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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
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Results for ZNF691
Z-value: 0.54
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Transcription factors associated with ZNF691
Network of associatons between targets according to the STRING database.
First level regulatory network of ZNF691
| Promoter | Score | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr1_+_26317950 Show fit | 10.47 |
ENST00000374213.3
|
CD52 molecule |
|
| chr12_-_51324091 Show fit | 8.30 |
ENST00000604560.6
|
bridging integrator 2 |
|
| chr12_-_51324164 Show fit | 7.26 |
ENST00000615107.6
|
bridging integrator 2 |
|
| chr12_-_51324138 Show fit | 7.24 |
ENST00000452142.7
|
bridging integrator 2 |
|
| chr1_+_27872536 Show fit | 6.57 |
ENST00000328928.11
ENST00000373921.8 ENST00000373925.5 ENST00000373927.7 ENST00000427466.1 ENST00000442118.5 |
thymocyte selection associated family member 2 |
|
| chr12_-_51324652 Show fit | 6.56 |
ENST00000544402.5
|
bridging integrator 2 |
|
| chr17_+_82458733 Show fit | 4.89 |
ENST00000309794.16
ENST00000577410.2 |
nuclear prelamin A recognition factor |
|
| chr6_+_31586269 Show fit | 4.76 |
ENST00000438075.7
|
leukocyte specific transcript 1 |
|
| chr2_+_68734773 Show fit | 4.55 |
ENST00000409202.8
|
Rho GTPase activating protein 25 |
|
| chrX_+_103215072 Show fit | 4.52 |
ENST00000372695.6
ENST00000372691.3 |
brain expressed X-linked 4 |
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.3 | 29.4 | GO:0097320 | membrane tubulation(GO:0097320) |
| 0.3 | 10.5 | GO:0045730 | respiratory burst(GO:0045730) |
| 0.1 | 8.3 | GO:0050672 | negative regulation of mononuclear cell proliferation(GO:0032945) negative regulation of lymphocyte proliferation(GO:0050672) |
| 0.0 | 7.0 | GO:0050852 | T cell receptor signaling pathway(GO:0050852) |
| 0.1 | 5.7 | GO:0090502 | RNA phosphodiester bond hydrolysis, endonucleolytic(GO:0090502) |
| 0.1 | 5.6 | GO:0061045 | negative regulation of wound healing(GO:0061045) |
| 0.3 | 5.3 | GO:0097296 | activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway(GO:0097296) |
| 1.2 | 4.6 | GO:0052148 | modulation by virus of host molecular function(GO:0039506) suppression by virus of host molecular function(GO:0039507) suppression by virus of host catalytic activity(GO:0039513) modulation by virus of host catalytic activity(GO:0039516) suppression by virus of host cysteine-type endopeptidase activity involved in apoptotic process(GO:0039650) negative regulation by symbiont of host catalytic activity(GO:0052053) negative regulation by symbiont of host molecular function(GO:0052056) modulation by symbiont of host catalytic activity(GO:0052148) |
| 1.5 | 4.5 | GO:1902960 | regulation of choline O-acetyltransferase activity(GO:1902769) positive regulation of choline O-acetyltransferase activity(GO:1902771) negative regulation of tau-protein kinase activity(GO:1902948) positive regulation of early endosome to recycling endosome transport(GO:1902955) negative regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process(GO:1902960) negative regulation of neurofibrillary tangle assembly(GO:1902997) negative regulation of aspartic-type peptidase activity(GO:1905246) |
| 0.1 | 4.3 | GO:0046949 | fatty-acyl-CoA biosynthetic process(GO:0046949) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.1 | 29.4 | GO:0001891 | phagocytic cup(GO:0001891) |
