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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)

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Results for ZNF232

Z-value: 0.58

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Transcription factors associated with ZNF232

Gene Symbol Gene ID Gene Info
ZNF232
ENSG00000167840.13 ZNF232

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
ZNF232hg38_v1_chr17_-_5111836_5111845,
hg38_v1_chr17_-_5123102_5123128		-0.386.4e-09Click!

Activity profile of ZNF232 motif

Sorted Z-values of ZNF232 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of ZNF232

PNG image of the network

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Top targets:

Promoter Score Transcript Gene Gene Info
chr4_-_87529460 32.06 ENST00000418378.5
SPARCL1
SPARC like 1
chr18_+_36129888 11.23 ENST00000351393.10
ENST00000442325.6
ENST00000423854.6
ENST00000358232.11
ENST00000350494.10
ENST00000542824.5
ELP2
elongator acetyltransferase complex subunit 2
chr3_-_185498964 9.49 ENST00000296254.3
TMEM41A
transmembrane protein 41A
chr3_-_185499022 9.13 ENST00000421852.6
TMEM41A
transmembrane protein 41A
chr9_-_112718021 8.42 ENST00000374234.1
ENST00000374242.9
ENST00000374236.5
INIP
INTS3 and NABP interacting protein
chr2_-_112764600 7.58 ENST00000302450.11
CKAP2L
cytoskeleton associated protein 2 like
chr6_+_109095110 7.54 ENST00000521277.5
ENST00000407272.5
ENST00000519286.5
CEP57L1
centrosomal protein 57 like 1
chr6_-_109094819 6.75 ENST00000436639.6
SESN1
sestrin 1
chr14_-_21048431 6.73 ENST00000555026.5
NDRG2
NDRG family member 2
chr4_+_95840084 6.29 ENST00000295266.6
PDHA2
pyruvate dehydrogenase E1 subunit alpha 2
chrY_+_12904102 5.87 ENST00000360160.8
ENST00000454054.5
DDX3Y
DEAD-box helicase 3 Y-linked
chr7_+_143132069 5.86 ENST00000291009.4
PIP
prolactin induced protein
chr6_-_46954922 5.54 ENST00000265417.7
ADGRF5
adhesion G protein-coupled receptor F5
chr6_+_109095481 4.96 ENST00000521522.5
ENST00000524064.5
ENST00000522608.5
ENST00000517392.6
ENST00000521503.5
ENST00000519407.5
ENST00000519095.5
ENST00000368968.6
ENST00000522490.5
ENST00000523209.5
ENST00000368970.6
ENST00000520883.5
ENST00000523787.5
CEP57L1
centrosomal protein 57 like 1
chrX_-_131289412 4.89 ENST00000652189.1
ENST00000651556.1
IGSF1
immunoglobulin superfamily member 1
chrY_+_12904860 4.74 ENST00000336079.8
DDX3Y
DEAD-box helicase 3 Y-linked
chr6_-_49713564 4.69 ENST00000616725.4
ENST00000618917.4
CRISP2
cysteine rich secretory protein 2
chr1_-_79006773 4.58 ENST00000671209.1
ADGRL4
adhesion G protein-coupled receptor L4
chr1_-_13285154 4.53 ENST00000357367.6
ENST00000614831.1
PRAMEF8
PRAME family member 8
chr6_-_49713521 4.31 ENST00000339139.5
CRISP2
cysteine rich secretory protein 2
chr14_-_24242600 3.88 ENST00000646753.1
ENST00000558566.1
ENST00000267415.12
ENST00000559019.1
ENST00000399423.8
ENST00000626689.2
TINF2
TERF1 interacting nuclear factor 2
chr5_-_180649579 3.44 ENST00000261937.11
ENST00000502649.5
FLT4
fms related receptor tyrosine kinase 4
chr7_-_83649097 3.20 ENST00000643230.2
SEMA3E
semaphorin 3E
chr12_+_55549602 3.20 ENST00000641569.1
ENST00000641851.1
OR6C4
olfactory receptor family 6 subfamily C member 4
chr1_-_79006680 3.04 ENST00000370742.4
ENST00000656841.1
ADGRL4
adhesion G protein-coupled receptor L4
chr17_-_19377876 3.03 ENST00000674596.1
ENST00000642870.2
B9D1
B9 domain containing 1
chr2_-_166149120 2.97 ENST00000641575.1
ENST00000641603.1
SCN1A
sodium voltage-gated channel alpha subunit 1
chrX_+_101550537 2.93 ENST00000372829.8
ARMCX1
armadillo repeat containing X-linked 1
chr5_+_150357629 2.85 ENST00000650162.1
ENST00000377797.7
ENST00000445265.6
ENST00000323668.11
ENST00000643257.2
ENST00000646961.1
ENST00000513538.2
ENST00000439160.6
ENST00000394269.7
ENST00000427724.7
ENST00000504761.6
ENST00000513346.5
ENST00000515516.1
TCOF1
