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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)

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Results for ZIC1

Z-value: 0.72

Motif logo

Transcription factors associated with ZIC1

Gene Symbol Gene ID Gene Info
ENSG00000152977.10 ZIC1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
ZIC1hg38_v1_chr3_+_147409357_147409381-0.082.6e-01Click!

Activity profile of ZIC1 motif

Sorted Z-values of ZIC1 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of ZIC1

PNG image of the network

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Promoter Score Transcript Gene Gene Info
chr14_-_68979436 13.58 ENST00000193403.10
actinin alpha 1
chr14_-_68979314 13.00 ENST00000684713.1
ENST00000683198.1
ENST00000684598.1
ENST00000682331.1
ENST00000682291.1
ENST00000683342.1
actinin alpha 1
chr14_-_68979274 12.82 ENST00000394419.9
actinin alpha 1
chr14_-_68979251 12.29 ENST00000438964.6
ENST00000679147.1
actinin alpha 1
chr14_-_68979076 12.28 ENST00000538545.6
ENST00000684639.1
actinin alpha 1
chr9_-_35103178 8.56 ENST00000452248.6
ENST00000619795.4
stomatin like 2
chr1_+_65147657 8.25 ENST00000546702.5
adenylate kinase 4
chr9_-_35103108 8.15 ENST00000356493.10
stomatin like 2
chr4_-_55636259 6.52 ENST00000505262.5
ENST00000507338.1
neuromedin U
chr4_-_55636284 6.46 ENST00000511469.5
ENST00000264218.7
neuromedin U
chr17_-_979726 6.36 ENST00000336868.8
nucleoredoxin
chr13_-_44474296 5.33 ENST00000611198.4
TSC22 domain family member 1
chrX_-_130165825 5.20 ENST00000675240.1
ENST00000319908.8
ENST00000674546.1
ENST00000287295.8
apoptosis inducing factor mitochondria associated 1
chrX_-_130165699 4.97 ENST00000676328.1
ENST00000675857.1
ENST00000675427.1
ENST00000675092.1
apoptosis inducing factor mitochondria associated 1
chrX_-_130165873 4.84 ENST00000676229.1
apoptosis inducing factor mitochondria associated 1
chr20_+_56629296 4.84 ENST00000201031.3
transcription factor AP-2 gamma
chr1_-_43367689 4.83 ENST00000621943.4
ELOVL fatty acid elongase 1
chrX_-_130165664 4.67 ENST00000535724.6
ENST00000346424.6
ENST00000676436.1
apoptosis inducing factor mitochondria associated 1
chr1_-_43367956 4.67 ENST00000372458.8
ELOVL fatty acid elongase 1
chr16_+_55479188 4.62 ENST00000219070.9
matrix metallopeptidase 2
chrX_+_46912276 4.59 ENST00000424392.5
ENST00000611250.4
jade family PHD finger 3
chrX_+_46912412 4.53 ENST00000614628.5
jade family PHD finger 3
chr8_-_63038788 4.53 ENST00000518113.2
ENST00000260118.7
ENST00000677482.1
gamma-glutamyl hydrolase
chr1_-_43368039 4.01 ENST00000413844.3
ELOVL fatty acid elongase 1
chr1_-_153670966 3.86 ENST00000368681.1
ENST00000361891.9
ENST00000615950.4
interleukin enhancer binding factor 2
chr1_+_65147514 3.77 ENST00000545314.5
adenylate kinase 4
chr4_+_6269831 3.70 ENST00000503569.5
ENST00000673991.1
ENST00000682275.1
ENST00000226760.5
wolframin ER transmembrane glycoprotein
chr4_-_185812209 3.60 ENST00000393523.6
ENST00000393528.7
ENST00000449407.6
sorbin and SH3 domain containing 2
chr1_+_23793649 3.59 ENST00000374501.1
lysophospholipase 2
chr14_+_73490926 3.54 ENST00000304061.8
ribosomal oxygenase 1
chr10_+_113709261 3.18 ENST00000672138.1
ENST00000452490.3
caspase 7
chr15_+_80060113 2.87 ENST00000618205.4
zinc finger AN1-type containing 6
chr9_-_16870702 2.85 ENST00000380667.6
ENST00000545497.5
ENST00000486514.5
basonuclin 2
chr19_-_42255119 2.83 ENST00000222329.9
ENST00000594664.1
ETS2 repressor factor
novel protein
chr14_+_22871732 2.83 ENST00000359591.9
LDL receptor related protein 10
chr9_-_109498251 2.81 ENST00000374541.4
ENST00000262539.7
protein tyrosine phosphatase non-receptor type 3
chr11_+_67056805 2.76 ENST00000308831.7
ras homolog family member D
chr3_-_50292404 2.64 ENST00000417626.8
interferon related developmental regulator 2
chr19_+_44809053 2.62 ENST00000611077.5
basal cell adhesion molecule (Lutheran blood group)
chr19_+_44809089 2.61 ENST00000270233.12
ENST00000591520.6
basal cell adhesion molecule (Lutheran blood group)
chr1_+_16022004 2.60 ENST00000439316.6
chloride voltage-gated channel Ka
chr4_+_6269869 2.57 ENST00000506362.2
wolframin ER transmembrane glycoprotein
chr9_-_16870662 2.52 ENST00000380672.9
basonuclin 2
chr10_-_33334625 2.47 ENST00000374875.5
ENST00000374822.8
ENST00000374867.7
neuropilin 1
chr11_+_116830529 2.46 ENST00000630701.1
