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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
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Results for ZNF652
Z-value: 1.30
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Transcription factors associated with ZNF652
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| ZNF652 | hg38_v1_chr17_-_49362206_49362279 | -0.36 | 4.1e-08 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of ZNF652
| Promoter | Score | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr11_-_111911759 Show fit | 30.63 |
ENST00000650687.2
|
crystallin alpha B |
|
| chr4_-_89836213 Show fit | 27.27 |
ENST00000618500.4
ENST00000508895.5 |
synuclein alpha |
|
| chrX_+_103776831 Show fit | 27.14 |
ENST00000621218.5
ENST00000619236.1 |
proteolipid protein 1 |
|
| chr11_+_45146631 Show fit | 22.60 |
ENST00000534751.3
ENST00000683152.1 |
PR/SET domain 11 |
|
| chr4_-_164977644 Show fit | 17.72 |
ENST00000329314.6
ENST00000508856.2 |
tripartite motif containing 61 |
|
| chr16_+_56589521 Show fit | 16.93 |
ENST00000200691.5
ENST00000570176.1 |
metallothionein 3 |
|
| chr10_-_15371225 Show fit | 16.62 |
ENST00000378116.9
|
family with sequence similarity 171 member A1 |
|
| chr21_-_26843063 Show fit | 15.73 |
ENST00000678221.1
|
ADAM metallopeptidase with thrombospondin type 1 motif 1 |
|
| chr21_-_26843012 Show fit | 15.33 |
ENST00000517777.6
|
ADAM metallopeptidase with thrombospondin type 1 motif 1 |
|
| chr6_-_6004040 Show fit | 14.40 |
ENST00000622188.4
|
neuritin 1 |
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 6.5 | 39.1 | GO:0051621 | negative regulation of dopamine uptake involved in synaptic transmission(GO:0051585) norepinephrine uptake(GO:0051620) regulation of norepinephrine uptake(GO:0051621) negative regulation of norepinephrine uptake(GO:0051622) negative regulation of catecholamine uptake involved in synaptic transmission(GO:0051945) regulation of glutathione peroxidase activity(GO:1903282) positive regulation of glutathione peroxidase activity(GO:1903284) positive regulation of hydrogen peroxide catabolic process(GO:1903285) regulation of peroxidase activity(GO:2000468) positive regulation of peroxidase activity(GO:2000470) |
| 1.8 | 30.6 | GO:0007021 | tubulin complex assembly(GO:0007021) |
| 1.6 | 28.6 | GO:0001542 | ovulation from ovarian follicle(GO:0001542) |
| 1.3 | 23.3 | GO:0050812 | regulation of acyl-CoA biosynthetic process(GO:0050812) |
| 1.0 | 22.0 | GO:0042759 | long-chain fatty acid biosynthetic process(GO:0042759) |
| 0.2 | 21.9 | GO:0007368 | determination of left/right symmetry(GO:0007368) |
| 0.2 | 18.4 | GO:1903955 | positive regulation of protein targeting to mitochondrion(GO:1903955) |
| 5.6 | 16.9 | GO:0097212 | lysosomal membrane organization(GO:0097212) negative regulation of hydrogen peroxide catabolic process(GO:2000296) regulation of oxygen metabolic process(GO:2000374) |
| 0.8 | 15.9 | GO:0098828 | positive regulation of inhibitory postsynaptic potential(GO:0097151) modulation of inhibitory postsynaptic potential(GO:0098828) |
| 0.3 | 15.6 | GO:0018149 | peptide cross-linking(GO:0018149) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 49.9 | GO:0005604 | basement membrane(GO:0005604) |
| 1.2 | 44.4 | GO:0031092 | platelet alpha granule membrane(GO:0031092) |
