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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
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Results for ZNF423
Z-value: 0.52
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Transcription factors associated with ZNF423
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| ZNF423 | hg38_v1_chr16_-_49664225_49664298 | -0.15 | 2.3e-02 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of ZNF423
| Promoter | Score | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chrX_+_49171918 Show fit | 8.74 |
ENST00000376322.7
|
proteolipid protein 2 |
|
| chr5_+_136049513 Show fit | 6.88 |
ENST00000514554.5
|
transforming growth factor beta induced |
|
| chr19_-_41353044 Show fit | 6.29 |
ENST00000600196.2
ENST00000677934.1 |
transforming growth factor beta 1 |
|
| chr5_+_151020438 Show fit | 5.20 |
ENST00000622181.4
ENST00000614343.4 ENST00000388825.9 ENST00000521650.5 ENST00000517973.1 |
glutathione peroxidase 3 |
|
| chr1_+_26317950 Show fit | 4.73 |
ENST00000374213.3
|
CD52 molecule |
|
| chr9_+_109780292 Show fit | 3.94 |
ENST00000374530.7
|
PALM2 and AKAP2 fusion |
|
| chr20_+_33993904 Show fit | 3.91 |
ENST00000246194.8
|
RALY heterogeneous nuclear ribonucleoprotein |
|
| chrX_+_49171889 Show fit | 3.72 |
ENST00000376327.6
|
proteolipid protein 2 |
|
| chr19_-_11578937 Show fit | 3.67 |
ENST00000592659.1
ENST00000592828.6 ENST00000218758.9 ENST00000412435.6 |
acid phosphatase 5, tartrate resistant |
|
| chr9_+_109780312 Show fit | 3.24 |
ENST00000483909.5
ENST00000413420.5 ENST00000302798.7 |
PALM2 and AKAP2 fusion |
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 9.8 | GO:0006935 | chemotaxis(GO:0006935) taxis(GO:0042330) |
| 0.3 | 6.9 | GO:2000188 | regulation of cholesterol homeostasis(GO:2000188) |
| 0.0 | 6.9 | GO:0002062 | chondrocyte differentiation(GO:0002062) |
| 1.6 | 6.3 | GO:0046732 | ossification involved in bone remodeling(GO:0043932) induction by symbiont of host defense response(GO:0044416) induction of host immune response by virus(GO:0046730) active induction of host immune response by virus(GO:0046732) modulation by symbiont of host defense response(GO:0052031) induction by organism of defense response of other organism involved in symbiotic interaction(GO:0052251) modulation by organism of defense response of other organism involved in symbiotic interaction(GO:0052255) positive regulation by symbiont of host defense response(GO:0052509) positive regulation by organism of defense response of other organism involved in symbiotic interaction(GO:0052510) modulation by organism of immune response of other organism involved in symbiotic interaction(GO:0052552) modulation by symbiont of host immune response(GO:0052553) modulation by virus of host immune response(GO:0075528) negative regulation of hyaluronan biosynthetic process(GO:1900126) |
| 0.3 | 5.9 | GO:0034380 | high-density lipoprotein particle assembly(GO:0034380) |
| 1.7 | 5.2 | GO:0006982 | response to lipid hydroperoxide(GO:0006982) |
| 0.1 | 5.0 | GO:0006636 | unsaturated fatty acid biosynthetic process(GO:0006636) |
| 0.1 | 4.7 | GO:0045730 | respiratory burst(GO:0045730) |
| 0.6 | 4.6 | GO:0070236 | regulation of activation-induced cell death of T cells(GO:0070235) negative regulation of activation-induced cell death of T cells(GO:0070236) |