apolipoprotein C3
chr3_+_51977833 2.42 ENST00000637978.1
ABHD14A-ACY1 readthrough
chr1_+_16021871 2.42 ENST00000375692.5
chloride voltage-gated channel Ka
chr1_+_16022030 2.38 ENST00000331433.5
chloride voltage-gated channel Ka
chr2_+_233760265 2.34 ENST00000305208.10
ENST00000360418.4
UDP glucuronosyltransferase family 1 member A1
chr3_-_79767987 2.33 ENST00000464233.6
roundabout guidance receptor 1
chrX_+_13689171 2.29 ENST00000618931.2
RAB9A, member RAS oncogene family
chr1_-_111449209 2.28 ENST00000235090.10
WD repeat domain 77
chr2_-_1744442 2.25 ENST00000433670.5
ENST00000425171.1
ENST00000252804.9
peroxidasin
chrX_+_24693879 2.20 ENST00000379068.8
ENST00000677890.1
ENST00000379059.7
DNA polymerase alpha 1, catalytic subunit
chr2_+_79120474 2.19 ENST00000233735.2
regenerating family member 1 alpha
chr1_-_153616289 2.10 ENST00000368701.5
ENST00000344616.4
S100 calcium binding protein A14
chr22_-_30591850 2.08 ENST00000335214.8
ENST00000406208.7
ENST00000402284.7
ENST00000354694.12
pescadillo ribosomal biogenesis factor 1
chr18_+_63752935 2.03 ENST00000425392.5
ENST00000336429.6
serpin family B member 7
chr4_+_678189 2.02 ENST00000507804.1
myosin light chain 5
chr10_-_33334898 2.00 ENST00000395995.5
neuropilin 1
chr17_+_30477362 1.99 ENST00000225724.9
ENST00000451249.7
ENST00000467337.6
ENST00000581721.5
ENST00000414833.2
golgi SNAP receptor complex member 1
chr15_+_80059568 1.96 ENST00000613266.4
ENST00000561060.5
zinc finger AN1-type containing 6
chr14_+_54567100 1.95 ENST00000554335.6
sterile alpha motif domain containing 4A
chr15_+_80059635 1.93 ENST00000559157.5
zinc finger AN1-type containing 6
chr14_-_57268810 1.89 ENST00000413566.6
ENST00000340918.11
ENST00000621441.5
exocyst complex component 5
chr6_+_110874775 1.89 ENST00000675380.1
ENST00000368882.8
ENST00000368877.9
ENST00000368885.8
ENST00000672937.2
adenosylmethionine decarboxylase 1
chr11_+_66011994 1.87 ENST00000312134.3
cystatin E/M
chr1_-_161118024 1.87 ENST00000368010.4
prefoldin subunit 2
chr17_-_55732074 1.80 ENST00000575734.5
transmembrane protein 100
chr4_+_24795560 1.75 ENST00000382120.4
superoxide dismutase 3
chr19_-_3028356 1.73 ENST00000586422.5
TLE family member 2, transcriptional corepressor
chr11_-_2161158 1.68 ENST00000421783.1
ENST00000397262.5
ENST00000381330.5
ENST00000250971.7
ENST00000397270.1
insulin
INS-IGF2 readthrough
chr1_+_161118083 1.67 ENST00000368009.7
ENST00000368007.8
ENST00000392190.9
ENST00000368008.5
nitrilase 1
chr10_-_33335074 1.66 ENST00000432372.6
neuropilin 1
chr22_+_39014282 1.63 ENST00000381568.9
novel protein
chr22_+_29306582 1.62 ENST00000616432.4
ENST00000416823.1
ENST00000428622.1
growth arrest specific 2 like 1
chr6_-_87095059 1.57 ENST00000369582.6
ENST00000610310.3
ENST00000630630.2
ENST00000627148.3
ENST00000625577.1
glycoprotein hormones, alpha polypeptide
chr11_-_134253248 1.57 ENST00000392595.6
ENST00000352327.5
ENST00000341541.8
ENST00000392594.7
thymocyte nuclear protein 1
chrX_+_13689116 1.53 ENST00000464506.2
ENST00000243325.6
RAB9A, member RAS oncogene family
chr12_-_102478539 1.51 ENST00000424202.6
insulin like growth factor 1
chr4_-_40515967 1.49 ENST00000381795.10
RNA binding motif protein 47
chr17_-_17836973 1.49 ENST00000261646.11
ENST00000355815.8
sterol regulatory element binding transcription factor 1
chr19_-_16660104 1.47 ENST00000593459.5
ENST00000627144.2
ENST00000358726.6
ENST00000487416.7
ENST00000597711.5
novel protein
small integral membrane protein 7
chr12_-_54588636 1.47 ENST00000257905.13
protein phosphatase 1 regulatory inhibitor subunit 1A
chr10_+_116590956 1.45 ENST00000358834.9
ENST00000528052.5
pancreatic lipase related protein 1
chr12_-_10884244 1.44 ENST00000543626.4
proline rich protein HaeIII subfamily 1
chr6_+_41787651 1.34 ENST00000398884.7
ENST00000398881.4
translocase of outer mitochondrial membrane 6
chr14_+_22271921 1.30 ENST00000390464.2
T cell receptor alpha variable 38-1
chr22_+_43923755 1.30 ENST00000423180.2
ENST00000216180.8
patatin like phospholipase domain containing 3
chr13_+_101452569 1.25 ENST00000618057.4
integrin subunit beta like 1
chr3_+_50155024 1.24 ENST00000414301.5
ENST00000450338.5
ENST00000413852.5
semaphorin 3F
chr11_+_67056875 1.19 ENST00000532559.1
ras homolog family member D
chr10_+_116591010 1.18 ENST00000530319.5
ENST00000527980.5
ENST00000471549.5
ENST00000534537.5
