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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
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Results for ZNF232
Z-value: 0.58
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Transcription factors associated with ZNF232
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| ZNF232 | hg38_v1_chr17_-_5111836_5111845, hg38_v1_chr17_-_5123102_5123128 | -0.38 | 6.4e-09 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of ZNF232
| Promoter | Score | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr4_-_87529460 Show fit | 32.06 |
ENST00000418378.5
|
SPARC like 1 |
|
| chr18_+_36129888 Show fit | 11.23 |
ENST00000351393.10
ENST00000442325.6 ENST00000423854.6 ENST00000358232.11 ENST00000350494.10 ENST00000542824.5 |
elongator acetyltransferase complex subunit 2 |
|
| chr3_-_185498964 Show fit | 9.49 |
ENST00000296254.3
|
transmembrane protein 41A |
|
| chr3_-_185499022 Show fit | 9.13 |
ENST00000421852.6
|
transmembrane protein 41A |
|
| chr9_-_112718021 Show fit | 8.42 |
ENST00000374234.1
ENST00000374242.9 ENST00000374236.5 |
INTS3 and NABP interacting protein |
|
| chr2_-_112764600 Show fit | 7.58 |
ENST00000302450.11
|
cytoskeleton associated protein 2 like |
|
| chr6_+_109095110 Show fit | 7.54 |
ENST00000521277.5
ENST00000407272.5 ENST00000519286.5 |
centrosomal protein 57 like 1 |
|
| chr6_-_109094819 Show fit | 6.75 |
ENST00000436639.6
|
sestrin 1 |
|
| chr14_-_21048431 Show fit | 6.73 |
ENST00000555026.5
|
NDRG family member 2 |
|
| chr4_+_95840084 Show fit | 6.29 |
ENST00000295266.6
|
pyruvate dehydrogenase E1 subunit alpha 2 |
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 18.5 | GO:0043687 | post-translational protein modification(GO:0043687) |
| 0.1 | 12.5 | GO:0000070 | mitotic sister chromatid segregation(GO:0000070) |
| 0.1 | 11.2 | GO:0006368 | transcription elongation from RNA polymerase II promoter(GO:0006368) |
| 0.2 | 10.6 | GO:0010501 | RNA secondary structure unwinding(GO:0010501) |
| 0.0 | 8.4 | GO:0010212 | response to ionizing radiation(GO:0010212) |
| 0.3 | 6.8 | GO:0070233 | negative regulation of T cell apoptotic process(GO:0070233) |
| 0.6 | 6.7 | GO:1904262 | negative regulation of TORC1 signaling(GO:1904262) |
| 0.4 | 6.7 | GO:0090360 | platelet-derived growth factor production(GO:0090360) regulation of platelet-derived growth factor production(GO:0090361) |
| 0.3 | 6.3 | GO:0010510 | regulation of acetyl-CoA biosynthetic process from pyruvate(GO:0010510) |
| 0.4 | 5.8 | GO:0098870 | neuronal action potential propagation(GO:0019227) action potential propagation(GO:0098870) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 34.8 | GO:0005578 | proteinaceous extracellular matrix(GO:0005578) |
| 0.0 | 12.5 | GO:0005874 | microtubule(GO:0005874) |
| 1.0 | 11.2 | GO:0033588 | Elongator holoenzyme complex(GO:0033588) |
| 0.0 | 10.6 | GO:0036464 | cytoplasmic ribonucleoprotein granule(GO:0036464) |
| 0.0 | 9.0 | GO:0030426 | growth cone(GO:0030426) |
| 0.3 | 8.5 | GO:0043194 | axon initial segment(GO:0043194) |
| 2.1 | 8.4 | GO:0070876 | SOSS complex(GO:0070876) |
| 0.1 | 7.6 | GO:0072686 | mitotic spindle(GO:0072686) |
| 0.8 | 6.7 | GO:0061700 | GATOR2 complex(GO:0061700) |
| 0.5 | 6.3 | GO:0045254 | pyruvate dehydrogenase complex(GO:0045254) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 32.1 | GO:0050840 | extracellular matrix binding(GO:0050840) |
| 0.0 | 13.2 | GO:0004930 | G-protein coupled receptor activity(GO:0004930) |
| 0.3 | 12.5 | GO:0043015 | gamma-tubulin binding(GO:0043015) |
| 0.3 | 11.2 | GO:0000993 | RNA polymerase II core binding(GO:0000993) |
| 0.1 | 10.6 | GO:0004004 | ATP-dependent RNA helicase activity(GO:0004004) |
| 1.1 | 6.7 | GO:0070728 | leucine binding(GO:0070728) |
| 1.6 | 6.3 | GO:0004739 | pyruvate dehydrogenase (acetyl-transferring) activity(GO:0004739) |
| 0.3 | 5.9 | GO:0019864 | IgG binding(GO:0019864) |
| 0.2 | 5.8 | GO:1905030 | voltage-gated sodium channel activity(GO:0005248) voltage-gated ion channel activity involved in regulation of postsynaptic membrane potential(GO:1905030) |
| 0.5 | 5.4 | GO:0005021 | vascular endothelial growth factor-activated receptor activity(GO:0005021) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 32.1 | NABA ECM GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 0.7 | 11.2 | ST INTERFERON GAMMA PATHWAY | Interferon gamma pathway. |
| 0.1 | 6.7 | PID MYC REPRESS PATHWAY | Validated targets of C-MYC transcriptional repression |
| 0.0 | 6.7 | PID P53 DOWNSTREAM PATHWAY | Direct p53 effectors |
| 0.3 | 5.4 | PID VEGF VEGFR PATHWAY | VEGF and VEGFR signaling network |
| 0.0 | 3.9 | PID TELOMERASE PATHWAY | Regulation of Telomerase |
| 0.0 | 3.2 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.0 | 2.2 | PID RAS PATHWAY | Regulation of Ras family activation |
| 0.0 | 1.9 | PID MTOR 4PATHWAY | mTOR signaling pathway |
| 0.1 | 1.8 | SA FAS SIGNALING | The TNF-type receptor Fas induces apoptosis on ligand binding. |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 5.4 | REACTOME VEGF LIGAND RECEPTOR INTERACTIONS | Genes involved in VEGF ligand-receptor interactions |
| 0.5 | 3.9 | REACTOME PACKAGING OF TELOMERE ENDS | Genes involved in Packaging Of Telomere Ends |
| 0.2 | 3.4 | REACTOME BILE SALT AND ORGANIC ANION SLC TRANSPORTERS | Genes involved in Bile salt and organic anion SLC transporters |
| 0.1 | 3.2 | REACTOME OTHER SEMAPHORIN INTERACTIONS | Genes involved in Other semaphorin interactions |
| 0.0 | 3.2 | REACTOME OLFACTORY SIGNALING PATHWAY | Genes involved in Olfactory Signaling Pathway |
| 0.1 | 2.8 | REACTOME INTERACTION BETWEEN L1 AND ANKYRINS | Genes involved in Interaction between L1 and Ankyrins |
| 0.1 | 2.6 | REACTOME METABOLISM OF POLYAMINES | Genes involved in Metabolism of polyamines |
| 0.0 | 2.3 | REACTOME INTERFERON ALPHA BETA SIGNALING | Genes involved in Interferon alpha/beta signaling |
| 0.1 | 2.2 | REACTOME RAS ACTIVATION UOPN CA2 INFUX THROUGH NMDA RECEPTOR | Genes involved in Ras activation uopn Ca2+ infux through NMDA receptor |
| 0.1 | 1.9 | REACTOME PURINE CATABOLISM | Genes involved in Purine catabolism |