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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)

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Results for ZNF35

Z-value: 0.27

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Transcription factors associated with ZNF35

Gene Symbol Gene ID Gene Info
ZNF35
ENSG00000169981.11 ZNF35

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
ZNF35hg38_v1_chr3_+_44648719_446487760.261.2e-04Click!

Activity profile of ZNF35 motif

Sorted Z-values of ZNF35 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of ZNF35

PNG image of the network

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Top targets:

Promoter Score Transcript Gene Gene Info
chr2_+_126656128 3.66 ENST00000259254.9
ENST00000409836.3
ENST00000356887.12
GYPC
glycophorin C (Gerbich blood group)
chr6_-_109440504 3.26 ENST00000520723.5
ENST00000518648.1
ENST00000417394.6
ENST00000521072.7
PPIL6
peptidylprolyl isomerase like 6
chr7_+_80602150 1.50 ENST00000309881.11
CD36
CD36 molecule
chr2_+_66435558 1.36 ENST00000488550.5
MEIS1
Meis homeobox 1
chr2_-_216695540 1.32 ENST00000233813.5
IGFBP5
insulin like growth factor binding protein 5
chr12_-_46372763 1.02 ENST00000256689.10
SLC38A2
solute carrier family 38 member 2
chr4_+_87832917 0.98 ENST00000395102.8
ENST00000497649.6
ENST00000540395.1
ENST00000560249.5
ENST00000511670.5
ENST00000361056.3
MEPE
matrix extracellular phosphoglycoprotein
chr3_-_149221811 0.96 ENST00000455472.3
ENST00000264613.11
CP
ceruloplasmin
chr12_+_54497712 0.89 ENST00000293373.11
NCKAP1L
NCK associated protein 1 like
chr12_+_4273751 0.88 ENST00000675880.1
ENST00000261254.8
CCND2
cyclin D2
chr5_-_39202991 0.85 ENST00000515010.5
FYB1
FYN binding protein 1
chr4_+_73436244 0.82 ENST00000226359.2
AFP
alpha fetoprotein
chr4_+_73436198 0.81 ENST00000395792.7
AFP
alpha fetoprotein
chr14_-_31420531 0.80 ENST00000382464.6
ENST00000543095.7
HEATR5A
HEAT repeat containing 5A
chr7_+_27242796 0.79 ENST00000496902.7
EVX1
even-skipped homeobox 1
chr3_+_69936583 0.76 ENST00000314557.10
ENST00000394351.9
MITF
melanocyte inducing transcription factor
chr12_-_102478539 0.72 ENST00000424202.6
IGF1
insulin like growth factor 1
chr10_+_61901678 0.70 ENST00000644638.1
ENST00000681100.1
ENST00000279873.12
ARID5B
AT-rich interaction domain 5B
chr13_-_35855758 0.70 ENST00000615680.4
DCLK1
doublecortin like kinase 1
chr12_-_22334683 0.67 ENST00000404299.3
ENST00000396037.9
ST8SIA1
ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1
chr10_-_50885619 0.66 ENST00000373997.8
A1CF
APOBEC1 complementation factor
chr18_+_41955186 0.61 ENST00000639914.1
ENST00000262039.9
ENST00000398870.7
ENST00000586545.5
ENST00000585528.5
PIK3C3
phosphatidylinositol 3-kinase catalytic subunit type 3