pancreatic lipase related protein 1
chr1_+_22636577 1.13 ENST00000374642.8
ENST00000438241.1
complement C1q A chain
chr13_+_101452629 1.13 ENST00000622834.4
ENST00000545560.6
ENST00000376180.8
integrin subunit beta like 1
chr14_-_64942720 1.08 ENST00000557049.1
ENST00000389614.6
glutathione peroxidase 2
chr12_-_52520371 1.08 ENST00000549420.1
ENST00000252242.9
ENST00000551275.1
ENST00000546577.1
keratin 5
chr1_+_16043736 1.07 ENST00000619181.4
chloride voltage-gated channel Kb
chr3_-_86991135 1.06 ENST00000398399.7
vestigial like family member 3
chr1_-_94121105 1.01 ENST00000649773.1
ENST00000370225.4
ATP binding cassette subfamily A member 4
chr3_+_49020443 1.01 ENST00000326912.8
NADH:ubiquinone oxidoreductase complex assembly factor 3
chr1_+_16043776 1.01 ENST00000375679.9
chloride voltage-gated channel Kb
chr1_+_15438435 0.98 ENST00000375943.6
ENST00000375949.5
chymotrypsin C
chr19_+_44905785 0.92 ENST00000446996.5
ENST00000252486.9
ENST00000434152.5
apolipoprotein E
chr9_-_124500986 0.87 ENST00000373587.3
nuclear receptor subfamily 5 group A member 1
chr1_+_111449442 0.87 ENST00000369722.8
ENST00000483994.1
ATP synthase peripheral stalk-membrane subunit b
chr17_+_62627628 0.85 ENST00000303375.10
mannose receptor C type 2
chr12_+_56996151 0.83 ENST00000556850.1
G protein-coupled receptor 182
chr6_+_31762996 0.83 ENST00000415669.3
ENST00000425424.4
suppressor APC domain containing 1
chr14_-_64942783 0.82 ENST00000612794.1
glutathione peroxidase 2
chr19_+_35449584 0.79 ENST00000246549.2
free fatty acid receptor 2
chrY_+_5000226 0.76 ENST00000333703.8
ENST00000622698.4
ENST00000621505.1
protocadherin 11 Y-linked
chr19_+_13024917 0.71 ENST00000587260.1
nuclear factor I X
chr8_-_81842192 0.68 ENST00000353788.8
ENST00000520618.5
ENST00000518183.5
ENST00000396330.6
ENST00000519119.5
sorting nexin 16
chr4_-_65670339 0.67 ENST00000273854.7
EPH receptor A5
chr11_-_22625804 0.67 ENST00000327470.6
FA complementation group F
chr3_-_12158901 0.60 ENST00000287814.5
TIMP metallopeptidase inhibitor 4
chr13_-_28495079 0.57 ENST00000615840.4
ENST00000282397.9
ENST00000541932.5
ENST00000539099.1
ENST00000639477.1
fms related receptor tyrosine kinase 1
chr4_-_65670478 0.57 ENST00000613740.5
ENST00000622150.4
ENST00000511294.1
EPH receptor A5
chr6_-_35688907 0.57 ENST00000539068.5
ENST00000357266.9
FKBP prolyl isomerase 5
chr7_-_100895878 0.53 ENST00000419336.6
ENST00000241069.11
ENST00000411582.4
ENST00000302913.8
acetylcholinesterase (Cartwright blood group)
chr12_+_5432101 0.50 ENST00000423158.4
neurotrophin 3
chr1_-_211134061 0.50 ENST00000639602.1
ENST00000638498.1
ENST00000367007.5
novel protein
potassium voltage-gated channel subfamily H member 1
chr11_-_2171805 0.49 ENST00000381178.5
ENST00000381175.5
ENST00000333684.9
ENST00000352909.8
tyrosine hydroxylase
chr14_+_38207893 0.48 ENST00000267377.3
somatostatin receptor 1
chr7_+_107744134 0.46 ENST00000222597.6
ENST00000440859.8
ENST00000415884.6
Cbl proto-oncogene like 1
chr22_-_30557586 0.46 ENST00000338911.6
ENST00000453479.1
galactose-3-O-sulfotransferase 1
chr4_-_108168950 0.45 ENST00000379951.6
lymphoid enhancer binding factor 1
chr22_-_24226112 0.42 ENST00000425408.5
gamma-glutamyltransferase 5
chr10_-_73495966 0.40 ENST00000342558.3
ENST00000360663.10
ENST00000394828.6
ENST00000394829.6
protein phosphatase 3 catalytic subunit beta
chr6_-_168075831 0.40 ENST00000440994.6
FERM domain containing 1
chr14_+_57268963 0.39 ENST00000261558.8
adaptor related protein complex 5 subunit mu 1
chr12_-_54588516 0.38 ENST00000547431.5
protein phosphatase 1 regulatory inhibitor subunit 1A
chr11_-_59845496 0.35 ENST00000257248.3
cobalamin binding intrinsic factor
chr1_-_211134135 0.35 ENST00000638983.1
ENST00000271751.10
ENST00000639952.1
novel protein
potassium voltage-gated channel subfamily H member 1
chr4_+_94995919 0.34 ENST00000509540.6
bone morphogenetic protein receptor type 1B
chr5_-_141673160 0.33 ENST00000513878.5
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3
chr19_+_38390055 0.32 ENST00000587947.5
ENST00000338502.8
sprouty related EVH1 domain containing 3
chr19_+_33796846 0.31 ENST00000590771.5
ENST00000589786.5
ENST00000284006.10
ENST00000683859.1
ENST00000588881.5
potassium channel tetramerization domain containing 15
chr21_-_38498415 0.29 ENST00000398905.5
ENST00000398907.5
ENST00000453032.6
ENST00000288319.12
