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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
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Results for ZIC1
Z-value: 0.72
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Transcription factors associated with ZIC1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| ZIC1 | hg38_v1_chr3_+_147409357_147409381 | -0.08 | 2.6e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of ZIC1
| Promoter | Score | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr14_-_68979436 Show fit | 13.58 |
ENST00000193403.10
|
actinin alpha 1 |
|
| chr14_-_68979314 Show fit | 13.00 |
ENST00000684713.1
ENST00000683198.1 ENST00000684598.1 ENST00000682331.1 ENST00000682291.1 ENST00000683342.1 |
actinin alpha 1 |
|
| chr14_-_68979274 Show fit | 12.82 |
ENST00000394419.9
|
actinin alpha 1 |
|
| chr14_-_68979251 Show fit | 12.29 |
ENST00000438964.6
ENST00000679147.1 |
actinin alpha 1 |
|
| chr14_-_68979076 Show fit | 12.28 |
ENST00000538545.6
ENST00000684639.1 |
actinin alpha 1 |
|
| chr9_-_35103178 Show fit | 8.56 |
ENST00000452248.6
ENST00000619795.4 |
stomatin like 2 |
|
| chr1_+_65147657 Show fit | 8.25 |
ENST00000546702.5
|
adenylate kinase 4 |
|
| chr9_-_35103108 Show fit | 8.15 |
ENST00000356493.10
|
stomatin like 2 |
|
| chr4_-_55636259 Show fit | 6.52 |
ENST00000505262.5
ENST00000507338.1 |
neuromedin U |
|
| chr4_-_55636284 Show fit | 6.46 |
ENST00000511469.5
ENST00000264218.7 |
neuromedin U |
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.8 | 64.0 | GO:0051639 | actin filament network formation(GO:0051639) |
| 4.9 | 19.7 | GO:1904045 | cellular response to aldosterone(GO:1904045) |
| 5.6 | 16.7 | GO:1901860 | positive regulation of mitochondrial DNA metabolic process(GO:1901860) |
| 1.5 | 14.7 | GO:2000252 | negative regulation of feeding behavior(GO:2000252) |
| 1.7 | 13.5 | GO:0034625 | fatty acid elongation, saturated fatty acid(GO:0019367) fatty acid elongation, unsaturated fatty acid(GO:0019368) fatty acid elongation, monounsaturated fatty acid(GO:0034625) fatty acid elongation, polyunsaturated fatty acid(GO:0034626) |
| 0.1 | 12.3 | GO:0098869 | cellular oxidant detoxification(GO:0098869) |
| 1.3 | 12.0 | GO:0046940 | nucleoside monophosphate phosphorylation(GO:0046940) |
| 0.2 | 9.5 | GO:1903959 | regulation of anion transmembrane transport(GO:1903959) |
| 0.7 | 9.1 | GO:0043983 | histone H4-K12 acetylation(GO:0043983) |
| 0.2 | 6.8 | GO:0072663 | protein targeting to peroxisome(GO:0006625) protein localization to peroxisome(GO:0072662) establishment of protein localization to peroxisome(GO:0072663) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.5 | 64.0 | GO:0005916 | fascia adherens(GO:0005916) |
| 0.2 | 18.4 | GO:0005758 | mitochondrial intermembrane space(GO:0005758) |
| 0.5 | 16.7 | GO:0042101 | T cell receptor complex(GO:0042101) |
| 0.1 | 16.7 | GO:0030176 | integral component of endoplasmic reticulum membrane(GO:0030176) |
| 0.0 | 12.0 | GO:0005759 | mitochondrial matrix(GO:0005759) |
| 0.1 | 11.5 | GO:0043195 | terminal bouton(GO:0043195) |
| 0.1 | 9.6 | GO:0034707 | chloride channel complex(GO:0034707) |
| 0.1 | 9.1 | GO:0000123 | histone acetyltransferase complex(GO:0000123) |
