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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
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Results for ZNF282
Z-value: 0.72
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Transcription factors associated with ZNF282
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| ZNF282 | hg38_v1_chr7_+_149195537_149195559 | 0.35 | 8.8e-08 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of ZNF282
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.7 | 45.5 | GO:0060397 | JAK-STAT cascade involved in growth hormone signaling pathway(GO:0060397) |
| 2.9 | 14.4 | GO:1902626 | assembly of large subunit precursor of preribosome(GO:1902626) |
| 0.2 | 14.1 | GO:0061178 | regulation of insulin secretion involved in cellular response to glucose stimulus(GO:0061178) |
| 0.1 | 13.9 | GO:0006614 | SRP-dependent cotranslational protein targeting to membrane(GO:0006614) |
| 0.1 | 13.5 | GO:0006521 | regulation of cellular amino acid metabolic process(GO:0006521) |
| 0.9 | 13.1 | GO:0046007 | negative regulation of activated T cell proliferation(GO:0046007) |
| 1.8 | 9.2 | GO:2001181 | positive regulation of interleukin-10 secretion(GO:2001181) |
| 0.1 | 8.6 | GO:0000381 | regulation of alternative mRNA splicing, via spliceosome(GO:0000381) |
| 2.7 | 8.1 | GO:2000521 | negative regulation of immunological synapse formation(GO:2000521) |
| 2.6 | 7.9 | GO:0018364 | peptidyl-glutamine methylation(GO:0018364) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 29.7 | GO:0031904 | endosome lumen(GO:0031904) |
| 0.4 | 14.4 | GO:0030687 | preribosome, large subunit precursor(GO:0030687) |
| 0.1 | 13.9 | GO:0022625 | cytosolic large ribosomal subunit(GO:0022625) |
| 1.1 | 13.5 | GO:0019773 | proteasome core complex, alpha-subunit complex(GO:0019773) |
| 0.7 | 13.1 | GO:0031588 | nucleotide-activated protein kinase complex(GO:0031588) |
| 3.7 | 11.0 | GO:0070195 | growth hormone receptor complex(GO:0070195) |
| 1.1 | 9.2 | GO:0045179 | apical cortex(GO:0045179) |
| 0.1 | 8.1 | GO:0001772 | immunological synapse(GO:0001772) |
| 1.6 | 7.9 | GO:0001652 | dense fibrillar component(GO:0001651) granular component(GO:0001652) |
| 0.1 | 7.7 | GO:0000502 | proteasome complex(GO:0000502) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 52.7 | GO:0005179 | hormone activity(GO:0005179) |
| 2.4 | 14.4 | GO:0043023 | ribosomal large subunit binding(GO:0043023) |
| 0.1 | 13.9 | GO:0003735 | structural constituent of ribosome(GO:0003735) |
| 0.5 | 13.5 | GO:0004298 | threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003) |
| 0.7 | 13.1 | GO:0008603 | cAMP-dependent protein kinase regulator activity(GO:0008603) |
| 0.3 | 12.8 | GO:0031492 | nucleosomal DNA binding(GO:0031492) |
| 2.8 | 11.0 | GO:0005148 | prolactin receptor binding(GO:0005148) |
| 0.4 | 9.2 | GO:0043560 | insulin receptor substrate binding(GO:0043560) |
| 1.0 | 8.1 | GO:0019863 | IgE binding(GO:0019863) |
| 0.5 | 7.9 | GO:0001094 | TFIID-class transcription factor binding(GO:0001094) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 61.9 | NABA SECRETED FACTORS | Genes encoding secreted soluble factors |
| 0.3 | 15.6 | PID RAS PATHWAY | Regulation of Ras family activation |
| 0.2 | 13.5 | PID AURORA B PATHWAY | Aurora B signaling |
| 0.2 | 13.1 | PID INTEGRIN A4B1 PATHWAY | Alpha4 beta1 integrin signaling events |
| 0.1 | 5.5 | ST DIFFERENTIATION PATHWAY IN PC12 CELLS | Differentiation Pathway in PC12 Cells; this is a specific case of PAC1 Receptor Pathway. |
| 0.0 | 4.1 | PID RB 1PATHWAY | Regulation of retinoblastoma protein |
| 0.0 | 3.4 | PID FOXO PATHWAY | FoxO family signaling |
| 0.0 | 3.4 | PID MYC ACTIV PATHWAY | Validated targets of C-MYC transcriptional activation |
| 0.0 | 3.1 | PID VEGFR1 2 PATHWAY | Signaling events mediated by VEGFR1 and VEGFR2 |
| 0.1 | 2.3 | PID SYNDECAN 4 PATHWAY | Syndecan-4-mediated signaling events |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.6 | 45.5 | REACTOME PROLACTIN RECEPTOR SIGNALING | Genes involved in Prolactin receptor signaling |
| 0.1 | 13.9 | REACTOME PEPTIDE CHAIN ELONGATION | Genes involved in Peptide chain elongation |
| 0.2 | 13.5 | REACTOME VIF MEDIATED DEGRADATION OF APOBEC3G | Genes involved in Vif-mediated degradation of APOBEC3G |
| 0.4 | 13.1 | REACTOME PKA MEDIATED PHOSPHORYLATION OF CREB | Genes involved in PKA-mediated phosphorylation of CREB |
| 0.4 | 9.2 | REACTOME TGF BETA RECEPTOR SIGNALING IN EMT EPITHELIAL TO MESENCHYMAL TRANSITION | Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) |
| 0.2 | 6.4 | REACTOME ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING | Genes involved in Advanced glycosylation endproduct receptor signaling |
| 0.2 | 5.7 | REACTOME SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI AND TRIPHOSPHATES | Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates |
| 0.2 | 5.5 | REACTOME POST CHAPERONIN TUBULIN FOLDING PATHWAY | Genes involved in Post-chaperonin tubulin folding pathway |
| 0.1 | 5.5 | REACTOME MITOCHONDRIAL PROTEIN IMPORT | Genes involved in Mitochondrial Protein Import |
| 0.0 | 3.7 | REACTOME ANTIVIRAL MECHANISM BY IFN STIMULATED GENES | Genes involved in Antiviral mechanism by IFN-stimulated genes |