| 1.0 | 11.2 | GO:0005638 | lamin filament(GO:0005638) |
| 0.1 | 10.4 | GO:0031225 | anchored component of membrane(GO:0031225) |
| 0.2 | 4.6 | GO:0097342 | ripoptosome(GO:0097342) |
| 0.2 | 4.5 | GO:0005641 | nuclear envelope lumen(GO:0005641) |
| 0.0 | 4.0 | GO:0009897 | external side of plasma membrane(GO:0009897) |
| 0.0 | 3.6 | GO:0016459 | myosin complex(GO:0016459) |
| 0.0 | 3.4 | GO:0005834 | heterotrimeric G-protein complex(GO:0005834) |
| 0.0 | 2.8 | GO:0001669 | acrosomal vesicle(GO:0001669) |
| 0.1 | 2.4 | GO:0030687 | preribosome, large subunit precursor(GO:0030687) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 30.2 | GO:0005543 | phospholipid binding(GO:0005543) |
| 0.4 | 11.2 | GO:0005521 | lamin binding(GO:0005521) |
| 0.0 | 9.5 | GO:0005096 | GTPase activator activity(GO:0005096) |
| 0.2 | 7.0 | GO:0005164 | tumor necrosis factor receptor binding(GO:0005164) |
| 1.1 | 5.7 | GO:0004522 | ribonuclease A activity(GO:0004522) |
| 0.1 | 5.6 | GO:0004867 | serine-type endopeptidase inhibitor activity(GO:0004867) |
| 0.8 | 4.6 | GO:0097199 | cysteine-type endopeptidase activity involved in apoptotic signaling pathway(GO:0097199) |
| 0.3 | 4.5 | GO:0030306 | ADP-ribosylation factor binding(GO:0030306) |
| 0.3 | 3.9 | GO:0019957 | C-C chemokine binding(GO:0019957) |
| 0.7 | 2.9 | GO:0004609 | phosphatidylserine decarboxylase activity(GO:0004609) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 10.0 | PID TRAIL PATHWAY | TRAIL signaling pathway |
| 0.0 | 3.9 | PID IL12 2PATHWAY | IL12-mediated signaling events |
| 0.1 | 2.9 | PID S1P S1P4 PATHWAY | S1P4 pathway |
| 0.0 | 2.9 | PID IL6 7 PATHWAY | IL6-mediated signaling events |
| 0.0 | 2.9 | PID HNF3A PATHWAY | FOXA1 transcription factor network |
| 0.0 | 2.0 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.1 | 1.8 | PID IL5 PATHWAY | IL5-mediated signaling events |
| 0.0 | 1.7 | PID CD40 PATHWAY | CD40/CD40L signaling |
| 0.0 | 1.6 | PID EPHRINB REV PATHWAY | Ephrin B reverse signaling |
| 0.0 | 1.4 | PID PRL SIGNALING EVENTS PATHWAY | Signaling events mediated by PRL |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 10.0 | REACTOME EXTRINSIC PATHWAY FOR APOPTOSIS | Genes involved in Extrinsic Pathway for Apoptosis |
| 0.0 | 8.2 | REACTOME SIGNALING BY RHO GTPASES | Genes involved in Signaling by Rho GTPases |
| 0.6 | 3.9 | REACTOME BINDING AND ENTRY OF HIV VIRION | Genes involved in Binding and entry of HIV virion |
| 0.0 | 3.3 | REACTOME PEPTIDE LIGAND BINDING RECEPTORS | Genes involved in Peptide ligand-binding receptors |
| 0.1 | 2.9 | REACTOME SIGNAL REGULATORY PROTEIN SIRP FAMILY INTERACTIONS | Genes involved in Signal regulatory protein (SIRP) family interactions |
| 0.1 | 2.9 | REACTOME INHIBITION OF INSULIN SECRETION BY ADRENALINE NORADRENALINE | Genes involved in Inhibition of Insulin Secretion by Adrenaline/Noradrenaline |
| 0.1 | 2.3 | REACTOME SYNTHESIS OF VERY LONG CHAIN FATTY ACYL COAS | Genes involved in Synthesis of very long-chain fatty acyl-CoAs |
| 0.0 | 2.2 | REACTOME STRIATED MUSCLE CONTRACTION | Genes involved in Striated Muscle Contraction |
| 0.0 | 2.1 | REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL | Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell |
| 0.1 | 1.8 | REACTOME REPAIR SYNTHESIS FOR GAP FILLING BY DNA POL IN TC NER | Genes involved in Repair synthesis for gap-filling by DNA polymerase in TC-NER |