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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)

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Results for ZBTB3

Z-value: 0.74

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Transcription factors associated with ZBTB3

Gene Symbol Gene ID Gene Info
ZBTB3
ENSG00000185670.9 ZBTB3

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
ZBTB3hg38_v1_chr11_-_62754141_627541840.119.6e-02Click!

Activity profile of ZBTB3 motif

Sorted Z-values of ZBTB3 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of ZBTB3

PNG image of the network

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Top targets:

Promoter Score Transcript Gene Gene Info
chr9_+_71911468 18.01 ENST00000377031.7
C9orf85
chromosome 9 open reading frame 85
chr21_-_46605073 15.04 ENST00000291700.9
ENST00000367071.4
S100B
S100 calcium binding protein B
chr19_+_35030626 13.29 ENST00000638536.1
SCN1B
sodium voltage-gated channel beta subunit 1
chr19_+_35030438 12.51 ENST00000415950.5
ENST00000262631.11
SCN1B
sodium voltage-gated channel beta subunit 1
chr1_+_244835616 12.24 ENST00000366528.3
ENST00000411948.7
COX20
cytochrome c oxidase assembly factor COX20
chr16_-_19884828 12.19 ENST00000300571.7
ENST00000570142.5
ENST00000562469.5
GPRC5B
G protein-coupled receptor class C group 5 member B
chr4_-_73069696 11.96 ENST00000507544.3
ENST00000295890.8
COX18
cytochrome c oxidase assembly factor COX18
chr5_+_75512058 11.28 ENST00000514296.5
POLK
DNA polymerase kappa
chr2_-_2326210 10.83 ENST00000647755.1
MYT1L
myelin transcription factor 1 like
chr2_-_151971750 10.81 ENST00000636598.1
CACNB4
calcium voltage-gated channel auxiliary subunit beta 4
chr3_-_39281261 10.02 ENST00000541347.5
ENST00000412814.1
CX3CR1
C-X3-C motif chemokine receptor 1
chr5_+_170861990 9.87 ENST00000523189.6
RANBP17
RAN binding protein 17
chr19_-_39532809 9.87 ENST00000326282.5
EID2B
EP300 interacting inhibitor of differentiation 2B
chr11_+_123358416 9.05 ENST00000638157.1
GRAMD1B
GRAM domain containing 1B
chr4_-_5893075 9.03 ENST00000324989.12
CRMP1
collapsin response mediator protein 1
chr5_+_77086682 8.59 ENST00000643365.1
ENST00000645183.1
ENST00000645374.1
ENST00000647364.1
ENST00000643848.1
ENST00000643603.1
ENST00000645459.1
ENST00000643269.1
ENST00000503969.6
ENST00000646262.1
ZBED3-AS1
ENSG00000284762.1
ZBED3 antisense RNA 1
phosphodiesterase 8B
chr16_-_2135898 8.54 ENST00000262304.9
ENST00000423118.5
PKD1
polycystin 1, transient receptor potential channel interacting
chr1_+_159171607 8.45 ENST00000368124.8
ENST00000368125.9
ENST00000416746.1
CADM3
cell adhesion molecule 3
chr2_-_2326378 7.66 ENST00000647618.1
MYT1L
myelin transcription factor 1 like
chr20_+_63658286 7.63 ENST00000360203.11
ENST00000508582.7
ENST00000318100.9
ENST00000356810.5
RTEL1
regulator of telomere elongation helicase 1
chr9_+_71911615 6.84 ENST00000334731.7
ENST00000486911.2
C9orf85
chromosome 9 open reading frame 85
chr11_+_64924673 6.65 ENST00000164133.7
ENST00000532850.1
PPP2R5B
protein phosphatase 2 regulatory subunit B'beta
chr11_+_26332117 5.72 ENST00000531646.1
ENST00000256737.8
ANO3
anoctamin 3
chr10_-_124744280 5.46 ENST00000337318.8
FAM53B
family with sequence similarity 53 member B
