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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)

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Results for ZKSCAN1

Z-value: 0.89

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Transcription factors associated with ZKSCAN1

Gene Symbol Gene ID Gene Info
ZKSCAN1
ENSG00000106261.17 ZKSCAN1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
ZKSCAN1hg38_v1_chr7_+_100015588_100015613-0.236.6e-04Click!

Activity profile of ZKSCAN1 motif

Sorted Z-values of ZKSCAN1 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of ZKSCAN1

PNG image of the network

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Top targets:

Promoter Score Transcript Gene Gene Info
chr5_+_136059151 54.01 ENST00000503087.1
TGFBI
transforming growth factor beta induced
chr5_+_136058849 48.31 ENST00000508076.5
TGFBI
transforming growth factor beta induced
chr17_-_75154503 25.59 ENST00000409753.8
ENST00000581874.1
JPT1
Jupiter microtubule associated homolog 1
chrX_+_47582408 21.54 ENST00000456754.6
ENST00000218388.9
ENST00000377017.5
ENST00000441738.1
TIMP1
TIMP metallopeptidase inhibitor 1
chr17_-_75154534 21.25 ENST00000356033.8
JPT1
Jupiter microtubule associated homolog 1
chr19_+_38647679 19.31 ENST00000390009.7
ENST00000589528.1
ACTN4
actinin alpha 4
chr11_-_58575846 18.79 ENST00000395074.7
LPXN
leupaxin
chr22_-_37244237 16.22 ENST00000401529.3
ENST00000249071.11
RAC2
Rac family small GTPase 2
chrX_-_110440218 14.93 ENST00000372057.1
ENST00000372054.3
AMMECR1
GNG5P2
AMMECR nuclear protein 1
G protein subunit gamma 5 pseudogene 2
chr11_+_70203287 13.83 ENST00000301838.5
FADD
Fas associated via death domain
chr1_-_53238485 13.10 ENST00000371466.4
ENST00000371470.8
MAGOH
mago homolog, exon junction complex subunit
chr1_+_62436297 12.31 ENST00000452143.5
ENST00000442679.5
ENST00000371146.5
USP1
ubiquitin specific peptidase 1
chr15_-_68820861 12.13 ENST00000560303.1
ENST00000465139.6
ANP32A
acidic nuclear phosphoprotein 32 family member A
chr15_-_34343112 11.86 ENST00000557912.1
ENST00000328848.6
NOP10
NOP10 ribonucleoprotein
chr15_+_52019206 11.68 ENST00000681888.1
ENST00000261845.7
ENST00000680066.1
ENST00000680777.1
ENST00000680652.1
MAPK6
mitogen-activated protein kinase 6
chr5_-_135399863 11.59 ENST00000510038.1
ENST00000304332.8
MACROH2A1
macroH2A.1 histone
chr19_+_38647614 11.44 ENST00000252699.7
ENST00000424234.7
ENST00000440400.2
ACTN4
actinin alpha 4
chr8_-_63038788 10.12 ENST00000518113.2
ENST00000260118.7
ENST00000677482.1
GGH
gamma-glutamyl hydrolase
chr3_+_184363427 10.08 ENST00000429568.1
POLR2H
RNA polymerase II, I and III subunit H
chr1_+_65147657 9.96 ENST00000546702.5
AK4
adenylate kinase 4
chr3_+_184363387 9.91 ENST00000452961.5
POLR2H
RNA polymerase II, I and III subunit H
chr22_-_37244417 9.83 ENST00000405484.5
ENST00000441619.5
ENST00000406508.5
RAC2
Rac family small GTPase 2
chr19_-_18941184 9.04 ENST00000594794.5
ENST00000392351.8
ENST00000596482.5
HOMER3
homer scaffold protein 3
chr17_+_77376083 8.99 ENST00000427674.6
SEPTIN9
septin 9
