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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)

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Results for ZFHX3

Z-value: 0.48

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Transcription factors associated with ZFHX3

Gene Symbol Gene ID Gene Info
ZFHX3
ENSG00000140836.17 ZFHX3

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
ZFHX3hg38_v1_chr16_-_73048104_73048136-0.019.1e-01Click!

Activity profile of ZFHX3 motif

Sorted Z-values of ZFHX3 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of ZFHX3

PNG image of the network

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Top targets:

Promoter Score Transcript Gene Gene Info
chr2_-_2324323 7.48 ENST00000648339.1
ENST00000647694.1
MYT1L
myelin transcription factor 1 like
chr2_-_2324642 7.25 ENST00000650485.1
ENST00000649207.1
MYT1L
myelin transcription factor 1 like
chr19_+_735026 6.88 ENST00000592155.5
ENST00000590161.2
PALM
paralemmin
chr4_-_154590735 6.52 ENST00000403106.8
ENST00000622532.1
ENST00000651975.1
FGA
fibrinogen alpha chain
chr14_+_94561435 5.31 ENST00000557004.6
ENST00000555095.5
ENST00000298841.5
ENST00000554220.5
ENST00000553780.5
SERPINA4
SERPINA5
serpin family A member 4
serpin family A member 5
chr7_+_130486171 4.75 ENST00000341441.9
ENST00000416162.7
MEST
mesoderm specific transcript
chr7_+_130486324 4.72 ENST00000427521.6
ENST00000378576.9
MEST
mesoderm specific transcript
chr3_+_35680994 4.34 ENST00000441454.5
ARPP21
cAMP regulated phosphoprotein 21
chr6_+_160702238 4.29 ENST00000366924.6
ENST00000308192.14
ENST00000418964.1
PLG
plasminogen
chr16_+_56191476 4.20 ENST00000262493.12
GNAO1
G protein subunit alpha o1
chr14_-_100569780 3.75 ENST00000355173.7
BEGAIN
brain enriched guanylate kinase associated
chr20_-_37178966 3.37 ENST00000422138.1
MROH8
maestro heat like repeat family member 8
chr19_-_35812838 3.36 ENST00000653904.2
PRODH2
proline dehydrogenase 2
chr9_-_121050264 3.22 ENST00000223642.3
C5
complement C5
chr15_+_58431985 3.19 ENST00000433326.2
ENST00000299022.10
LIPC
lipase C, hepatic type
chr7_-_100428657 3.15 ENST00000360951.8
ENST00000398027.6
ENST00000684423.1
ENST00000472716.1
ZCWPW1
zinc finger CW-type and PWWP domain containing 1
chr17_+_42900791 3.03 ENST00000592383.5
ENST00000253801.7
ENST00000585489.1
G6PC1
glucose-6-phosphatase catalytic subunit 1
chr18_+_34976928 3.01 ENST00000591734.5
ENST00000413393.5
ENST00000589180.5
ENST00000587359.5
MAPRE2
microtubule associated protein RP/EB family member 2
chr8_-_18684033 2.87 ENST00000614430.3
PSD3
pleckstrin and Sec7 domain containing 3
chr8_-_18684093 2.55 ENST00000428502.6
PSD3
pleckstrin and Sec7 domain containing 3
chrX_+_103376389 2.47 ENST00000372645.3
ENST00000372635.1
BEX3
brain expressed X-linked 3
chr1_+_159587817 2.39 ENST00000255040.3
APCS
amyloid P component, serum
chr1_+_62597510 2.36 ENST00000371129.4
ANGPTL3
angiopoietin like 3
chr14_+_64704380 2.35 ENST00000247226.13
ENST00000394691.7
PLEKHG3
pleckstrin homology and RhoGEF domain containing G3
chr12_-_130716264 2.32 ENST00000643940.1
RIMBP2
RIMS binding protein 2
chr3_-_39280021 2.13 ENST00000399220.3
CX3CR1
C-X3-C motif chemokine receptor 1
chr2_+_233712905 2.12 ENST00000373414.4
UGT1A5
UDP glucuronosyltransferase family 1 member A5
chr2_+_233729042 2.07 ENST00000482026.6
UGT1A3
UDP glucuronosyltransferase family 1 member A3
chr2_+_87748087 2.05 ENST00000359481.9
PLGLB2
plasminogen like B2
chr2_-_60553409 1.92 ENST00000358510.6
ENST00000643004.1
BCL11A
BAF chromatin remodeling complex subunit BCL11A
chr2_+_233718734 1.91 ENST00000373409.8
UGT1A4
UDP glucuronosyltransferase family 1 member A4
chr4_-_148444674 1.82 ENST00000344721.8
NR3C2
nuclear receptor subfamily 3 group C member 2
chr8_+_103819244 1.80 ENST00000262231.14
ENST00000507740.5
ENST00000408894.6
RIMS2
regulating synaptic membrane exocytosis 2
chr3_-_114758940 1.80 ENST00000464560.5
ZBTB20
zinc finger and BTB domain containing 20
chr6_-_160664270 1.72 ENST00000316300.10
LPA
lipoprotein(a)
chr2_-_87021844 1.57 ENST00000355705.4
ENST00000409310.6
PLGLB1
plasminogen like B1