ETS transcription factor ERG
chr17_+_77453993 0.27 ENST00000592951.5
septin 9
chr11_+_62242232 0.27 ENST00000244926.4
secretoglobin family 1D member 2
chr4_-_108168919 0.25 ENST00000265165.6
lymphoid enhancer binding factor 1
chr7_-_124929938 0.25 ENST00000668382.1
ENST00000655761.1
ENST00000393329.5
protection of telomeres 1
chr11_+_68010339 0.24 ENST00000617288.4
aldehyde dehydrogenase 3 family member B1
chr7_-_124929801 0.24 ENST00000653241.1
ENST00000664366.1
ENST00000446993.6
ENST00000654766.1
ENST00000357628.8
ENST00000609702.5
protection of telomeres 1
chr1_+_99850485 0.21 ENST00000370165.7
ENST00000370163.7
ENST00000294724.8
amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase
chr5_+_153491174 0.20 ENST00000521843.6
glutamate ionotropic receptor AMPA type subunit 1
chr1_-_59926724 0.19 ENST00000371204.4
cytochrome P450 family 2 subfamily J member 2
chr20_-_44210697 0.17 ENST00000255174.3
oxidative stress responsive serine rich 1
chr15_+_84980440 0.16 ENST00000310298.8
ENST00000557957.5
phosphodiesterase 8A
chr2_-_74507664 0.15 ENST00000233630.11
polycomb group ring finger 1
chr2_-_98936155 0.15 ENST00000428096.5
ENST00000397899.7
ENST00000420294.1
CRACD like
chr8_-_81841958 0.14 ENST00000519817.5
ENST00000521773.5
ENST00000523757.5
ENST00000345957.9
sorting nexin 16
chr4_-_174829212 0.13 ENST00000340217.5
ENST00000274093.8
glycine receptor alpha 3
chr1_-_52698320 0.13 ENST00000371538.5
cytochrome c oxidase assembly factor 7
chr19_-_14475307 0.11 ENST00000292513.4
prostaglandin E receptor 1
chr17_+_27456393 0.09 ENST00000644974.1
kinase suppressor of ras 1
chr4_-_65669935 0.09 ENST00000354839.8
ENST00000432638.6
EPH receptor A5
chr17_-_41034871 0.07 ENST00000344363.7
keratin associated protein 1-3
chr21_+_43789522 0.07 ENST00000497547.2
ribosomal RNA processing 1
chr1_+_18631513 0.04 ENST00000400661.3
paired box 7
chr1_+_61952036 0.03 ENST00000646453.1
ENST00000635137.1
PATJ crumbs cell polarity complex component
chr11_+_68010281 0.02 ENST00000615463.4
ENST00000342456.11
aldehyde dehydrogenase 3 family member B1
chr11_+_7576975 0.00 ENST00000684215.1
ENST00000650027.1
PPFIA binding protein 2

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
5.6 16.7 GO:1901860 positive regulation of mitochondrial DNA metabolic process(GO:1901860)
4.9 19.7 GO:1904045 cellular response to aldosterone(GO:1904045)
2.8 64.0 GO:0051639 actin filament network formation(GO:0051639)
2.1 6.3 GO:1903892 negative regulation of ATF6-mediated unfolded protein response(GO:1903892)
1.7 13.5 GO:0034625 fatty acid elongation, saturated fatty acid(GO:0019367) fatty acid elongation, unsaturated fatty acid(GO:0019368) fatty acid elongation, monounsaturated fatty acid(GO:0034625) fatty acid elongation, polyunsaturated fatty acid(GO:0034626)
1.5 6.1 GO:0021649 vestibulocochlear nerve structural organization(GO:0021649) positive regulation of cytokine activity(GO:0060301) ganglion morphogenesis(GO:0061552) endothelial tip cell fate specification(GO:0097102) VEGF-activated neuropilin signaling pathway involved in axon guidance(GO:1902378) dorsal root ganglion morphogenesis(GO:1904835) otic placode development(GO:1905040)
1.5 14.7 GO:2000252 negative regulation of feeding behavior(GO:2000252)
1.3 12.0 GO:0046940 nucleoside monophosphate phosphorylation(GO:0046940)
1.1 4.5 GO:0046900 tetrahydrofolylpolyglutamate metabolic process(GO:0046900)
0.9 4.6 GO:0036072 intramembranous ossification(GO:0001957) direct ossification(GO:0036072)
0.9 3.5 GO:0030961 peptidyl-arginine hydroxylation(GO:0030961)
0.7 9.1 GO:0043983 histone H4-K12 acetylation(GO:0043983)
0.6 2.5 GO:0060621 regulation of high-density lipoprotein particle clearance(GO:0010982) regulation of cholesterol import(GO:0060620) negative regulation of cholesterol import(GO:0060621) regulation of sterol import(GO:2000909) negative regulation of sterol import(GO:2000910)
0.6 2.3 GO:0018879 biphenyl metabolic process(GO:0018879)
0.6 2.3 GO:0021823 cerebral cortex tangential migration using cell-cell interactions(GO:0021823) postnatal olfactory bulb interneuron migration(GO:0021827) chemorepulsion involved in postnatal olfactory bulb interneuron migration(GO:0021836) regulation of negative chemotaxis(GO:0050923)
0.6 2.3 GO:0060528 secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development(GO:0060528)
