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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
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Results for ZNF784
Z-value: 1.19
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Transcription factors associated with ZNF784
Network of associatons between targets according to the STRING database.
First level regulatory network of ZNF784
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.0 | 41.4 | GO:0035235 | ionotropic glutamate receptor signaling pathway(GO:0035235) |
| 6.8 | 40.6 | GO:0051621 | negative regulation of dopamine uptake involved in synaptic transmission(GO:0051585) norepinephrine uptake(GO:0051620) regulation of norepinephrine uptake(GO:0051621) negative regulation of norepinephrine uptake(GO:0051622) negative regulation of catecholamine uptake involved in synaptic transmission(GO:0051945) regulation of glutathione peroxidase activity(GO:1903282) positive regulation of glutathione peroxidase activity(GO:1903284) positive regulation of hydrogen peroxide catabolic process(GO:1903285) regulation of peroxidase activity(GO:2000468) positive regulation of peroxidase activity(GO:2000470) |
| 1.4 | 40.5 | GO:0050651 | dermatan sulfate proteoglycan biosynthetic process(GO:0050651) |
| 12.3 | 36.9 | GO:2000097 | regulation of smooth muscle cell-matrix adhesion(GO:2000097) |
| 10.6 | 31.8 | GO:0050760 | negative regulation of thymidylate synthase biosynthetic process(GO:0050760) |
| 10.3 | 30.9 | GO:0030185 | nitric oxide transport(GO:0030185) |
| 3.4 | 30.6 | GO:0060075 | regulation of resting membrane potential(GO:0060075) |
| 1.1 | 29.2 | GO:0071420 | cellular response to histamine(GO:0071420) |
| 6.3 | 25.3 | GO:0031117 | positive regulation of microtubule depolymerization(GO:0031117) |
| 1.7 | 24.3 | GO:0032099 | negative regulation of response to food(GO:0032096) negative regulation of appetite(GO:0032099) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 52.0 | GO:0043202 | lysosomal lumen(GO:0043202) |
| 15.0 | 45.0 | GO:0098843 | postsynaptic endocytic zone(GO:0098843) |
| 0.1 | 39.0 | GO:0043025 | neuronal cell body(GO:0043025) |
| 1.0 | 37.8 | GO:0031092 | platelet alpha granule membrane(GO:0031092) |
| 7.7 | 30.9 | GO:0031838 | haptoglobin-hemoglobin complex(GO:0031838) |
| 4.4 | 30.6 | GO:0044326 | dendritic spine neck(GO:0044326) |
| 0.7 | 29.2 | GO:1902711 | GABA-A receptor complex(GO:1902711) |
| 4.0 | 28.1 | GO:1990761 | growth cone lamellipodium(GO:1990761) |
| 0.1 | 25.3 | GO:0030426 | growth cone(GO:0030426) |
| 2.2 | 24.3 | GO:0043203 | axon hillock(GO:0043203) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 5.6 | 45.0 | GO:0004971 | AMPA glutamate receptor activity(GO:0004971) |
| 6.8 | 40.6 | GO:0060961 | phospholipase D inhibitor activity(GO:0060961) |
| 0.6 | 36.9 | GO:0015485 | cholesterol binding(GO:0015485) |
| 1.6 | 31.7 | GO:0048156 | tau protein binding(GO:0048156) |
| 0.7 | 31.3 | GO:0017091 | AU-rich element binding(GO:0017091) |
| 4.4 | 30.9 | GO:0030492 | hemoglobin binding(GO:0030492) |
| 2.4 | 30.6 | GO:0005391 | sodium:potassium-exchanging ATPase activity(GO:0005391) steroid hormone binding(GO:1990239) |
| 0.3 | 28.8 | GO:0005518 | collagen binding(GO:0005518) |
| 4.5 | 26.9 | GO:0099529 | neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential(GO:0099529) transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential(GO:1904315) |
| 0.2 | 26.2 | GO:0005089 | Rho guanyl-nucleotide exchange factor activity(GO:0005089) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 46.8 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.7 | 40.6 | PID ALPHA SYNUCLEIN PATHWAY | Alpha-synuclein signaling |
| 0.6 | 37.1 | PID NCADHERIN PATHWAY | N-cadherin signaling events |
| 0.3 | 32.9 | PID ERA GENOMIC PATHWAY | Validated nuclear estrogen receptor alpha network |
| 0.6 | 32.4 | NABA PROTEOGLYCANS | Genes encoding proteoglycans |
| 0.5 | 25.2 | ST WNT BETA CATENIN PATHWAY | Wnt/beta-catenin Pathway |
| 0.1 | 19.7 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.1 | 16.3 | PID P53 DOWNSTREAM PATHWAY | Direct p53 effectors |
| 0.1 | 14.9 | PID AR PATHWAY | Coregulation of Androgen receptor activity |
| 0.5 | 14.6 | PID S1P S1P1 PATHWAY | S1P1 pathway |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.7 | 45.0 | REACTOME TRAFFICKING OF GLUR2 CONTAINING AMPA RECEPTORS | Genes involved in Trafficking of GluR2-containing AMPA receptors |
| 0.8 | 38.1 | REACTOME AMYLOIDS | Genes involved in Amyloids |
| 0.6 | 30.6 | REACTOME ION TRANSPORT BY P TYPE ATPASES | Genes involved in Ion transport by P-type ATPases |
| 0.2 | 30.0 | REACTOME PEPTIDE LIGAND BINDING RECEPTORS | Genes involved in Peptide ligand-binding receptors |
| 0.8 | 29.2 | REACTOME GABA A RECEPTOR ACTIVATION | Genes involved in GABA A receptor activation |
| 0.4 | 24.6 | REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES | Genes involved in Chemokine receptors bind chemokines |
| 0.6 | 24.3 | REACTOME A TETRASACCHARIDE LINKER SEQUENCE IS REQUIRED FOR GAG SYNTHESIS | Genes involved in A tetrasaccharide linker sequence is required for GAG synthesis |
| 0.1 | 20.8 | REACTOME FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION | Genes involved in Factors involved in megakaryocyte development and platelet production |
| 0.3 | 20.1 | REACTOME NCAM1 INTERACTIONS | Genes involved in NCAM1 interactions |
| 0.6 | 19.3 | REACTOME METABOLISM OF PORPHYRINS | Genes involved in Metabolism of porphyrins |