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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
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Results for ZFHX3
Z-value: 0.48
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Transcription factors associated with ZFHX3
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| ZFHX3 | hg38_v1_chr16_-_73048104_73048136 | -0.01 | 9.1e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of ZFHX3
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 14.7 | GO:0048665 | neuron fate specification(GO:0048665) |
| 0.1 | 9.5 | GO:0007498 | mesoderm development(GO:0007498) |
| 1.0 | 6.9 | GO:0060160 | negative regulation of dopamine receptor signaling pathway(GO:0060160) |
| 0.6 | 6.5 | GO:0043152 | induction of bacterial agglutination(GO:0043152) |
| 0.5 | 6.1 | GO:0052697 | flavonoid glucuronidation(GO:0052696) xenobiotic glucuronidation(GO:0052697) |
| 0.2 | 5.4 | GO:0032012 | regulation of ARF protein signal transduction(GO:0032012) |
| 1.1 | 5.3 | GO:0061107 | seminal vesicle development(GO:0061107) |
| 0.2 | 4.9 | GO:0034374 | low-density lipoprotein particle remodeling(GO:0034374) |
| 1.4 | 4.3 | GO:0052047 | interaction with other organism via secreted substance involved in symbiotic interaction(GO:0052047) negative regulation of cell-cell adhesion mediated by cadherin(GO:2000048) |
| 0.0 | 4.3 | GO:0034605 | cellular response to heat(GO:0034605) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 16.9 | GO:0005789 | endoplasmic reticulum membrane(GO:0005789) |
| 0.0 | 13.8 | GO:0005694 | chromosome(GO:0005694) |
| 0.3 | 6.9 | GO:0032591 | dendritic spine membrane(GO:0032591) |
| 0.5 | 6.5 | GO:0005577 | fibrinogen complex(GO:0005577) |
| 0.0 | 5.4 | GO:0032587 | ruffle membrane(GO:0032587) |
| 1.8 | 5.3 | GO:0036030 | protein C inhibitor-TMPRSS7 complex(GO:0036024) protein C inhibitor-TMPRSS11E complex(GO:0036025) protein C inhibitor-PLAT complex(GO:0036026) protein C inhibitor-PLAU complex(GO:0036027) protein C inhibitor-thrombin complex(GO:0036028) protein C inhibitor-KLK3 complex(GO:0036029) protein C inhibitor-plasma kallikrein complex(GO:0036030) serine protease inhibitor complex(GO:0097180) protein C inhibitor-coagulation factor V complex(GO:0097181) protein C inhibitor-coagulation factor Xa complex(GO:0097182) protein C inhibitor-coagulation factor XI complex(GO:0097183) |
| 0.7 | 4.3 | GO:0031232 | extrinsic component of external side of plasma membrane(GO:0031232) |
| 0.1 | 4.2 | GO:0005834 | heterotrimeric G-protein complex(GO:0005834) |
| 0.0 | 3.6 | GO:0072562 | blood microparticle(GO:0072562) |
| 0.0 | 3.5 | GO:0099572 | postsynaptic density(GO:0014069) postsynaptic specialization(GO:0099572) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 21.1 | GO:0001078 | transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078) |
| 0.2 | 6.9 | GO:0050780 | dopamine receptor binding(GO:0050780) |
| 0.0 | 6.5 | GO:0030674 | protein binding, bridging(GO:0030674) |
| 0.2 | 6.1 | GO:0015020 | glucuronosyltransferase activity(GO:0015020) |
| 0.2 | 5.4 | GO:0005086 | ARF guanyl-nucleotide exchange factor activity(GO:0005086) |
| 0.6 | 5.3 | GO:0032190 | acrosin binding(GO:0032190) |
| 0.2 | 4.9 | GO:0034185 | apolipoprotein binding(GO:0034185) |
| 0.0 | 4.4 | GO:0005516 | calmodulin binding(GO:0005516) |
| 0.5 | 4.3 | GO:1990405 | protein antigen binding(GO:1990405) |
| 0.3 | 4.2 | GO:0031821 | G-protein coupled serotonin receptor binding(GO:0031821) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 10.8 | PID UPA UPAR PATHWAY | Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling |
| 0.1 | 5.3 | ST INTERLEUKIN 4 PATHWAY | Interleukin 4 (IL-4) Pathway |
| 0.2 | 4.2 | PID S1P S1P4 PATHWAY | S1P4 pathway |
| 0.0 | 2.8 | PID HNF3B PATHWAY | FOXA2 and FOXA3 transcription factor networks |
| 0.0 | 2.6 | ST GA13 PATHWAY | G alpha 13 Pathway |
| 0.0 | 2.4 | PID AVB3 INTEGRIN PATHWAY | Integrins in angiogenesis |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 6.1 | REACTOME GLUCURONIDATION | Genes involved in Glucuronidation |
| 0.3 | 5.6 | REACTOME COMMON PATHWAY | Genes involved in Common Pathway |
| 0.2 | 4.3 | REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS | Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs) |
| 0.1 | 4.2 | REACTOME INHIBITION OF INSULIN SECRETION BY ADRENALINE NORADRENALINE | Genes involved in Inhibition of Insulin Secretion by Adrenaline/Noradrenaline |
| 0.2 | 3.9 | REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT | Genes involved in Chylomicron-mediated lipid transport |
| 0.1 | 2.4 | REACTOME AMYLOIDS | Genes involved in Amyloids |
| 0.0 | 2.1 | REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES | Genes involved in Chemokine receptors bind chemokines |
| 0.0 | 1.8 | REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY | Genes involved in Nuclear Receptor transcription pathway |
| 0.1 | 1.7 | REACTOME LIPOPROTEIN METABOLISM | Genes involved in Lipoprotein metabolism |
| 0.0 | 1.6 | REACTOME COMPLEMENT CASCADE | Genes involved in Complement cascade |