treacle ribosome biogenesis factor 1
chr2_-_166149204 2.79 ENST00000635750.1
SCN1A
sodium voltage-gated channel alpha subunit 1
chr10_-_60141004 2.76 ENST00000355288.6
ANK3
ankyrin 3
chr1_-_204685700 2.72 ENST00000367177.4
LRRN2
leucine rich repeat neuronal 2
chr11_+_66509079 2.65 ENST00000419755.3
ENSG00000256349.1
novel protein
chr20_+_4148779 2.62 ENST00000621355.4
ENST00000339123.10
ENST00000278795.7
ENST00000305958.9
ENST00000346595.6
SMOX
spermine oxidase
chr16_+_30650932 2.28 ENST00000300835.9
PRR14
proline rich 14
chr15_-_79090760 2.23 ENST00000419573.7
ENST00000558480.7
RASGRF1
Ras protein specific guanine nucleotide releasing factor 1
chr14_-_106269133 2.20 ENST00000390609.3
IGHV3-23
immunoglobulin heavy variable 3-23
chr10_+_89283685 2.20 ENST00000638108.1
IFIT2
interferon induced protein with tetratricopeptide repeats 2
chr9_+_5231413 2.16 ENST00000239316.4
INSL4
insulin like 4
chr18_+_63970029 2.11 ENST00000353706.6
ENST00000542677.5
ENST00000397985.7
ENST00000636430.1
ENST00000397988.7
ENST00000448851.5
SERPINB8
serpin family B member 8
chr5_-_180649613 1.99 ENST00000393347.7
ENST00000619105.4
FLT4
fms related receptor tyrosine kinase 4
chr22_-_42614911 1.92 ENST00000617178.4
ENST00000348657.6
ENST00000451060.6
POLDIP3
DNA polymerase delta interacting protein 3
chr2_-_31414694 1.90 ENST00000379416.4
XDH
xanthine dehydrogenase
chr12_-_47725483 1.80 ENST00000422538.8
ENDOU
endonuclease, poly(U) specific
chr14_+_22547495 1.77 ENST00000611116.2
TRAC
T cell receptor alpha constant
chr17_+_28473278 1.75 ENST00000444914.7
SLC13A2
solute carrier family 13 member 2
chr2_+_233917371 1.71 ENST00000324695.9
ENST00000433712.6
TRPM8
transient receptor potential cation channel subfamily M member 8
chr17_+_28473635 1.66 ENST00000314669.10
ENST00000545060.2
SLC13A2
solute carrier family 13 member 2
chr4_+_39406917 1.55 ENST00000257408.5
KLB
klotho beta
chr13_+_27251569 1.55 ENST00000272274.8
ENST00000319826.8
ENST00000326092.8
RPL21
ribosomal protein L21
chr16_+_30651039 1.52 ENST00000542965.2
PRR14
proline rich 14
chrX_-_101293057 1.49 ENST00000372907.7
TAF7L
TATA-box binding protein associated factor 7 like
chr1_+_182450132 1.45 ENST00000294854.13
RGSL1
regulator of G protein signaling like 1
chr10_-_114144599 1.23 ENST00000428953.1
CCDC186
coiled-coil domain containing 186
chr1_-_160579439 1.17 ENST00000368054.8
ENST00000368048.7
ENST00000311224.8
ENST00000368051.3
ENST00000534968.5
CD84
CD84 molecule
chr14_-_70359630 1.14 ENST00000389912.7
COX16
cytochrome c oxidase assembly factor COX16
chr2_-_224947030 1.09 ENST00000409592.7
DOCK10
dedicator of cytokinesis 10
chr14_-_106675544 1.01 ENST00000390632.2
IGHV3-66
immunoglobulin heavy variable 3-66
chr7_-_100479142 0.95 ENST00000300181.7
ENST00000393991.5
TSC22D4
TSC22 domain family member 4
chr9_+_114323098 0.94 ENST00000259396.9
ORM1
orosomucoid 1
chr14_-_106360320 0.78 ENST00000390615.2
IGHV3-33
immunoglobulin heavy variable 3-33
chr10_+_49609095 0.56 ENST00000339797.5
CHAT
choline O-acetyltransferase
chr2_-_74392025 0.43 ENST00000440727.1
ENST00000409240.5
DCTN1
dynactin subunit 1
chr1_-_152115443 0.33 ENST00000614923.1
TCHH
trichohyalin
chr1_+_203795614 0.24 ENST00000367210.3
ENST00000432282.5
ENST00000453771.5
ENST00000367214.5
ENST00000639812.1
ENST00000367212.7
ENST00000332127.8
ENST00000550078.2
ZC3H11A
ZBED6
zinc finger CCCH-type containing 11A
zinc finger BED-type containing 6
chr21_+_37420299 0.11 ENST00000455097.6
ENST00000643854.1
ENST00000645424.1
ENST00000642309.1
ENST00000645774.1
ENST00000398956.2
DYRK1A
dual specificity tyrosine phosphorylation regulated kinase 1A
chr4_+_74308463 0.09 ENST00000413830.6
EPGN
epithelial mitogen
chr19_-_10380558 0.07 ENST00000524462.5
ENST00000525621.6
ENST00000531836.5
TYK2
tyrosine kinase 2
chr14_-_20454741 0.06 ENST00000206542.9
ENST00000553640.3
OSGEP
O-sialoglycoprotein endopeptidase