chr17_+_7627963 5.32 ENST00000575729.5
ENST00000340624.9
SHBG
sex hormone binding globulin
chr6_-_31972290 5.19 ENST00000375349.7
DXO
decapping exoribonuclease
chrX_+_135032346 4.98 ENST00000257013.9
RTL8C
retrotransposon Gag like 8C
chr11_-_130916437 4.83 ENST00000533214.1
ENST00000528555.5
ENST00000530356.5
ENST00000265909.9
SNX19
sorting nexin 19
chr6_-_31971958 4.67 ENST00000375356.7
DXO
decapping exoribonuclease
chr19_-_3772211 4.54 ENST00000555978.5
ENST00000555633.3
RAX2
retina and anterior neural fold homeobox 2
chr19_+_52274443 4.53 ENST00000600821.5
ENST00000595149.5
ENST00000595000.5
ENST00000593612.1
ZNF766
zinc finger protein 766
chr6_-_31972123 4.21 ENST00000337523.10
DXO
decapping exoribonuclease
chr12_+_41188301 4.11 ENST00000402685.7
PDZRN4
PDZ domain containing ring finger 4
chr8_-_42768781 3.95 ENST00000276410.7
CHRNA6
cholinergic receptor nicotinic alpha 6 subunit
chr14_-_91947654 3.86 ENST00000342058.9
FBLN5
fibulin 5
chr1_-_204494752 3.78 ENST00000684373.1
PIK3C2B
phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 beta
chr5_+_76083360 3.65 ENST00000502798.7
SV2C
synaptic vesicle glycoprotein 2C
chrX_+_11758159 3.47 ENST00000361672.6
ENST00000337339.7
ENST00000647869.1
ENST00000312196.10
ENST00000647857.1
ENST00000649130.1
MSL3
MSL complex subunit 3
chrX_-_386900 3.34 ENST00000390665.9
PPP2R3B
protein phosphatase 2 regulatory subunit B''beta
chr6_+_122779707 3.30 ENST00000368444.8
ENST00000356535.4
FABP7
fatty acid binding protein 7
chr1_-_110606347 3.29 ENST00000316361.10
KCNA2
potassium voltage-gated channel subfamily A member 2
chr2_-_74343397 3.19 ENST00000394019.6
ENST00000377634.8
ENST00000436454.1
SLC4A5
solute carrier family 4 member 5
chr19_-_55038256 3.10 ENST00000417454.5
ENST00000310373.7
ENST00000333884.2
GP6
glycoprotein VI platelet
chr8_-_42768602 3.10 ENST00000534622.5
CHRNA6
cholinergic receptor nicotinic alpha 6 subunit
chr1_-_169586539 2.92 ENST00000367796.3
F5
coagulation factor V
chr1_-_110606009 2.65 ENST00000640774.2
ENST00000638616.2
KCNA2
potassium voltage-gated channel subfamily A member 2
chr10_+_97572493 2.65 ENST00000307518.9
ENST00000298808.9
ANKRD2
ankyrin repeat domain 2
chr14_-_91947383 2.58 ENST00000267620.14
FBLN5
fibulin 5
chr5_+_114362043 2.51 ENST00000673685.1
KCNN2
potassium calcium-activated channel subfamily N member 2
chr5_-_150290093 2.25 ENST00000672479.1
CAMK2A
calcium/calmodulin dependent protein kinase II alpha
chr9_+_123033660 2.22 ENST00000616002.3
GPR21
G protein-coupled receptor 21
chr17_-_58517835 2.18 ENST00000579921.1
ENST00000579925.5
ENST00000323456.9
MTMR4
myotubularin related protein 4
chrX_-_155334580 2.16 ENST00000369449.7
ENST00000321926.4
CLIC2
chloride intracellular channel 2
chr5_-_170297746 2.11 ENST00000046794.10
LCP2
lymphocyte cytosolic protein 2
chr1_-_169586471 1.97 ENST00000367797.9
F5
coagulation factor V
chr1_+_209827964 1.97 ENST00000491415.7
UTP25
UTP25 small subunit processor component
chr5_+_141135199 1.89 ENST00000231134.8
ENST00000623915.1
PCDHB5
protocadherin beta 5
chr2_-_2326161 1.88 ENST00000649810.1
ENST00000648318.1
MYT1L
myelin transcription factor 1 like
chr10_-_75109172 1.73 ENST00000372700.7
ENST00000473072.2
ENST00000491677.6
ENST00000372702.7
DUSP13
