ISMARA results: ZBTB3

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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)

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Results for ZBTB3

Z-value: 0.74

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Transcription factors associated with ZBTB3

Gene Symbol	Gene ID	Gene Info
ZBTB3 Ensembl NCBI GeneCards UniProt	ENSG00000185670.9	ZBTB3

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
ZBTB3	hg38_v1_chr11_-_62754141_62754184	0.11	9.6e-02	Click!

Activity profile of ZBTB3 motif

Sorted Z-values of ZBTB3 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of ZBTB3

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Top targets:

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Promoter	Score	Transcript	Gene	Gene Info
chr9_+_71911468 Show fit	18.01	ENST00000377031.7	C9orf85 Ensembl NCBI GeneCards UniProt Show fit	chromosome 9 open reading frame 85
chr21_-_46605073 Show fit	15.04	ENST00000291700.9 ENST00000367071.4	S100B Ensembl NCBI GeneCards UniProt Show fit	S100 calcium binding protein B
chr19_+_35030626 Show fit	13.29	ENST00000638536.1	SCN1B Ensembl NCBI GeneCards UniProt Show fit	sodium voltage-gated channel beta subunit 1
chr19_+_35030438 Show fit	12.51	ENST00000415950.5 ENST00000262631.11	SCN1B Ensembl NCBI GeneCards UniProt Show fit	sodium voltage-gated channel beta subunit 1
chr1_+_244835616 Show fit	12.24	ENST00000366528.3 ENST00000411948.7	COX20 Ensembl NCBI GeneCards UniProt Show fit	cytochrome c oxidase assembly factor COX20
chr16_-_19884828 Show fit	12.19	ENST00000300571.7 ENST00000570142.5 ENST00000562469.5	GPRC5B Ensembl NCBI GeneCards UniProt Show fit	G protein-coupled receptor class C group 5 member B
chr4_-_73069696 Show fit	11.96	ENST00000507544.3 ENST00000295890.8	COX18 Ensembl NCBI GeneCards UniProt Show fit	cytochrome c oxidase assembly factor COX18
chr5_+_75512058 Show fit	11.28	ENST00000514296.5	POLK Ensembl NCBI GeneCards UniProt Show fit	DNA polymerase kappa
chr2_-_2326210 Show fit	10.83	ENST00000647755.1	MYT1L Ensembl NCBI GeneCards UniProt Show fit	myelin transcription factor 1 like
chr2_-_151971750 Show fit	10.81	ENST00000636598.1	CACNB4 Ensembl NCBI GeneCards UniProt Show fit	calcium voltage-gated channel auxiliary subunit beta 4

Showing 1 to 10 of 94 entries

Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
4.3	25.8	GO:0021966	corticospinal neuron axon guidance(GO:0021966)
1.2	24.2	GO:0008535	respiratory chain complex IV assembly(GO:0008535)
0.5	20.4	GO:0048665	neuron fate specification(GO:0048665)
1.1	15.0	GO:2001015	negative regulation of skeletal muscle cell differentiation(GO:2001015)
0.8	14.1	GO:0071028	nuclear RNA surveillance(GO:0071027) nuclear mRNA surveillance(GO:0071028)
0.6	12.2	GO:0060907	positive regulation of macrophage cytokine production(GO:0060907)
0.4	11.3	GO:0042276	error-prone translesion synthesis(GO:0042276)
0.2	10.8	GO:1901385	regulation of voltage-gated calcium channel activity(GO:1901385)
2.5	10.0	GO:0002881	negative regulation of chronic inflammatory response to non-antigenic stimulus(GO:0002881)
3.0	9.0	GO:1904529	regulation of actin filament binding(GO:1904529) regulation of actin binding(GO:1904616)