chr4_+_73436198 1.42 ENST00000395792.7
AFP
alpha fetoprotein
chr2_-_60553558 1.41 ENST00000642439.1
ENST00000356842.9
BCL11A
BAF chromatin remodeling complex subunit BCL11A
chr4_+_3441960 1.40 ENST00000382774.8
ENST00000511533.1
HGFAC
HGF activator
chr6_+_28349907 1.35 ENST00000252211.7
ENST00000341464.9
ENST00000377255.3
ZKSCAN3
zinc finger with KRAB and SCAN domains 3
chr4_+_73436244 1.34 ENST00000226359.2
AFP
alpha fetoprotein
chr11_-_61920267 1.24 ENST00000531922.2
ENST00000301773.9
RAB3IL1
RAB3A interacting protein like 1
chr4_+_73481737 1.23 ENST00000226355.5
AFM
afamin
chr7_-_44541318 0.98 ENST00000381160.8
NPC1L1
NPC1 like intracellular cholesterol transporter 1
chr7_-_44541262 0.92 ENST00000289547.8
ENST00000546276.5
ENST00000423141.1
NPC1L1
NPC1 like intracellular cholesterol transporter 1
chr8_-_140764386 0.90 ENST00000520151.5
ENST00000519024.5
ENST00000519465.5
PTK2
protein tyrosine kinase 2
chr17_-_69244846 0.88 ENST00000269081.8
ABCA10
ATP binding cassette subfamily A member 10
chr20_+_43558968 0.83 ENST00000647834.1
ENST00000373100.7
ENST00000648083.1
ENST00000648530.1
SGK2
serum/glucocorticoid regulated kinase 2
chr22_-_30574572 0.77 ENST00000402369.5
GAL3ST1
galactose-3-O-sulfotransferase 1
chr6_-_32407123 0.73 ENST00000374993.4
ENST00000544175.2
ENST00000454136.7
ENST00000446536.2
BTNL2
butyrophilin like 2
chr4_+_99574812 0.70 ENST00000422897.6
ENST00000265517.10
MTTP
microsomal triglyceride transfer protein
chr20_-_7940444 0.60 ENST00000378789.4
HAO1
hydroxyacid oxidase 1
chr11_-_102705737 0.58 ENST00000260229.5
MMP27
matrix metallopeptidase 27
chr12_-_7665897 0.52 ENST00000229304.5
APOBEC1
apolipoprotein B mRNA editing enzyme catalytic subunit 1
chr18_-_55422306 0.52 ENST00000566777.5
ENST00000626584.2
TCF4
transcription factor 4
chr7_+_151028422 0.50 ENST00000542328.5
ENST00000461373.5
ENST00000297504.10
ENST00000358849.9
ENST00000498578.5
ENST00000477719.5
ENST00000477092.5
ABCB8
ATP binding cassette subfamily B member 8
chrX_-_18672101 0.48 ENST00000379984.4
RS1
retinoschisin 1
chr4_-_99435134 0.47 ENST00000476959.5
ENST00000482593.5
ADH7
alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide
chr14_+_39233908 0.47 ENST00000280082.4
MIA2
MIA SH3 domain ER export factor 2
chr12_-_55296569 0.46 ENST00000358433.3
OR6C6
olfactory receptor family 6 subfamily C member 6
chr5_+_141475928 0.42 ENST00000611950.1
ENST00000308177.5
ENST00000617641.4
ENST00000621008.1
ENST00000617222.4
PCDHGC3
protocadherin gamma subfamily C, 3
chr1_-_160579439 0.42 ENST00000368054.8
ENST00000368048.7
ENST00000311224.8
ENST00000368051.3
ENST00000534968.5
CD84
CD84 molecule
chr18_+_58341038 0.41 ENST00000679791.1
NEDD4L
NEDD4 like E3 ubiquitin protein ligase
chr4_+_70592253 0.39 ENST00000322937.10
ENST00000613447.4
AMBN
ameloblastin
chr3_-_167474026 0.37 ENST00000466903.1
ENST00000264677.8
SERPINI2
serpin family I member 2
chr6_+_25754699 0.33 ENST00000439485.6
ENST00000377905.9
SLC17A4
solute carrier family 17 member 4
chr6_+_29111560 0.33 ENST00000377169.2
OR2J3
olfactory receptor family 2 subfamily J member 3
chr5_+_141245384 0.33 ENST00000623671.1
ENST00000231173.6
PCDHB15
protocadherin beta 15
chr19_+_49513353 0.31 ENST00000596975.5
FCGRT
Fc fragment of IgG receptor and transporter
chr4_-_99435336 0.28 ENST00000437033.7
ADH7
alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide
chr2_+_184598520 0.23 ENST00000302277.7
ZNF804A
zinc finger protein 804A
chrX_-_32155462 0.22 ENST00000359836.5
ENST00000378707.7
ENST00000541735.5
ENST00000684130.1
ENST00000682238.1
ENST00000620040.5
ENST00000474231.5
DMD
dystrophin
chr19_+_53962925 0.21 ENST00000270458.4
CACNG8
calcium voltage-gated channel auxiliary subunit gamma 8
chr8_-_69833338 0.20 ENST00000524945.5
SLCO5A1
solute carrier organic anion transporter family member 5A1
chr11_+_8019193 0.09 ENST00000534099.5
TUB
TUB bipartite transcription factor
chr3_-_108529322 0.04 ENST00000273353.4
MYH15
myosin heavy chain 15
chr6_-_116126120 0.01 ENST00000452729.1
ENST00000651968.1
ENST00000243222.8
COL10A1
collagen type X alpha 1 chain
chr7_+_48924559 0.01 ENST00000650262.1
CDC14C
cell division cycle 14C