dual specificity phosphatase 13
chr5_-_95081482 1.72 ENST00000312216.12
ENST00000512425.5
ENST00000505208.5
ENST00000429576.6
ENST00000508509.5
ENST00000510732.5
MCTP1
multiple C2 and transmembrane domain containing 1
chr10_-_75109085 1.67 ENST00000607131.5
DUSP13
dual specificity phosphatase 13
chr11_-_83071917 1.64 ENST00000534141.5
RAB30
RAB30, member RAS oncogene family
chrX_+_71144818 1.47 ENST00000536169.5
ENST00000358741.4
ENST00000395855.6
ENST00000374051.7
NLGN3
neuroligin 3
chr6_+_42173358 1.38 ENST00000372958.2
GUCA1A
guanylate cyclase activator 1A
chr16_+_89720980 1.28 ENST00000289816.9
ENST00000568064.5
ZNF276
zinc finger protein 276
chr18_+_12407896 1.27 ENST00000590956.5
ENST00000336990.8
ENST00000440960.6
ENST00000588729.5
PRELID3A
PRELI domain containing 3A
chr20_+_56412393 1.26 ENST00000679529.1
CASS4
Cas scaffold protein family member 4
chr19_-_6670151 1.25 ENST00000675206.1
TNFSF14
TNF superfamily member 14
chr6_+_30882914 1.22 ENST00000509639.5
ENST00000412274.6
ENST00000507901.5
ENST00000507046.5
ENST00000437124.6
ENST00000454612.6
ENST00000396342.6
DDR1
discoidin domain receptor tyrosine kinase 1
chr3_+_178558700 1.21 ENST00000432997.5
ENST00000455865.5
KCNMB2
potassium calcium-activated channel subfamily M regulatory beta subunit 2
chrX_-_86047527 1.13 ENST00000615443.1
ENST00000357749.7
CHM
CHM Rab escort protein
chr19_-_6670117 1.09 ENST00000245912.7
TNFSF14
TNF superfamily member 14
chr21_+_43789522 1.05 ENST00000497547.2
RRP1
ribosomal RNA processing 1
chr7_-_127585566 1.00 ENST00000321407.3
GCC1
GRIP and coiled-coil domain containing 1
chr1_+_171781635 0.99 ENST00000361735.4
ENST00000362019.7
ENST00000367737.9
EEF1AKNMT
eEF1A lysine and N-terminal methyltransferase
chr6_+_138773747 0.96 ENST00000617445.5
CCDC28A
coiled-coil domain containing 28A
chr15_+_32030481 0.94 ENST00000454250.7
ENST00000675428.1
ENST00000637552.1
CHRNA7
cholinergic receptor nicotinic alpha 7 subunit
chr20_+_56412112 0.92 ENST00000360314.7
CASS4
Cas scaffold protein family member 4
chr12_-_114406133 0.88 ENST00000405440.7
TBX5
T-box transcription factor 5
chr17_-_5584448 0.87 ENST00000269280.8
ENST00000571451.6
ENST00000572272.6
ENST00000613500.4
ENST00000619223.4
ENST00000617618.4
ENST00000345221.7
ENST00000262467.10
NLRP1
NLR family pyrin domain containing 1
chr20_+_56412249 0.85 ENST00000679887.1
ENST00000434344.2
CASS4
Cas scaffold protein family member 4
chr11_+_67240047 0.83 ENST00000530342.2
KDM2A
lysine demethylase 2A
chr17_+_74987581 0.81 ENST00000337231.5
CDR2L
cerebellar degeneration related protein 2 like
chr2_-_153478753 0.74 ENST00000325926.4
RPRM
reprimo, TP53 dependent G2 arrest mediator homolog
chr1_+_160190567 0.73 ENST00000368078.8
CASQ1
calsequestrin 1
chr3_+_98531965 0.72 ENST00000284311.5
GPR15
G protein-coupled receptor 15
chr15_+_32030506 0.56 ENST00000306901.9
ENST00000636440.1
CHRNA7
cholinergic receptor nicotinic alpha 7 subunit
chr7_+_143935233 0.46 ENST00000408955.3
OR2F2
olfactory receptor family 2 subfamily F member 2
chr4_-_15938740 0.36 ENST00000382333.2
FGFBP1
fibroblast growth factor binding protein 1
chr6_+_44158807 0.35 ENST00000532171.5
ENST00000398776.2
CAPN11
calpain 11
chr11_-_83071819 0.32 ENST00000524635.1
ENST00000526205.5
ENST00000533486.5