0.5 2.2 GO:0006272 DNA replication, synthesis of RNA primer(GO:0006269) leading strand elongation(GO:0006272)
0.5 0.5 GO:0018963 phthalate metabolic process(GO:0018963)
0.4 3.6 GO:0002084 protein depalmitoylation(GO:0002084)
0.4 1.2 GO:0036486 trunk segmentation(GO:0035290) trunk neural crest cell migration(GO:0036484) ventral trunk neural crest cell migration(GO:0036486)
0.4 2.0 GO:0090362 positive regulation of platelet-derived growth factor production(GO:0090362)
0.4 3.2 GO:0072734 response to staurosporine(GO:0072733) cellular response to staurosporine(GO:0072734)
0.3 2.8 GO:0052405 negative regulation by host of symbiont molecular function(GO:0052405)
0.3 3.4 GO:0051045 negative regulation of membrane protein ectodomain proteolysis(GO:0051045)
0.3 1.5 GO:1904075 regulation of trophectodermal cell proliferation(GO:1904073) positive regulation of trophectodermal cell proliferation(GO:1904075)
0.3 2.1 GO:0007000 nucleolus organization(GO:0007000)
0.3 1.9 GO:0008295 spermine metabolic process(GO:0008215) spermidine biosynthetic process(GO:0008295)
0.3 0.8 GO:0002752 cell surface pattern recognition receptor signaling pathway(GO:0002752)
0.2 1.5 GO:0016554 cytidine to uridine editing(GO:0016554)
0.2 0.9 GO:1902952 positive regulation of dendritic spine maintenance(GO:1902952)
0.2 6.8 GO:0072663 protein targeting to peroxisome(GO:0006625) protein localization to peroxisome(GO:0072662) establishment of protein localization to peroxisome(GO:0072663)
0.2 0.9 GO:0007538 primary sex determination(GO:0007538)
0.2 6.1 GO:0043586 tongue development(GO:0043586)
0.2 9.5 GO:1903959 regulation of anion transmembrane transport(GO:1903959)
0.2 0.5 GO:0060382 regulation of DNA strand elongation(GO:0060382)
0.1 1.8 GO:0060842 arterial endothelial cell differentiation(GO:0060842)
0.1 1.5 GO:0045542 positive regulation of cholesterol biosynthetic process(GO:0045542)
0.1 1.3 GO:0036155 acylglycerol acyl-chain remodeling(GO:0036155)
0.1 0.5 GO:0038170 somatostatin receptor signaling pathway(GO:0038169) somatostatin signaling pathway(GO:0038170)
0.1 2.1 GO:0090026 positive regulation of monocyte chemotaxis(GO:0090026)
0.1 12.3 GO:0098869 cellular oxidant detoxification(GO:0098869)
0.1 4.5 GO:2000249 regulation of actin cytoskeleton reorganization(GO:2000249)
0.1 2.6 GO:0003298 physiological muscle hypertrophy(GO:0003298) physiological cardiac muscle hypertrophy(GO:0003301) cell growth involved in cardiac muscle cell development(GO:0061049)
0.1 0.3 GO:0003199 endocardial cushion to mesenchymal transition involved in heart valve formation(GO:0003199)
0.1 1.6 GO:0097067 cellular response to thyroid hormone stimulus(GO:0097067)
0.1 1.3 GO:0032793 positive regulation of CREB transcription factor activity(GO:0032793)
0.1 0.5 GO:0019375 galactosylceramide biosynthetic process(GO:0006682) galactolipid biosynthetic process(GO:0019375)
0.0 0.3 GO:0035021 negative regulation of Rac protein signal transduction(GO:0035021)
0.0 0.4 GO:0001915 negative regulation of T cell mediated cytotoxicity(GO:0001915)
0.0 1.1 GO:0031581 hemidesmosome assembly(GO:0031581)
0.0 0.6 GO:0030949 positive regulation of vascular endothelial growth factor receptor signaling pathway(GO:0030949)
0.0 1.0 GO:0009235 cobalamin metabolic process(GO:0009235)
0.0 1.0 GO:0034204 lipid translocation(GO:0034204) phospholipid translocation(GO:0045332)
0.0 0.3 GO:0000160 phosphorelay signal transduction system(GO:0000160)
0.0 2.0 GO:0006891 intra-Golgi vesicle-mediated transport(GO:0006891)
0.0 1.9 GO:0006893 Golgi to plasma membrane transport(GO:0006893)
0.0 0.4 GO:1901750 leukotriene D4 metabolic process(GO:1901748) leukotriene D4 biosynthetic process(GO:1901750)
0.0 1.9 GO:0000289 nuclear-transcribed mRNA poly(A) tail shortening(GO:0000289)
0.0 1.7 GO:1904837 beta-catenin-TCF complex assembly(GO:1904837)
0.0 0.2 GO:0099566 regulation of postsynaptic cytosolic calcium ion concentration(GO:0099566)
0.0 4.8 GO:0046546 male gonad development(GO:0008584) development of primary male sexual characteristics(GO:0046546)
0.0 0.8 GO:0006622 protein targeting to lysosome(GO:0006622)
0.0 1.2 GO:0016486 peptide hormone processing(GO:0016486)
0.0 1.1 GO:0010039 response to iron ion(GO:0010039)
0.0 0.3 GO:0046185 aldehyde catabolic process(GO:0046185)
0.0 5.1 GO:0007160 cell-matrix adhesion(GO:0007160)
0.0 0.5 GO:0035635 entry of bacterium into host cell(GO:0035635)