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
1.0 3.9 GO:0010836 negative regulation of protein ADP-ribosylation(GO:0010836)
0.7 2.8 GO:0072658 maintenance of protein location in membrane(GO:0072658) maintenance of protein location in plasma membrane(GO:0072660) positive regulation of membrane depolarization during cardiac muscle cell action potential(GO:1900827)
0.6 1.9 GO:0006145 purine nucleobase catabolic process(GO:0006145) xanthine metabolic process(GO:0046110)
0.6 6.7 GO:1904262 negative regulation of TORC1 signaling(GO:1904262)
0.5 2.6 GO:0046208 spermine catabolic process(GO:0046208)
0.5 5.5 GO:0043129 surfactant homeostasis(GO:0043129)
0.5 5.4 GO:0090037 positive regulation of protein kinase C signaling(GO:0090037)
0.4 6.7 GO:0090360 platelet-derived growth factor production(GO:0090360) regulation of platelet-derived growth factor production(GO:0090361)
0.4 1.2 GO:0032661 regulation of interleukin-18 production(GO:0032661)
0.4 5.8 GO:0098870 neuronal action potential propagation(GO:0019227) action potential propagation(GO:0098870)
0.3 6.3 GO:0010510 regulation of acetyl-CoA biosynthetic process from pyruvate(GO:0010510)
0.3 1.7 GO:0050955 thermoception(GO:0050955)
0.3 6.8 GO:0070233 negative regulation of T cell apoptotic process(GO:0070233)
0.2 1.5 GO:0090080 positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway(GO:0090080)
0.2 10.6 GO:0010501 RNA secondary structure unwinding(GO:0010501)
0.2 2.9 GO:0014029 neural crest formation(GO:0014029)
0.2 2.2 GO:0035457 cellular response to interferon-alpha(GO:0035457)
0.1 2.2 GO:0035020 regulation of Rac protein signal transduction(GO:0035020)
0.1 2.1 GO:0090136 epithelial cell-cell adhesion(GO:0090136)
0.1 2.2 GO:0016973 poly(A)+ mRNA export from nucleus(GO:0016973)
0.1 1.1 GO:0002315 marginal zone B cell differentiation(GO:0002315)
0.1 3.2 GO:0071526 semaphorin-plexin signaling pathway(GO:0071526)
0.1 0.9 GO:1904469 positive regulation of tumor necrosis factor secretion(GO:1904469)
0.1 11.2 GO:0006368 transcription elongation from RNA polymerase II promoter(GO:0006368)
0.1 12.5 GO:0000070 mitotic sister chromatid segregation(GO:0000070)
0.1 0.4 GO:0090063 positive regulation of microtubule nucleation(GO:0090063)
0.0 1.5 GO:0051123 RNA polymerase II transcriptional preinitiation complex assembly(GO:0051123)
0.0 3.2 GO:0006910 phagocytosis, recognition(GO:0006910)
0.0 3.0 GO:0042733 embryonic digit morphogenesis(GO:0042733)
0.0 8.4 GO:0010212 response to ionizing radiation(GO:0010212)
0.0 18.5 GO:0043687 post-translational protein modification(GO:0043687)
0.0 3.2 GO:0050911 detection of chemical stimulus involved in sensory perception of smell(GO:0050911)
0.0 3.4 GO:0006835 dicarboxylic acid transport(GO:0006835)
0.0 1.8 GO:0090502 RNA phosphodiester bond hydrolysis, endonucleolytic(GO:0090502)
0.0 0.6 GO:0042136 neurotransmitter biosynthetic process(GO:0042136)
0.0 0.1 GO:0002949 tRNA threonylcarbamoyladenosine modification(GO:0002949)
0.0 1.8 GO:0031295 T cell costimulation(GO:0031295)
0.0 1.5 GO:0006614 SRP-dependent cotranslational protein targeting to membrane(GO:0006614)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
2.1 8.4 GO:0070876 SOSS complex(GO:0070876)
1.0 11.2 GO:0033588 Elongator holoenzyme complex(GO:0033588)
0.8 6.7 GO:0061700 GATOR2 complex(GO:0061700)
0.5 6.3 GO:0045254 pyruvate dehydrogenase complex(GO:0045254)
0.5 3.9 GO:0070187 telosome(GO:0070187)
0.3 8.5 GO:0043194 axon initial segment(GO:0043194)
0.2 3.0 GO:0036038 MKS complex(GO:0036038)
0.1 2.2 GO:0000346 transcription export complex(GO:0000346)
0.1 34.8 GO:0005578 proteinaceous extracellular matrix(GO:0005578)