ENST00000533276.6
ENST00000527633.6
RAB30
RAB30, member RAS oncogene family
chr1_+_171257930 0.23 ENST00000354841.4
FMO1
flavin containing dimethylaniline monoxygenase 1
chr17_+_77127865 0.21 ENST00000586429.5
SEC14L1
SEC14 like lipid binding 1
chr4_-_122621011 0.18 ENST00000611104.2
ENST00000648588.1
IL21
interleukin 21

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
4.3 25.8 GO:0021966 corticospinal neuron axon guidance(GO:0021966)
3.0 9.0 GO:1904529 regulation of actin filament binding(GO:1904529) regulation of actin binding(GO:1904616)
2.5 7.6 GO:1904430 negative regulation of t-circle formation(GO:1904430)
2.5 10.0 GO:0002881 negative regulation of chronic inflammatory response to non-antigenic stimulus(GO:0002881)
2.2 6.7 GO:0070317 negative regulation of G0 to G1 transition(GO:0070317)
2.1 8.5 GO:0072237 metanephric proximal tubule development(GO:0072237)
1.9 5.7 GO:0061591 calcium activated phospholipid scrambling(GO:0061588) calcium activated phosphatidylcholine scrambling(GO:0061590) calcium activated galactosylceramide scrambling(GO:0061591)
1.6 3.2 GO:0033326 cerebrospinal fluid secretion(GO:0033326)
1.2 4.8 GO:1990502 dense core granule maturation(GO:1990502)
1.2 24.2 GO:0008535 respiratory chain complex IV assembly(GO:0008535)
1.1 15.0 GO:2001015 negative regulation of skeletal muscle cell differentiation(GO:2001015)
0.8 4.9 GO:0032571 response to vitamin K(GO:0032571)
0.8 14.1 GO:0071028 nuclear RNA surveillance(GO:0071027) nuclear mRNA surveillance(GO:0071028)
0.6 12.2 GO:0060907 positive regulation of macrophage cytokine production(GO:0060907)
0.6 5.9 GO:0021633 optic nerve structural organization(GO:0021633)
0.6 2.3 GO:0008588 release of cytoplasmic sequestered NF-kappaB(GO:0008588)
0.5 20.4 GO:0048665 neuron fate specification(GO:0048665)
0.5 5.8 GO:0048251 elastic fiber assembly(GO:0048251)
0.4 1.5 GO:0060024 rhythmic synaptic transmission(GO:0060024)
0.4 11.3 GO:0042276 error-prone translesion synthesis(GO:0042276)
0.3 0.9 GO:0072513 cardiac left ventricle formation(GO:0003218) positive regulation of secondary heart field cardioblast proliferation(GO:0072513)
0.2 1.5 GO:0050893 sensory processing(GO:0050893)
0.2 2.9 GO:0014894 response to muscle inactivity involved in regulation of muscle adaptation(GO:0014877) response to denervation involved in regulation of muscle adaptation(GO:0014894)
0.2 7.0 GO:0014046 dopamine secretion(GO:0014046) regulation of dopamine secretion(GO:0014059)
0.2 2.2 GO:0060315 negative regulation of ryanodine-sensitive calcium-release channel activity(GO:0060315)
0.2 2.5 GO:0098914 membrane repolarization during atrial cardiac muscle cell action potential(GO:0098914)
0.2 2.7 GO:2000291 regulation of myoblast proliferation(GO:2000291)
0.2 10.8 GO:1901385 regulation of voltage-gated calcium channel activity(GO:1901385)
0.2 3.3 GO:0060134 prepulse inhibition(GO:0060134)
0.1 5.5 GO:0035411 catenin import into nucleus(GO:0035411)
0.1 1.2 GO:0061302 smooth muscle cell-matrix adhesion(GO:0061302)
0.1 8.5 GO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0007157)
0.1 1.1 GO:0018344 protein geranylgeranylation(GO:0018344)
0.1 2.2 GO:0038166 angiotensin-activated signaling pathway(GO:0038166)
0.1 1.4 GO:0031284 positive regulation of guanylate cyclase activity(GO:0031284)
