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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
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Results for ZIC2_GLI1
Z-value: 1.54
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Transcription factors associated with ZIC2_GLI1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| GLI1 | hg38_v1_chr12_+_57459782_57459796, hg38_v1_chr12_+_57460127_57460151 | 0.67 | 9.0e-30 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of ZIC2_GLI1
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 16.9 | 286.9 | GO:0007021 | tubulin complex assembly(GO:0007021) |
| 3.6 | 65.7 | GO:0001542 | ovulation from ovarian follicle(GO:0001542) |
| 2.2 | 59.9 | GO:0071420 | cellular response to histamine(GO:0071420) |
| 1.6 | 44.1 | GO:0007214 | gamma-aminobutyric acid signaling pathway(GO:0007214) |
| 8.6 | 43.2 | GO:1902613 | regulation of anti-Mullerian hormone signaling pathway(GO:1902612) negative regulation of anti-Mullerian hormone signaling pathway(GO:1902613) anti-Mullerian hormone signaling pathway(GO:1990262) |
| 8.5 | 42.3 | GO:0030070 | insulin processing(GO:0030070) |
| 4.4 | 39.9 | GO:0009249 | protein lipoylation(GO:0009249) |
| 1.1 | 39.8 | GO:0061641 | chromatin remodeling at centromere(GO:0031055) CENP-A containing nucleosome assembly(GO:0034080) CENP-A containing chromatin organization(GO:0061641) |
| 3.9 | 38.5 | GO:2000348 | regulation of CD40 signaling pathway(GO:2000348) |
| 1.5 | 35.2 | GO:0097150 | neuronal stem cell population maintenance(GO:0097150) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 17.9 | 286.9 | GO:0097512 | cardiac myofibril(GO:0097512) |
| 1.5 | 59.9 | GO:1902711 | GABA receptor complex(GO:1902710) GABA-A receptor complex(GO:1902711) |
| 0.4 | 57.9 | GO:0005604 | basement membrane(GO:0005604) |
| 11.0 | 44.1 | GO:0038039 | G-protein coupled receptor heterodimeric complex(GO:0038039) |
| 1.9 | 38.5 | GO:0016580 | Sin3 complex(GO:0016580) |
| 0.2 | 36.3 | GO:0030658 | transport vesicle membrane(GO:0030658) |
| 0.0 | 35.3 | GO:0005615 | extracellular space(GO:0005615) |
| 2.9 | 35.2 | GO:0043240 | Fanconi anaemia nuclear complex(GO:0043240) |
| 0.3 | 32.2 | GO:0000777 | condensed chromosome kinetochore(GO:0000777) |
| 1.9 | 31.9 | GO:0033010 | paranodal junction(GO:0033010) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 9.8 | 293.7 | GO:0005212 | structural constituent of eye lens(GO:0005212) |
| 0.6 | 71.0 | GO:0004222 | metalloendopeptidase activity(GO:0004222) |
| 2.9 | 47.1 | GO:0008503 | benzodiazepine receptor activity(GO:0008503) |
| 2.7 | 45.6 | GO:0042043 | neurexin family protein binding(GO:0042043) |
| 11.0 | 44.1 | GO:0004965 | G-protein coupled GABA receptor activity(GO:0004965) |
| 2.3 | 38.5 | GO:0001222 | transcription corepressor binding(GO:0001222) |
| 1.0 | 38.5 | GO:0070182 | DNA polymerase binding(GO:0070182) |
| 0.2 | 34.5 | GO:0008168 | methyltransferase activity(GO:0008168) |
| 0.9 | 28.2 | GO:0043548 | phosphatidylinositol 3-kinase binding(GO:0043548) |
| 1.9 | 28.1 | GO:0043522 | leucine zipper domain binding(GO:0043522) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.4 | 73.8 | PID FANCONI PATHWAY | Fanconi anemia pathway |
| 0.2 | 55.9 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.2 | 49.6 | NABA ECM GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 0.8 | 43.2 | ST WNT BETA CATENIN PATHWAY | Wnt/beta-catenin Pathway |
| 0.4 | 31.8 | PID ARF6 TRAFFICKING PATHWAY | Arf6 trafficking events |
| 0.3 | 24.6 | PID FGF PATHWAY | FGF signaling pathway |
| 0.7 | 22.4 | PID HEDGEHOG 2PATHWAY | Signaling events mediated by the Hedgehog family |
| 0.6 | 20.9 | PID HDAC CLASSIII PATHWAY | Signaling events mediated by HDAC Class III |
| 0.4 | 18.6 | PID REELIN PATHWAY | Reelin signaling pathway |
| 1.1 | 17.3 | PID BETA CATENIN DEG PATHWAY | Degradation of beta catenin |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.6 | 59.9 | REACTOME GABA A RECEPTOR ACTIVATION | Genes involved in GABA A receptor activation |
| 2.4 | 47.5 | REACTOME CLASS C 3 METABOTROPIC GLUTAMATE PHEROMONE RECEPTORS | Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors) |
| 1.7 | 42.3 | REACTOME INSULIN SYNTHESIS AND PROCESSING | Genes involved in Insulin Synthesis and Processing |
| 1.7 | 39.8 | REACTOME DEPOSITION OF NEW CENPA CONTAINING NUCLEOSOMES AT THE CENTROMERE | Genes involved in Deposition of New CENPA-containing Nucleosomes at the Centromere |
| 3.2 | 38.5 | REACTOME REGULATION OF THE FANCONI ANEMIA PATHWAY | Genes involved in Regulation of the Fanconi anemia pathway |
| 2.7 | 35.2 | REACTOME FANCONI ANEMIA PATHWAY | Genes involved in Fanconi Anemia pathway |
| 0.4 | 32.9 | REACTOME CIRCADIAN CLOCK | Genes involved in Circadian Clock |
| 0.5 | 25.1 | REACTOME SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE | Genes involved in Synthesis of PIPs at the plasma membrane |
| 0.6 | 17.3 | REACTOME SIGNALING BY HIPPO | Genes involved in Signaling by Hippo |
| 0.4 | 16.8 | REACTOME INTERACTION BETWEEN L1 AND ANKYRINS | Genes involved in Interaction between L1 and Ankyrins |