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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
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Results for ZBTB16
Z-value: 0.67
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Transcription factors associated with ZBTB16
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| ZBTB16 | hg38_v1_chr11_+_114059702_114059749 | -0.48 | 4.4e-14 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of ZBTB16
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.9 | 23.1 | GO:0014038 | regulation of Schwann cell differentiation(GO:0014038) Golgi disassembly(GO:0090166) |
| 0.3 | 16.1 | GO:2000816 | negative regulation of mitotic sister chromatid separation(GO:2000816) |
| 2.0 | 12.3 | GO:1903435 | positive regulation of constitutive secretory pathway(GO:1903435) |
| 0.6 | 11.6 | GO:0042448 | ovulation from ovarian follicle(GO:0001542) progesterone metabolic process(GO:0042448) |
| 1.0 | 11.3 | GO:2000645 | negative regulation of receptor catabolic process(GO:2000645) |
| 0.2 | 10.9 | GO:0071549 | cellular response to dexamethasone stimulus(GO:0071549) |
| 1.5 | 9.1 | GO:0015853 | adenine transport(GO:0015853) |
| 1.7 | 8.3 | GO:1900262 | regulation of DNA-directed DNA polymerase activity(GO:1900262) positive regulation of DNA-directed DNA polymerase activity(GO:1900264) |
| 1.0 | 8.2 | GO:0000727 | double-strand break repair via break-induced replication(GO:0000727) |
| 1.2 | 7.5 | GO:0035105 | sterol regulatory element binding protein import into nucleus(GO:0035105) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 5.8 | 23.1 | GO:0097125 | cyclin B1-CDK1 complex(GO:0097125) |
| 0.1 | 18.5 | GO:0008021 | synaptic vesicle(GO:0008021) |
| 0.9 | 12.3 | GO:0033093 | Weibel-Palade body(GO:0033093) |
| 0.0 | 11.8 | GO:0005788 | endoplasmic reticulum lumen(GO:0005788) |
| 2.3 | 9.1 | GO:0071817 | MMXD complex(GO:0071817) |
| 1.4 | 8.3 | GO:0031390 | Ctf18 RFC-like complex(GO:0031390) |
| 2.1 | 8.2 | GO:0000811 | GINS complex(GO:0000811) |
| 0.7 | 7.5 | GO:0005638 | lamin filament(GO:0005638) |
| 0.5 | 7.0 | GO:0045275 | mitochondrial respiratory chain complex III(GO:0005750) respiratory chain complex III(GO:0045275) |
| 0.1 | 6.1 | GO:0031970 | organelle envelope lumen(GO:0031970) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.0 | 23.1 | GO:0008353 | RNA polymerase II carboxy-terminal domain kinase activity(GO:0008353) |
| 0.2 | 13.5 | GO:0004869 | cysteine-type endopeptidase inhibitor activity(GO:0004869) |
| 0.5 | 12.3 | GO:0031489 | myosin V binding(GO:0031489) |
| 0.5 | 11.3 | GO:0052629 | phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity(GO:0052629) |
| 2.3 | 9.1 | GO:0015207 | ATP:ADP antiporter activity(GO:0005471) adenine transmembrane transporter activity(GO:0015207) |
| 0.9 | 9.0 | GO:0001162 | RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding(GO:0001162) |
| 1.2 | 8.3 | GO:0033170 | DNA clamp loader activity(GO:0003689) protein-DNA loading ATPase activity(GO:0033170) |
| 0.6 | 8.2 | GO:0043138 | 3'-5' DNA helicase activity(GO:0043138) |
| 0.0 | 7.6 | GO:0003714 | transcription corepressor activity(GO:0003714) |
| 0.0 | 7.6 | GO:0003924 | GTPase activity(GO:0003924) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.6 | 23.1 | SA G2 AND M PHASES | Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition. |
| 0.2 | 11.6 | PID HNF3B PATHWAY | FOXA2 and FOXA3 transcription factor networks |
| 0.2 | 8.3 | PID FANCONI PATHWAY | Fanconi anemia pathway |
| 0.1 | 7.5 | PID CASPASE PATHWAY | Caspase cascade in apoptosis |
| 0.1 | 6.5 | PID E2F PATHWAY | E2F transcription factor network |
| 0.2 | 5.9 | ST G ALPHA S PATHWAY | G alpha s Pathway |
| 0.1 | 4.1 | PID PRL SIGNALING EVENTS PATHWAY | Signaling events mediated by PRL |
| 0.1 | 4.0 | PID IL27 PATHWAY | IL27-mediated signaling events |
| 0.1 | 3.1 | PID SYNDECAN 4 PATHWAY | Syndecan-4-mediated signaling events |
| 0.0 | 3.1 | PID RHOA REG PATHWAY | Regulation of RhoA activity |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.8 | 23.1 | REACTOME E2F ENABLED INHIBITION OF PRE REPLICATION COMPLEX FORMATION | Genes involved in E2F-enabled inhibition of pre-replication complex formation |
| 0.2 | 18.8 | REACTOME RESPIRATORY ELECTRON TRANSPORT | Genes involved in Respiratory electron transport |
| 0.2 | 16.5 | REACTOME APC C CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS | Genes involved in APC/C:Cdc20 mediated degradation of mitotic proteins |
| 0.5 | 12.3 | REACTOME INSULIN SYNTHESIS AND PROCESSING | Genes involved in Insulin Synthesis and Processing |
| 0.6 | 10.2 | REACTOME SYNTHESIS OF PIPS AT THE LATE ENDOSOME MEMBRANE | Genes involved in Synthesis of PIPs at the late endosome membrane |
| 0.5 | 8.3 | REACTOME POL SWITCHING | Genes involved in Polymerase switching |
| 0.5 | 8.2 | REACTOME UNWINDING OF DNA | Genes involved in Unwinding of DNA |
| 0.2 | 7.6 | REACTOME INTERACTIONS OF VPR WITH HOST CELLULAR PROTEINS | Genes involved in Interactions of Vpr with host cellular proteins |
| 0.1 | 7.5 | REACTOME MEIOTIC SYNAPSIS | Genes involved in Meiotic Synapsis |
| 0.1 | 7.3 | REACTOME APOPTOTIC EXECUTION PHASE | Genes involved in Apoptotic execution phase |