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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
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Results for ZNF148
Z-value: 1.05
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Transcription factors associated with ZNF148
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| ZNF148 | hg38_v1_chr3_-_125375249_125375330 | -0.03 | 7.1e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of ZNF148
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 49.6 | GO:0043488 | regulation of mRNA stability(GO:0043488) |
| 0.2 | 34.0 | GO:0030705 | cytoskeleton-dependent intracellular transport(GO:0030705) |
| 2.7 | 27.0 | GO:0071787 | endoplasmic reticulum tubular network assembly(GO:0071787) |
| 2.7 | 26.9 | GO:0010756 | positive regulation of plasminogen activation(GO:0010756) |
| 2.3 | 20.6 | GO:2000582 | regulation of ATP-dependent microtubule motor activity, plus-end-directed(GO:2000580) positive regulation of ATP-dependent microtubule motor activity, plus-end-directed(GO:2000582) |
| 1.6 | 17.9 | GO:0000056 | ribosomal small subunit export from nucleus(GO:0000056) |
| 2.8 | 17.0 | GO:0048549 | positive regulation of pinocytosis(GO:0048549) |
| 4.1 | 16.6 | GO:0002541 | activation of plasma proteins involved in acute inflammatory response(GO:0002541) |
| 2.3 | 16.3 | GO:0030421 | defecation(GO:0030421) |
| 0.3 | 16.1 | GO:0070534 | protein K63-linked ubiquitination(GO:0070534) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.6 | 40.0 | GO:0005881 | cytoplasmic microtubule(GO:0005881) |
| 0.3 | 29.3 | GO:0032580 | Golgi cisterna membrane(GO:0032580) |
| 3.4 | 26.9 | GO:0000015 | phosphopyruvate hydratase complex(GO:0000015) |
| 0.0 | 26.2 | GO:0000139 | Golgi membrane(GO:0000139) |
| 0.8 | 21.0 | GO:0005868 | cytoplasmic dynein complex(GO:0005868) |
| 0.3 | 18.1 | GO:0012507 | ER to Golgi transport vesicle membrane(GO:0012507) |
| 1.1 | 17.9 | GO:0005642 | annulate lamellae(GO:0005642) |
| 0.9 | 17.0 | GO:0033643 | host cell part(GO:0033643) |
| 0.2 | 16.8 | GO:0005834 | heterotrimeric G-protein complex(GO:0005834) |
| 0.5 | 16.6 | GO:0031233 | intrinsic component of external side of plasma membrane(GO:0031233) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 49.4 | GO:0005200 | structural constituent of cytoskeleton(GO:0005200) |
| 0.7 | 31.1 | GO:0048027 | mRNA 5'-UTR binding(GO:0048027) |
| 0.2 | 30.2 | GO:0002020 | protease binding(GO:0002020) |
| 3.4 | 26.9 | GO:0004634 | phosphopyruvate hydratase activity(GO:0004634) |
| 0.9 | 25.4 | GO:0008574 | ATP-dependent microtubule motor activity, plus-end-directed(GO:0008574) |
| 0.9 | 19.6 | GO:0032036 | myosin heavy chain binding(GO:0032036) |
| 0.1 | 18.4 | GO:0005096 | GTPase activator activity(GO:0005096) |
| 1.2 | 17.9 | GO:0005049 | nuclear export signal receptor activity(GO:0005049) |
| 0.1 | 17.3 | GO:0008017 | microtubule binding(GO:0008017) |
| 0.4 | 16.7 | GO:0061631 | ubiquitin conjugating enzyme activity(GO:0061631) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 46.0 | ST DIFFERENTIATION PATHWAY IN PC12 CELLS | Differentiation Pathway in PC12 Cells; this is a specific case of PAC1 Receptor Pathway. |
| 0.2 | 18.5 | PID NOTCH PATHWAY | Notch signaling pathway |
| 0.8 | 17.9 | PID RANBP2 PATHWAY | Sumoylation by RanBP2 regulates transcriptional repression |
| 0.2 | 16.4 | PID DELTA NP63 PATHWAY | Validated transcriptional targets of deltaNp63 isoforms |
| 0.1 | 14.5 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.3 | 11.8 | PID NECTIN PATHWAY | Nectin adhesion pathway |
| 0.1 | 9.8 | SIG INSULIN RECEPTOR PATHWAY IN CARDIAC MYOCYTES | Genes related to the insulin receptor pathway |
| 0.1 | 9.0 | PID RHOA REG PATHWAY | Regulation of RhoA activity |
| 0.6 | 8.4 | PID TCR RAS PATHWAY | Ras signaling in the CD4+ TCR pathway |
| 0.1 | 8.3 | PID RAC1 REG PATHWAY | Regulation of RAC1 activity |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.7 | 38.6 | REACTOME GLYCOLYSIS | Genes involved in Glycolysis |
| 1.2 | 33.6 | REACTOME POST CHAPERONIN TUBULIN FOLDING PATHWAY | Genes involved in Post-chaperonin tubulin folding pathway |
| 0.1 | 26.1 | REACTOME DIABETES PATHWAYS | Genes involved in Diabetes pathways |
| 0.8 | 22.5 | REACTOME CYCLIN A B1 ASSOCIATED EVENTS DURING G2 M TRANSITION | Genes involved in Cyclin A/B1 associated events during G2/M transition |
| 0.5 | 18.1 | REACTOME PROSTACYCLIN SIGNALLING THROUGH PROSTACYCLIN RECEPTOR | Genes involved in Prostacyclin signalling through prostacyclin receptor |
| 0.1 | 17.5 | REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION | Genes involved in Antigen processing: Ubiquitination & Proteasome degradation |
| 0.6 | 17.4 | REACTOME N GLYCAN ANTENNAE ELONGATION IN THE MEDIAL TRANS GOLGI | Genes involved in N-glycan antennae elongation in the medial/trans-Golgi |
| 0.3 | 16.3 | REACTOME FORMATION OF FIBRIN CLOT CLOTTING CASCADE | Genes involved in Formation of Fibrin Clot (Clotting Cascade) |
| 0.2 | 14.2 | REACTOME CROSS PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS ENDOSOMES | Genes involved in Cross-presentation of soluble exogenous antigens (endosomes) |
| 0.3 | 13.8 | REACTOME FATTY ACYL COA BIOSYNTHESIS | Genes involved in Fatty Acyl-CoA Biosynthesis |