chr3_+_184363351 8.65 ENST00000443489.5
POLR2H
RNA polymerase II, I and III subunit H
chr5_+_110738983 8.59 ENST00000355943.8
ENST00000447245.6
SLC25A46
solute carrier family 25 member 46
chrX_+_110002635 8.04 ENST00000372072.7
TMEM164
transmembrane protein 164
chr17_-_42018488 7.85 ENST00000589773.5
ENST00000674214.1
DNAJC7
DnaJ heat shock protein family (Hsp40) member C7
chr19_-_18938982 7.65 ENST00000594439.5
ENST00000221222.15
HOMER3
homer scaffold protein 3
chr20_-_50153637 7.32 ENST00000341698.2
ENST00000371652.9
ENST00000371650.9
PEDS1-UBE2V1
PEDS1
PEDS1-UBE2V1 readthrough
plasmanylethanolamine desaturase 1
chr5_-_132227472 6.90 ENST00000428369.6
P4HA2
prolyl 4-hydroxylase subunit alpha 2
chr3_+_12287859 6.55 ENST00000309576.11
ENST00000397015.7
PPARG
peroxisome proliferator activated receptor gamma
chr5_-_135399211 6.39 ENST00000312469.8
ENST00000423969.6
MACROH2A1
macroH2A.1 histone
chr12_+_8843236 6.34 ENST00000541459.5
A2ML1
alpha-2-macroglobulin like 1
chr6_+_36676489 6.29 ENST00000448526.6
CDKN1A
cyclin dependent kinase inhibitor 1A
chr6_+_36676455 6.21 ENST00000615513.4
CDKN1A
cyclin dependent kinase inhibitor 1A
chr3_+_12287962 6.07 ENST00000643197.2
ENST00000644622.2
PPARG
peroxisome proliferator activated receptor gamma
chr20_+_44714853 6.03 ENST00000372865.4
CCN5
cellular communication network factor 5
chr8_-_130016622 5.89 ENST00000518283.5
ENST00000519110.5
CYRIB
CYFIP related Rac1 interactor B
chr10_-_86521737 5.57 ENST00000298767.10
WAPL
WAPL cohesin release factor
chr12_-_119804472 5.44 ENST00000678087.1
ENST00000677993.1
CIT
citron rho-interacting serine/threonine kinase
chr20_+_44714835 5.41 ENST00000372868.6
CCN5
cellular communication network factor 5
chr7_+_74174323 5.26 ENST00000677570.1
ENST00000265753.13
ENST00000353999.6
ENST00000679266.1
ENST00000679287.1
ENST00000677681.1
EIF4H
eukaryotic translation initiation factor 4H
chr17_+_28744034 5.25 ENST00000444415.7
ENST00000262396.10
TRAF4
TNF receptor associated factor 4
chr12_-_119804298 5.17 ENST00000678652.1
ENST00000678494.1
CIT
citron rho-interacting serine/threonine kinase
chr1_-_36149450 5.17 ENST00000373163.5
TRAPPC3
trafficking protein particle complex 3
chr3_+_12287899 5.09 ENST00000643888.2
PPARG
peroxisome proliferator activated receptor gamma
chr19_-_55149193 5.07 ENST00000587758.5
ENST00000588981.6
ENST00000356783.9
ENST00000291901.12
ENST00000588426.5
ENST00000536926.5
ENST00000588147.5
TNNT1
troponin T1, slow skeletal type
chr12_+_121888751 4.96 ENST00000261817.6
ENST00000538613.5
ENST00000542602.1
ENST00000541212.6
PSMD9
proteasome 26S subunit, non-ATPase 9
chr12_-_48925483 4.74 ENST00000550765.6
ENST00000552878.5
ENST00000453172.2
FKBP11
FKBP prolyl isomerase 11
chr19_-_3063101 4.57 ENST00000221561.12
TLE5
TLE family member 5, transcriptional modulator
chr1_+_65147514 4.36 ENST00000545314.5
AK4
adenylate kinase 4
chr6_+_32976347 4.34 ENST00000606059.1
BRD2
bromodomain containing 2
chr10_+_110919595 4.30 ENST00000369452.9
SHOC2
SHOC2 leucine rich repeat scaffold protein
chr22_+_36863091 4.04 ENST00000650698.1
NCF4
neutrophil cytosolic factor 4
