THROUGH JNK Genes involved in NRAGE signals death through JNK
0.1 14.2 REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 Genes involved in Response to elevated platelet cytosolic Ca2+
0.1 6.8 REACTOME RESPIRATORY ELECTRON TRANSPORT Genes involved in Respiratory electron transport
0.1 3.1 REACTOME TIGHT JUNCTION INTERACTIONS Genes involved in Tight junction interactions
0.1 9.3 REACTOME PPARA ACTIVATES GENE EXPRESSION Genes involved in PPARA Activates Gene Expression
0.1 1.4 REACTOME PREFOLDIN MEDIATED TRANSFER OF SUBSTRATE TO CCT TRIC Genes involved in Prefoldin mediated transfer of substrate to CCT/TriC
0.0 1.4 REACTOME PROLACTIN RECEPTOR SIGNALING Genes involved in Prolactin receptor signaling
0.0 1.3 REACTOME SYNTHESIS OF PC Genes involved in Synthesis of PC
0.0 1.2 REACTOME STRIATED MUSCLE CONTRACTION Genes involved in Striated Muscle Contraction
0.0 0.4 REACTOME P2Y RECEPTORS Genes involved in P2Y receptors
0.0 2.7 REACTOME INFLUENZA VIRAL RNA TRANSCRIPTION AND REPLICATION Genes involved in Influenza Viral RNA Transcription and Replication