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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
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Results for ZFX
Z-value: 2.23
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Transcription factors associated with ZFX
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| ZFX | hg38_v1_chrX_+_24149629_24149696 | -0.67 | 5.6e-30 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of ZFX
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.9 | 287.4 | GO:0006521 | regulation of cellular amino acid metabolic process(GO:0006521) |
| 0.2 | 116.1 | GO:0002283 | neutrophil activation involved in immune response(GO:0002283) neutrophil degranulation(GO:0043312) |
| 7.2 | 114.9 | GO:0045116 | protein neddylation(GO:0045116) |
| 7.7 | 100.0 | GO:0006265 | DNA topological change(GO:0006265) |
| 2.0 | 81.7 | GO:0070979 | protein K11-linked ubiquitination(GO:0070979) |
| 3.5 | 69.6 | GO:0032968 | positive regulation of transcription elongation from RNA polymerase II promoter(GO:0032968) |
| 1.1 | 66.4 | GO:0000245 | spliceosomal complex assembly(GO:0000245) |
| 20.5 | 61.5 | GO:1901254 | modulation by host of viral RNA genome replication(GO:0044830) positive regulation of intracellular transport of viral material(GO:1901254) |
| 1.4 | 59.8 | GO:0034314 | Arp2/3 complex-mediated actin nucleation(GO:0034314) |
| 0.9 | 59.5 | GO:0032435 | negative regulation of proteasomal ubiquitin-dependent protein catabolic process(GO:0032435) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.3 | 224.4 | GO:0042470 | melanosome(GO:0042470) pigment granule(GO:0048770) |
| 1.8 | 112.5 | GO:0000502 | proteasome complex(GO:0000502) |
| 9.0 | 107.9 | GO:0019773 | proteasome core complex, alpha-subunit complex(GO:0019773) |
| 0.8 | 94.6 | GO:0035578 | azurophil granule lumen(GO:0035578) |
| 0.8 | 83.7 | GO:0022625 | cytosolic large ribosomal subunit(GO:0022625) |
| 1.7 | 77.8 | GO:0090544 | BAF-type complex(GO:0090544) |
| 0.2 | 75.2 | GO:0016607 | nuclear speck(GO:0016607) |
| 0.8 | 74.1 | GO:0005643 | nuclear pore(GO:0005643) |
| 2.6 | 72.0 | GO:0005680 | anaphase-promoting complex(GO:0005680) |
| 0.2 | 70.9 | GO:0005743 | mitochondrial inner membrane(GO:0005743) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 162.8 | GO:0003723 | RNA binding(GO:0003723) |
| 2.9 | 133.2 | GO:0008139 | nuclear localization sequence binding(GO:0008139) |
| 4.5 | 125.1 | GO:0004298 | threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003) |
| 2.8 | 113.9 | GO:0070577 | lysine-acetylated histone binding(GO:0070577) |
| 0.3 | 113.5 | GO:0045296 | cadherin binding(GO:0045296) |
| 1.2 | 101.5 | GO:0019003 | GDP binding(GO:0019003) |
| 0.3 | 99.8 | GO:0003713 | transcription coactivator activity(GO:0003713) |
| 2.6 | 78.9 | GO:0008301 | DNA binding, bending(GO:0008301) |
| 1.4 | 78.1 | GO:0003743 | translation initiation factor activity(GO:0003743) |
| 10.7 | 74.7 | GO:0019788 | NEDD8 transferase activity(GO:0019788) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.7 | 151.6 | PID P53 REGULATION PATHWAY | p53 pathway |
| 3.2 | 129.1 | PID SMAD2 3PATHWAY | Regulation of cytoplasmic and nuclear SMAD2/3 signaling |
| 1.0 | 118.1 | PID MYC ACTIV PATHWAY | Validated targets of C-MYC transcriptional activation |
| 3.8 | 106.5 | PID ERB GENOMIC PATHWAY | Validated nuclear estrogen receptor beta network |
| 2.1 | 106.4 | PID BARD1 PATHWAY | BARD1 signaling events |
| 1.7 | 71.1 | PID ALK1 PATHWAY | ALK1 signaling events |
| 0.8 | 66.2 | PID RAC1 PATHWAY | RAC1 signaling pathway |
| 1.7 | 64.8 | PID P38 MK2 PATHWAY | p38 signaling mediated by MAPKAP kinases |
| 2.3 | 62.7 | PID ARF 3PATHWAY | Arf1 pathway |
| 0.9 | 57.9 | PID PLK1 PATHWAY | PLK1 signaling events |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 4.0 | 312.9 | REACTOME SCF BETA TRCP MEDIATED DEGRADATION OF EMI1 | Genes involved in SCF-beta-TrCP mediated degradation of Emi1 |
| 3.1 | 124.3 | REACTOME FATTY ACYL COA BIOSYNTHESIS | Genes involved in Fatty Acyl-CoA Biosynthesis |
| 1.3 | 116.7 | REACTOME RESPIRATORY ELECTRON TRANSPORT ATP SYNTHESIS BY CHEMIOSMOTIC COUPLING AND HEAT PRODUCTION BY UNCOUPLING PROTEINS | Genes involved in Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. |
| 0.8 | 115.2 | REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION | Genes involved in Antigen processing: Ubiquitination & Proteasome degradation |
| 1.4 | 105.5 | REACTOME ACTIVATION OF THE MRNA UPON BINDING OF THE CAP BINDING COMPLEX AND EIFS AND SUBSEQUENT BINDING TO 43S | Genes involved in Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S |
| 1.1 | 105.2 | REACTOME INFLUENZA VIRAL RNA TRANSCRIPTION AND REPLICATION | Genes involved in Influenza Viral RNA Transcription and Replication |
| 1.4 | 82.7 | REACTOME TRANSPORT OF MATURE TRANSCRIPT TO CYTOPLASM | Genes involved in Transport of Mature Transcript to Cytoplasm |
| 1.4 | 71.9 | REACTOME ANTIVIRAL MECHANISM BY IFN STIMULATED GENES | Genes involved in Antiviral mechanism by IFN-stimulated genes |
| 3.1 | 65.1 | REACTOME AUTODEGRADATION OF CDH1 BY CDH1 APC C | Genes involved in Autodegradation of Cdh1 by Cdh1:APC/C |
| 1.5 | 63.6 | REACTOME MRNA SPLICING MINOR PATHWAY | Genes involved in mRNA Splicing - Minor Pathway |