chr19_-_4535221 0.60 ENST00000381848.7
ENST00000586133.1
PLIN5
perilipin 5
chr10_-_50885656 0.59 ENST00000374001.6
ENST00000395489.6
ENST00000282641.6
ENST00000395495.5
ENST00000373995.7
ENST00000414883.1
A1CF
APOBEC1 complementation factor
chr3_+_69936629 0.58 ENST00000394348.2
ENST00000531774.1
MITF
melanocyte inducing transcription factor
chr3_-_58537181 0.54 ENST00000302819.10
ACOX2
acyl-CoA oxidase 2
chr6_-_134950081 0.53 ENST00000367847.2
ENST00000265605.7
ENST00000367845.6
ALDH8A1
aldehyde dehydrogenase 8 family member A1
chr4_+_67558719 0.53 ENST00000265404.7
ENST00000396225.1
STAP1
signal transducing adaptor family member 1
chr16_+_56191476 0.52 ENST00000262493.12
GNAO1
G protein subunit alpha o1
chr3_-_58537283 0.52 ENST00000459701.6
ACOX2
acyl-CoA oxidase 2
chr7_+_27242700 0.50 ENST00000222761.7
EVX1
even-skipped homeobox 1
chr3_+_29281552 0.49 ENST00000452462.5
ENST00000456853.1
RBMS3
RNA binding motif single stranded interacting protein 3
chr1_+_86424154 0.49 ENST00000370565.5
CLCA2
chloride channel accessory 2
chr21_-_40847149 0.46 ENST00000400454.6
DSCAM
DS cell adhesion molecule
chr16_-_4273014 0.44 ENST00000204517.11
TFAP4
transcription factor AP-4
chr22_-_36703723 0.42 ENST00000300105.7
CACNG2
calcium voltage-gated channel auxiliary subunit gamma 2
chr7_+_123848070 0.41 ENST00000476325.5
HYAL4
hyaluronidase 4
chr4_-_88823214 0.35 ENST00000513837.5
ENST00000503556.5
FAM13A
family with sequence similarity 13 member A
chr8_-_94262308 0.34 ENST00000297596.3
ENST00000396194.6
GEM
GTP binding protein overexpressed in skeletal muscle
chr13_-_35855627 0.34 ENST00000379893.5
DCLK1
doublecortin like kinase 1
chr13_+_77535669 0.30 ENST00000535157.5
SCEL
sciellin
chr13_+_77535681 0.30 ENST00000349847.4
SCEL
sciellin
chr7_-_28958321 0.29 ENST00000539664.3
TRIL
TLR4 interactor with leucine rich repeats
chr6_-_132763424 0.29 ENST00000532012.1
ENST00000525270.5
ENST00000530536.5
ENST00000524919.5
VNN2
vanin 2
chrM_+_4467 0.25 ENST00000361453.3
MT-ND2
mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 2
chr3_-_33218793 0.25 ENST00000412539.1
ENST00000309558.8
SUSD5
sushi domain containing 5
chr7_-_87713287 0.20 ENST00000416177.1
ENST00000265724.8
ENST00000543898.5
ABCB1
ATP binding cassette subfamily B member 1
chr17_+_43483949 0.11 ENST00000540306.5
ENST00000262415.8
DHX8
DEAH-box helicase 8
chr19_+_926001 0.06 ENST00000263620.8
ARID3A
AT-rich interaction domain 3A
chr13_+_108596152 0.05 ENST00000356711.7
ENST00000251041.10
MYO16
myosin XVI
chr4_-_98929092 0.04 ENST00000280892.10
ENST00000511644.5
ENST00000504432.5
ENST00000450253.7
ENST00000505992.1
EIF4E
eukaryotic translation initiation factor 4E
chr14_-_91732059 0.02 ENST00000553329.5
ENST00000256343.8
CATSPERB
cation channel sperm associated auxiliary subunit beta

