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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
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Results for ZBTB4
Z-value: 1.30
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Transcription factors associated with ZBTB4
Network of associatons between targets according to the STRING database.
First level regulatory network of ZBTB4
| Promoter | Score | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chrX_+_103376389 Show fit | 35.77 |
ENST00000372645.3
ENST00000372635.1 |
brain expressed X-linked 3 |
|
| chrX_+_103376488 Show fit | 35.59 |
ENST00000361298.9
|
brain expressed X-linked 3 |
|
| chr14_-_68979251 Show fit | 30.80 |
ENST00000438964.6
ENST00000679147.1 |
actinin alpha 1 |
|
| chr14_-_68979274 Show fit | 30.79 |
ENST00000394419.9
|
actinin alpha 1 |
|
| chr14_-_68979314 Show fit | 30.52 |
ENST00000684713.1
ENST00000683198.1 ENST00000684598.1 ENST00000682331.1 ENST00000682291.1 ENST00000683342.1 |
actinin alpha 1 |
|
| chr14_-_68979076 Show fit | 30.26 |
ENST00000538545.6
ENST00000684639.1 |
actinin alpha 1 |
|
| chr14_-_68979436 Show fit | 27.32 |
ENST00000193403.10
|
actinin alpha 1 |
|
| chr12_+_104215772 Show fit | 21.44 |
ENST00000429002.6
ENST00000525566.6 |
thioredoxin reductase 1 |
|
| chr7_+_157337520 Show fit | 20.38 |
ENST00000412557.5
ENST00000453383.5 |
DnaJ heat shock protein family (Hsp40) member B6 |
|
| chr19_-_10420121 Show fit | 18.65 |
ENST00000593124.1
|
cell division cycle 37, HSP90 cochaperone |
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 6.5 | 149.7 | GO:0051639 | actin filament network formation(GO:0051639) |
| 0.5 | 71.4 | GO:0006919 | activation of cysteine-type endopeptidase activity involved in apoptotic process(GO:0006919) |
| 6.2 | 55.8 | GO:0070315 | G1 to G0 transition involved in cell differentiation(GO:0070315) |
| 1.3 | 33.9 | GO:0043968 | histone H2A acetylation(GO:0043968) |
| 3.8 | 30.0 | GO:0060715 | syncytiotrophoblast cell differentiation involved in labyrinthine layer development(GO:0060715) |
| 3.1 | 27.9 | GO:0031584 | activation of phospholipase D activity(GO:0031584) |
| 0.0 | 26.8 | GO:0030163 | protein catabolic process(GO:0030163) |
| 2.7 | 21.4 | GO:0001887 | selenium compound metabolic process(GO:0001887) |
| 0.1 | 21.0 | GO:0043488 | regulation of mRNA stability(GO:0043488) |
| 3.4 | 20.7 | GO:0048549 | positive regulation of pinocytosis(GO:0048549) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 5.8 | 149.7 | GO:0005916 | fascia adherens(GO:0005916) |
| 0.0 | 75.0 | GO:0070062 | extracellular exosome(GO:0070062) |
| 0.5 | 55.8 | GO:0030315 | T-tubule(GO:0030315) |
| 1.7 | 33.9 | GO:0016580 | Sin3 complex(GO:0016580) |
| 0.2 | 32.2 | GO:0043197 | dendritic spine(GO:0043197) |
| 0.2 | 30.0 | GO:0030018 | Z disc(GO:0030018) |
| 0.1 | 25.2 | GO:0031301 | integral component of organelle membrane(GO:0031301) |
| 0.1 | 23.4 | GO:0000922 | spindle pole(GO:0000922) |
| 0.9 | 20.7 | GO:0031143 | pseudopodium(GO:0031143) |
| 0.1 | 20.4 | GO:0001650 | fibrillar center(GO:0001650) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 5.4 | 152.4 | GO:0017166 | vinculin binding(GO:0017166) |
| 17.8 | 71.4 | GO:0005163 | nerve growth factor receptor binding(GO:0005163) |
| 3.3 | 55.8 | GO:0031432 | titin binding(GO:0031432) |
| 0.2 | 43.6 | GO:0047485 | protein N-terminus binding(GO:0047485) |
| 0.9 | 30.0 | GO:0001671 | ATPase activator activity(GO:0001671) |
| 0.1 | 28.5 | GO:0061630 | ubiquitin protein ligase activity(GO:0061630) |
| 0.8 | 27.9 | GO:0005086 | ARF guanyl-nucleotide exchange factor activity(GO:0005086) |
| 0.2 | 23.2 | GO:0003730 | mRNA 3'-UTR binding(GO:0003730) |
| 0.1 | 22.1 | GO:0005200 | structural constituent of cytoskeleton(GO:0005200) |
| 0.4 | 20.7 | GO:0042974 | retinoic acid receptor binding(GO:0042974) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.2 | 149.7 | PID SYNDECAN 4 PATHWAY | Syndecan-4-mediated signaling events |
| 0.2 | 36.4 | PID ERBB1 DOWNSTREAM PATHWAY | ErbB1 downstream signaling |
| 0.2 | 20.7 | PID PDGFRB PATHWAY | PDGFR-beta signaling pathway |
| 0.5 | 20.1 | PID PRL SIGNALING EVENTS PATHWAY | Signaling events mediated by PRL |
| 0.2 | 20.0 | PID ILK PATHWAY | Integrin-linked kinase signaling |
| 0.2 | 16.4 | PID CDC42 REG PATHWAY | Regulation of CDC42 activity |
| 0.2 | 13.9 | PID FOXM1 PATHWAY | FOXM1 transcription factor network |
| 0.1 | 13.9 | NABA ECM GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 0.1 | 12.0 | PID MYC REPRESS PATHWAY | Validated targets of C-MYC transcriptional repression |
| 0.2 | 10.1 | PID A6B1 A6B4 INTEGRIN PATHWAY | a6b1 and a6b4 Integrin signaling |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 4.5 | 149.7 | REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS | Genes involved in Cell-extracellular matrix interactions |
| 0.1 | 31.5 | REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION | Genes involved in Antigen processing: Ubiquitination & Proteasome degradation |
| 1.2 | 25.1 | REACTOME TETRAHYDROBIOPTERIN BH4 SYNTHESIS RECYCLING SALVAGE AND REGULATION | Genes involved in Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation |
| 0.7 | 22.5 | REACTOME SIGNALING BY CONSTITUTIVELY ACTIVE EGFR | Genes involved in Signaling by constitutively active EGFR |
| 0.6 | 21.4 | REACTOME SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI AND TRIPHOSPHATES | Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates |
| 0.7 | 20.7 | REACTOME NEPHRIN INTERACTIONS | Genes involved in Nephrin interactions |
| 0.9 | 17.9 | REACTOME ERKS ARE INACTIVATED | Genes involved in ERKs are inactivated |
| 0.2 | 17.0 | REACTOME ACTIVATION OF CHAPERONE GENES BY XBP1S | Genes involved in Activation of Chaperone Genes by XBP1(S) |
| 0.3 | 15.1 | REACTOME MITOCHONDRIAL PROTEIN IMPORT | Genes involved in Mitochondrial Protein Import |
| 0.3 | 14.9 | REACTOME G1 PHASE | Genes involved in G1 Phase |