chr1_+_236795254 3.90 ENST00000366577.10
ENST00000674797.2
MTR
5-methyltetrahydrofolate-homocysteine methyltransferase
chr1_-_36149464 3.89 ENST00000373166.8
ENST00000373159.1
ENST00000373162.5
ENST00000616074.4
ENST00000616395.4
TRAPPC3
trafficking protein particle complex 3
chr6_-_30672984 3.03 ENST00000415603.1
ENST00000376442.8
DHX16
DEAH-box helicase 16
chr10_-_110918934 2.95 ENST00000605742.5
BBIP1
BBSome interacting protein 1
chr12_-_24902243 2.91 ENST00000538118.5
BCAT1
branched chain amino acid transaminase 1
chr16_+_8642375 2.86 ENST00000562973.1
METTL22
methyltransferase like 22
chr17_+_28744002 2.85 ENST00000618771.1
ENST00000262395.10
ENST00000422344.5
TRAF4
TNF receptor associated factor 4
chr14_-_106639589 2.66 ENST00000390630.3
IGHV4-61
immunoglobulin heavy variable 4-61
chr9_-_109498251 2.62 ENST00000374541.4
ENST00000262539.7
PTPN3
protein tyrosine phosphatase non-receptor type 3
chr16_+_32066065 2.57 ENST00000354689.6
IGHV3OR16-9
immunoglobulin heavy variable 3/OR16-9 (non-functional)
chr2_-_74507664 2.49 ENST00000233630.11
PCGF1
polycomb group ring finger 1
chr1_+_16022004 2.46 ENST00000439316.6
CLCNKA
chloride voltage-gated channel Ka
chr22_+_21567705 2.45 ENST00000342192.9
UBE2L3
ubiquitin conjugating enzyme E2 L3
chr2_-_65432591 2.39 ENST00000356388.9
SPRED2
sprouty related EVH1 domain containing 2
chr15_-_37098281 2.26 ENST00000559085.5
ENST00000397624.7
MEIS2
Meis homeobox 2
chrX_-_40177213 2.07 ENST00000672922.2
ENST00000378455.8
ENST00000342274.8
BCOR
BCL6 corepressor
chr1_+_16022030 2.04 ENST00000331433.5
CLCNKA
chloride voltage-gated channel Ka
chr17_-_41034871 1.97 ENST00000344363.7
KRTAP1-3
keratin associated protein 1-3
chr1_-_149936324 1.93 ENST00000369140.7
MTMR11
myotubularin related protein 11
chr15_-_78077657 1.90 ENST00000300584.8
ENST00000409931.7
TBC1D2B
TBC1 domain family member 2B
chr15_-_19988117 1.85 ENST00000558565.2
IGHV3OR15-7
immunoglobulin heavy variable 3/OR15-7 (pseudogene)
chr6_+_159761991 1.78 ENST00000367048.5
ACAT2
acetyl-CoA acetyltransferase 2
chr3_-_52056552 1.75 ENST00000495880.2
DUSP7
dual specificity phosphatase 7
chr19_+_51127030 1.70 ENST00000599948.1
SIGLEC9
sialic acid binding Ig like lectin 9
chr12_+_112978386 1.63 ENST00000342315.8
OAS2
2'-5'-oligoadenylate synthetase 2
chr19_-_3062464 1.53 ENST00000327141.9
TLE5
TLE family member 5, transcriptional modulator
chr1_+_16021871 1.51 ENST00000375692.5
CLCNKA
chloride voltage-gated channel Ka
chr22_+_20507571 1.43 ENST00000414658.5
ENST00000432052.5
ENST00000292733.11
ENST00000263205.11
ENST00000406969.5
MED15
mediator complex subunit 15
chr15_+_75201873 1.37 ENST00000394987.5
C15orf39
chromosome 15 open reading frame 39
chr15_+_40439721 1.32 ENST00000561234.5
BAHD1
bromo adjacent homology domain containing 1
chr7_-_27130733 1.24 ENST00000428284.2
ENST00000360046.10
ENST00000610970.1
HOXA4
homeobox A4
chr19_-_3062772 1.12 ENST00000586742.5
TLE5
TLE family member 5, transcriptional modulator
chr15_-_79923084 1.01 ENST00000615374.5
ST20-MTHFS
ST20-MTHFS readthrough
chr10_+_23095556 1.00 ENST00000376510.8
MSRB2
