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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
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Results for ZBTB6
Z-value: 1.39
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Transcription factors associated with ZBTB6
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| ZBTB6 | hg38_v1_chr9_-_122913299_122913333 | 0.14 | 4.5e-02 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of ZBTB6
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 8.9 | 53.1 | GO:0033274 | response to vitamin B2(GO:0033274) heterochromatin maintenance(GO:0070829) |
| 0.9 | 51.3 | GO:0006891 | intra-Golgi vesicle-mediated transport(GO:0006891) |
| 4.5 | 40.7 | GO:1903898 | negative regulation of PERK-mediated unfolded protein response(GO:1903898) negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation(GO:1903912) |
| 3.8 | 30.5 | GO:0007506 | gonadal mesoderm development(GO:0007506) |
| 0.5 | 30.4 | GO:0015701 | bicarbonate transport(GO:0015701) |
| 0.1 | 22.4 | GO:0035023 | regulation of Rho protein signal transduction(GO:0035023) |
| 0.2 | 21.5 | GO:0046854 | phosphatidylinositol phosphorylation(GO:0046854) |
| 5.3 | 21.2 | GO:0071879 | positive regulation of adrenergic receptor signaling pathway(GO:0071879) negative regulation of type B pancreatic cell development(GO:2000077) |
| 0.8 | 21.1 | GO:0031581 | hemidesmosome assembly(GO:0031581) |
| 5.2 | 20.9 | GO:1900138 | negative regulation of phospholipase A2 activity(GO:1900138) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 100.4 | GO:0005887 | integral component of plasma membrane(GO:0005887) |
| 0.3 | 43.4 | GO:0031225 | anchored component of membrane(GO:0031225) |
| 0.0 | 41.8 | GO:0016021 | integral component of membrane(GO:0016021) |
| 1.9 | 32.2 | GO:0000164 | protein phosphatase type 1 complex(GO:0000164) |
| 0.7 | 28.7 | GO:0045095 | keratin filament(GO:0045095) |
| 0.2 | 24.6 | GO:0005796 | Golgi lumen(GO:0005796) |
| 1.1 | 23.2 | GO:0030877 | beta-catenin destruction complex(GO:0030877) |
| 0.1 | 19.7 | GO:0005793 | endoplasmic reticulum-Golgi intermediate compartment(GO:0005793) |
| 0.8 | 18.6 | GO:0016471 | vacuolar proton-transporting V-type ATPase complex(GO:0016471) |
| 0.3 | 18.5 | GO:0031907 | peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 67.7 | GO:0005509 | calcium ion binding(GO:0005509) |
| 2.1 | 55.1 | GO:0031489 | myosin V binding(GO:0031489) |
| 8.9 | 53.1 | GO:0004489 | methylenetetrahydrofolate reductase (NAD(P)H) activity(GO:0004489) |
| 1.5 | 42.9 | GO:0050321 | tau-protein kinase activity(GO:0050321) |
| 0.3 | 35.4 | GO:0005089 | Rho guanyl-nucleotide exchange factor activity(GO:0005089) |
| 2.0 | 34.7 | GO:1990380 | Lys48-specific deubiquitinase activity(GO:1990380) |
| 1.5 | 30.4 | GO:0008510 | sodium:bicarbonate symporter activity(GO:0008510) |
| 0.2 | 29.5 | GO:0004222 | metalloendopeptidase activity(GO:0004222) |
| 0.2 | 28.4 | GO:0005200 | structural constituent of cytoskeleton(GO:0005200) |
| 0.2 | 26.0 | GO:0019888 | protein phosphatase regulator activity(GO:0019888) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 42.9 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.1 | 30.3 | NABA ECM GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 0.4 | 27.2 | ST JNK MAPK PATHWAY | JNK MAPK Pathway |
| 0.8 | 26.8 | PID BETA CATENIN DEG PATHWAY | Degradation of beta catenin |
| 0.3 | 26.4 | PID DELTA NP63 PATHWAY | Validated transcriptional targets of deltaNp63 isoforms |
| 0.5 | 21.9 | PID NCADHERIN PATHWAY | N-cadherin signaling events |
| 0.5 | 20.4 | PID EPHB FWD PATHWAY | EPHB forward signaling |
| 0.6 | 17.9 | PID S1P S1P4 PATHWAY | S1P4 pathway |
| 0.4 | 15.9 | PID ALK1 PATHWAY | ALK1 signaling events |
| 0.4 | 15.5 | PID NETRIN PATHWAY | Netrin-mediated signaling events |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.8 | 64.9 | REACTOME METABOLISM OF VITAMINS AND COFACTORS | Genes involved in Metabolism of vitamins and cofactors |
| 0.2 | 55.8 | REACTOME GENERIC TRANSCRIPTION PATHWAY | Genes involved in Generic Transcription Pathway |
| 0.5 | 33.8 | REACTOME NCAM1 INTERACTIONS | Genes involved in NCAM1 interactions |
| 0.2 | 32.0 | REACTOME TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES | Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides |
| 0.3 | 29.2 | REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY | Genes involved in Nuclear Receptor transcription pathway |
| 1.5 | 22.5 | REACTOME ROLE OF DCC IN REGULATING APOPTOSIS | Genes involved in Role of DCC in regulating apoptosis |
| 0.5 | 22.0 | REACTOME SIGNALING BY BMP | Genes involved in Signaling by BMP |
| 1.3 | 21.7 | REACTOME ACTIVATION OF CHAPERONES BY ATF6 ALPHA | Genes involved in Activation of Chaperones by ATF6-alpha |
| 1.1 | 21.2 | REACTOME AKT PHOSPHORYLATES TARGETS IN THE CYTOSOL | Genes involved in AKT phosphorylates targets in the cytosol |
| 0.5 | 20.6 | REACTOME GABA SYNTHESIS RELEASE REUPTAKE AND DEGRADATION | Genes involved in GABA synthesis, release, reuptake and degradation |