0.1 7.6 GO:0072686 mitotic spindle(GO:0072686)
0.1 3.2 GO:0042571 immunoglobulin complex, circulating(GO:0042571)
0.0 10.6 GO:0036464 cytoplasmic ribonucleoprotein granule(GO:0036464)
0.0 9.0 GO:0030426 growth cone(GO:0030426)
0.0 0.4 GO:0005869 dynactin complex(GO:0005869)
0.0 1.5 GO:0005669 transcription factor TFIID complex(GO:0005669)
0.0 12.5 GO:0005874 microtubule(GO:0005874)
0.0 2.9 GO:0001650 fibrillar center(GO:0001650)
0.0 1.5 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
0.0 1.3 GO:0016529 sarcoplasmic reticulum(GO:0016529)
0.0 0.9 GO:1904724 tertiary granule lumen(GO:1904724)
0.0 0.1 GO:0000408 EKC/KEOPS complex(GO:0000408)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
1.6 6.3 GO:0004739 pyruvate dehydrogenase (acetyl-transferring) activity(GO:0004739)
1.1 3.4 GO:0017153 sodium:dicarboxylate symporter activity(GO:0017153)
1.1 6.7 GO:0070728 leucine binding(GO:0070728)
0.7 2.6 GO:0052901 polyamine oxidase activity(GO:0046592) spermine:oxygen oxidoreductase (spermidine-forming) activity(GO:0052901)
0.5 4.9 GO:0034711 inhibin binding(GO:0034711)
0.5 5.4 GO:0005021 vascular endothelial growth factor-activated receptor activity(GO:0005021)
0.4 1.9 GO:0043546 molybdopterin cofactor binding(GO:0043546)
0.4 3.0 GO:0008158 hedgehog receptor activity(GO:0008158)
0.4 32.1 GO:0050840 extracellular matrix binding(GO:0050840)
0.3 5.9 GO:0019864 IgG binding(GO:0019864)
0.3 11.2 GO:0000993 RNA polymerase II core binding(GO:0000993)
0.3 12.5 GO:0043015 gamma-tubulin binding(GO:0043015)
0.3 1.5 GO:0008422 beta-glucosidase activity(GO:0008422)
0.3 2.9 GO:0001042 RNA polymerase I core binding(GO:0001042)
0.2 3.2 GO:0030215 semaphorin receptor binding(GO:0030215)
0.2 5.8 GO:1905030 voltage-gated sodium channel activity(GO:0005248) voltage-gated ion channel activity involved in regulation of postsynaptic membrane potential(GO:1905030)
0.1 0.6 GO:0004102 choline O-acetyltransferase activity(GO:0004102)
0.1 1.8 GO:0030247 pattern binding(GO:0001871) polysaccharide binding(GO:0030247)
0.1 10.6 GO:0004004 ATP-dependent RNA helicase activity(GO:0004004)
0.1 3.9 GO:0042162 telomeric DNA binding(GO:0042162)
0.1 3.2 GO:0034987 immunoglobulin receptor binding(GO:0034987)
0.0 2.8 GO:0030507 spectrin binding(GO:0030507)
0.0 2.2 GO:0005159 insulin-like growth factor receptor binding(GO:0005159)
0.0 3.2 GO:0004984 olfactory receptor activity(GO:0004984)
0.0 13.2 GO:0004930 G-protein coupled receptor activity(GO:0004930)
0.0 2.2 GO:0035254 glutamate receptor binding(GO:0035254)
0.0 1.5 GO:0035035 histone acetyltransferase binding(GO:0035035)
0.0 2.1 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.0 0.1 GO:0005131 growth hormone receptor binding(GO:0005131)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 11.2 ST INTERFERON GAMMA PATHWAY Interferon gamma pathway.
0.3 5.4 PID VEGF VEGFR PATHWAY VEGF and VEGFR signaling network
0.1 32.1 NABA ECM GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.1 1.8 SA FAS SIGNALING The TNF-type receptor Fas induces apoptosis on ligand binding.
0.1 6.7 PID MYC REPRESS PATHWAY Validated targets of C-MYC transcriptional repression
0.0 2.2 PID RAS PATHWAY Regulation of Ras family activation
0.0 3.9 PID TELOMERASE PATHWAY Regulation of Telomerase
0.0 6.7 PID P53 DOWNSTREAM PATHWAY Direct p53 effectors
0.0 1.9 PID MTOR 4PATHWAY mTOR signaling pathway
0.0 1.5 PID FGF PATHWAY FGF signaling pathway
0.0 3.2 NABA ECM AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.0 1.1 PID CDC42 REG PATHWAY Regulation of CDC42 activity
0.0 0.1 ST TYPE I INTERFERON PATHWAY Type I Interferon (alpha/beta IFN) Pathway
0.0 0.4 PID NCADHERIN PATHWAY N-cadherin signaling events