methionine sulfoxide reductase B2
chr10_-_101776104 0.99 ENST00000320185.7
ENST00000344255.8
FGF8
fibroblast growth factor 8
chr11_-_111379268 0.99 ENST00000393067.8
POU2AF1
POU class 2 homeobox associating factor 1
chr16_+_56865202 0.93 ENST00000566786.5
ENST00000438926.6
ENST00000563236.6
ENST00000262502.5
SLC12A3
solute carrier family 12 member 3
chr19_+_48019726 0.92 ENST00000593413.1
ELSPBP1
epididymal sperm binding protein 1
chr20_-_63568074 0.74 ENST00000427522.6
HELZ2
helicase with zinc finger 2
chr2_+_129979641 0.68 ENST00000410061.4
RAB6C
RAB6C, member RAS oncogene family
chr1_-_151831768 0.67 ENST00000318247.7
RORC
RAR related orphan receptor C
chr14_+_54509885 0.65 ENST00000557317.1
ENST00000216420.12
CGRRF1
cell growth regulator with ring finger domain 1
chr15_+_75206398 0.60 ENST00000565074.1
C15orf39
chromosome 15 open reading frame 39
chr5_+_156326735 0.54 ENST00000435422.7
SGCD
sarcoglycan delta
chr12_-_102481744 0.45 ENST00000644491.1
IGF1
insulin like growth factor 1
chr7_-_27130182 0.41 ENST00000511914.1
HOXA4
homeobox A4
chr1_+_16043776 0.39 ENST00000375679.9
CLCNKB
chloride voltage-gated channel Kb
chr2_-_131364168 0.37 ENST00000623617.3
RAB6D
RAB6D, member RAS oncogene family
chr6_+_35297809 0.30 ENST00000316637.7
DEF6
DEF6 guanine nucleotide exchange factor
chr19_+_13024917 0.25 ENST00000587260.1
NFIX
nuclear factor I X
chr5_+_174724549 0.20 ENST00000239243.7
ENST00000507785.2
MSX2
msh homeobox 2
chr1_+_6034980 0.16 ENST00000378092.6
ENST00000472700.7
KCNAB2
potassium voltage-gated channel subfamily A regulatory beta subunit 2
chr16_-_11276473 0.15 ENST00000241808.9
ENST00000435245.2
PRM2
protamine 2
chr20_-_3663399 0.15 ENST00000290417.7
ENST00000319242.8
GFRA4
GDNF family receptor alpha 4
chr3_-_45796467 0.08 ENST00000353278.8
ENST00000456124.6
SLC6A20
solute carrier family 6 member 20

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
5.1 30.7 GO:0048549 positive regulation of pinocytosis(GO:0048549)
4.0 11.9 GO:0000454 snoRNA guided rRNA pseudouridine synthesis(GO:0000454)
3.6 21.5 GO:1901164 negative regulation of trophoblast cell migration(GO:1901164)
3.5 13.8 GO:0072683 T cell extravasation(GO:0072683)
2.9 8.6 GO:0090149 mitochondrial membrane fission(GO:0090149)
2.5 17.7 GO:2000230 negative regulation of pancreatic stellate cell proliferation(GO:2000230)
2.5 10.1 GO:0046900 tetrahydrofolylpolyglutamate metabolic process(GO:0046900)
2.3 18.8 GO:0050859 negative regulation of B cell receptor signaling pathway(GO:0050859)
2.3 25.5 GO:0060753 regulation of mast cell chemotaxis(GO:0060753)
1.9 5.6 GO:0060623 establishment of sister chromatid cohesion(GO:0034085) regulation of chromosome condensation(GO:0060623) cohesin loading(GO:0071921) regulation of cohesin loading(GO:0071922)
1.7 5.0 GO:0070682 proteasome regulatory particle assembly(GO:0070682)
1.6 14.3 GO:0046940 nucleoside monophosphate phosphorylation(GO:0046940)
1.4 12.5 GO:0060574 intestinal epithelial cell maturation(GO:0060574)
0.8 8.1 GO:0090073 positive regulation of protein homodimerization activity(GO:0090073)
