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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
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Results for ZNF524
Z-value: 1.04
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Transcription factors associated with ZNF524
Network of associatons between targets according to the STRING database.
First level regulatory network of ZNF524
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 4.1 | 20.6 | GO:1902612 | regulation of anti-Mullerian hormone signaling pathway(GO:1902612) negative regulation of anti-Mullerian hormone signaling pathway(GO:1902613) anti-Mullerian hormone signaling pathway(GO:1990262) |
| 1.2 | 17.1 | GO:0015074 | DNA integration(GO:0015074) |
| 4.1 | 16.4 | GO:0006542 | glutamine biosynthetic process(GO:0006542) |
| 3.3 | 13.3 | GO:0019072 | viral genome packaging(GO:0019072) viral RNA genome packaging(GO:0019074) |
| 1.9 | 13.2 | GO:0034587 | piRNA metabolic process(GO:0034587) |
| 3.1 | 12.5 | GO:0018230 | peptidyl-L-cysteine S-palmitoylation(GO:0018230) peptidyl-S-diacylglycerol-L-cysteine biosynthetic process from peptidyl-cysteine(GO:0018231) |
| 0.2 | 11.8 | GO:0045652 | regulation of megakaryocyte differentiation(GO:0045652) |
| 0.9 | 11.4 | GO:0001955 | blood vessel maturation(GO:0001955) |
| 1.1 | 11.0 | GO:0033629 | negative regulation of cell adhesion mediated by integrin(GO:0033629) |
| 0.3 | 10.6 | GO:0007140 | male meiosis(GO:0007140) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 71.8 | GO:0005615 | extracellular space(GO:0005615) |
| 0.1 | 21.7 | GO:0072562 | blood microparticle(GO:0072562) |
| 0.3 | 19.0 | GO:0045171 | intercellular bridge(GO:0045171) |
| 0.7 | 17.4 | GO:0097386 | glial cell projection(GO:0097386) |
| 0.1 | 16.9 | GO:0034705 | voltage-gated potassium channel complex(GO:0008076) potassium channel complex(GO:0034705) |
| 0.1 | 12.5 | GO:0016323 | basolateral plasma membrane(GO:0016323) |
| 0.1 | 12.4 | GO:0043679 | axon terminus(GO:0043679) |
| 0.1 | 11.5 | GO:0005581 | collagen trimer(GO:0005581) |
| 0.2 | 11.4 | GO:0016460 | myosin II complex(GO:0016460) |
| 0.1 | 11.0 | GO:0005796 | Golgi lumen(GO:0005796) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 36.0 | GO:0001071 | nucleic acid binding transcription factor activity(GO:0001071) transcription factor activity, sequence-specific DNA binding(GO:0003700) |
| 4.5 | 18.2 | GO:0097001 | ceramide binding(GO:0097001) |
| 4.1 | 16.4 | GO:0004356 | glutamate-ammonia ligase activity(GO:0004356) ammonia ligase activity(GO:0016211) acid-ammonia (or amide) ligase activity(GO:0016880) |
| 0.2 | 14.9 | GO:0005089 | Rho guanyl-nucleotide exchange factor activity(GO:0005089) |
| 0.7 | 13.9 | GO:0004185 | serine-type carboxypeptidase activity(GO:0004185) |
| 1.5 | 13.1 | GO:0004565 | beta-galactosidase activity(GO:0004565) |
| 0.1 | 12.6 | GO:0008083 | growth factor activity(GO:0008083) |
| 0.1 | 12.1 | GO:0017137 | Rab GTPase binding(GO:0017137) |
| 0.1 | 12.0 | GO:0005516 | calmodulin binding(GO:0005516) |
| 0.0 | 11.4 | GO:0005096 | GTPase activator activity(GO:0005096) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 31.6 | NABA SECRETED FACTORS | Genes encoding secreted soluble factors |
| 0.2 | 30.3 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.1 | 23.5 | NABA ECM GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 0.4 | 17.3 | NABA BASEMENT MEMBRANES | Genes encoding structural components of basement membranes |
| 0.3 | 15.6 | ST WNT BETA CATENIN PATHWAY | Wnt/beta-catenin Pathway |
| 0.3 | 15.4 | PID NEPHRIN NEPH1 PATHWAY | Nephrin/Neph1 signaling in the kidney podocyte |
| 0.2 | 12.7 | PID SYNDECAN 4 PATHWAY | Syndecan-4-mediated signaling events |
| 0.2 | 9.9 | PID PRL SIGNALING EVENTS PATHWAY | Signaling events mediated by PRL |
| 0.1 | 8.9 | PID ILK PATHWAY | Integrin-linked kinase signaling |
| 0.1 | 7.8 | PID ERBB4 PATHWAY | ErbB4 signaling events |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 38.3 | REACTOME GENERIC TRANSCRIPTION PATHWAY | Genes involved in Generic Transcription Pathway |
| 0.3 | 16.8 | REACTOME VOLTAGE GATED POTASSIUM CHANNELS | Genes involved in Voltage gated Potassium channels |
| 0.1 | 15.9 | REACTOME CLASS B 2 SECRETIN FAMILY RECEPTORS | Genes involved in Class B/2 (Secretin family receptors) |
| 0.1 | 15.5 | REACTOME PEPTIDE LIGAND BINDING RECEPTORS | Genes involved in Peptide ligand-binding receptors |
| 0.2 | 13.2 | REACTOME GLUCONEOGENESIS | Genes involved in Gluconeogenesis |
| 0.2 | 12.8 | REACTOME COLLAGEN FORMATION | Genes involved in Collagen formation |
| 0.2 | 10.8 | REACTOME ION TRANSPORT BY P TYPE ATPASES | Genes involved in Ion transport by P-type ATPases |
| 0.2 | 10.6 | REACTOME SMOOTH MUSCLE CONTRACTION | Genes involved in Smooth Muscle Contraction |
| 0.3 | 9.2 | REACTOME AMINO ACID SYNTHESIS AND INTERCONVERSION TRANSAMINATION | Genes involved in Amino acid synthesis and interconversion (transamination) |
| 0.5 | 8.6 | REACTOME REVERSIBLE HYDRATION OF CARBON DIOXIDE | Genes involved in Reversible Hydration of Carbon Dioxide |