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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
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Results for ZBTB12
Z-value: 1.00
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Transcription factors associated with ZBTB12
Network of associatons between targets according to the STRING database.
First level regulatory network of ZBTB12
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 3.2 | 45.4 | GO:0015074 | DNA integration(GO:0015074) |
| 7.4 | 44.5 | GO:1903435 | positive regulation of constitutive secretory pathway(GO:1903435) |
| 1.5 | 34.3 | GO:0043968 | histone H2A acetylation(GO:0043968) |
| 5.8 | 29.2 | GO:0019747 | regulation of isoprenoid metabolic process(GO:0019747) |
| 0.3 | 27.6 | GO:0032435 | negative regulation of proteasomal ubiquitin-dependent protein catabolic process(GO:0032435) |
| 0.5 | 27.0 | GO:0032731 | positive regulation of interleukin-1 beta production(GO:0032731) |
| 1.5 | 26.4 | GO:0075522 | IRES-dependent viral translational initiation(GO:0075522) |
| 0.3 | 25.2 | GO:0051439 | negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle(GO:0051436) regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle(GO:0051439) |
| 4.3 | 21.3 | GO:0051754 | meiotic sister chromatid cohesion, centromeric(GO:0051754) |
| 0.2 | 19.8 | GO:0048208 | vesicle targeting, rough ER to cis-Golgi(GO:0048207) COPII vesicle coating(GO:0048208) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 45.4 | GO:0000793 | condensed chromosome(GO:0000793) |
| 3.4 | 44.5 | GO:0033093 | Weibel-Palade body(GO:0033093) |
| 1.1 | 34.3 | GO:1902562 | NuA4 histone acetyltransferase complex(GO:0035267) H4/H2A histone acetyltransferase complex(GO:0043189) H4 histone acetyltransferase complex(GO:1902562) |
| 0.0 | 30.4 | GO:0005925 | focal adhesion(GO:0005925) |
| 0.1 | 29.3 | GO:0005741 | mitochondrial outer membrane(GO:0005741) |
| 0.2 | 29.2 | GO:0035578 | azurophil granule lumen(GO:0035578) |
| 0.0 | 27.0 | GO:0005730 | nucleolus(GO:0005730) |
| 1.8 | 21.3 | GO:0000940 | condensed chromosome outer kinetochore(GO:0000940) |
| 0.3 | 19.8 | GO:0012507 | ER to Golgi transport vesicle membrane(GO:0012507) |
| 3.6 | 18.1 | GO:0001651 | dense fibrillar component(GO:0001651) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 64.2 | GO:0047485 | protein N-terminus binding(GO:0047485) |
| 0.1 | 60.7 | GO:0004674 | protein serine/threonine kinase activity(GO:0004674) |
| 1.7 | 44.5 | GO:0031489 | myosin V binding(GO:0031489) |
| 0.1 | 35.0 | GO:0003924 | GTPase activity(GO:0003924) |
| 0.5 | 29.2 | GO:0015485 | cholesterol binding(GO:0015485) |
| 3.3 | 26.4 | GO:1990829 | C-rich single-stranded DNA binding(GO:1990829) |
| 1.2 | 25.7 | GO:0008191 | metalloendopeptidase inhibitor activity(GO:0008191) |
| 6.3 | 25.2 | GO:0030622 | U4atac snRNA binding(GO:0030622) |
| 0.8 | 23.7 | GO:0070003 | threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003) |
| 0.1 | 22.5 | GO:0001078 | transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 21.3 | PID PLK1 PATHWAY | PLK1 signaling events |
| 0.6 | 17.1 | PID HIF1A PATHWAY | Hypoxic and oxygen homeostasis regulation of HIF-1-alpha |
| 0.3 | 15.7 | PID AURORA B PATHWAY | Aurora B signaling |
| 0.2 | 13.7 | PID DELTA NP63 PATHWAY | Validated transcriptional targets of deltaNp63 isoforms |
| 0.3 | 12.6 | PID HDAC CLASSIII PATHWAY | Signaling events mediated by HDAC Class III |
| 0.1 | 12.4 | PID ERA GENOMIC PATHWAY | Validated nuclear estrogen receptor alpha network |
| 0.1 | 11.7 | PID TRKR PATHWAY | Neurotrophic factor-mediated Trk receptor signaling |
| 0.2 | 10.7 | SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES | Genes related to regulation of the actin cytoskeleton |
| 0.2 | 9.9 | NABA PROTEOGLYCANS | Genes encoding proteoglycans |
| 0.2 | 8.9 | PID IL1 PATHWAY | IL1-mediated signaling events |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 4.1 | 45.4 | REACTOME APOBEC3G MEDIATED RESISTANCE TO HIV1 INFECTION | Genes involved in APOBEC3G mediated resistance to HIV-1 infection |
| 1.8 | 44.5 | REACTOME INSULIN SYNTHESIS AND PROCESSING | Genes involved in Insulin Synthesis and Processing |
| 0.2 | 30.4 | REACTOME MRNA SPLICING | Genes involved in mRNA Splicing |
| 0.6 | 26.4 | REACTOME NEGATIVE REGULATORS OF RIG I MDA5 SIGNALING | Genes involved in Negative regulators of RIG-I/MDA5 signaling |
| 0.4 | 23.7 | REACTOME AUTODEGRADATION OF CDH1 BY CDH1 APC C | Genes involved in Autodegradation of Cdh1 by Cdh1:APC/C |
| 0.8 | 22.8 | REACTOME INHIBITION OF THE PROTEOLYTIC ACTIVITY OF APC C REQUIRED FOR THE ONSET OF ANAPHASE BY MITOTIC SPINDLE CHECKPOINT COMPONENTS | Genes involved in Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components |
| 0.6 | 18.1 | REACTOME POST CHAPERONIN TUBULIN FOLDING PATHWAY | Genes involved in Post-chaperonin tubulin folding pathway |
| 0.5 | 17.1 | REACTOME OXYGEN DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA INDUCIBLE FACTOR ALPHA | Genes involved in Oxygen-dependent Proline Hydroxylation of Hypoxia-inducible Factor Alpha |
| 0.6 | 15.7 | REACTOME KINESINS | Genes involved in Kinesins |
| 0.1 | 14.2 | REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 | Genes involved in Response to elevated platelet cytosolic Ca2+ |