0.0 0.7 GO:0036297 interstrand cross-link repair(GO:0036297)
0.0 0.1 GO:0060012 synaptic transmission, glycinergic(GO:0060012)
0.0 2.8 GO:0048839 inner ear development(GO:0048839)
0.0 1.0 GO:0097031 NADH dehydrogenase complex assembly(GO:0010257) mitochondrial respiratory chain complex I assembly(GO:0032981) mitochondrial respiratory chain complex I biogenesis(GO:0097031)
0.0 0.0 GO:0032223 negative regulation of synaptic transmission, cholinergic(GO:0032223) neurotransmitter receptor biosynthetic process(GO:0045212)
0.0 0.9 GO:0030574 collagen catabolic process(GO:0030574)
0.0 1.1 GO:0005977 glycogen metabolic process(GO:0005977)
0.0 0.2 GO:0043651 linoleic acid metabolic process(GO:0043651)
0.0 1.9 GO:2000117 negative regulation of cysteine-type endopeptidase activity(GO:2000117)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
2.5 64.0 GO:0005916 fascia adherens(GO:0005916)
0.6 6.1 GO:0097443 sorting endosome(GO:0097443)
0.5 16.7 GO:0042101 T cell receptor complex(GO:0042101)
0.5 3.4 GO:0034363 intermediate-density lipoprotein particle(GO:0034363)
0.4 2.0 GO:0005797 Golgi medial cisterna(GO:0005797)
0.4 2.2 GO:0005658 alpha DNA polymerase:primase complex(GO:0005658)
0.3 2.1 GO:0070545 PeBoW complex(GO:0070545)
0.3 1.1 GO:0005602 complement component C1 complex(GO:0005602)
0.3 1.9 GO:0016272 prefoldin complex(GO:0016272)
0.2 1.3 GO:0005742 mitochondrial outer membrane translocase complex(GO:0005742)
0.2 1.5 GO:0035867 alphav-beta3 integrin-IGF-1-IGF1R complex(GO:0035867)
0.2 18.4 GO:0005758 mitochondrial intermembrane space(GO:0005758)
0.2 2.3 GO:0034663 endoplasmic reticulum chaperone complex(GO:0034663)
0.1 2.3 GO:0034709 methylosome(GO:0034709)
0.1 0.8 GO:0031313 extrinsic component of endosome membrane(GO:0031313)
0.1 1.9 GO:0000145 exocyst(GO:0000145)
0.1 9.6 GO:0034707 chloride channel complex(GO:0034707)
0.1 11.5 GO:0043195 terminal bouton(GO:0043195)
0.1 8.4 GO:1904724 tertiary granule lumen(GO:1904724)
0.1 16.7 GO:0030176 integral component of endoplasmic reticulum membrane(GO:0030176)
0.1 9.1 GO:0000123 histone acetyltransferase complex(GO:0000123)
0.1 0.5 GO:0070187 telosome(GO:0070187)
0.1 0.7 GO:1990907 beta-catenin-TCF complex(GO:1990907)
0.1 3.8 GO:0030670 phagocytic vesicle membrane(GO:0030670)
0.1 0.7 GO:0043240 Fanconi anaemia nuclear complex(GO:0043240)
0.0 2.0 GO:0005859 muscle myosin complex(GO:0005859)
0.0 1.9 GO:0001533 cornified envelope(GO:0001533)
0.0 0.2 GO:0044308 axonal spine(GO:0044308)
0.0 5.0 GO:0005796 Golgi lumen(GO:0005796)
0.0 1.0 GO:0097381 photoreceptor disc membrane(GO:0097381)
0.0 0.4 GO:0005955 calcineurin complex(GO:0005955)
0.0 1.5 GO:0012507 ER to Golgi transport vesicle membrane(GO:0012507)
0.0 7.8 GO:0030017 sarcomere(GO:0030017)
0.0 2.3 GO:0005905 clathrin-coated pit(GO:0005905)
0.0 12.0 GO:0005759 mitochondrial matrix(GO:0005759)
0.0 1.3 GO:0005791 rough endoplasmic reticulum(GO:0005791)
0.0 1.9 GO:0001650 fibrillar center(GO:0001650)
0.0 1.0 GO:0005811 lipid particle(GO:0005811)
0.0 0.4 GO:0030119 AP-type membrane coat adaptor complex(GO:0030119)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
2.4 12.0 GO:0046899 nucleoside triphosphate adenylate kinase activity(GO:0046899)
2.3 64.0 GO:0017166 vinculin binding(GO:0017166)
1.7 5.2 GO:0005055 laminin receptor activity(GO:0005055)
1.7 13.5 GO:0102338 fatty acid elongase activity(GO:0009922) 3-oxo-arachidoyl-CoA synthase activity(GO:0102336) 3-oxo-cerotoyl-CoA synthase activity(GO:0102337) 3-oxo-lignoceronyl-CoA synthase activity(GO:0102338)
1.6 19.7 GO:0016174 NAD(P)H oxidase activity(GO:0016174)
1.1 6.4 GO:0047134 protein-disulfide reductase activity(GO:0047134)
1.0 16.7 GO:1901612 cardiolipin binding(GO:1901612)
0.8 6.1 GO:0038085 vascular endothelial growth factor binding(GO:0038085)
0.5 2.5 GO:0070653 high-density lipoprotein particle receptor binding(GO:0070653)
0.5 9.5 GO:0005247 voltage-gated chloride channel activity(GO:0005247)
0.5 2.3 GO:0005152 interleukin-1 receptor antagonist activity(GO:0005152)
0.4 2.4 GO:0004046 aminoacylase activity(GO:0004046)
0.4 1.5 GO:0032810 sterol response element binding(GO:0032810)
0.3 1.0 GO:0090555 phosphatidylethanolamine-translocating ATPase activity(GO:0090555)
0.3 3.6 GO:0008474 palmitoyl-(protein) hydrolase activity(GO:0008474) palmitoyl hydrolase activity(GO:0098599)
