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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
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Results for ZKSCAN3
Z-value: 0.41
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Transcription factors associated with ZKSCAN3
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| ZKSCAN3 | hg38_v1_chr6_+_28349907_28349983 | -0.46 | 1.0e-12 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of ZKSCAN3
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.9 | 23.3 | GO:0042866 | pyruvate biosynthetic process(GO:0042866) |
| 2.2 | 15.1 | GO:0051490 | negative regulation of filopodium assembly(GO:0051490) |
| 0.1 | 11.4 | GO:0006958 | complement activation, classical pathway(GO:0006958) |
| 0.9 | 5.4 | GO:0006543 | glutamine catabolic process(GO:0006543) |
| 1.6 | 4.9 | GO:0035752 | lysosomal lumen pH elevation(GO:0035752) |
| 0.5 | 4.6 | GO:2000002 | negative regulation of DNA damage checkpoint(GO:2000002) |
| 0.3 | 4.6 | GO:0030050 | vesicle transport along actin filament(GO:0030050) |
| 0.1 | 4.5 | GO:0061641 | chromatin remodeling at centromere(GO:0031055) CENP-A containing nucleosome assembly(GO:0034080) CENP-A containing chromatin organization(GO:0061641) |
| 0.0 | 4.5 | GO:0006521 | regulation of cellular amino acid metabolic process(GO:0006521) |
| 0.1 | 4.0 | GO:0043928 | exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay(GO:0043928) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 23.3 | GO:0101002 | ficolin-1-rich granule(GO:0101002) ficolin-1-rich granule lumen(GO:1904813) |
| 1.3 | 15.1 | GO:0071203 | F-actin capping protein complex(GO:0008290) WASH complex(GO:0071203) |
| 0.7 | 8.6 | GO:0005688 | U6 snRNP(GO:0005688) |
| 0.1 | 5.6 | GO:0042571 | immunoglobulin complex, circulating(GO:0042571) |
| 0.1 | 4.9 | GO:0005776 | autophagosome(GO:0005776) |
| 0.0 | 4.6 | GO:0005938 | cell cortex(GO:0005938) |
| 0.3 | 4.5 | GO:0019774 | proteasome core complex, beta-subunit complex(GO:0019774) |
| 0.2 | 4.5 | GO:0010369 | chromocenter(GO:0010369) |
| 0.4 | 3.5 | GO:0098559 | cytoplasmic side of early endosome membrane(GO:0098559) |
| 0.0 | 3.5 | GO:0072562 | blood microparticle(GO:0072562) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 5.8 | 23.3 | GO:0004743 | pyruvate kinase activity(GO:0004743) |
| 0.1 | 15.1 | GO:0051015 | actin filament binding(GO:0051015) |
| 0.2 | 12.2 | GO:0004864 | protein phosphatase inhibitor activity(GO:0004864) |
| 0.1 | 5.6 | GO:0034987 | immunoglobulin receptor binding(GO:0034987) |
| 0.9 | 5.4 | GO:0004359 | glutaminase activity(GO:0004359) |
| 0.0 | 5.3 | GO:0003823 | antigen binding(GO:0003823) |
| 0.0 | 4.9 | GO:0051082 | unfolded protein binding(GO:0051082) |
| 0.5 | 4.6 | GO:0030621 | U4 snRNA binding(GO:0030621) |
| 0.2 | 4.5 | GO:0004298 | threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003) |
| 0.3 | 4.0 | GO:0017070 | U6 snRNA binding(GO:0017070) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 12.2 | PID ILK PATHWAY | Integrin-linked kinase signaling |
| 0.0 | 4.8 | NABA ECM GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 0.0 | 1.9 | PID RB 1PATHWAY | Regulation of retinoblastoma protein |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 5.4 | REACTOME AMINO ACID SYNTHESIS AND INTERCONVERSION TRANSAMINATION | Genes involved in Amino acid synthesis and interconversion (transamination) |
| 0.2 | 4.5 | REACTOME DEPOSITION OF NEW CENPA CONTAINING NUCLEOSOMES AT THE CENTROMERE | Genes involved in Deposition of New CENPA-containing Nucleosomes at the Centromere |
| 0.1 | 4.5 | REACTOME CROSS PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS ENDOSOMES | Genes involved in Cross-presentation of soluble exogenous antigens (endosomes) |
| 0.1 | 1.0 | REACTOME TRAFFICKING AND PROCESSING OF ENDOSOMAL TLR | Genes involved in Trafficking and processing of endosomal TLR |