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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
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Results for ZNF740_ZNF219
Z-value: 1.28
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Transcription factors associated with ZNF740_ZNF219
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| ZNF219 | hg38_v1_chr14_-_21098848_21099014, hg38_v1_chr14_-_21098570_21098678 | -0.19 | 4.0e-03 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of ZNF740_ZNF219
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.1 | 119.0 | GO:0043486 | histone exchange(GO:0043486) |
| 6.8 | 75.0 | GO:0000056 | ribosomal small subunit export from nucleus(GO:0000056) |
| 6.5 | 58.2 | GO:0072553 | terminal button organization(GO:0072553) |
| 0.5 | 54.1 | GO:0042035 | regulation of cytokine biosynthetic process(GO:0042035) |
| 0.7 | 45.3 | GO:0006334 | nucleosome assembly(GO:0006334) |
| 0.5 | 45.2 | GO:0006369 | termination of RNA polymerase II transcription(GO:0006369) |
| 3.8 | 38.2 | GO:1903377 | negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway(GO:1903377) |
| 2.4 | 31.6 | GO:0043983 | histone H4-K12 acetylation(GO:0043983) |
| 0.3 | 28.3 | GO:0036498 | IRE1-mediated unfolded protein response(GO:0036498) |
| 0.3 | 28.1 | GO:0031146 | SCF-dependent proteasomal ubiquitin-dependent protein catabolic process(GO:0031146) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 213.8 | GO:0005654 | nucleoplasm(GO:0005654) |
| 6.1 | 115.1 | GO:0000812 | Swr1 complex(GO:0000812) |
| 4.8 | 77.4 | GO:0005642 | annulate lamellae(GO:0005642) |
| 0.1 | 56.7 | GO:0016607 | nuclear speck(GO:0016607) |
| 0.3 | 42.5 | GO:0016605 | PML body(GO:0016605) |
| 1.4 | 35.4 | GO:0090545 | NuRD complex(GO:0016581) CHD-type complex(GO:0090545) |
| 0.1 | 30.8 | GO:0016604 | nuclear body(GO:0016604) |
| 1.4 | 29.7 | GO:0035098 | ESC/E(Z) complex(GO:0035098) |
| 3.1 | 27.5 | GO:0042382 | paraspeckles(GO:0042382) |
| 0.8 | 26.7 | GO:0071564 | SWI/SNF complex(GO:0016514) npBAF complex(GO:0071564) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.8 | 100.1 | GO:0019212 | phosphatase inhibitor activity(GO:0019212) |
| 5.3 | 78.9 | GO:0005049 | nuclear export signal receptor activity(GO:0005049) |
| 1.5 | 72.7 | GO:0031492 | nucleosomal DNA binding(GO:0031492) |
| 0.6 | 70.5 | GO:0000979 | RNA polymerase II core promoter sequence-specific DNA binding(GO:0000979) |
| 1.4 | 60.7 | GO:0048027 | mRNA 5'-UTR binding(GO:0048027) |
| 1.4 | 47.2 | GO:0070577 | lysine-acetylated histone binding(GO:0070577) |
| 0.8 | 33.5 | GO:0046966 | thyroid hormone receptor binding(GO:0046966) |
| 0.7 | 29.9 | GO:0061650 | ubiquitin conjugating enzyme activity(GO:0061631) ubiquitin-like protein conjugating enzyme activity(GO:0061650) |
| 4.9 | 29.6 | GO:0008420 | CTD phosphatase activity(GO:0008420) |
| 0.4 | 27.2 | GO:0003705 | transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0003705) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 3.3 | 75.0 | PID RANBP2 PATHWAY | Sumoylation by RanBP2 regulates transcriptional repression |
| 0.5 | 59.2 | PID RB 1PATHWAY | Regulation of retinoblastoma protein |
| 0.5 | 46.6 | PID HDAC CLASSI PATHWAY | Signaling events mediated by HDAC Class I |
| 0.5 | 39.7 | PID TGFBR PATHWAY | TGF-beta receptor signaling |
| 0.5 | 39.4 | PID PLK1 PATHWAY | PLK1 signaling events |
| 1.0 | 36.5 | PID SMAD2 3PATHWAY | Regulation of cytoplasmic and nuclear SMAD2/3 signaling |
| 0.4 | 32.4 | PID AP1 PATHWAY | AP-1 transcription factor network |
| 0.5 | 30.0 | ST ERK1 ERK2 MAPK PATHWAY | ERK1/ERK2 MAPK Pathway |
| 1.5 | 28.8 | PID CIRCADIAN PATHWAY | Circadian rhythm pathway |
| 0.4 | 26.0 | PID TELOMERASE PATHWAY | Regulation of Telomerase |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.7 | 78.6 | REACTOME CYCLIN A B1 ASSOCIATED EVENTS DURING G2 M TRANSITION | Genes involved in Cyclin A/B1 associated events during G2/M transition |
| 0.4 | 75.1 | REACTOME DIABETES PATHWAYS | Genes involved in Diabetes pathways |
| 0.4 | 63.4 | REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION | Genes involved in Antigen processing: Ubiquitination & Proteasome degradation |
| 0.8 | 37.7 | REACTOME DOWNREGULATION OF SMAD2 3 SMAD4 TRANSCRIPTIONAL ACTIVITY | Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity |
| 0.2 | 37.1 | REACTOME MRNA SPLICING | Genes involved in mRNA Splicing |
| 0.7 | 34.7 | REACTOME MEIOTIC SYNAPSIS | Genes involved in Meiotic Synapsis |
| 0.5 | 34.6 | REACTOME CROSS PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS ENDOSOMES | Genes involved in Cross-presentation of soluble exogenous antigens (endosomes) |
| 0.5 | 28.9 | REACTOME G1 PHASE | Genes involved in G1 Phase |
| 0.6 | 22.4 | REACTOME DEADENYLATION OF MRNA | Genes involved in Deadenylation of mRNA |
| 0.5 | 21.1 | REACTOME NUCLEAR EVENTS KINASE AND TRANSCRIPTION FACTOR ACTIVATION | Genes involved in Nuclear Events (kinase and transcription factor activation) |