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.3 GO:1904204 regulation of skeletal muscle hypertrophy(GO:1904204)
0.4 1.3 GO:0021913 regulation of transcription from RNA polymerase II promoter involved in ventral spinal cord interneuron specification(GO:0021913)
0.3 0.9 GO:0043376 regulation of CD8-positive, alpha-beta T cell differentiation(GO:0043376)
0.2 1.3 GO:0016554 cytidine to uridine editing(GO:0016554)
0.2 0.5 GO:1902227 negative regulation of macrophage colony-stimulating factor signaling pathway(GO:1902227) negative regulation of response to macrophage colony-stimulating factor(GO:1903970) negative regulation of cellular response to macrophage colony-stimulating factor stimulus(GO:1903973)
0.2 1.5 GO:2000332 response to linoleic acid(GO:0070543) blood microparticle formation(GO:0072564) regulation of blood microparticle formation(GO:2000332) positive regulation of blood microparticle formation(GO:2000334)
0.2 0.6 GO:0035359 negative regulation of peroxisome proliferator activated receptor signaling pathway(GO:0035359)
0.1 1.0 GO:0032328 alanine transport(GO:0032328)
0.1 0.7 GO:1904073 regulation of trophectodermal cell proliferation(GO:1904073) positive regulation of trophectodermal cell proliferation(GO:1904075)
0.1 0.6 GO:0030242 pexophagy(GO:0030242)
0.1 0.3 GO:1901842 negative regulation of high voltage-gated calcium channel activity(GO:1901842)
0.1 1.6 GO:0001542 ovulation from ovarian follicle(GO:0001542)
0.1 0.4 GO:0099590 neurotransmitter receptor internalization(GO:0099590)
0.1 1.4 GO:0060044 negative regulation of cardiac muscle cell proliferation(GO:0060044)
0.1 3.3 GO:0000413 protein peptidyl-prolyl isomerization(GO:0000413)
0.1 0.5 GO:0042904 9-cis-retinoic acid biosynthetic process(GO:0042904) 9-cis-retinoic acid metabolic process(GO:0042905)
0.1 3.7 GO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0007157)
0.1 1.1 GO:0033539 fatty acid beta-oxidation using acyl-CoA dehydrogenase(GO:0033539)
0.0 0.9 GO:0071481 cellular response to X-ray(GO:0071481)
0.0 1.0 GO:0030502 negative regulation of bone mineralization(GO:0030502)
0.0 0.5 GO:0048842 positive regulation of axon extension involved in axon guidance(GO:0048842)
0.0 1.0 GO:0006825 copper ion transport(GO:0006825)
0.0 0.4 GO:0043922 negative regulation by host of viral transcription(GO:0043922)
0.0 1.3 GO:2000144 positive regulation of DNA-templated transcription, initiation(GO:2000144)
0.0 0.2 GO:1901529 positive regulation of anion channel activity(GO:1901529)
0.0 0.3 GO:0015939 pantothenate metabolic process(GO:0015939)
0.0 0.7 GO:0006688 glycosphingolipid biosynthetic process(GO:0006688) sialylation(GO:0097503)
0.0 1.0 GO:0021952 central nervous system projection neuron axonogenesis(GO:0021952)
0.0 0.7 GO:0016577 histone demethylation(GO:0016577) adipose tissue development(GO:0060612)
0.0 0.4 GO:0030207 chondroitin sulfate catabolic process(GO:0030207)
0.0 0.5 GO:0014072 response to isoquinoline alkaloid(GO:0014072) response to morphine(GO:0043278)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.3 GO:0030895 apolipoprotein B mRNA editing enzyme complex(GO:0030895)
0.2 2.0 GO:0042567 insulin-like growth factor ternary complex(GO:0042567)
0.2 0.6 GO:0034271 phosphatidylinositol 3-kinase complex, class III, type I(GO:0034271) phosphatidylinositol 3-kinase complex, class III, type II(GO:0034272)
0.1 0.9 GO:0097129 cyclin D2-CDK4 complex(GO:0097129)
0.1 0.9 GO:0031209 SCAR complex(GO:0031209)