| 0.1 | 4.1 | GO:0042347 | negative regulation of NF-kappaB import into nucleus(GO:0042347) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 7.5 | GO:0005604 | basement membrane(GO:0005604) |
| 0.1 | 6.3 | GO:0005902 | microvillus(GO:0005902) |
| 0.0 | 5.5 | GO:0071013 | catalytic step 2 spliceosome(GO:0071013) |
| 0.0 | 4.8 | GO:0005578 | proteinaceous extracellular matrix(GO:0005578) |
| 0.6 | 4.1 | GO:0098560 | cytoplasmic side of late endosome membrane(GO:0098560) |
| 0.1 | 4.0 | GO:0005581 | collagen trimer(GO:0005581) |
| 0.0 | 3.9 | GO:0031225 | anchored component of membrane(GO:0031225) |
| 0.0 | 3.2 | GO:0097610 | cleavage furrow(GO:0032154) cell surface furrow(GO:0097610) |
| 0.0 | 3.2 | GO:0043197 | dendritic spine(GO:0043197) |
| 0.6 | 1.8 | GO:0034686 | integrin alphav-beta8 complex(GO:0034686) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 12.5 | GO:0019956 | chemokine binding(GO:0019956) |
| 0.1 | 10.4 | GO:0005518 | collagen binding(GO:0005518) |
| 0.1 | 6.9 | GO:0004222 | metalloendopeptidase activity(GO:0004222) |
| 1.3 | 6.3 | GO:0034714 | type III transforming growth factor beta receptor binding(GO:0034714) |
| 0.4 | 5.2 | GO:0008430 | selenium binding(GO:0008430) |
| 0.5 | 4.6 | GO:0043426 | MRF binding(GO:0043426) |
| 0.1 | 4.1 | GO:0050699 | WW domain binding(GO:0050699) |
| 0.3 | 3.7 | GO:0008199 | ferric iron binding(GO:0008199) |
| 0.8 | 3.2 | GO:0035402 | histone kinase activity (H3-T11 specific)(GO:0035402) |
| 0.1 | 3.2 | GO:0001965 | G-protein alpha-subunit binding(GO:0001965) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 8.7 | PID INTEGRIN2 PATHWAY | Beta2 integrin cell surface interactions |
| 0.0 | 6.9 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.2 | 6.3 | PID IL27 PATHWAY | IL27-mediated signaling events |
| 0.0 | 4.1 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.2 | 3.2 | PID P38 GAMMA DELTA PATHWAY | Signaling mediated by p38-gamma and p38-delta |
| 0.1 | 3.2 | ST WNT BETA CATENIN PATHWAY | Wnt/beta-catenin Pathway |
| 0.2 | 2.0 | ST IL 13 PATHWAY | Interleukin 13 (IL-13) Pathway |
| 0.0 | 1.9 | PID BMP PATHWAY | BMP receptor signaling |
| 0.1 | 1.8 | PID INTEGRIN5 PATHWAY | Beta5 beta6 beta7 and beta8 integrin cell surface interactions |
| 0.0 | 1.8 | ST T CELL SIGNAL TRANSDUCTION | T Cell Signal Transduction |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 6.9 | REACTOME AMYLOIDS | Genes involved in Amyloids |
| 0.3 | 6.3 | REACTOME TGF BETA RECEPTOR SIGNALING IN EMT EPITHELIAL TO MESENCHYMAL TRANSITION | Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) |
| 0.2 | 5.9 | REACTOME HDL MEDIATED LIPID TRANSPORT | Genes involved in HDL-mediated lipid transport |
| 0.1 | 4.8 | REACTOME METABOLISM OF VITAMINS AND COFACTORS | Genes involved in Metabolism of vitamins and cofactors |
| 0.0 | 3.8 | REACTOME INTEGRIN CELL SURFACE INTERACTIONS | Genes involved in Integrin cell surface interactions |
| 0.2 | 3.0 | REACTOME ORGANIC CATION ANION ZWITTERION TRANSPORT | Genes involved in Organic cation/anion/zwitterion transport |
| 0.0 | 2.5 | REACTOME MRNA SPLICING | Genes involved in mRNA Splicing |
| 0.1 | 2.1 | REACTOME TRAFFICKING AND PROCESSING OF ENDOSOMAL TLR | Genes involved in Trafficking and processing of endosomal TLR |
| 0.0 | 2.1 | REACTOME SMOOTH MUSCLE CONTRACTION | Genes involved in Smooth Muscle Contraction |
| 0.0 | 1.8 | REACTOME EFFECTS OF PIP2 HYDROLYSIS | Genes involved in Effects of PIP2 hydrolysis |