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
1.4 4.3 GO:0052047 interaction with other organism via secreted substance involved in symbiotic interaction(GO:0052047) negative regulation of cell-cell adhesion mediated by cadherin(GO:2000048)
1.1 3.4 GO:0010133 proline catabolic process to glutamate(GO:0010133)
1.1 5.3 GO:0061107 seminal vesicle development(GO:0061107)
1.0 6.9 GO:0060160 negative regulation of dopamine receptor signaling pathway(GO:0060160)
0.8 3.2 GO:2000173 negative regulation of dendrite extension(GO:1903860) regulation of neuron remodeling(GO:1904799) negative regulation of neuron remodeling(GO:1904800) negative regulation of branching morphogenesis of a nerve(GO:2000173)
0.8 3.2 GO:0010760 negative regulation of macrophage chemotaxis(GO:0010760)
0.8 2.4 GO:1903015 regulation of exo-alpha-sialidase activity(GO:1903015)
0.6 6.5 GO:0043152 induction of bacterial agglutination(GO:0043152)
0.5 2.1 GO:0002881 negative regulation of chronic inflammatory response to non-antigenic stimulus(GO:0002881)
0.5 6.1 GO:0052697 flavonoid glucuronidation(GO:0052696) xenobiotic glucuronidation(GO:0052697)
0.4 14.7 GO:0048665 neuron fate specification(GO:0048665)
0.3 2.4 GO:0010519 negative regulation of phospholipase activity(GO:0010519)
0.2 4.9 GO:0034374 low-density lipoprotein particle remodeling(GO:0034374)
0.2 1.8 GO:0098814 spontaneous neurotransmitter secretion(GO:0061669) spontaneous synaptic transmission(GO:0098814)
0.2 5.4 GO:0032012 regulation of ARF protein signal transduction(GO:0032012)
0.2 0.8 GO:0010430 fatty acid omega-oxidation(GO:0010430)
0.2 0.7 GO:0034196 acylglycerol transport(GO:0034196) triglyceride transport(GO:0034197)
0.2 2.8 GO:0001542 ovulation from ovarian follicle(GO:0001542)
0.1 0.4 GO:0032661 regulation of interleukin-18 production(GO:0032661)
0.1 1.4 GO:2000773 negative regulation of cellular senescence(GO:2000773)
0.1 0.3 GO:0002416 IgG immunoglobulin transcytosis in epithelial cells mediated by FcRn immunoglobulin receptor(GO:0002416)
0.1 1.9 GO:0030299 intestinal cholesterol absorption(GO:0030299) intestinal lipid absorption(GO:0098856)
0.1 4.2 GO:0043278 response to isoquinoline alkaloid(GO:0014072) response to morphine(GO:0043278)
0.1 0.5 GO:0016554 cytidine to uridine editing(GO:0016554) DNA cytosine deamination(GO:0070383)
0.1 0.8 GO:0006682 galactosylceramide biosynthetic process(GO:0006682) galactolipid biosynthetic process(GO:0019375)
0.1 0.6 GO:0009441 glycolate metabolic process(GO:0009441)
0.1 0.9 GO:0051964 negative regulation of synapse assembly(GO:0051964)
0.1 9.5 GO:0007498 mesoderm development(GO:0007498)
0.0 0.4 GO:2001288 positive regulation of caveolin-mediated endocytosis(GO:2001288)
0.0 0.5 GO:0009642 response to light intensity(GO:0009642)
0.0 2.3 GO:0010923 negative regulation of phosphatase activity(GO:0010923)
0.0 1.2 GO:0051180 vitamin transport(GO:0051180)
0.0 4.3 GO:0034605 cellular response to heat(GO:0034605)
0.0 2.5 GO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process(GO:0006919)
0.0 0.2 GO:0014809 regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion(GO:0014809)
0.0 0.3 GO:0035435 phosphate ion transmembrane transport(GO:0035435)
0.0 1.1 GO:0032760 positive regulation of tumor necrosis factor production(GO:0032760)
0.0 2.4 GO:0035023 regulation of Rho protein signal transduction(GO:0035023)
0.0 0.4 GO:0016339 calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0016339)
0.0 0.1 GO:0097500 receptor localization to nonmotile primary cilium(GO:0097500)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
1.8 5.3 GO:0036030 protein C inhibitor-TMPRSS7 complex(GO:0036024) protein C inhibitor-TMPRSS11E complex(GO:0036025) protein C inhibitor-PLAT complex(GO:0036026) protein C inhibitor-PLAU complex(GO:0036027) protein C inhibitor-thrombin complex(GO:0036028) protein C inhibitor-KLK3 complex(GO:0036029) protein C inhibitor-plasma kallikrein complex(GO:0036030) serine protease inhibitor complex(GO:0097180) protein C inhibitor-coagulation factor V complex(GO:0097181) protein C inhibitor-coagulation factor Xa complex(GO:0097182) protein C inhibitor-coagulation factor XI complex(GO:0097183)
0.7 4.3 GO:0031232 extrinsic component of external side of plasma membrane(GO:0031232)
0.5 6.5 GO:0005577 fibrinogen complex(GO:0005577)