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 3.9 REACTOME PACKAGING OF TELOMERE ENDS Genes involved in Packaging Of Telomere Ends
0.3 5.4 REACTOME VEGF LIGAND RECEPTOR INTERACTIONS Genes involved in VEGF ligand-receptor interactions
0.2 3.4 REACTOME BILE SALT AND ORGANIC ANION SLC TRANSPORTERS Genes involved in Bile salt and organic anion SLC transporters
0.1 2.6 REACTOME METABOLISM OF POLYAMINES Genes involved in Metabolism of polyamines
0.1 3.2 REACTOME OTHER SEMAPHORIN INTERACTIONS Genes involved in Other semaphorin interactions
0.1 1.9 REACTOME PURINE CATABOLISM Genes involved in Purine catabolism
0.1 2.2 REACTOME RAS ACTIVATION UOPN CA2 INFUX THROUGH NMDA RECEPTOR Genes involved in Ras activation uopn Ca2+ infux through NMDA receptor
0.1 2.8 REACTOME INTERACTION BETWEEN L1 AND ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.0 1.5 REACTOME FGFR LIGAND BINDING AND ACTIVATION Genes involved in FGFR ligand binding and activation
0.0 3.2 REACTOME OLFACTORY SIGNALING PATHWAY Genes involved in Olfactory Signaling Pathway
0.0 0.6 REACTOME ACETYLCHOLINE NEUROTRANSMITTER RELEASE CYCLE Genes involved in Acetylcholine Neurotransmitter Release Cycle
0.0 2.3 REACTOME INTERFERON ALPHA BETA SIGNALING Genes involved in Interferon alpha/beta signaling