Showing 1 to 10 of 57 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.0	25.8	GO:0001518	voltage-gated sodium channel complex(GO:0001518)
0.0	19.3	GO:0030659	cytoplasmic vesicle membrane(GO:0030659)
0.5	16.0	GO:0044298	neuronal cell body membrane(GO:0032809) cell body membrane(GO:0044298)
0.1	15.0	GO:0001726	ruffle(GO:0001726)
0.4	12.0	GO:0031305	intrinsic component of mitochondrial inner membrane(GO:0031304) integral component of mitochondrial inner membrane(GO:0031305)
0.2	10.8	GO:0005891	voltage-gated calcium channel complex(GO:0005891)
0.2	10.0	GO:0000159	protein phosphatase type 2A complex(GO:0000159)
0.1	9.9	GO:0005643	nuclear pore(GO:0005643)
0.0	9.0	GO:0030496	midbody(GO:0030496)
0.3	8.5	GO:0005892	acetylcholine-gated channel complex(GO:0005892)

Showing 1 to 10 of 31 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
5.2	25.8	GO:0086062	voltage-gated sodium channel activity involved in Purkinje myocyte action potential(GO:0086062)
0.1	20.4	GO:0001078	transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.7	15.0	GO:0050786	RAGE receptor binding(GO:0050786)
3.5	14.1	GO:0034353	RNA pyrophosphohydrolase activity(GO:0034353)
0.1	12.2	GO:0030295	protein kinase activator activity(GO:0030295)
0.1	12.0	GO:0008565	protein transporter activity(GO:0008565)
0.4	11.3	GO:0003887	DNA-directed DNA polymerase activity(GO:0003887)
0.3	10.8	GO:0008331	high voltage-gated calcium channel activity(GO:0008331)
2.5	10.0	GO:0016495	C-X3-C chemokine receptor activity(GO:0016495)
0.1	10.0	GO:0019888	protein phosphatase regulator activity(GO:0019888)

Showing 1 to 10 of 47 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	17.7	NABA SECRETED FACTORS	Genes encoding secreted soluble factors
0.1	5.3	PID AR NONGENOMIC PATHWAY	Nongenotropic Androgen signaling
0.0	3.8	PID KIT PATHWAY	Signaling events mediated by Stem cell factor receptor (c-Kit)
0.0	3.3	PID RB 1PATHWAY	Regulation of retinoblastoma protein
0.0	2.6	NABA ECM GLYCOPROTEINS	Genes encoding structural ECM glycoproteins
0.1	2.2	ST WNT CA2 CYCLIC GMP PATHWAY	Wnt/Ca2+/cyclic GMP signaling.
0.1	2.1	PID TCR JNK PATHWAY	JNK signaling in the CD4+ TCR pathway
0.1	1.4	PID CONE PATHWAY	Visual signal transduction: Cones
0.1	0.9	PID ANTHRAX PATHWAY	Cellular roles of Anthrax toxin

Showing 1 to 9 of 9 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.6	25.8	REACTOME INTERACTION BETWEEN L1 AND ANKYRINS	Genes involved in Interaction between L1 and Ankyrins
0.6	15.0	REACTOME ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING	Genes involved in Advanced glycosylation endproduct receptor signaling
0.1	10.3	REACTOME NCAM1 INTERACTIONS	Genes involved in NCAM1 interactions
0.2	10.0	REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES	Genes involved in Chemokine receptors bind chemokines
0.3	9.0	REACTOME CRMPS IN SEMA3A SIGNALING	Genes involved in CRMPs in Sema3A signaling
0.4	8.5	REACTOME HIGHLY CALCIUM PERMEABLE POSTSYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS	Genes involved in Highly calcium permeable postsynaptic nicotinic acetylcholine receptors
0.2	6.7	REACTOME PLATELET SENSITIZATION BY LDL	Genes involved in Platelet sensitization by LDL
0.1	5.9	REACTOME VOLTAGE GATED POTASSIUM CHANNELS	Genes involved in Voltage gated Potassium channels
0.3	4.9	REACTOME COMMON PATHWAY	Genes involved in Common Pathway
0.1	3.8	REACTOME SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE	Genes involved in Synthesis of PIPs at the plasma membrane

Showing 1 to 10 of 18 entries

Results for ZBTB3

Z-value: 0.74

Motif logo

Transcription factors associated with ZBTB3

Activity-expression correlation:

Activity profile of ZBTB3 motif

Sorted Z-values of ZBTB3 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of ZBTB3

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.

Top targets:

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: