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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)

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Results for ZNF274

Z-value: 0.65

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Transcription factors associated with ZNF274

Gene Symbol Gene ID Gene Info
ZNF274
ENSG00000171606.18 ZNF274

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
ZNF274hg38_v1_chr19_+_58183375_581834940.453.0e-12Click!

Activity profile of ZNF274 motif

Sorted Z-values of ZNF274 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of ZNF274

PNG image of the network

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Top targets:

Promoter Score Transcript Gene Gene Info
chrX_+_120604199 22.79 ENST00000371315.3
MCTS1
MCTS1 re-initiation and release factor
chrX_+_120604084 20.26 ENST00000371317.10
MCTS1
MCTS1 re-initiation and release factor
chr1_-_15944348 19.66 ENST00000444358.1
ZBTB17
zinc finger and BTB domain containing 17
chr5_+_32531786 17.36 ENST00000512913.5
SUB1
SUB1 regulator of transcription
chr18_+_9103959 15.31 ENST00000400033.1
NDUFV2
NADH:ubiquinone oxidoreductase core subunit V2
chr12_-_54259531 14.82 ENST00000550411.5
ENST00000439541.6
CBX5
chromobox 5
chr11_+_16738614 14.30 ENST00000524439.5
ENST00000228136.9
ENST00000528634.5
ENST00000525684.1
C11orf58
chromosome 11 open reading frame 58
chr16_-_4752565 13.56 ENST00000588099.1
ENST00000588942.1
ENSG00000266994.1
ZNF500
novel transcript
zinc finger protein 500
chr1_+_44739825 12.84 ENST00000372224.9
KIF2C
kinesin family member 2C
chr16_+_29807775 11.18 ENST00000568411.5
ENST00000563012.1
ENST00000562557.5
MAZ
MYC associated zinc finger protein
chr6_+_30720335 10.03 ENST00000327892.13
TUBB
tubulin beta class I
chr20_-_59042748 9.85 ENST00000355937.9
ENST00000371033.9
PRELID3B
PRELI domain containing 3B
chr16_+_29807536 9.62 ENST00000567444.5
MAZ
MYC associated zinc finger protein
chr3_-_69080350 8.52 ENST00000630585.1
ENST00000361055.9
ENST00000415609.6
ENST00000349511.8
UBA3
ubiquitin like modifier activating enzyme 3
chr16_+_29808051 7.66 ENST00000568544.5
ENST00000569978.1
MAZ
MYC associated zinc finger protein
chr19_+_39655907 7.40 ENST00000392051.4
LGALS16
galectin 16
chr22_+_38957522 7.02 ENST00000618553.1
ENST00000249116.7
APOBEC3A
apolipoprotein B mRNA editing enzyme catalytic subunit 3A
chr16_+_29808125 6.95 ENST00000568282.1
MAZ
MYC associated zinc finger protein
chr10_+_69278492 6.88 ENST00000643399.2
HK1
hexokinase 1
chr12_-_49187369 5.20 ENST00000547939.6
TUBA1A
tubulin alpha 1a
chr2_+_236569817 4.61 ENST00000272928.4
ACKR3
atypical chemokine receptor 3
chr6_-_83431038 4.57 ENST00000369705.4
ME1
malic enzyme 1
chr17_+_35587239 4.33 ENST00000621914.4
ENST00000621668.4
ENST00000616681.4
ENST00000612035.4
ENST00000610402.5
ENST00000614600.4
ENST00000590432.5
ENST00000612116.5
AP2B1
adaptor related protein complex 2 subunit beta 1
chr19_-_42877988 4.04 ENST00000597058.1
PSG1
pregnancy specific beta-1-glycoprotein 1
chr1_-_113871665 2.17 ENST00000528414.5
ENST00000460620.5
ENST00000359785.10
ENST00000420377.6
ENST00000525799.1
ENST00000538253.5
PTPN22
protein tyrosine phosphatase non-receptor type 22
chr3_+_50246888 2.12 ENST00000451956.1
GNAI2
G protein subunit alpha i2
chr6_-_127459364 1.89 ENST00000487331.2
ENST00000483725.8
KIAA0408
KIAA0408
chrX_-_142205260 1.15 ENST00000247452.4
MAGEC2
MAGE family member C2
chr11_+_89926762 0.84 ENST00000526396.3
TRIM49D2
tripartite motif containing 49D2
chr14_+_21941122 0.78 ENST00000390441.2
TRAV9-2
T cell receptor alpha variable 9-2
chr2_+_158456939 0.52 ENST00000389759.8
ENST00000628904.2
ENST00000389757.7
PKP4
plakophilin 4
chr6_+_125153649 0.45 ENST00000304877.17
ENST00000368402.9
ENST00000368388.6
ENST00000534000.6
TPD52L1
TPD52 like 1
chr19_+_15793951 0.16 ENST00000308940.8
OR10H5
olfactory receptor family 10 subfamily H member 5
chr12_+_49741544 0.12 ENST00000549966.5
ENST00000547832.5
ENST00000547187.5
ENST00000548894.5
ENST00000546914.5
ENST00000552699.5
ENST00000267115.10
TMBIM6
transmembrane BAX inhibitor motif containing 6

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
10.8 43.0 GO:0002188 translation reinitiation(GO:0002188)
2.1 8.5 GO:0007113 endomitotic cell cycle(GO:0007113)
1.4 12.8 GO:0030951 establishment or maintenance of microtubule cytoskeleton polarity(GO:0030951)
1.2 7.0 GO:0070383 DNA cytosine deamination(GO:0070383)
0.9 4.6 GO:0006741 NADP biosynthetic process(GO:0006741)
0.9 4.3 GO:0099590 neurotransmitter receptor internalization(GO:0099590)
0.7 6.9 GO:0072656 maintenance of protein location in mitochondrion(GO:0072656)
0.6 19.7 GO:0007398 ectoderm development(GO:0007398)
0.5 17.4 GO:0060261 positive regulation of transcription initiation from RNA polymerase II promoter(GO:0060261)
0.5 7.1 GO:0070234 positive regulation of T cell apoptotic process(GO:0070234)
0.4 2.2 GO:1902523 negative regulation of nucleotide-binding oligomerization domain containing signaling pathway(GO:0070425) negative regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway(GO:0070433) positive regulation of protein K63-linked ubiquitination(GO:1902523)
0.4 35.4 GO:0006369 termination of RNA polymerase II transcription(GO:0006369)
0.2 15.3 GO:0006120 mitochondrial electron transport, NADH to ubiquinone(GO:0006120)
0.1 10.0 GO:0042267 natural killer cell mediated cytotoxicity(GO:0042267)
0.1 2.1 GO:0001973 adenosine receptor signaling pathway(GO:0001973)
0.1 4.6 GO:1902230 negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage(GO:1902230)
0.1 7.3 GO:0015914 phospholipid transport(GO:0015914)
0.0 14.8 GO:0007596 blood coagulation(GO:0007596)
0.0 5.2 GO:0030705 cytoskeleton-dependent intracellular transport(GO:0030705)
0.0 0.1 GO:0031438 negative regulation of mRNA cleavage(GO:0031438) negative regulation of mRNA endonucleolytic cleavage involved in unfolded protein response(GO:1904721)
0.0 4.0 GO:0007565 female pregnancy(GO:0007565)
0.0 0.5 GO:0032467 positive regulation of cytokinesis(GO:0032467)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
3.1 15.3 GO:0045272 plasma membrane respiratory chain complex I(GO:0045272)
1.1 14.8 GO:0031618 nuclear pericentric heterochromatin(GO:0031618)
0.6 43.0 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
0.5 10.0 GO:0005641 nuclear envelope lumen(GO:0005641)
0.4 12.8 GO:0035371 microtubule plus-end(GO:0035371)
0.2 6.9 GO:0097228 sperm principal piece(GO:0097228)
0.2 4.3 GO:0036020 endolysosome membrane(GO:0036020)
0.1 19.7 GO:0032993 protein-DNA complex(GO:0032993)
0.1 9.9 GO:0005758 mitochondrial intermembrane space(GO:0005758) organelle envelope lumen(GO:0031970)
0.1 5.2 GO:0005881 cytoplasmic microtubule(GO:0005881)
0.0 4.6 GO:0005905 clathrin-coated pit(GO:0005905)
0.0 2.1 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.0 12.5 GO:0005667 transcription factor complex(GO:0005667)
0.0 0.5 GO:0051233 spindle midzone(GO:0051233)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
3.3 9.9 GO:1990050 phosphatidic acid transporter activity(GO:1990050)
2.5 7.4 GO:0048030 disaccharide binding(GO:0048030)
1.6 12.8 GO:0019237 centromeric DNA binding(GO:0019237)
1.4 7.0 GO:0047844 deoxycytidine deaminase activity(GO:0047844)
1.2 8.5 GO:0019788 NEDD8 transferase activity(GO:0019788)
0.9 4.6 GO:0004471 malate dehydrogenase (decarboxylating) (NAD+) activity(GO:0004471) malate dehydrogenase (decarboxylating) (NADP+) activity(GO:0004473) oxaloacetate decarboxylase activity(GO:0008948)
0.8 19.7 GO:0001223 transcription coactivator binding(GO:0001223)
0.8 6.9 GO:0004396 glucokinase activity(GO:0004340) hexokinase activity(GO:0004396) fructokinase activity(GO:0008865) mannokinase activity(GO:0019158)
0.7 15.3 GO:0051537 2 iron, 2 sulfur cluster binding(GO:0051537)
0.6 43.0 GO:0003743 translation initiation factor activity(GO:0003743)
0.4 4.6 GO:0019958 C-X-C chemokine binding(GO:0019958)
0.4 10.0 GO:0032794 GTPase activating protein binding(GO:0032794)
0.3 17.4 GO:0001205 transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001205)
0.3 35.4 GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding(GO:0000979)
0.2 14.8 GO:0035064 methylated histone binding(GO:0035064)
0.2 4.3 GO:0098748 clathrin adaptor activity(GO:0035615) endocytic adaptor activity(GO:0098748)
0.1 2.1 GO:0031683 G-protein beta/gamma-subunit complex binding(GO:0031683)
0.0 5.2 GO:0005200 structural constituent of cytoskeleton(GO:0005200)
0.0 0.1 GO:0060698 endoribonuclease inhibitor activity(GO:0060698)
0.0 2.2 GO:0004725 protein tyrosine phosphatase activity(GO:0004725)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 27.7 PID AURORA B PATHWAY Aurora B signaling
0.4 19.7 PID MYC PATHWAY C-MYC pathway
0.3 8.5 PID ERB GENOMIC PATHWAY Validated nuclear estrogen receptor beta network
0.1 2.1 PID S1P S1P4 PATHWAY S1P4 pathway
0.1 5.2 ST DIFFERENTIATION PATHWAY IN PC12 CELLS Differentiation Pathway in PC12 Cells; this is a specific case of PAC1 Receptor Pathway.
0.0 7.1 NABA ECM AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.0 4.3 PID HIF1 TFPATHWAY HIF-1-alpha transcription factor network

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 12.8 REACTOME KINESINS Genes involved in Kinesins
0.3 19.7 REACTOME ACTIVATION OF CHAPERONE GENES BY XBP1S Genes involved in Activation of Chaperone Genes by XBP1(S)
0.2 15.3 REACTOME RESPIRATORY ELECTRON TRANSPORT Genes involved in Respiratory electron transport
0.2 5.2 REACTOME POST CHAPERONIN TUBULIN FOLDING PATHWAY Genes involved in Post-chaperonin tubulin folding pathway
0.2 4.3 REACTOME RETROGRADE NEUROTROPHIN SIGNALLING Genes involved in Retrograde neurotrophin signalling
0.1 6.9 REACTOME GLUCOSE TRANSPORT Genes involved in Glucose transport
0.1 10.0 REACTOME LOSS OF NLP FROM MITOTIC CENTROSOMES Genes involved in Loss of Nlp from mitotic centrosomes
0.1 14.8 REACTOME FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION Genes involved in Factors involved in megakaryocyte development and platelet production
0.1 2.1 REACTOME ADENYLATE CYCLASE INHIBITORY PATHWAY Genes involved in Adenylate cyclase inhibitory pathway
0.1 4.6 REACTOME PPARA ACTIVATES GENE EXPRESSION Genes involved in PPARA Activates Gene Expression
0.0 13.6 REACTOME GENERIC TRANSCRIPTION PATHWAY Genes involved in Generic Transcription Pathway
0.0 8.5 REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION Genes involved in Antigen processing: Ubiquitination & Proteasome degradation