0.8 12.3 GO:0035520 monoubiquitinated protein deubiquitination(GO:0035520)
0.7 28.6 GO:0006363 termination of RNA polymerase I transcription(GO:0006363)
0.6 102.2 GO:0002062 chondrocyte differentiation(GO:0002062)
0.6 16.7 GO:0007216 G-protein coupled glutamate receptor signaling pathway(GO:0007216)
0.6 2.9 GO:0009098 branched-chain amino acid biosynthetic process(GO:0009082) leucine biosynthetic process(GO:0009098) valine biosynthetic process(GO:0009099)
0.6 5.1 GO:0031444 slow-twitch skeletal muscle fiber contraction(GO:0031444)
0.5 5.3 GO:0001731 formation of translation preinitiation complex(GO:0001731)
0.5 2.1 GO:0000415 negative regulation of histone H3-K36 methylation(GO:0000415)
0.5 1.0 GO:0060128 corticotropin hormone secreting cell differentiation(GO:0060128)
0.5 7.9 GO:0070389 chaperone cofactor-dependent protein refolding(GO:0070389)
0.3 6.9 GO:0019511 peptidyl-proline hydroxylation(GO:0019511)
0.3 2.6 GO:0098902 regulation of membrane depolarization during action potential(GO:0098902)
0.3 3.9 GO:0009086 methionine biosynthetic process(GO:0009086)
0.2 12.1 GO:0043486 histone exchange(GO:0043486)
0.2 10.6 GO:0032467 positive regulation of cytokinesis(GO:0032467)
0.2 2.4 GO:0043517 positive regulation of DNA damage response, signal transduction by p53 class mediator(GO:0043517)
0.2 13.1 GO:0000381 regulation of alternative mRNA splicing, via spliceosome(GO:0000381)
0.2 1.5 GO:0097500 receptor localization to nonmotile primary cilium(GO:0097500)
0.1 2.5 GO:0035518 histone H2A monoubiquitination(GO:0035518)
0.1 1.0 GO:0030091 protein repair(GO:0030091)
0.1 1.3 GO:0031507 heterochromatin assembly(GO:0031507)
0.1 4.0 GO:0045730 respiratory burst(GO:0045730)
0.1 9.1 GO:0048207 vesicle targeting, rough ER to cis-Golgi(GO:0048207) COPII vesicle coating(GO:0048208)
0.1 7.1 GO:0006910 phagocytosis, recognition(GO:0006910)
0.1 5.2 GO:1903959 regulation of anion transmembrane transport(GO:1903959)
0.1 0.4 GO:1904073 regulation of trophectodermal cell proliferation(GO:1904073) positive regulation of trophectodermal cell proliferation(GO:1904075)
0.1 0.9 GO:0018377 protein myristoylation(GO:0018377)
0.1 4.3 GO:0006334 nucleosome assembly(GO:0006334)
0.1 4.3 GO:0046579 positive regulation of Ras protein signal transduction(GO:0046579)
0.1 2.5 GO:0070979 protein K11-linked ubiquitination(GO:0070979)
0.0 0.9 GO:0048240 sperm capacitation(GO:0048240)
0.0 1.7 GO:0000188 inactivation of MAPK activity(GO:0000188)
0.0 0.7 GO:0060850 regulation of transcription involved in cell fate commitment(GO:0060850)
0.0 2.3 GO:0008542 visual learning(GO:0008542)
0.0 0.3 GO:0009396 folic acid-containing compound biosynthetic process(GO:0009396)
0.0 1.9 GO:1902017 regulation of cilium assembly(GO:1902017)
0.0 0.2 GO:0035860 glial cell-derived neurotrophic factor receptor signaling pathway(GO:0035860)
0.0 2.9 GO:0018022 peptidyl-lysine methylation(GO:0018022)
0.0 1.8 GO:0006635 fatty acid beta-oxidation(GO:0006635)
0.0 0.7 GO:0010824 regulation of centrosome duplication(GO:0010824)
0.0 2.0 GO:0031424 keratinization(GO:0031424)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