| 0.1 | 8.4 | GO:1904724 | tertiary granule lumen(GO:1904724) |
| 0.0 | 7.8 | GO:0030017 | sarcomere(GO:0030017) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.3 | 64.0 | GO:0017166 | vinculin binding(GO:0017166) |
| 1.6 | 19.7 | GO:0016174 | NAD(P)H oxidase activity(GO:0016174) |
| 1.0 | 16.7 | GO:1901612 | cardiolipin binding(GO:1901612) |
| 1.7 | 13.5 | GO:0102338 | fatty acid elongase activity(GO:0009922) 3-oxo-arachidoyl-CoA synthase activity(GO:0102336) 3-oxo-cerotoyl-CoA synthase activity(GO:0102337) 3-oxo-lignoceronyl-CoA synthase activity(GO:0102338) |
| 0.3 | 13.0 | GO:0071855 | neuropeptide receptor binding(GO:0071855) |
| 2.4 | 12.0 | GO:0046899 | nucleoside triphosphate adenylate kinase activity(GO:0046899) |
| 0.5 | 9.5 | GO:0005247 | voltage-gated chloride channel activity(GO:0005247) |
| 0.1 | 9.1 | GO:0051117 | ATPase binding(GO:0051117) |
| 1.1 | 6.4 | GO:0047134 | protein-disulfide reductase activity(GO:0047134) |
| 0.8 | 6.1 | GO:0038085 | vascular endothelial growth factor binding(GO:0038085) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.9 | 64.0 | PID SYNDECAN 4 PATHWAY | Syndecan-4-mediated signaling events |
| 0.2 | 21.3 | PID CERAMIDE PATHWAY | Ceramide signaling pathway |
| 0.4 | 6.7 | PID VEGF VEGFR PATHWAY | VEGF and VEGFR signaling network |
| 0.1 | 6.7 | PID TAP63 PATHWAY | Validated transcriptional targets of TAp63 isoforms |
| 0.1 | 4.7 | SA CASPASE CASCADE | Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade. |
| 0.1 | 4.6 | PID SYNDECAN 2 PATHWAY | Syndecan-2-mediated signaling events |
| 0.0 | 4.5 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.1 | 3.6 | PID INSULIN PATHWAY | Insulin Pathway |
| 0.0 | 2.8 | PID AJDISS 2PATHWAY | Posttranslational regulation of adherens junction stability and dissassembly |
| 0.0 | 2.4 | WNT SIGNALING | Genes related to Wnt-mediated signal transduction |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.9 | 64.0 | REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS | Genes involved in Cell-extracellular matrix interactions |
| 0.1 | 13.2 | REACTOME PEPTIDE LIGAND BINDING RECEPTORS | Genes involved in Peptide ligand-binding receptors |
| 0.4 | 12.9 | REACTOME SYNTHESIS OF VERY LONG CHAIN FATTY ACYL COAS | Genes involved in Synthesis of very long-chain fatty acyl-CoAs |
| 0.4 | 6.7 | REACTOME VEGF LIGAND RECEPTOR INTERACTIONS | Genes involved in VEGF ligand-receptor interactions |
| 0.1 | 6.3 | REACTOME ACTIVATION OF CHAPERONE GENES BY XBP1S | Genes involved in Activation of Chaperone Genes by XBP1(S) |
| 0.2 | 4.6 | REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS | Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs) |
| 0.0 | 4.2 | REACTOME SIGNALING BY RHO GTPASES | Genes involved in Signaling by Rho GTPases |
| 0.1 | 3.6 | REACTOME INSULIN SYNTHESIS AND PROCESSING | Genes involved in Insulin Synthesis and Processing |
| 0.2 | 3.4 | REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT | Genes involved in Chylomicron-mediated lipid transport |
| 0.1 | 3.2 | REACTOME CASPASE MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS | Genes involved in Caspase-mediated cleavage of cytoskeletal proteins |