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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
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Results for ZNF143
Z-value: 3.83
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Transcription factors associated with ZNF143
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| ZNF143 | hg38_v1_chr11_+_9461003_9461057 | 0.65 | 1.6e-27 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of ZNF143
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.4 | 475.1 | GO:0000375 | RNA splicing, via transesterification reactions(GO:0000375) |
| 1.8 | 349.3 | GO:0006364 | rRNA processing(GO:0006364) |
| 35.7 | 250.2 | GO:0030423 | targeting of mRNA for destruction involved in RNA interference(GO:0030423) |
| 14.8 | 207.1 | GO:0018206 | peptidyl-methionine modification(GO:0018206) |
| 12.2 | 195.7 | GO:1990001 | inhibition of cysteine-type endopeptidase activity involved in apoptotic process(GO:1990001) |
| 2.9 | 191.5 | GO:0006120 | mitochondrial electron transport, NADH to ubiquinone(GO:0006120) |
| 4.4 | 182.3 | GO:0071174 | mitotic spindle checkpoint(GO:0071174) |
| 14.7 | 162.0 | GO:0036481 | intrinsic apoptotic signaling pathway in response to hydrogen peroxide(GO:0036481) |
| 51.2 | 153.5 | GO:0075732 | viral penetration into host nucleus(GO:0075732) multi-organism nuclear import(GO:1902594) |
| 21.5 | 150.6 | GO:0046726 | positive regulation by virus of viral protein levels in host cell(GO:0046726) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 5.3 | 398.4 | GO:0010494 | cytoplasmic stress granule(GO:0010494) |
| 0.4 | 354.8 | GO:0005730 | nucleolus(GO:0005730) |
| 2.8 | 277.3 | GO:0071013 | catalytic step 2 spliceosome(GO:0071013) |
| 30.2 | 271.6 | GO:0032133 | chromosome passenger complex(GO:0032133) |
| 2.4 | 220.0 | GO:0005643 | nuclear pore(GO:0005643) |
| 19.9 | 199.3 | GO:0035068 | micro-ribonucleoprotein complex(GO:0035068) |
| 10.6 | 170.1 | GO:0034709 | methylosome(GO:0034709) |
| 16.8 | 168.1 | GO:0071541 | eukaryotic translation initiation factor 3 complex, eIF3m(GO:0071541) |
| 1.8 | 153.1 | GO:0005681 | spliceosomal complex(GO:0005681) |
| 1.5 | 150.3 | GO:0022625 | cytosolic large ribosomal subunit(GO:0022625) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 759.4 | GO:0003723 | RNA binding(GO:0003723) |
| 5.3 | 283.6 | GO:0008536 | Ran GTPase binding(GO:0008536) |
| 1.2 | 264.3 | GO:0003735 | structural constituent of ribosome(GO:0003735) |
| 7.1 | 213.9 | GO:0017056 | structural constituent of nuclear pore(GO:0017056) |
| 19.9 | 199.3 | GO:0070883 | pre-miRNA binding(GO:0070883) |
| 6.9 | 193.5 | GO:0008574 | ATP-dependent microtubule motor activity, plus-end-directed(GO:0008574) |
| 2.6 | 173.7 | GO:0003743 | translation initiation factor activity(GO:0003743) |
| 1.0 | 169.1 | GO:0047485 | protein N-terminus binding(GO:0047485) |
| 0.5 | 160.5 | GO:0045296 | cadherin binding(GO:0045296) |
| 4.2 | 150.6 | GO:0008157 | protein phosphatase 1 binding(GO:0008157) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 6.0 | 363.0 | PID AURORA B PATHWAY | Aurora B signaling |
| 2.9 | 144.0 | PID MYC PATHWAY | C-MYC pathway |
| 1.8 | 138.3 | PID P53 REGULATION PATHWAY | p53 pathway |
| 1.2 | 137.6 | PID AR PATHWAY | Coregulation of Androgen receptor activity |
| 1.4 | 131.8 | PID MYC ACTIV PATHWAY | Validated targets of C-MYC transcriptional activation |
| 3.3 | 130.8 | PID SMAD2 3PATHWAY | Regulation of cytoplasmic and nuclear SMAD2/3 signaling |
| 0.7 | 111.1 | PID P53 DOWNSTREAM PATHWAY | Direct p53 effectors |
| 3.6 | 103.5 | PID DNA PK PATHWAY | DNA-PK pathway in nonhomologous end joining |
| 1.1 | 81.6 | PID INTEGRIN A4B1 PATHWAY | Alpha4 beta1 integrin signaling events |
| 0.8 | 81.2 | PID P73PATHWAY | p73 transcription factor network |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 4.5 | 439.4 | REACTOME ACTIVATION OF THE MRNA UPON BINDING OF THE CAP BINDING COMPLEX AND EIFS AND SUBSEQUENT BINDING TO 43S | Genes involved in Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S |
| 11.1 | 232.6 | REACTOME PROCESSIVE SYNTHESIS ON THE LAGGING STRAND | Genes involved in Processive synthesis on the lagging strand |
| 6.3 | 232.2 | REACTOME TRANSPORT OF RIBONUCLEOPROTEINS INTO THE HOST NUCLEUS | Genes involved in Transport of Ribonucleoproteins into the Host Nucleus |
| 2.7 | 229.1 | REACTOME RESPIRATORY ELECTRON TRANSPORT | Genes involved in Respiratory electron transport |
| 2.9 | 204.7 | REACTOME APC C CDH1 MEDIATED DEGRADATION OF CDC20 AND OTHER APC C CDH1 TARGETED PROTEINS IN LATE MITOSIS EARLY G1 | Genes involved in APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 |
| 1.7 | 198.5 | REACTOME SRP DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE | Genes involved in SRP-dependent cotranslational protein targeting to membrane |
| 4.0 | 179.3 | REACTOME MRNA 3 END PROCESSING | Genes involved in mRNA 3'-end processing |
| 6.1 | 171.3 | REACTOME INHIBITION OF THE PROTEOLYTIC ACTIVITY OF APC C REQUIRED FOR THE ONSET OF ANAPHASE BY MITOTIC SPINDLE CHECKPOINT COMPONENTS | Genes involved in Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components |
| 5.6 | 163.3 | REACTOME MICRORNA MIRNA BIOGENESIS | Genes involved in MicroRNA (miRNA) Biogenesis |
| 1.6 | 155.2 | REACTOME APOPTOTIC EXECUTION PHASE | Genes involved in Apoptotic execution phase |