0.4 3.2 GO:0005579 membrane attack complex(GO:0005579)
0.3 6.9 GO:0032591 dendritic spine membrane(GO:0032591)
0.1 3.0 GO:0035371 microtubule plus-end(GO:0035371)
0.1 0.6 GO:0042406 extrinsic component of endoplasmic reticulum membrane(GO:0042406)
0.1 3.2 GO:0034364 high-density lipoprotein particle(GO:0034364)
0.1 1.7 GO:1990777 plasma lipoprotein particle(GO:0034358) lipoprotein particle(GO:1990777)
0.1 2.1 GO:0032809 neuronal cell body membrane(GO:0032809) cell body membrane(GO:0044298)
0.1 4.2 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.1 0.5 GO:0043190 ATP-binding cassette (ABC) transporter complex(GO:0043190)
0.0 1.8 GO:0048786 presynaptic active zone(GO:0048786)
0.0 5.4 GO:0032587 ruffle membrane(GO:0032587)
0.0 1.9 GO:0031526 brush border membrane(GO:0031526)
0.0 0.2 GO:0016013 syntrophin complex(GO:0016013)
0.0 3.6 GO:0072562 blood microparticle(GO:0072562)
0.0 16.9 GO:0005789 endoplasmic reticulum membrane(GO:0005789)
0.0 3.3 GO:0030027 lamellipodium(GO:0030027)
0.0 3.5 GO:0099572 postsynaptic density(GO:0014069) postsynaptic specialization(GO:0099572)
0.0 13.8 GO:0005694 chromosome(GO:0005694)
0.0 0.6 GO:0031907 peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907)
0.0 0.3 GO:0032391 photoreceptor connecting cilium(GO:0032391)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 2.5 GO:0005163 nerve growth factor receptor binding(GO:0005163)
0.6 5.3 GO:0032190 acrosin binding(GO:0032190)
0.5 4.3 GO:1990405 protein antigen binding(GO:1990405)
0.5 2.1 GO:0016495 C-X3-C chemokine receptor activity(GO:0016495)
0.4 1.2 GO:0008431 vitamin E binding(GO:0008431)
0.3 1.4 GO:0016623 oxidoreductase activity, acting on the aldehyde or oxo group of donors, oxygen as acceptor(GO:0016623)
0.3 4.2 GO:0031821 G-protein coupled serotonin receptor binding(GO:0031821)
0.2 4.9 GO:0034185 apolipoprotein binding(GO:0034185)
0.2 6.9 GO:0050780 dopamine receptor binding(GO:0050780)
0.2 6.1 GO:0015020 glucuronosyltransferase activity(GO:0015020)
0.2 5.4 GO:0005086 ARF guanyl-nucleotide exchange factor activity(GO:0005086)
0.1 3.4 GO:0071949 FAD binding(GO:0071949)
0.1 0.8 GO:0001849 complement component C1q binding(GO:0001849)
0.1 21.1 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.1 0.8 GO:0050694 galactosylceramide sulfotransferase activity(GO:0001733) galactose 3-O-sulfotransferase activity(GO:0050694)
0.1 2.4 GO:0004859 phospholipase inhibitor activity(GO:0004859)
0.1 0.3 GO:0019770 IgG receptor activity(GO:0019770)
0.1 1.9 GO:0031489 myosin V binding(GO:0031489)
0.1 3.2 GO:0008009 chemokine activity(GO:0008009)
0.1 0.5 GO:0004126 cytidine deaminase activity(GO:0004126)
0.0 0.4 GO:0030021 extracellular matrix structural constituent conferring compression resistance(GO:0030021) structural constituent of tooth enamel(GO:0030345)
0.0 0.5 GO:0070492 oligosaccharide binding(GO:0070492)
0.0 0.9 GO:0008432 JUN kinase binding(GO:0008432)
0.0 0.8 GO:0017081 chloride channel regulator activity(GO:0017081)
0.0 0.3 GO:0005436 sodium:phosphate symporter activity(GO:0005436)
0.0 0.5 GO:0001087 transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, TFIIB-class binding(GO:0001087)
0.0 1.2 GO:0017112 Rab guanyl-nucleotide exchange factor activity(GO:0017112)
0.0 0.4 GO:0019871 sodium channel inhibitor activity(GO:0019871)
0.0 6.5 GO:0030674 protein binding, bridging(GO:0030674)
0.0 2.4 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.0 1.8 GO:0003707 steroid hormone receptor activity(GO:0003707)
0.0 4.4 GO:0005516 calmodulin binding(GO:0005516)
0.0 0.2 GO:0050998 nitric-oxide synthase binding(GO:0050998)
0.0 0.7 GO:0005548 phospholipid transporter activity(GO:0005548)
0.0 1.8 GO:0017137 Rab GTPase binding(GO:0017137)
0.0 1.4 GO:0042626 ATPase activity, coupled to transmembrane movement of substances(GO:0042626)
0.0 3.0 GO:0008017 microtubule binding(GO:0008017)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 10.8 PID UPA UPAR PATHWAY Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
0.2 4.2 PID S1P S1P4 PATHWAY S1P4 pathway
0.1 5.3 ST INTERLEUKIN 4 PATHWAY Interleukin 4 (IL-4) Pathway
0.0 2.6 ST GA13 PATHWAY G alpha 13 Pathway
0.0 2.8 PID HNF3B PATHWAY FOXA2 and FOXA3 transcription factor networks
0.0 2.4 PID AVB3 INTEGRIN PATHWAY Integrins in angiogenesis

