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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
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Results for ZNF263
Z-value: 1.44
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Transcription factors associated with ZNF263
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| ZNF263 | hg38_v1_chr16_+_3283443_3283544 | -0.40 | 5.5e-10 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of ZNF263
| Promoter | Score | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr11_+_92224801 Show fit | 20.89 |
ENST00000525166.6
|
FAT atypical cadherin 3 |
|
| chr5_+_138465472 Show fit | 20.31 |
ENST00000239938.5
|
early growth response 1 |
|
| chr5_-_151686908 Show fit | 20.08 |
ENST00000231061.9
|
secreted protein acidic and cysteine rich |
|
| chr12_-_91179355 Show fit | 17.56 |
ENST00000550563.5
ENST00000546370.5 |
decorin |
|
| chr12_-_91179472 Show fit | 17.48 |
ENST00000550099.5
ENST00000546391.5 |
decorin |
|
| chr12_-_91179517 Show fit | 17.11 |
ENST00000551354.1
|
decorin |
|
| chr14_+_94612383 Show fit | 15.79 |
ENST00000393080.8
ENST00000555820.1 ENST00000393078.5 ENST00000467132.5 |
serpin family A member 3 |
|
| chr5_-_150155828 Show fit | 15.63 |
ENST00000261799.9
|
platelet derived growth factor receptor beta |
|
| chr14_-_26598025 Show fit | 14.82 |
ENST00000539517.7
|
NOVA alternative splicing regulator 1 |
|
| chr12_-_27780236 Show fit | 14.52 |
ENST00000381273.4
|
MANSC domain containing 4 |
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 4.0 | 52.2 | GO:1900747 | negative regulation of vascular endothelial growth factor signaling pathway(GO:1900747) |
| 0.3 | 46.5 | GO:0007156 | homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156) |
| 3.1 | 33.7 | GO:2000427 | positive regulation of apoptotic cell clearance(GO:2000427) |
| 2.6 | 33.2 | GO:0045794 | response to carbon monoxide(GO:0034465) negative regulation of cell volume(GO:0045794) |
| 1.3 | 25.4 | GO:0033539 | fatty acid beta-oxidation using acyl-CoA dehydrogenase(GO:0033539) |
| 1.6 | 24.0 | GO:0031642 | negative regulation of myelination(GO:0031642) |
| 0.3 | 23.2 | GO:0051965 | positive regulation of synapse assembly(GO:0051965) |
| 0.2 | 22.7 | GO:0030449 | regulation of complement activation(GO:0030449) |
| 4.5 | 22.4 | GO:2000857 | positive regulation of mineralocorticoid secretion(GO:2000857) positive regulation of aldosterone secretion(GO:2000860) |
| 2.4 | 21.6 | GO:2000124 | regulation of endocannabinoid signaling pathway(GO:2000124) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 186.4 | GO:0031226 | intrinsic component of plasma membrane(GO:0031226) |
| 0.2 | 68.7 | GO:0005788 | endoplasmic reticulum lumen(GO:0005788) |
| 4.0 | 52.2 | GO:0098647 | collagen type VI trimer(GO:0005589) collagen beaded filament(GO:0098647) |
| 0.0 | 45.0 | GO:0005615 | extracellular space(GO:0005615) |
| 0.6 | 44.6 | GO:0005891 | voltage-gated calcium channel complex(GO:0005891) |
| 0.4 | 43.8 | GO:0005901 | caveola(GO:0005901) |
| 0.3 | 34.1 | GO:0031091 | platelet alpha granule(GO:0031091) |
| 0.6 | 29.7 | GO:0005581 | collagen trimer(GO:0005581) |
| 0.3 | 26.1 | GO:0005791 | rough endoplasmic reticulum(GO:0005791) |
| 0.1 | 25.9 | GO:0005578 | proteinaceous extracellular matrix(GO:0005578) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 76.4 | GO:0004252 | serine-type endopeptidase activity(GO:0004252) |
| 0.9 | 73.6 | GO:0050840 | extracellular matrix binding(GO:0050840) |
| 0.2 | 62.8 | GO:0001077 | transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077) |
| 0.1 | 49.9 | GO:0004930 | G-protein coupled receptor activity(GO:0004930) |
| 3.7 | 33.2 | GO:0060072 | large conductance calcium-activated potassium channel activity(GO:0060072) |
| 1.0 | 31.0 | GO:0008331 | high voltage-gated calcium channel activity(GO:0008331) |
| 1.2 | 25.0 | GO:0005112 | Notch binding(GO:0005112) |
| 0.4 | 24.8 | GO:0005518 | collagen binding(GO:0005518) |
| 1.9 | 24.7 | GO:0042608 | T cell receptor binding(GO:0042608) |
| 2.1 | 23.4 | GO:0048407 | platelet-derived growth factor binding(GO:0048407) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 93.5 | NABA ECM GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 1.2 | 78.4 | PID FRA PATHWAY | Validated transcriptional targets of AP1 family members Fra1 and Fra2 |
| 0.2 | 64.1 | NABA MATRISOME ASSOCIATED | Ensemble of genes encoding ECM-associated proteins including ECM-affilaited proteins, ECM regulators and secreted factors |
| 0.2 | 59.1 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 1.0 | 51.4 | PID UPA UPAR PATHWAY | Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling |
| 0.9 | 44.5 | NABA COLLAGENS | Genes encoding collagen proteins |
| 0.2 | 42.1 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.6 | 33.6 | PID RXR VDR PATHWAY | RXR and RAR heterodimerization with other nuclear receptor |
| 0.4 | 30.1 | PID NFAT TFPATHWAY | Calcineurin-regulated NFAT-dependent transcription in lymphocytes |
| 0.4 | 25.6 | PID DELTA NP63 PATHWAY | Validated transcriptional targets of deltaNp63 isoforms |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.9 | 67.3 | REACTOME NCAM1 INTERACTIONS | Genes involved in NCAM1 interactions |
| 1.9 | 52.2 | REACTOME CS DS DEGRADATION | Genes involved in CS/DS degradation |
| 0.5 | 31.9 | REACTOME GAB1 SIGNALOSOME | Genes involved in GAB1 signalosome |
| 0.3 | 30.7 | REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY | Genes involved in Nuclear Receptor transcription pathway |
| 1.3 | 23.9 | REACTOME INITIAL TRIGGERING OF COMPLEMENT | Genes involved in Initial triggering of complement |
| 0.1 | 22.9 | REACTOME PEPTIDE LIGAND BINDING RECEPTORS | Genes involved in Peptide ligand-binding receptors |
| 0.6 | 21.6 | REACTOME HORMONE SENSITIVE LIPASE HSL MEDIATED TRIACYLGLYCEROL HYDROLYSIS | Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis |
| 0.1 | 19.9 | REACTOME TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES | Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides |
| 0.7 | 16.9 | REACTOME HDL MEDIATED LIPID TRANSPORT | Genes involved in HDL-mediated lipid transport |
| 0.2 | 15.3 | REACTOME NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION | Genes involved in NOTCH1 Intracellular Domain Regulates Transcription |