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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
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Results for ZBTB33_CHD2
Z-value: 3.93
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Transcription factors associated with ZBTB33_CHD2
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| CHD2 | hg38_v1_chr15_+_92900189_92900331 | -0.84 | 1.9e-59 | Click! |
| ZBTB33 | hg38_v1_chrX_+_120250752_120250866 | -0.71 | 2.5e-34 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of ZBTB33_CHD2
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 11.7 | 537.5 | GO:0070979 | protein K11-linked ubiquitination(GO:0070979) |
| 2.6 | 335.2 | GO:0006613 | cotranslational protein targeting to membrane(GO:0006613) |
| 1.8 | 226.2 | GO:0007062 | sister chromatid cohesion(GO:0007062) |
| 0.5 | 225.0 | GO:0008380 | RNA splicing(GO:0008380) |
| 9.7 | 202.8 | GO:0007064 | mitotic sister chromatid cohesion(GO:0007064) |
| 5.3 | 180.6 | GO:0019054 | NLS-bearing protein import into nucleus(GO:0006607) modulation by virus of host process(GO:0019054) |
| 11.3 | 157.6 | GO:1904871 | regulation of protein localization to Cajal body(GO:1904869) positive regulation of protein localization to Cajal body(GO:1904871) |
| 5.3 | 157.6 | GO:0000470 | maturation of LSU-rRNA(GO:0000470) |
| 31.2 | 156.1 | GO:0015742 | alpha-ketoglutarate transport(GO:0015742) |
| 12.9 | 141.7 | GO:0006552 | leucine catabolic process(GO:0006552) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.8 | 361.7 | GO:0016607 | nuclear speck(GO:0016607) |
| 5.0 | 353.5 | GO:0022627 | cytosolic small ribosomal subunit(GO:0022627) |
| 2.9 | 306.5 | GO:0022625 | cytosolic large ribosomal subunit(GO:0022625) |
| 2.7 | 288.9 | GO:0005643 | nuclear pore(GO:0005643) |
| 2.5 | 282.8 | GO:0005840 | ribosome(GO:0005840) |
| 0.6 | 278.9 | GO:0010008 | endosome membrane(GO:0010008) |
| 1.4 | 200.5 | GO:0000922 | spindle pole(GO:0000922) |
| 0.7 | 191.5 | GO:0019866 | mitochondrial inner membrane(GO:0005743) organelle inner membrane(GO:0019866) |
| 6.5 | 188.3 | GO:0005680 | anaphase-promoting complex(GO:0005680) |
| 22.8 | 182.5 | GO:0000796 | condensin complex(GO:0000796) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 3.2 | 667.3 | GO:0003735 | structural constituent of ribosome(GO:0003735) |
| 12.9 | 606.4 | GO:0061631 | ubiquitin conjugating enzyme activity(GO:0061631) |
| 0.7 | 318.0 | GO:0045296 | cadherin binding(GO:0045296) |
| 26.9 | 188.3 | GO:0010997 | anaphase-promoting complex binding(GO:0010997) |
| 4.0 | 183.7 | GO:0008139 | nuclear localization sequence binding(GO:0008139) |
| 20.4 | 163.5 | GO:0008379 | thioredoxin peroxidase activity(GO:0008379) |
| 0.4 | 156.3 | GO:0005525 | GTP binding(GO:0005525) |
| 52.0 | 156.1 | GO:0015140 | malate transmembrane transporter activity(GO:0015140) |
| 5.1 | 147.3 | GO:0004129 | cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676) |
| 14.7 | 146.8 | GO:0055104 | ligase inhibitor activity(GO:0055104) ubiquitin ligase inhibitor activity(GO:1990948) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 10.2 | 519.2 | PID NFKAPPAB CANONICAL PATHWAY | Canonical NF-kappaB pathway |
| 3.8 | 275.8 | PID PLK1 PATHWAY | PLK1 signaling events |
| 3.6 | 191.8 | PID AURORA B PATHWAY | Aurora B signaling |
| 2.6 | 179.4 | PID HES HEY PATHWAY | Notch-mediated HES/HEY network |
| 4.3 | 172.7 | PID SMAD2 3PATHWAY | Regulation of cytoplasmic and nuclear SMAD2/3 signaling |
| 5.2 | 155.1 | PID NFKAPPAB ATYPICAL PATHWAY | Atypical NF-kappaB pathway |
| 2.9 | 146.2 | PID ATR PATHWAY | ATR signaling pathway |
| 0.8 | 91.4 | PID CMYB PATHWAY | C-MYB transcription factor network |
| 1.9 | 89.1 | PID FOXM1 PATHWAY | FOXM1 transcription factor network |
| 1.6 | 84.4 | ST B CELL ANTIGEN RECEPTOR | B Cell Antigen Receptor |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 15.9 | 571.9 | REACTOME OXYGEN DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA INDUCIBLE FACTOR ALPHA | Genes involved in Oxygen-dependent Proline Hydroxylation of Hypoxia-inducible Factor Alpha |
| 3.8 | 357.1 | REACTOME MITOTIC PROMETAPHASE | Genes involved in Mitotic Prometaphase |
| 3.0 | 302.4 | REACTOME PEPTIDE CHAIN ELONGATION | Genes involved in Peptide chain elongation |
| 4.0 | 296.1 | REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX | Genes involved in Formation of the ternary complex, and subsequently, the 43S complex |
| 9.3 | 241.5 | REACTOME INHIBITION OF THE PROTEOLYTIC ACTIVITY OF APC C REQUIRED FOR THE ONSET OF ANAPHASE BY MITOTIC SPINDLE CHECKPOINT COMPONENTS | Genes involved in Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components |
| 2.5 | 233.1 | REACTOME ANTIVIRAL MECHANISM BY IFN STIMULATED GENES | Genes involved in Antiviral mechanism by IFN-stimulated genes |
| 2.2 | 186.6 | REACTOME RESPIRATORY ELECTRON TRANSPORT | Genes involved in Respiratory electron transport |
| 2.2 | 159.6 | REACTOME REGULATION OF ORNITHINE DECARBOXYLASE ODC | Genes involved in Regulation of ornithine decarboxylase (ODC) |
| 4.9 | 157.6 | REACTOME FORMATION OF TUBULIN FOLDING INTERMEDIATES BY CCT TRIC | Genes involved in Formation of tubulin folding intermediates by CCT/TriC |
| 6.7 | 140.2 | REACTOME DSCAM INTERACTIONS | Genes involved in DSCAM interactions |