0.3 3.5 GO:0032453 histone demethylase activity (H3-K4 specific)(GO:0032453)
0.3 2.3 GO:0008046 axon guidance receptor activity(GO:0008046)
0.3 13.0 GO:0071855 neuropeptide receptor binding(GO:0071855)
0.2 1.9 GO:0004865 protein serine/threonine phosphatase inhibitor activity(GO:0004865)
0.2 0.9 GO:0070326 very-low-density lipoprotein particle receptor binding(GO:0070326)
0.2 4.9 GO:0008242 omega peptidase activity(GO:0008242)
0.2 1.3 GO:0004465 lipoprotein lipase activity(GO:0004465)
0.2 1.8 GO:0016721 superoxide dismutase activity(GO:0004784) oxidoreductase activity, acting on superoxide radicals as acceptor(GO:0016721)
0.2 4.5 GO:0008093 cytoskeletal adaptor activity(GO:0008093)
0.2 0.5 GO:0010521 telomerase inhibitor activity(GO:0010521)
0.2 2.3 GO:0016273 arginine N-methyltransferase activity(GO:0016273) protein-arginine N-methyltransferase activity(GO:0016274)
0.1 1.3 GO:0005005 transmembrane-ephrin receptor activity(GO:0005005)
0.1 2.4 GO:0004806 triglyceride lipase activity(GO:0004806)
0.1 3.2 GO:0097200 cysteine-type endopeptidase activity involved in execution phase of apoptosis(GO:0097200)
0.1 2.8 GO:0005041 low-density lipoprotein receptor activity(GO:0005041)
0.1 0.5 GO:0005166 neurotrophin p75 receptor binding(GO:0005166)
0.1 0.5 GO:0004994 somatostatin receptor activity(GO:0004994)
0.1 1.9 GO:0017160 Ral GTPase binding(GO:0017160)
0.1 3.2 GO:0005159 insulin-like growth factor receptor binding(GO:0005159)
0.1 0.6 GO:0005021 vascular endothelial growth factor-activated receptor activity(GO:0005021)
0.1 2.2 GO:0003887 DNA-directed DNA polymerase activity(GO:0003887)
0.1 0.5 GO:0016714 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen(GO:0016714) tetrahydrobiopterin binding(GO:0034617)
0.1 0.7 GO:0030284 estrogen receptor activity(GO:0030284)
0.1 9.1 GO:0051117 ATPase binding(GO:0051117)
0.1 1.2 GO:0038191 neuropilin binding(GO:0038191)
0.1 2.3 GO:0001972 retinoic acid binding(GO:0001972) glucuronosyltransferase activity(GO:0015020)
0.1 1.9 GO:0030371 translation repressor activity(GO:0030371)
0.1 1.9 GO:0004602 glutathione peroxidase activity(GO:0004602)
0.1 0.5 GO:0001733 galactosylceramide sulfotransferase activity(GO:0001733) galactose 3-O-sulfotransferase activity(GO:0050694)
0.1 3.0 GO:0031593 polyubiquitin binding(GO:0031593)
0.0 1.9 GO:0044183 protein binding involved in protein folding(GO:0044183)
0.0 3.8 GO:0019003 GDP binding(GO:0019003)
0.0 0.4 GO:0033192 protein phosphatase 2B binding(GO:0030346) calmodulin-dependent protein phosphatase activity(GO:0033192)
0.0 2.0 GO:0005484 SNAP receptor activity(GO:0005484)
0.0 0.3 GO:0000155 phosphorelay sensor kinase activity(GO:0000155)
0.0 4.6 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.0 1.9 GO:0016831 carboxy-lyase activity(GO:0016831)
0.0 2.1 GO:0042379 chemokine receptor binding(GO:0042379)
0.0 3.9 GO:0003725 double-stranded RNA binding(GO:0003725)
0.0 0.6 GO:0008191 metalloendopeptidase inhibitor activity(GO:0008191)
0.0 0.1 GO:0016934 extracellular-glycine-gated ion channel activity(GO:0016933) extracellular-glycine-gated chloride channel activity(GO:0016934)
0.0 0.2 GO:0004971 AMPA glutamate receptor activity(GO:0004971)
0.0 1.9 GO:0004869 cysteine-type endopeptidase inhibitor activity(GO:0004869)
0.0 2.0 GO:0008307 structural constituent of muscle(GO:0008307)
0.0 4.2 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.0 2.0 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.0 2.8 GO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001227)
0.0 2.0 GO:0003705 transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0003705)
0.0 0.3 GO:0004030 aldehyde dehydrogenase [NAD(P)+] activity(GO:0004030)
0.0 4.0 GO:0003924 GTPase activity(GO:0003924)
0.0 0.3 GO:0043325 phosphatidylinositol-3,4-bisphosphate binding(GO:0043325)
0.0 1.1 GO:0005179 hormone activity(GO:0005179)
0.0 0.1 GO:0004957 prostaglandin E receptor activity(GO:0004957)
0.0 0.0 GO:0003990 acetylcholinesterase activity(GO:0003990)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.9 64.0 PID SYNDECAN 4 PATHWAY Syndecan-4-mediated signaling events
0.4 6.7 PID VEGF VEGFR PATHWAY VEGF and VEGFR signaling network
0.2 21.3 PID CERAMIDE PATHWAY Ceramide signaling pathway
0.2 2.2 ST TYPE I INTERFERON PATHWAY Type I Interferon (alpha/beta IFN) Pathway
0.1 4.7 SA CASPASE CASCADE Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.