0.0 1.5 GO:0031092 platelet alpha granule membrane(GO:0031092)
0.0 0.3 GO:0046696 lipopolysaccharide receptor complex(GO:0046696)
0.0 0.4 GO:0098839 postsynaptic density membrane(GO:0098839)
0.0 3.6 GO:0005913 cell-cell adherens junction(GO:0005913)
0.0 1.1 GO:0005782 peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907)
0.0 0.6 GO:0001533 cornified envelope(GO:0001533)
0.0 0.5 GO:0009925 basal plasma membrane(GO:0009925)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.0 GO:1990430 extracellular matrix protein binding(GO:1990430)
0.2 1.5 GO:0070892 lipoteichoic acid receptor activity(GO:0070892)
0.2 1.1 GO:0016402 pristanoyl-CoA oxidase activity(GO:0016402)
0.2 0.6 GO:0035473 lipase binding(GO:0035473)
0.1 1.0 GO:0004322 ferroxidase activity(GO:0004322) oxidoreductase activity, oxidizing metal ions, oxygen as acceptor(GO:0016724)
0.1 1.3 GO:0031995 insulin-like growth factor II binding(GO:0031995)
0.1 0.5 GO:0005157 macrophage colony-stimulating factor receptor binding(GO:0005157)
0.1 0.7 GO:0003828 alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity(GO:0003828)
0.1 0.3 GO:0017159 pantetheine hydrolase activity(GO:0017159)
0.1 0.2 GO:0090555 phosphatidylethanolamine-translocating ATPase activity(GO:0090555)
0.1 3.3 GO:0003755 peptidyl-prolyl cis-trans isomerase activity(GO:0003755)
0.0 0.5 GO:0001758 retinal dehydrogenase activity(GO:0001758)
0.0 0.4 GO:0004415 hyalurononglucosaminidase activity(GO:0004415)
0.0 0.5 GO:0005229 intracellular calcium activated chloride channel activity(GO:0005229)
0.0 0.5 GO:0031821 G-protein coupled serotonin receptor binding(GO:0031821)
0.0 1.8 GO:0070888 E-box binding(GO:0070888)
0.0 0.7 GO:0032452 histone demethylase activity(GO:0032452)
0.0 0.7 GO:0005158 insulin receptor binding(GO:0005158)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 1.6 PID HNF3B PATHWAY FOXA2 and FOXA3 transcription factor networks
0.0 1.4 PID P38 ALPHA BETA DOWNSTREAM PATHWAY Signaling mediated by p38-alpha and p38-beta
0.0 0.5 PID S1P S1P4 PATHWAY S1P4 pathway
0.0 0.9 PID IL2 STAT5 PATHWAY IL2 signaling events mediated by STAT5
0.0 0.7 PID ER NONGENOMIC PATHWAY Plasma membrane estrogen receptor signaling
0.0 1.2 PID HIF1 TFPATHWAY HIF-1-alpha transcription factor network
0.0 2.3 NABA ECM GLYCOPROTEINS Genes encoding structural ECM glycoproteins

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.3 REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.0 1.1 REACTOME SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 7ALPHA HYDROXYCHOLESTEROL Genes involved in Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol
0.0 1.0 REACTOME METAL ION SLC TRANSPORTERS Genes involved in Metal ion SLC transporters
0.0 0.6 REACTOME SYNTHESIS OF PIPS AT THE LATE ENDOSOME MEMBRANE Genes involved in Synthesis of PIPs at the late endosome membrane
0.0 1.0 REACTOME GLUTAMATE NEUROTRANSMITTER RELEASE CYCLE Genes involved in Glutamate Neurotransmitter Release Cycle
0.0 0.5 REACTOME DSCAM INTERACTIONS Genes involved in DSCAM interactions
0.0 0.2 REACTOME ABACAVIR TRANSPORT AND METABOLISM Genes involved in Abacavir transport and metabolism
0.0 1.5 REACTOME TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION Genes involved in Transcriptional Regulation of White Adipocyte Differentiation
0.0 0.9 REACTOME G1 PHASE Genes involved in G1 Phase
0.0 0.5 REACTOME INHIBITION OF INSULIN SECRETION BY ADRENALINE NORADRENALINE Genes involved in Inhibition of Insulin Secretion by Adrenaline/Noradrenaline