0.1 3.5 GO:0043984 histone H4-K16 acetylation(GO:0043984)
0.1 1.2 GO:0005513 detection of calcium ion(GO:0005513)
0.1 5.3 GO:0006611 protein export from nucleus(GO:0006611)
0.1 1.9 GO:0016339 calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0016339)
0.1 0.4 GO:0045743 positive regulation of fibroblast growth factor receptor signaling pathway(GO:0045743)
0.1 0.8 GO:0070544 histone H3-K36 demethylation(GO:0070544)
0.1 2.2 GO:0040018 positive regulation of multicellular organism growth(GO:0040018)
0.0 3.8 GO:0036092 phosphatidylinositol-3-phosphate biosynthetic process(GO:0036092)
0.0 1.0 GO:0000042 protein targeting to Golgi(GO:0000042)
0.0 0.9 GO:0032495 response to muramyl dipeptide(GO:0032495)
0.0 0.2 GO:0070995 NADPH oxidation(GO:0070995)
0.0 3.4 GO:0035335 peptidyl-tyrosine dephosphorylation(GO:0035335)
0.0 5.2 GO:0030168 platelet activation(GO:0030168)
0.0 4.5 GO:0007601 visual perception(GO:0007601)
0.0 0.2 GO:0045078 positive regulation of interferon-gamma biosynthetic process(GO:0045078)
0.0 0.2 GO:0015871 choline transport(GO:0015871)
0.0 1.3 GO:0015914 phospholipid transport(GO:0015914)
0.0 0.7 GO:0072678 T cell migration(GO:0072678)
0.0 7.4 GO:0007517 muscle organ development(GO:0007517)
0.0 3.2 GO:0006836 neurotransmitter transport(GO:0006836)
0.0 3.6 GO:0007050 cell cycle arrest(GO:0007050)
0.0 1.7 GO:0019722 calcium-mediated signaling(GO:0019722)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
1.0 25.8 GO:0001518 voltage-gated sodium channel complex(GO:0001518)
0.6 5.8 GO:0071953 elastic fiber(GO:0071953)
0.5 16.0 GO:0044298 neuronal cell body membrane(GO:0032809) cell body membrane(GO:0044298)
0.4 3.5 GO:0072487 MSL complex(GO:0072487)
0.4 2.1 GO:0036398 TCR signalosome(GO:0036398)
0.4 12.0 GO:0031305 intrinsic component of mitochondrial inner membrane(GO:0031304) integral component of mitochondrial inner membrane(GO:0031305)
0.3 3.1 GO:0097197 tetraspanin-enriched microdomain(GO:0097197)
0.3 8.5 GO:0005892 acetylcholine-gated channel complex(GO:0005892)
0.3 1.1 GO:0005968 Rab-protein geranylgeranyltransferase complex(GO:0005968)
0.2 10.0 GO:0000159 protein phosphatase type 2A complex(GO:0000159)
0.2 0.7 GO:0014802 terminal cisterna(GO:0014802)
0.2 0.9 GO:0072558 NLRP1 inflammasome complex(GO:0072558)
0.2 10.8 GO:0005891 voltage-gated calcium channel complex(GO:0005891)
0.1 3.8 GO:0005942 phosphatidylinositol 3-kinase complex(GO:0005942)
0.1 1.0 GO:0030688 preribosome, small subunit precursor(GO:0030688)
0.1 6.3 GO:0030660 Golgi-associated vesicle membrane(GO:0030660)
0.1 9.9 GO:0005643 nuclear pore(GO:0005643)
0.1 15.0 GO:0001726 ruffle(GO:0001726)
0.1 1.4 GO:0097381 photoreceptor disc membrane(GO:0097381)
0.1 4.9 GO:0033116 endoplasmic reticulum-Golgi intermediate compartment membrane(GO:0033116)
0.1 7.9 GO:0005913 cell-cell adherens junction(GO:0005913)
0.0 9.0 GO:0030496 midbody(GO:0030496)
0.0 7.6 GO:0000781 chromosome, telomeric region(GO:0000781)
0.0 2.0 GO:0005801 cis-Golgi network(GO:0005801)
0.0 3.7 GO:0099501 synaptic vesicle membrane(GO:0030672) exocytic vesicle membrane(GO:0099501)
0.0 2.2 GO:0034707 chloride channel complex(GO:0034707)
0.0 5.2 GO:0031674 I band(GO:0031674)