0.1 4.6 PID SYNDECAN 2 PATHWAY Syndecan-2-mediated signaling events
0.1 6.7 PID TAP63 PATHWAY Validated transcriptional targets of TAp63 isoforms
0.1 3.6 PID INSULIN PATHWAY Insulin Pathway
0.0 1.3 PID EPHA FWDPATHWAY EPHA forward signaling
0.0 2.8 PID AJDISS 2PATHWAY Posttranslational regulation of adherens junction stability and dissassembly
0.0 1.0 PID UPA UPAR PATHWAY Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
0.0 2.2 PID E2F PATHWAY E2F transcription factor network
0.0 2.4 WNT SIGNALING Genes related to Wnt-mediated signal transduction
0.0 1.1 PID DELTA NP63 PATHWAY Validated transcriptional targets of deltaNp63 isoforms
0.0 4.5 NABA ECM REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.0 0.7 PID FANCONI PATHWAY Fanconi anemia pathway
0.0 0.5 PID ALPHA SYNUCLEIN PATHWAY Alpha-synuclein signaling
0.0 2.3 NABA ECM GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.0 0.5 PID SHP2 PATHWAY SHP2 signaling
0.0 1.0 PID REG GR PATHWAY Glucocorticoid receptor regulatory network

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
1.9 64.0 REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS Genes involved in Cell-extracellular matrix interactions
0.4 12.9 REACTOME SYNTHESIS OF VERY LONG CHAIN FATTY ACYL COAS Genes involved in Synthesis of very long-chain fatty acyl-CoAs
0.4 6.7 REACTOME VEGF LIGAND RECEPTOR INTERACTIONS Genes involved in VEGF ligand-receptor interactions
0.2 4.6 REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.2 3.4 REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT Genes involved in Chylomicron-mediated lipid transport
0.1 3.6 REACTOME INSULIN SYNTHESIS AND PROCESSING Genes involved in Insulin Synthesis and Processing
0.1 2.2 REACTOME POL SWITCHING Genes involved in Polymerase switching
0.1 1.6 REACTOME GLYCOPROTEIN HORMONES Genes involved in Glycoprotein hormones
0.1 1.1 REACTOME CREATION OF C4 AND C2 ACTIVATORS Genes involved in Creation of C4 and C2 activators
0.1 1.9 REACTOME METABOLISM OF POLYAMINES Genes involved in Metabolism of polyamines
0.1 2.3 REACTOME GLUCURONIDATION Genes involved in Glucuronidation
0.1 3.2 REACTOME CASPASE MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS Genes involved in Caspase-mediated cleavage of cytoskeletal proteins
0.1 6.3 REACTOME ACTIVATION OF CHAPERONE GENES BY XBP1S Genes involved in Activation of Chaperone Genes by XBP1(S)
0.1 13.2 REACTOME PEPTIDE LIGAND BINDING RECEPTORS Genes involved in Peptide ligand-binding receptors
0.1 0.5 REACTOME PACKAGING OF TELOMERE ENDS Genes involved in Packaging Of Telomere Ends
0.1 1.3 REACTOME ACTIVATION OF RAC Genes involved in Activation of Rac
0.0 1.9 REACTOME PREFOLDIN MEDIATED TRANSFER OF SUBSTRATE TO CCT TRIC Genes involved in Prefoldin mediated transfer of substrate to CCT/TriC
0.0 1.5 REACTOME RORA ACTIVATES CIRCADIAN EXPRESSION Genes involved in RORA Activates Circadian Expression
0.0 2.3 REACTOME METABOLISM OF NON CODING RNA Genes involved in Metabolism of non-coding RNA
0.0 0.7 REACTOME FANCONI ANEMIA PATHWAY Genes involved in Fanconi Anemia pathway
0.0 0.5 REACTOME AMINE DERIVED HORMONES Genes involved in Amine-derived hormones
0.0 1.0 REACTOME ABC FAMILY PROTEINS MEDIATED TRANSPORT Genes involved in ABC-family proteins mediated transport
0.0 4.2 REACTOME SIGNALING BY RHO GTPASES Genes involved in Signaling by Rho GTPases
0.0 0.9 REACTOME CROSS PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS ENDOSOMES Genes involved in Cross-presentation of soluble exogenous antigens (endosomes)
0.0 0.4 REACTOME GLUTATHIONE CONJUGATION Genes involved in Glutathione conjugation