| 0.2 | 37.8 | GO:0043209 | myelin sheath(GO:0043209) |
| 1.9 | 30.6 | GO:0097512 | cardiac myofibril(GO:0097512) |
| 0.2 | 30.0 | GO:0043202 | lysosomal lumen(GO:0043202) |
| 3.9 | 23.3 | GO:0005967 | mitochondrial pyruvate dehydrogenase complex(GO:0005967) |
| 0.0 | 23.0 | GO:0031226 | intrinsic component of plasma membrane(GO:0031226) |
| 0.3 | 18.5 | GO:0048786 | presynaptic active zone(GO:0048786) |
| 0.5 | 18.4 | GO:0016581 | NuRD complex(GO:0016581) CHD-type complex(GO:0090545) |
| 0.1 | 18.3 | GO:0045211 | postsynaptic membrane(GO:0045211) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 6.5 | 39.1 | GO:0060961 | phospholipase D inhibitor activity(GO:0060961) |
| 3.2 | 38.5 | GO:0019911 | structural constituent of myelin sheath(GO:0019911) |
| 1.0 | 31.3 | GO:0005212 | structural constituent of eye lens(GO:0005212) |
| 0.2 | 31.0 | GO:0004222 | metalloendopeptidase activity(GO:0004222) |
| 0.3 | 26.9 | GO:0004867 | serine-type endopeptidase inhibitor activity(GO:0004867) |
| 0.0 | 23.5 | GO:0046872 | metal ion binding(GO:0046872) |
| 3.9 | 23.3 | GO:0004740 | pyruvate dehydrogenase (acetyl-transferring) kinase activity(GO:0004740) |
| 0.1 | 18.1 | GO:0017137 | Rab GTPase binding(GO:0017137) |
| 0.6 | 17.9 | GO:0097109 | neuroligin family protein binding(GO:0097109) |
| 1.3 | 16.9 | GO:0046870 | cadmium ion binding(GO:0046870) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 93.8 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.7 | 40.3 | PID ALPHA SYNUCLEIN PATHWAY | Alpha-synuclein signaling |
| 0.7 | 33.4 | PID INTEGRIN2 PATHWAY | Beta2 integrin cell surface interactions |
| 0.1 | 29.8 | NABA ECM GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 0.3 | 15.4 | NABA COLLAGENS | Genes encoding collagen proteins |
| 0.2 | 12.1 | ST MYOCYTE AD PATHWAY | Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway. |
| 0.1 | 8.0 | PID AR TF PATHWAY | Regulation of Androgen receptor activity |
| 0.1 | 7.1 | PID SMAD2 3NUCLEAR PATHWAY | Regulation of nuclear SMAD2/3 signaling |
| 0.1 | 6.4 | NABA PROTEOGLYCANS | Genes encoding proteoglycans |
| 0.1 | 5.8 | PID SYNDECAN 4 PATHWAY | Syndecan-4-mediated signaling events |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.1 | 53.8 | REACTOME AMYLOIDS | Genes involved in Amyloids |
| 1.4 | 23.3 | REACTOME REGULATION OF PYRUVATE DEHYDROGENASE PDH COMPLEX | Genes involved in Regulation of pyruvate dehydrogenase (PDH) complex |
| 0.7 | 15.9 | REACTOME NOREPINEPHRINE NEUROTRANSMITTER RELEASE CYCLE | Genes involved in Norepinephrine Neurotransmitter Release Cycle |
| 0.2 | 15.4 | REACTOME COLLAGEN FORMATION | Genes involved in Collagen formation |
| 0.6 | 14.0 | REACTOME INTRINSIC PATHWAY | Genes involved in Intrinsic Pathway |
| 0.7 | 11.2 | REACTOME KERATAN SULFATE DEGRADATION | Genes involved in Keratan sulfate degradation |
| 0.2 | 10.5 | REACTOME VOLTAGE GATED POTASSIUM CHANNELS | Genes involved in Voltage gated Potassium channels |
| 0.5 | 9.3 | REACTOME PROCESSING OF INTRONLESS PRE MRNAS | Genes involved in Processing of Intronless Pre-mRNAs |
| 0.8 | 9.0 | REACTOME NEGATIVE REGULATION OF THE PI3K AKT NETWORK | Genes involved in Negative regulation of the PI3K/AKT network |
| 0.5 | 8.9 | REACTOME XENOBIOTICS | Genes involved in Xenobiotics |