2.5 12.5 GO:0070557 PCNA-p21 complex(GO:0070557)
1.8 28.6 GO:0005736 DNA-directed RNA polymerase I complex(GO:0005736)
1.7 11.9 GO:0031429 box H/ACA snoRNP complex(GO:0031429) box H/ACA RNP complex(GO:0072588) box H/ACA scaRNP complex(GO:0072589) box H/ACA telomerase RNP complex(GO:0090661)
1.0 30.7 GO:0031143 pseudopodium(GO:0031143)
0.9 120.4 GO:0005604 basement membrane(GO:0005604)
0.8 9.1 GO:0030008 TRAPP complex(GO:0030008)
0.7 13.8 GO:0097342 ripoptosome(GO:0097342)
0.6 5.6 GO:0008278 cohesin complex(GO:0008278)
0.5 13.1 GO:0035145 exon-exon junction complex(GO:0035145)
0.4 4.0 GO:0032010 phagolysosome(GO:0032010)
0.4 18.8 GO:0002102 podosome(GO:0002102)
0.3 26.0 GO:0030670 phagocytic vesicle membrane(GO:0030670)
0.3 5.0 GO:0008540 proteasome regulatory particle, base subcomplex(GO:0008540)
0.3 5.3 GO:0016281 eukaryotic translation initiation factor 4F complex(GO:0016281)
0.3 4.3 GO:0000164 protein phosphatase type 1 complex(GO:0000164)
0.2 5.1 GO:0005861 troponin complex(GO:0005861)
0.2 16.7 GO:0045178 basal part of cell(GO:0045178)
0.2 1.5 GO:0034464 BBSome(GO:0034464)
0.1 7.1 GO:0042571 immunoglobulin complex, circulating(GO:0042571)
0.1 10.1 GO:1904724 tertiary granule lumen(GO:1904724)
0.1 1.3 GO:0005677 chromatin silencing complex(GO:0005677)
0.1 41.3 GO:0031965 nuclear membrane(GO:0031965)
0.1 18.7 GO:0090575 RNA polymerase II transcription factor complex(GO:0090575)
0.1 10.6 GO:0031985 Golgi cisterna(GO:0031985)
0.1 4.6 GO:0031519 PcG protein complex(GO:0031519)
0.1 5.2 GO:0034707 chloride channel complex(GO:0034707)
0.1 0.4 GO:0035867 alphav-beta3 integrin-IGF-1-IGF1R complex(GO:0035867)
0.1 8.1 GO:0005923 bicellular tight junction(GO:0005923)
0.0 2.0 GO:0045095 keratin filament(GO:0045095)
0.0 1.4 GO:0016592 mediator complex(GO:0016592)
0.0 8.6 GO:0005741 mitochondrial outer membrane(GO:0005741) organelle outer membrane(GO:0031968)
0.0 13.7 GO:0005759 mitochondrial matrix(GO:0005759)
0.0 5.9 GO:0005788 endoplasmic reticulum lumen(GO:0005788)
0.0 2.4 GO:0030658 transport vesicle membrane(GO:0030658)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
2.9 14.3 GO:0046899 nucleoside triphosphate adenylate kinase activity(GO:0046899)
2.5 12.5 GO:0019912 cyclin-dependent protein kinase activating kinase activity(GO:0019912)
1.8 28.6 GO:0001054 RNA polymerase I activity(GO:0001054)
1.8 17.7 GO:0050692 DBD domain binding(GO:0050692)
1.7 11.9 GO:0034513 box H/ACA snoRNA binding(GO:0034513)
1.5 13.8 GO:0089720 caspase binding(GO:0089720)
1.4 6.9 GO:0004656 procollagen-proline 4-dioxygenase activity(GO:0004656)
1.2 102.3 GO:0050840 extracellular matrix binding(GO:0050840)
0.9 18.1 GO:0008191 metalloendopeptidase inhibitor activity(GO:0008191)
0.9 16.7 GO:0035256 G-protein coupled glutamate receptor binding(GO:0035256)
0.8 2.4 GO:0005173 stem cell factor receptor binding(GO:0005173)
0.7 30.7 GO:0042974 retinoic acid receptor binding(GO:0042974)
0.6 2.9 GO:0052655 branched-chain-amino-acid transaminase activity(GO:0004084) L-leucine transaminase activity(GO:0052654) L-valine transaminase activity(GO:0052655) L-isoleucine transaminase activity(GO:0052656)