0.0 19.3 GO:0030659 cytoplasmic vesicle membrane(GO:0030659)
0.0 1.3 GO:0000777 condensed chromosome kinetochore(GO:0000777)
0.0 1.3 GO:0005758 mitochondrial intermembrane space(GO:0005758)
0.0 1.2 GO:0034705 voltage-gated potassium channel complex(GO:0008076) potassium channel complex(GO:0034705)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
5.2 25.8 GO:0086062 voltage-gated sodium channel activity involved in Purkinje myocyte action potential(GO:0086062)
3.5 14.1 GO:0034353 RNA pyrophosphohydrolase activity(GO:0034353)
2.5 10.0 GO:0016495 C-X3-C chemokine receptor activity(GO:0016495)
0.9 2.7 GO:0061629 RNA polymerase II sequence-specific DNA binding transcription factor binding(GO:0061629)
0.8 5.3 GO:0005497 androgen binding(GO:0005497)
0.7 15.0 GO:0050786 RAGE receptor binding(GO:0050786)
0.7 9.9 GO:0005049 nuclear export signal receptor activity(GO:0005049)
0.6 2.2 GO:0001588 dopamine neurotransmitter receptor activity, coupled via Gs(GO:0001588)
0.4 1.3 GO:1990050 phosphatidic acid transporter activity(GO:1990050)
0.4 9.0 GO:0031005 filamin binding(GO:0031005)
0.4 5.7 GO:0005229 intracellular calcium activated chloride channel activity(GO:0005229)
0.4 3.8 GO:0035005 lipid kinase activity(GO:0001727) 1-phosphatidylinositol-4-phosphate 3-kinase activity(GO:0035005)
0.4 11.3 GO:0003887 DNA-directed DNA polymerase activity(GO:0003887)
0.3 10.8 GO:0008331 high voltage-gated calcium channel activity(GO:0008331)
0.3 8.5 GO:0022848 acetylcholine-gated cation channel activity(GO:0022848)
0.3 1.4 GO:0008048 calcium sensitive guanylate cyclase activator activity(GO:0008048)
0.3 5.9 GO:0015271 outward rectifier potassium channel activity(GO:0015271)
0.3 2.5 GO:0016286 small conductance calcium-activated potassium channel activity(GO:0016286)
0.2 1.1 GO:0004663 Rab geranylgeranyltransferase activity(GO:0004663)
0.2 1.2 GO:0038062 protein tyrosine kinase collagen receptor activity(GO:0038062)
0.2 3.2 GO:0008510 sodium:bicarbonate symporter activity(GO:0008510)
0.2 7.6 GO:0051539 4 iron, 4 sulfur cluster binding(GO:0051539)
0.1 4.8 GO:0032266 phosphatidylinositol-3-phosphate binding(GO:0032266)
0.1 20.4 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.1 12.2 GO:0030295 protein kinase activator activity(GO:0030295)
0.1 2.2 GO:0052629 phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity(GO:0052629)
0.1 12.0 GO:0008565 protein transporter activity(GO:0008565)
0.1 1.5 GO:0042043 neurexin family protein binding(GO:0042043)
0.1 10.0 GO:0019888 protein phosphatase regulator activity(GO:0019888)
0.1 8.5 GO:0005262 calcium channel activity(GO:0005262)
0.1 2.2 GO:0004602 glutathione peroxidase activity(GO:0004602)
0.1 3.4 GO:0008138 protein tyrosine/serine/threonine phosphatase activity(GO:0008138)
0.1 4.9 GO:0005507 copper ion binding(GO:0005507)
0.1 0.8 GO:0051864 histone demethylase activity (H3-K36 specific)(GO:0051864)
0.1 2.3 GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027)
0.0 1.2 GO:0005227 calcium activated cation channel activity(GO:0005227) calcium-activated potassium channel activity(GO:0015269)
0.0 3.5 GO:0035064 methylated histone binding(GO:0035064)
0.0 0.2 GO:0005134 interleukin-2 receptor binding(GO:0005134)
0.0 0.2 GO:0039552 RIG-I binding(GO:0039552)
0.0 5.8 GO:0005178 integrin binding(GO:0005178)