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 5.6 REACTOME COMMON PATHWAY Genes involved in Common Pathway
0.2 6.1 REACTOME GLUCURONIDATION Genes involved in Glucuronidation
0.2 4.3 REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.2 3.9 REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT Genes involved in Chylomicron-mediated lipid transport
0.1 4.2 REACTOME INHIBITION OF INSULIN SECRETION BY ADRENALINE NORADRENALINE Genes involved in Inhibition of Insulin Secretion by Adrenaline/Noradrenaline
0.1 1.7 REACTOME LIPOPROTEIN METABOLISM Genes involved in Lipoprotein metabolism
0.1 0.8 REACTOME ETHANOL OXIDATION Genes involved in Ethanol oxidation
0.1 2.4 REACTOME AMYLOIDS Genes involved in Amyloids
0.0 0.9 REACTOME ABCA TRANSPORTERS IN LIPID HOMEOSTASIS Genes involved in ABCA transporters in lipid homeostasis
0.0 0.9 REACTOME P130CAS LINKAGE TO MAPK SIGNALING FOR INTEGRINS Genes involved in p130Cas linkage to MAPK signaling for integrins
0.0 1.6 REACTOME COMPLEMENT CASCADE Genes involved in Complement cascade
0.0 2.1 REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES Genes involved in Chemokine receptors bind chemokines
0.0 1.8 REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.0 0.8 REACTOME GLYCOSPHINGOLIPID METABOLISM Genes involved in Glycosphingolipid metabolism