0.6 3.9 GO:0008172 S-methyltransferase activity(GO:0008172)
0.5 4.0 GO:0016176 superoxide-generating NADPH oxidase activator activity(GO:0016176)
0.5 10.1 GO:0008242 omega peptidase activity(GO:0008242)
0.4 8.1 GO:0031996 thioesterase binding(GO:0031996)
0.4 1.8 GO:0003985 acetyl-CoA C-acetyltransferase activity(GO:0003985)
0.4 5.3 GO:0033592 RNA strand annealing activity(GO:0033592)
0.4 11.7 GO:0004707 MAP kinase activity(GO:0004707)
0.4 5.1 GO:0031014 troponin T binding(GO:0031014)
0.2 5.2 GO:0005247 voltage-gated chloride channel activity(GO:0005247)
0.2 7.9 GO:0001671 ATPase activator activity(GO:0001671)
0.2 2.5 GO:0097027 ubiquitin-protein transferase activator activity(GO:0097027)
0.2 1.0 GO:0033743 peptide-methionine (R)-S-oxide reductase activity(GO:0033743)
0.2 9.1 GO:0017112 Rab guanyl-nucleotide exchange factor activity(GO:0017112)
0.2 2.0 GO:0030280 structural constituent of epidermis(GO:0030280)
0.1 12.3 GO:0004843 thiol-dependent ubiquitin-specific protease activity(GO:0004843)
0.1 7.1 GO:0034987 immunoglobulin receptor binding(GO:0034987)
0.1 1.7 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017)
0.1 4.3 GO:0008157 protein phosphatase 1 binding(GO:0008157)
0.1 0.7 GO:0008142 oxysterol binding(GO:0008142)
0.1 4.3 GO:0070577 lysine-acetylated histone binding(GO:0070577)
0.1 0.3 GO:0030272 5-formyltetrahydrofolate cyclo-ligase activity(GO:0030272)
0.1 9.1 GO:0097110 scaffold protein binding(GO:0097110)
0.1 26.0 GO:0019887 protein kinase regulator activity(GO:0019887)
0.1 0.9 GO:0001730 2'-5'-oligoadenylate synthetase activity(GO:0001730)
0.1 12.1 GO:0042393 histone binding(GO:0042393)
0.1 0.9 GO:0015377 cation:chloride symporter activity(GO:0015377)
0.1 2.6 GO:0001784 phosphotyrosine binding(GO:0001784)
0.0 3.0 GO:0004004 ATP-dependent RNA helicase activity(GO:0004004)
0.0 31.4 GO:0003712 transcription cofactor activity(GO:0003712)
0.0 2.9 GO:0016278 lysine N-methyltransferase activity(GO:0016278) protein-lysine N-methyltransferase activity(GO:0016279)
0.0 1.0 GO:0005104 fibroblast growth factor receptor binding(GO:0005104)
0.0 0.2 GO:0016167 glial cell-derived neurotrophic factor receptor activity(GO:0016167)
0.0 0.2 GO:0046870 cadmium ion binding(GO:0046870)
0.0 1.7 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.0 0.4 GO:0005159 insulin-like growth factor receptor binding(GO:0005159)
0.0 1.9 GO:0017137 Rab GTPase binding(GO:0017137)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
2.1 102.3 PID INTEGRIN2 PATHWAY Beta2 integrin cell surface interactions
0.9 12.5 SA G2 AND M PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.4 21.9 PID IL8 CXCR2 PATHWAY IL8- and CXCR2-mediated signaling events
0.3 17.7 PID RXR VDR PATHWAY RXR and RAR heterodimerization with other nuclear receptor
0.3 13.8 PID TRAIL PATHWAY TRAIL signaling pathway
0.3 12.3 PID FANCONI PATHWAY Fanconi anemia pathway
0.2 19.5 PID IL6 7 PATHWAY IL6-mediated signaling events
0.2 30.7 PID PDGFRB PATHWAY PDGFR-beta signaling pathway
0.2 10.6 PID RHOA PATHWAY RhoA signaling pathway
0.1 12.1 PID ERA GENOMIC PATHWAY Validated nuclear estrogen receptor alpha network
0.1 8.1 PID TAP63 PATHWAY Validated transcriptional targets of TAp63 isoforms
0.1 2.5 PID BARD1 PATHWAY BARD1 signaling events
0.1 2.4 PID KIT PATHWAY Signaling events mediated by Stem cell factor receptor (c-Kit)
0.0 4.3 PID RB 1PATHWAY Regulation of retinoblastoma protein
0.0 2.1 PID HDAC CLASSII PATHWAY Signaling events mediated by HDAC Class II
0.0 0.4 PID IGF1 PATHWAY IGF1 pathway
0.0 1.0 PID FGF PATHWAY FGF signaling pathway
0.0 1.4 PID SMAD2 3NUCLEAR PATHWAY Regulation of nuclear SMAD2/3 signaling
0.0 1.1 PID MYC ACTIV PATHWAY Validated targets of C-MYC transcriptional activation

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
2.2 102.3 REACTOME AMYLOIDS Genes involved in Amyloids
1.3 26.8 REACTOME RNA POL III CHAIN ELONGATION Genes involved in RNA Polymerase III Chain Elongation
1.0 12.3 REACTOME REGULATION OF THE FANCONI ANEMIA PATHWAY Genes involved in Regulation of the Fanconi anemia pathway
0.8 30.7 REACTOME NEPHRIN INTERACTIONS Genes involved in Nephrin interactions
0.7 13.8 REACTOME NFKB ACTIVATION THROUGH FADD RIP1 PATHWAY MEDIATED BY CASPASE 8 AND10 Genes involved in NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10
0.6 26.0 REACTOME SEMA4D INDUCED CELL MIGRATION AND GROWTH CONE COLLAPSE Genes involved in Sema4D induced cell migration and growth-cone collapse
0.6 12.5 REACTOME AKT PHOSPHORYLATES TARGETS IN THE CYTOSOL Genes involved in AKT phosphorylates targets in the cytosol
0.5 21.5 REACTOME DEGRADATION OF THE EXTRACELLULAR MATRIX Genes involved in Degradation of the extracellular matrix
0.2 13.1 REACTOME TRANSPORT OF MATURE TRANSCRIPT TO CYTOPLASM Genes involved in Transport of Mature Transcript to Cytoplasm
0.2 18.4 REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.1 3.9 REACTOME SULFUR AMINO ACID METABOLISM Genes involved in Sulfur amino acid metabolism
0.1 17.1 REACTOME REGULATION OF MRNA STABILITY BY PROTEINS THAT BIND AU RICH ELEMENTS Genes involved in Regulation of mRNA Stability by Proteins that Bind AU-rich Elements
0.1 2.9 REACTOME BRANCHED CHAIN AMINO ACID CATABOLISM Genes involved in Branched-chain amino acid catabolism
0.1 4.0 REACTOME ANTIGEN PROCESSING CROSS PRESENTATION Genes involved in Antigen processing-Cross presentation
0.1 1.7 REACTOME ERKS ARE INACTIVATED Genes involved in ERKs are inactivated
0.1 5.1 REACTOME STRIATED MUSCLE CONTRACTION Genes involved in Striated Muscle Contraction
0.1 5.3 REACTOME ACTIVATION OF THE MRNA UPON BINDING OF THE CAP BINDING COMPLEX AND EIFS AND SUBSEQUENT BINDING TO 43S Genes involved in Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
0.1 1.0 REACTOME FGFR4 LIGAND BINDING AND ACTIVATION Genes involved in FGFR4 ligand binding and activation
0.0 1.4 REACTOME TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION Genes involved in Transcriptional Regulation of White Adipocyte Differentiation
0.0 2.5 REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION Genes involved in Antigen processing: Ubiquitination & Proteasome degradation