0.0 0.2 GO:0004499 N,N-dimethylaniline monooxygenase activity(GO:0004499)
0.0 0.9 GO:0008656 cysteine-type endopeptidase activator activity involved in apoptotic process(GO:0008656)
0.0 3.1 GO:0005518 collagen binding(GO:0005518)
0.0 1.7 GO:0005544 calcium-dependent phospholipid binding(GO:0005544)
0.0 2.2 GO:0035254 glutamate receptor binding(GO:0035254)
0.0 0.4 GO:0017134 fibroblast growth factor binding(GO:0017134)
0.0 5.4 GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding(GO:0000978)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 2.1 PID TCR JNK PATHWAY JNK signaling in the CD4+ TCR pathway
0.1 5.3 PID AR NONGENOMIC PATHWAY Nongenotropic Androgen signaling
0.1 1.4 PID CONE PATHWAY Visual signal transduction: Cones
0.1 2.2 ST WNT CA2 CYCLIC GMP PATHWAY Wnt/Ca2+/cyclic GMP signaling.
0.1 0.9 PID ANTHRAX PATHWAY Cellular roles of Anthrax toxin
0.0 3.8 PID KIT PATHWAY Signaling events mediated by Stem cell factor receptor (c-Kit)
0.0 17.7 NABA SECRETED FACTORS Genes encoding secreted soluble factors
0.0 3.3 PID RB 1PATHWAY Regulation of retinoblastoma protein
0.0 2.6 NABA ECM GLYCOPROTEINS Genes encoding structural ECM glycoproteins

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 25.8 REACTOME INTERACTION BETWEEN L1 AND ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.6 15.0 REACTOME ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING Genes involved in Advanced glycosylation endproduct receptor signaling
0.4 8.5 REACTOME HIGHLY CALCIUM PERMEABLE POSTSYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS Genes involved in Highly calcium permeable postsynaptic nicotinic acetylcholine receptors
0.4 3.3 REACTOME INHIBITION OF REPLICATION INITIATION OF DAMAGED DNA BY RB1 E2F1 Genes involved in Inhibition of replication initiation of damaged DNA by RB1/E2F1
0.3 9.0 REACTOME CRMPS IN SEMA3A SIGNALING Genes involved in CRMPs in Sema3A signaling
0.3 4.9 REACTOME COMMON PATHWAY Genes involved in Common Pathway
0.2 6.7 REACTOME PLATELET SENSITIZATION BY LDL Genes involved in Platelet sensitization by LDL
0.2 10.0 REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES Genes involved in Chemokine receptors bind chemokines
0.1 2.2 REACTOME SYNTHESIS OF PIPS AT THE LATE ENDOSOME MEMBRANE Genes involved in Synthesis of PIPs at the late endosome membrane
0.1 10.3 REACTOME NCAM1 INTERACTIONS Genes involved in NCAM1 interactions
0.1 5.9 REACTOME VOLTAGE GATED POTASSIUM CHANNELS Genes involved in Voltage gated Potassium channels
0.1 3.8 REACTOME SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE Genes involved in Synthesis of PIPs at the plasma membrane
0.1 2.2 REACTOME UNBLOCKING OF NMDA RECEPTOR GLUTAMATE BINDING AND ACTIVATION Genes involved in Unblocking of NMDA receptor, glutamate binding and activation
0.1 2.1 REACTOME GPVI MEDIATED ACTIVATION CASCADE Genes involved in GPVI-mediated activation cascade
0.0 3.7 REACTOME POTASSIUM CHANNELS Genes involved in Potassium Channels
0.0 0.9 REACTOME INFLAMMASOMES Genes involved in Inflammasomes
0.0 0.9 REACTOME YAP1 AND WWTR1 TAZ STIMULATED GENE EXPRESSION Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression
0.0 3.2 REACTOME TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides